Research Topics
| Iain A WilsonSummaryAffiliation: University of Kuopio Country: Finland Publications
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Detail Information
Publications
Estrogen and NMDA receptor antagonism: effects upon reference and working memoryI A Wilson
Department of Neuroscience and Neurology, University of Kuopio, Finland
Eur J Pharmacol 381:93-9. 1999..These results suggest that short term estrogen deprivation has no effect upon spatial-reference memory, while it impairs spatial working memory. This effect is probably not mediated by NMDA receptors...
Place cell rigidity correlates with impaired spatial learning in aged ratsI A Wilson
Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
Neurobiol Aging 24:297-305. 2003....
Cognitive aging and the hippocampus: how old rats represent new environmentsIain A Wilson
Department of Neuroscience and Neurology, University of Kuopio, Kuopio 70211, Finland
J Neurosci 24:3870-8. 2004..These observations help to reconcile previously divergent characterizations of spatial representation in aged rats and suggest a model of cognitive aging and hippocampal function...
Place cells of aged rats in two visually identical compartmentsIain A Wilson
Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627 Harjulantie 1, Kuopio 70211, Finland
Neurobiol Aging 26:1099-106. 2005..These findings suggest that the hippocampal network of aged rats is able to process changes in internally generated cues without rigidity, but that incomplete processing of external landmark cues may lead to impaired spatial learning...
Age-associated alterations of hippocampal place cells are subregion specificIain A Wilson
Department of Neuroscience and Neurology, University of Kuopio, Kuopio 70211, Finland
J Neurosci 25:6877-86. 2005..Thus, aged CA3 cells failed to rapidly encode new spatial information compared with young CA3 cells. These data suggest an important and selective contribution of CA3 dysfunction to age-related memory impairment...
Neurocognitive aging: prior memories hinder new hippocampal encodingIain A Wilson
Department of Neuroscience and Neurology, University of Kuopio, Kuopio 70211, Finland
Trends Neurosci 29:662-70. 2006..As a result of such reorganization in aged memory-impaired individuals, information that is already stored would become the dominant pattern of the hippocampus to the detriment of the ability to encode new information...
