Jukka Westermarck

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. pmc CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice
    Sami Ventelä
    Turku Centre for Biotechnology, University of Turku, Turku, Finland
    PLoS ONE 7:e33209. 2012
  2. pmc ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells
    Anchit Khanna
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    PLoS ONE 6:e17979. 2011
  3. ncbi request reprint Regulation of matrix metalloproteinase expression in tumor invasion
    J Westermarck
    MediCity Research Laboratory, Department of Medical Biochemistry, University of Turku, Finland
    FASEB J 13:781-92. 1999
  4. pmc p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, University of Turku, FIN 20520 Turku, Finland
    Mol Cell Biol 21:2373-83. 2001
  5. ncbi request reprint Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, Finland
    Cancer Res 60:7156-62. 2000
  6. pmc Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme
    Kristian Ovaska
    Computational Systems Biology Laboratory, Institute of Biomedicine and Genome Scale Biology Research Program, University of Helsinki, Haartmaninkatu 8, Helsinki, FIN 00014, Finland
    Genome Med 2:65. 2010
  7. pmc Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1
    Anni Laine
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    Cancer Discov 3:182-97. 2013
  8. ncbi request reprint p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2
    Song Ping Li
    Turku Centre for Biotechnology, University of Turku, Finland
    Cancer Res 63:3473-7. 2003
  9. doi request reprint CIP2A is associated with human breast cancer aggressivity
    Christophe Come
    Centre for Biotechnology, University of Turku, Turku, Finland
    Clin Cancer Res 15:5092-100. 2009
  10. doi request reprint MYC-dependent regulation and prognostic role of CIP2A in gastric cancer
    Anchit Khanna
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Natl Cancer Inst 101:793-805. 2009

Collaborators

Detail Information

Publications21

  1. pmc CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice
    Sami Ventelä
    Turku Centre for Biotechnology, University of Turku, Turku, Finland
    PLoS ONE 7:e33209. 2012
    ....
  2. pmc ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells
    Anchit Khanna
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    PLoS ONE 6:e17979. 2011
    ..These results also suggest that in addition to its established role in invasion and angiogenesis, ETS1 may support malignant cellular growth via regulation of CIP2A expression and protein phosphatase 2A inhibition...
  3. ncbi request reprint Regulation of matrix metalloproteinase expression in tumor invasion
    J Westermarck
    MediCity Research Laboratory, Department of Medical Biochemistry, University of Turku, Finland
    FASEB J 13:781-92. 1999
    ....
  4. pmc p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, University of Turku, FIN 20520 Turku, Finland
    Mol Cell Biol 21:2373-83. 2001
    ..These results provide evidence that activation of signaling cascade MKK3-MKK3b-->p38alpha blocks the ERK1,2 pathway at the level of MEK1,2 via PP1-PP2A and inhibits the activation of MMP-1 gene expression...
  5. ncbi request reprint Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, Finland
    Cancer Res 60:7156-62. 2000
    ....
  6. pmc Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme
    Kristian Ovaska
    Computational Systems Biology Laboratory, Institute of Biomedicine and Genome Scale Biology Research Program, University of Helsinki, Haartmaninkatu 8, Helsinki, FIN 00014, Finland
    Genome Med 2:65. 2010
    ..Anduril is available at http://csbi.ltdk.helsinki.fi/anduril/The glioblastoma multiforme analysis results are available at http://csbi.ltdk.helsinki.fi/anduril/tcga-gbm/..
  7. pmc Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1
    Anni Laine
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    Cancer Discov 3:182-97. 2013
    ..This feedback loop also constitutes a promising prosenescence target for therapy of cancers with an inactivated p53-p21 pathway...
  8. ncbi request reprint p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2
    Song Ping Li
    Turku Centre for Biotechnology, University of Turku, Finland
    Cancer Res 63:3473-7. 2003
    ..In addition, we show that in all transformed cell lines we have studied thus far, the function of this pathway is impaired...
  9. doi request reprint CIP2A is associated with human breast cancer aggressivity
    Christophe Come
    Centre for Biotechnology, University of Turku, Turku, Finland
    Clin Cancer Res 15:5092-100. 2009
    ..To investigate the clinical relevance of the recently characterized human oncoprotein cancerous inhibitor of protein phosphatase 2A (CIP2A) in human breast cancer...
  10. doi request reprint MYC-dependent regulation and prognostic role of CIP2A in gastric cancer
    Anchit Khanna
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Natl Cancer Inst 101:793-805. 2009
    ..However, the clinical relevance of CIP2A to human cancers had not been demonstrated, but the mechanism of its regulation and its clinical role in cancer were completely unknown...
  11. pmc Hypoxia-activated Smad3-specific dephosphorylation by PP2A
    Pekka T Heikkinen
    Turku Centre for Biotechnology, Turku University, Turku, Finland
    J Biol Chem 285:3740-9. 2010
    ..Our data demonstrate the existence of a Smad3-specific phosphatase and identify a novel role for PP2A. Moreover, our data implicate a novel mechanism by which hypoxia regulates growth factor responses...
  12. pmc PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma
    Pietri Puustinen
    Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    Cancer Res 69:2870-7. 2009
    ....
  13. doi request reprint Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target
    Anchit Khanna
    Authors Affiliations Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Hospital, University of New South Wales UNSW Medicine Translational Cancer Research Network, University of New South Wales UNSW, Sydney, Australia Turku Centre for Biotechnology, University of Turku and Åbo Akademi University and Department of Pathology, University of Turku, Turku, Finland
    Cancer Res 73:6548-53. 2013
    ..The potential approaches and feasibility of targeting CIP2A are discussed here...
  14. ncbi request reprint Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
    Melissa R Junttila
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    FASEB J 22:954-65. 2008
    ..In addition, we will discuss the potential functional relevance of negative regulation of ERK pathway activity, for physiological and pathological conditions (e.g., cellular transformation)...
  15. doi request reprint Identification and regulation of a stage-specific stem cell niche enriched by Nanog-positive spermatogonial stem cells in the mouse testis
    Sami Ventelä
    Department of Physiology, University of Turku, Kiinamyllynkatu, Turku, Finland
    Stem Cells 30:1008-20. 2012
    ..This study demonstrates the existence and location of a previously unknown stage-specific spermatogonial stem cell niche and reports the regulation of radioresistant spermatogonial stem cells...
  16. ncbi request reprint Activation of p53 in cervical cancer cells by human papillomavirus E6 RNA interference is transient, but can be sustained by inhibiting endogenous nuclear export-dependent p53 antagonists
    Riku Koivusalo
    The Joint Clinical Biochemistry Laboratory of University of Turku, Turku University Central Hospital and Wallac Oy, Turku, Finland
    Cancer Res 66:11817-24. 2006
    ..The present results indicate that several cellular p53 antagonists must be inhibited for sustained p53 activity if E6 siRNA therapy is attempted and if no combined genotoxic therapy is applied...
  17. doi request reprint Regulation of transcription factor function by targeted protein degradation: an overview focusing on p53, c-Myc, and c-Jun
    Jukka Westermarck
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    Methods Mol Biol 647:31-6. 2010
    ..Lastly, we discuss the common theme among p53, c-Myc, and c-Jun proteins that the N-terminal phosphorylation both increases the transactivation capacity of the protein and protects the protein from proteolytic degradation...
  18. ncbi request reprint Single-step Strep-tag purification for the isolation and identification of protein complexes from mammalian cells
    Melissa R Junttila
    Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    Proteomics 5:1199-203. 2005
    ..The benefits and potential applications of the Strep-tag method for protein complex purification are discussed...
  19. doi request reprint Multiple pathways regulated by the tumor suppressor PP2A in transformation
    Jukka Westermarck
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland
    Trends Mol Med 14:152-60. 2008
    ..Here, we review recent progress in our understanding of how PP2A regulates mitogenic signaling pathways in cancer pathogenesis and how PP2A activity is modulated in human cancers...
  20. doi request reprint PRELI is a mitochondrial regulator of human primary T-helper cell apoptosis, STAT6, and Th2-cell differentiation
    Johanna Tahvanainen
    Turku Centre for Biotechnology, University of Turku and Abo Akademi, Turku, Finland
    Blood 113:1268-77. 2009
    ..This study identifies PRELI as a novel factor influencing the human primary Th-cell death and differentiation...
  21. pmc Identification of protein interactions involved in cellular signaling
    Jukka Westermarck
    Centre for Biotechnology, University of Turku and Abo Akademi, Turku, Finland
    Mol Cell Proteomics 12:1752-63. 2013
    ..Finally, we discuss shotgun and quantitative information that can be gleaned by MS-coupled methods for analysis of multiprotein complexes. ..