Jukka Westermarck

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint Regulation of matrix metalloproteinase expression in tumor invasion
    J Westermarck
    MediCity Research Laboratory, Department of Medical Biochemistry, University of Turku, Finland
    FASEB J 13:781-92. 1999
  2. ncbi request reprint Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, Finland
    Cancer Res 60:7156-62. 2000
  3. pmc p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, University of Turku, FIN 20520 Turku, Finland
    Mol Cell Biol 21:2373-83. 2001
  4. pmc Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme
    Kristian Ovaska
    Computational Systems Biology Laboratory, Institute of Biomedicine and Genome Scale Biology Research Program, University of Helsinki, Haartmaninkatu 8, Helsinki, FIN 00014, Finland
    Genome Med 2:65. 2010
  5. pmc Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1
    Anni Laine
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    Cancer Discov 3:182-97. 2013
  6. ncbi request reprint p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2
    Song Ping Li
    Turku Centre for Biotechnology, University of Turku, Finland
    Cancer Res 63:3473-7. 2003
  7. ncbi request reprint Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
    Melissa R Junttila
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    FASEB J 22:954-65. 2008
  8. pmc CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice
    Sami Ventelä
    Turku Centre for Biotechnology, University of Turku, Turku, Finland
    PLoS ONE 7:e33209. 2012
  9. doi request reprint Identification and regulation of a stage-specific stem cell niche enriched by Nanog-positive spermatogonial stem cells in the mouse testis
    Sami Ventelä
    Department of Physiology, University of Turku, Kiinamyllynkatu, Turku, Finland
    Stem Cells 30:1008-20. 2012
  10. pmc Hypoxia-activated Smad3-specific dephosphorylation by PP2A
    Pekka T Heikkinen
    Turku Centre for Biotechnology, Turku University, Turku, Finland
    J Biol Chem 285:3740-9. 2010

Collaborators

  • V M Kahari
  • Edward K Chan
  • T Kallunki
  • Kevin M Ryan
  • Gerard I Evan
  • Harri Sihto
  • Pirkko Liisa Kellokumpu-Lehtinen
  • S Li
  • Johanna Ivaska
  • Olli Kallioniemi
  • Jos Jonkers
  • J Han
  • Caroline S Hill
  • Sami Ventelä
  • Christophe Come
  • Anni Laine
  • Melissa R Junttila
  • Juho Antti Mäkelä
  • Jorma Toppari
  • Kristian Ovaska
  • Pekka T Heikkinen
  • Heikki Joensuu
  • Mathias T Rosenfeldt
  • Anchit Khanna
  • Aleksandra Zwolinska
  • Minna Niemelä
  • Jean Christophe Marine
  • Owen J Sansom
  • Markku Kallajoki
  • Robin M Hobbs
  • Pier Paolo Pandolfi
  • Leni Mannermaa
  • Jarmo Kulmala
  • Anna Maria Lahesmaa-Korpinen
  • Lilli Saarinen
  • Sirkku Karinen
  • Ville Rantanen
  • Minna Miettinen
  • Pekka Kohonen
  • Jianmin Wu
  • Marika Nummela
  • Viljami Aittomäki
  • Javier Núñez-Fontarnau
  • Suvi Katri Leivonen
  • Riku Louhimo
  • Panu M Jaakkola
  • Marko Laakso
  • Saija Haapa-Paananen
  • Ping Chen
  • Kari Nousiainen
  • Erkka Valo
  • Sampsa Hautaniemi
  • Elina Mattila
  • Jean Marie Darbon
  • Henrik Edgren
  • Maia Chanrion
  • Xiaoling Liu
  • Jorma Isola
  • Simon Thezenas

Detail Information

Publications11

  1. ncbi request reprint Regulation of matrix metalloproteinase expression in tumor invasion
    J Westermarck
    MediCity Research Laboratory, Department of Medical Biochemistry, University of Turku, Finland
    FASEB J 13:781-92. 1999
    ....
  2. ncbi request reprint Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, Finland
    Cancer Res 60:7156-62. 2000
    ....
  3. pmc p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, University of Turku, FIN 20520 Turku, Finland
    Mol Cell Biol 21:2373-83. 2001
    ..These results provide evidence that activation of signaling cascade MKK3-MKK3b-->p38alpha blocks the ERK1,2 pathway at the level of MEK1,2 via PP1-PP2A and inhibits the activation of MMP-1 gene expression...
  4. pmc Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme
    Kristian Ovaska
    Computational Systems Biology Laboratory, Institute of Biomedicine and Genome Scale Biology Research Program, University of Helsinki, Haartmaninkatu 8, Helsinki, FIN 00014, Finland
    Genome Med 2:65. 2010
    ..Anduril is available at http://csbi.ltdk.helsinki.fi/anduril/The glioblastoma multiforme analysis results are available at http://csbi.ltdk.helsinki.fi/anduril/tcga-gbm/..
  5. pmc Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1
    Anni Laine
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    Cancer Discov 3:182-97. 2013
    ..This feedback loop also constitutes a promising prosenescence target for therapy of cancers with an inactivated p53-p21 pathway...
  6. ncbi request reprint p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2
    Song Ping Li
    Turku Centre for Biotechnology, University of Turku, Finland
    Cancer Res 63:3473-7. 2003
    ..In addition, we show that in all transformed cell lines we have studied thus far, the function of this pathway is impaired...
  7. ncbi request reprint Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
    Melissa R Junttila
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    FASEB J 22:954-65. 2008
    ..In addition, we will discuss the potential functional relevance of negative regulation of ERK pathway activity, for physiological and pathological conditions (e.g., cellular transformation)...
  8. pmc CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice
    Sami Ventelä
    Turku Centre for Biotechnology, University of Turku, Turku, Finland
    PLoS ONE 7:e33209. 2012
    ....
  9. doi request reprint Identification and regulation of a stage-specific stem cell niche enriched by Nanog-positive spermatogonial stem cells in the mouse testis
    Sami Ventelä
    Department of Physiology, University of Turku, Kiinamyllynkatu, Turku, Finland
    Stem Cells 30:1008-20. 2012
    ..This study demonstrates the existence and location of a previously unknown stage-specific spermatogonial stem cell niche and reports the regulation of radioresistant spermatogonial stem cells...
  10. pmc Hypoxia-activated Smad3-specific dephosphorylation by PP2A
    Pekka T Heikkinen
    Turku Centre for Biotechnology, Turku University, Turku, Finland
    J Biol Chem 285:3740-9. 2010
    ..Our data demonstrate the existence of a Smad3-specific phosphatase and identify a novel role for PP2A. Moreover, our data implicate a novel mechanism by which hypoxia regulates growth factor responses...
  11. doi request reprint CIP2A is associated with human breast cancer aggressivity
    Christophe Come
    Centre for Biotechnology, University of Turku, Turku, Finland
    Clin Cancer Res 15:5092-100. 2009
    ..To investigate the clinical relevance of the recently characterized human oncoprotein cancerous inhibitor of protein phosphatase 2A (CIP2A) in human breast cancer...