Jukka Westermarck

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi Regulation of matrix metalloproteinase expression in tumor invasion
    J Westermarck
    MediCity Research Laboratory, Department of Medical Biochemistry, University of Turku, Finland
    FASEB J 13:781-92. 1999
  2. ncbi Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, Finland
    Cancer Res 60:7156-62. 2000
  3. ncbi p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, University of Turku, FIN 20520 Turku, Finland
    Mol Cell Biol 21:2373-83. 2001
  4. ncbi Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme
    Kristian Ovaska
    Computational Systems Biology Laboratory, Institute of Biomedicine and Genome Scale Biology Research Program, University of Helsinki, Haartmaninkatu 8, Helsinki, FIN 00014, Finland
    Genome Med 2:65. 2010
  5. ncbi p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2
    Song Ping Li
    Turku Centre for Biotechnology, University of Turku, Finland
    Cancer Res 63:3473-7. 2003
  6. ncbi Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
    Melissa R Junttila
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    FASEB J 22:954-65. 2008
  7. ncbi CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice
    Sami Ventelä
    Turku Centre for Biotechnology, University of Turku, Turku, Finland
    PLoS ONE 7:e33209. 2012
  8. ncbi Identification and regulation of a stage-specific stem cell niche enriched by Nanog-positive spermatogonial stem cells in the mouse testis
    Sami Ventelä
    Department of Physiology, University of Turku, Kiinamyllynkatu, Turku, Finland
    Stem Cells 30:1008-20. 2012
  9. ncbi Hypoxia-activated Smad3-specific dephosphorylation by PP2A
    Pekka T Heikkinen
    Turku Centre for Biotechnology, Turku University, Turku, Finland
    J Biol Chem 285:3740-9. 2010
  10. ncbi CIP2A is associated with human breast cancer aggressivity
    Christophe Come
    Centre for Biotechnology, University of Turku, Turku, Finland
    Clin Cancer Res 15:5092-100. 2009

Collaborators

  • V M Kahari
  • T Kallunki
  • S Li
  • Edward K Chan
  • Johanna Ivaska
  • Olli Kallioniemi
  • Jos Jonkers
  • Caroline S Hill
  • J Han
  • Sami Ventelä
  • Christophe Come
  • Jorma Toppari
  • Juho Antti Mäkelä
  • Pekka T Heikkinen
  • Kristian Ovaska
  • Melissa R Junttila
  • Leni Mannermaa
  • Pier Paolo Pandolfi
  • Jarmo Kulmala
  • Robin M Hobbs
  • Markku Kallajoki
  • Lilli Saarinen
  • Pekka Kohonen
  • Erkka Valo
  • Anna Maria Lahesmaa-Korpinen
  • Ping Chen
  • Sampsa Hautaniemi
  • Ville Rantanen
  • Jianmin Wu
  • Riku Louhimo
  • Panu M Jaakkola
  • Saija Haapa-Paananen
  • Minna Miettinen
  • Marika Nummela
  • Viljami Aittomäki
  • Suvi Katri Leivonen
  • Sirkku Karinen
  • Marko Laakso
  • Kari Nousiainen
  • Javier Núñez-Fontarnau
  • Simon Thezenas
  • Elina Mattila
  • Maia Chanrion
  • Jorma Isola
  • Jean Marie Darbon
  • Xiaoling Liu
  • Henrik Edgren
  • Anni Laine

Detail Information

Publications10

  1. ncbi Regulation of matrix metalloproteinase expression in tumor invasion
    J Westermarck
    MediCity Research Laboratory, Department of Medical Biochemistry, University of Turku, Finland
    FASEB J 13:781-92. 1999
    ....
  2. ncbi Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, Finland
    Cancer Res 60:7156-62. 2000
    ....
  3. ncbi p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, University of Turku, FIN 20520 Turku, Finland
    Mol Cell Biol 21:2373-83. 2001
    ..These results provide evidence that activation of signaling cascade MKK3-MKK3b-->p38alpha blocks the ERK1,2 pathway at the level of MEK1,2 via PP1-PP2A and inhibits the activation of MMP-1 gene expression...
  4. ncbi Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme
    Kristian Ovaska
    Computational Systems Biology Laboratory, Institute of Biomedicine and Genome Scale Biology Research Program, University of Helsinki, Haartmaninkatu 8, Helsinki, FIN 00014, Finland
    Genome Med 2:65. 2010
    ..Anduril is available at http://csbi.ltdk.helsinki.fi/anduril/The glioblastoma multiforme analysis results are available at http://csbi.ltdk.helsinki.fi/anduril/tcga-gbm/..
  5. ncbi p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2
    Song Ping Li
    Turku Centre for Biotechnology, University of Turku, Finland
    Cancer Res 63:3473-7. 2003
    ..In addition, we show that in all transformed cell lines we have studied thus far, the function of this pathway is impaired...
  6. ncbi Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
    Melissa R Junttila
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    FASEB J 22:954-65. 2008
    ..In addition, we will discuss the potential functional relevance of negative regulation of ERK pathway activity, for physiological and pathological conditions (e.g., cellular transformation)...
  7. ncbi CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice
    Sami Ventelä
    Turku Centre for Biotechnology, University of Turku, Turku, Finland
    PLoS ONE 7:e33209. 2012
    ....
  8. ncbi Identification and regulation of a stage-specific stem cell niche enriched by Nanog-positive spermatogonial stem cells in the mouse testis
    Sami Ventelä
    Department of Physiology, University of Turku, Kiinamyllynkatu, Turku, Finland
    Stem Cells 30:1008-20. 2012
    ..This study demonstrates the existence and location of a previously unknown stage-specific spermatogonial stem cell niche and reports the regulation of radioresistant spermatogonial stem cells...
  9. ncbi Hypoxia-activated Smad3-specific dephosphorylation by PP2A
    Pekka T Heikkinen
    Turku Centre for Biotechnology, Turku University, Turku, Finland
    J Biol Chem 285:3740-9. 2010
    ..Our data demonstrate the existence of a Smad3-specific phosphatase and identify a novel role for PP2A. Moreover, our data implicate a novel mechanism by which hypoxia regulates growth factor responses...
  10. ncbi CIP2A is associated with human breast cancer aggressivity
    Christophe Come
    Centre for Biotechnology, University of Turku, Turku, Finland
    Clin Cancer Res 15:5092-100. 2009
    ..To investigate the clinical relevance of the recently characterized human oncoprotein cancerous inhibitor of protein phosphatase 2A (CIP2A) in human breast cancer...