J Westerbacka

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Glargine and regular human insulin similarly acutely enhance endothelium-dependent vasodilatation in normal subjects
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, P O Box 340, FIN 00029 HUCH, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 24:320-4. 2004
  2. doi request reprint Insulin regulation of MCP-1 in human adipose tissue of obese and lean women
    Jukka Westerbacka
    University of Helsinki, Department of Medicine, Division of Diabetes, Biomedicum, FIN 00029 HUCH, Helsinki, Finland
    Am J Physiol Endocrinol Metab 294:E841-5. 2008
  3. ncbi request reprint Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, P O Box 700, Room C418B, FIN 00029 HUCH, Helsinki, Finland
    Diabetes 56:2759-65. 2007
  4. ncbi request reprint Comparison of in vivo effects of nitroglycerin and insulin on the aortic pressure waveform
    J Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, Finland
    Eur J Clin Invest 34:1-8. 2004
  5. ncbi request reprint Increased augmentation of central blood pressure is associated with increases in carotid intima-media thickness in type 2 diabetic patients
    J Westerbacka
    Department of Medicine, University of Helsinki, Finland
    Diabetologia 48:1654-62. 2005
  6. ncbi request reprint Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk
    J Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Diabetologia 47:1360-9. 2004
  7. ncbi request reprint Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects
    J Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, P O Box 340, FIN 00029 HUCH, Helsinki, Finland
    Diabetologia 49:132-40. 2006
  8. ncbi request reprint Dietary fat content modifies liver fat in overweight nondiabetic subjects
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, Obesity Research Unit, University of Helsinki, P O Box 340, FIN 00029 HUCH, Helsinki, Finland
    J Clin Endocrinol Metab 90:2804-9. 2005
  9. ncbi request reprint Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity
    J Makkonen
    Division of Diabetes, Department of Medicine, University of Helsinki and Minerva Medical Research Institute, FIN 00029 HUCH, Helsinki, Finland
    Int J Obes (Lond) 31:1617-25. 2007
  10. ncbi request reprint Insulin sensitivity regulates autonomic control of heart rate variation independent of body weight in normal subjects
    R Bergholm
    Division of Diabetes, Department of Medicine, University of Helsinki, Helsinki 00290, Finland
    J Clin Endocrinol Metab 86:1403-9. 2001

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Glargine and regular human insulin similarly acutely enhance endothelium-dependent vasodilatation in normal subjects
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, P O Box 340, FIN 00029 HUCH, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 24:320-4. 2004
    ..In the present study, we compared effects of glargine and regular human insulin on blood flow responses to endothelium-dependent and endothelium-independent vasoactive agents in vivo in normal subjects...
  2. doi request reprint Insulin regulation of MCP-1 in human adipose tissue of obese and lean women
    Jukka Westerbacka
    University of Helsinki, Department of Medicine, Division of Diabetes, Biomedicum, FIN 00029 HUCH, Helsinki, Finland
    Am J Physiol Endocrinol Metab 294:E841-5. 2008
    ..MIP-1alpha was undetectable in serum. Insulin regulation of CCL2 differs between insulin-sensitive and -resistant subjects in a direction that could exacerbate adipose tissue inflammation...
  3. ncbi request reprint Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, P O Box 700, Room C418B, FIN 00029 HUCH, Helsinki, Finland
    Diabetes 56:2759-65. 2007
    ..The objective of this study is to quantitate expression of genes possibly contributing to insulin resistance and fat deposition in the human liver...
  4. ncbi request reprint Comparison of in vivo effects of nitroglycerin and insulin on the aortic pressure waveform
    J Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, Finland
    Eur J Clin Invest 34:1-8. 2004
    ..The aim of this study was to determine whether resistance to the haemodynamic effects of insulin is a defect specific to insulin or whether individuals resistant to the vascular actions of insulin are also resistant to GTN...
  5. ncbi request reprint Increased augmentation of central blood pressure is associated with increases in carotid intima-media thickness in type 2 diabetic patients
    J Westerbacka
    Department of Medicine, University of Helsinki, Finland
    Diabetologia 48:1654-62. 2005
    ..The aim of this study was to determine the relationships between intima-media thickness (IMT), an established marker of atherosclerosis, large artery function and other determinants of cardiovascular risk in type 2 diabetic patients...
  6. ncbi request reprint Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk
    J Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Diabetologia 47:1360-9. 2004
    ..It remains to be established how fat in the liver correlates with that in other depots, and whether any association differs between men and women...
  7. ncbi request reprint Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects
    J Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, P O Box 340, FIN 00029 HUCH, Helsinki, Finland
    Diabetologia 49:132-40. 2006
    ..We determined the response of selected genes to in vivo insulin in adipose tissue in 21 non-diabetic women...
  8. ncbi request reprint Dietary fat content modifies liver fat in overweight nondiabetic subjects
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, Obesity Research Unit, University of Helsinki, P O Box 340, FIN 00029 HUCH, Helsinki, Finland
    J Clin Endocrinol Metab 90:2804-9. 2005
    ..The reason for interindividual variation in liver fat content is unknown. Cross-sectional data suggest that dietary fat content may influence liver fat, but this possibility has not been directly tested in humans...
  9. ncbi request reprint Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity
    J Makkonen
    Division of Diabetes, Department of Medicine, University of Helsinki and Minerva Medical Research Institute, FIN 00029 HUCH, Helsinki, Finland
    Int J Obes (Lond) 31:1617-25. 2007
    ....
  10. ncbi request reprint Insulin sensitivity regulates autonomic control of heart rate variation independent of body weight in normal subjects
    R Bergholm
    Division of Diabetes, Department of Medicine, University of Helsinki, Helsinki 00290, Finland
    J Clin Endocrinol Metab 86:1403-9. 2001
    ..These data suggest that sympathetic overactivity is not a consequence of hyperinsulinemia...
  11. doi request reprint Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations
    A Kotronen
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland
    Diabetologia 52:684-90. 2009
    ....
  12. ncbi request reprint The fatty liver and insulin resistance
    H Yki-Jarvinen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki Finland
    Curr Mol Med 5:287-95. 2005
    ..The fatty liver thus may help to explain why some but not all obese individuals are insulin resistant and why even lean individuals may be insulin resistant, and thereby at risk of developing type 2 diabetes and cardiovascular disease...
  13. ncbi request reprint Insulin therapy improves insulin actions on glucose metabolism and aortic wave reflection in type 2 diabetic patients
    M K Tamminen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Eur J Clin Invest 33:855-60. 2003
    ..We determined whether 6 months of insulin therapy affects insulin actions on glucose metabolism and vascular function...
  14. ncbi request reprint Low-grade inflammation, endothelial activation and carotid intima-media thickness in type 2 diabetes
    E S Leinonen
    Department of Medicine, Division of Cardiology, University of Helsinki, Helsinki, Finland
    J Intern Med 256:119-27. 2004
    ..The objective of this study was to assess the relationship between inflammation, endothelial activation and incipient atherosclerosis in type 2 diabetes...
  15. doi request reprint A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
    A Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Diabetologia 52:1056-60. 2009
    ....
  16. ncbi request reprint Insulin-induced decreases in aortic wave reflection and central systolic pressure are impaired in type 2 diabetes
    Marjo Tamminen
    Department of Medicine, Division of Diabetes, University of Helsinki, Finland
    Diabetes Care 25:2314-9. 2002
    ..To determine whether large arteries are resistant to insulin...
  17. ncbi request reprint Obesity is associated with impaired platelet-inhibitory effect of acetylsalicylic acid in nondiabetic subjects
    M Tamminen
    Division of Diabetes, University of Helsinki, Finland
    Int J Obes Relat Metab Disord 27:907-11. 2003
    ..We determined whether variation in insulin action is associated with that of ASA on platelets...
  18. ncbi request reprint Rosiglitazone in the treatment of HAART-associated lipodystrophy--a randomized double-blind placebo-controlled study
    Jussi Sutinen
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland
    Antivir Ther 8:199-207. 2003
    ..Rosiglitazone unexpectedly caused significant increases in serum triglyceride and cholesterol concentrations, which must be carefully monitored if glitazones are used in these patients...
  19. ncbi request reprint Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    Anneli Seppälä-Lindroos
    Department of Medicine, Division of Diabetes, University of Helsinki, FIN 00029 HUCH, Helsinki, Finland
    J Clin Endocrinol Metab 87:3023-8. 2002
    ..min; P = NS). Fat accumulation in the liver is, independent of body mass index and intraabdominal and overall obesity, characterized by several features of insulin resistance in normal weight and moderately overweight subjects...
  20. ncbi request reprint Inhibition of platelet-collagen interaction: an in vivo action of insulin abolished by insulin resistance in obesity
    Jukka Westerbacka
    Department of Medicine, University of Helsinki, Finland
    Arterioscler Thromb Vasc Biol 22:167-72. 2002
    ..These platelet-inhibitory actions of insulin are blunted or absent in obese subjects and could provide 1 mechanism linking insulin resistance to atherothrombotic disease...
  21. ncbi request reprint Resistance to acute insulin induced decreases in large artery stiffness accompanies the insulin resistance syndrome
    J Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, FIN-00290 Helsinki, Finland
    J Clin Endocrinol Metab 86:5262-8. 2001
    ..Resistance of large arteries to insulin-induced decrease in their stiffness is therefore another facet of insulin resistance that could contribute to the association between insulin resistance and cardiovascular disease...
  22. ncbi request reprint Low HDL cholesterol concentration is associated with increased intima-media thickness independent of arterial stiffness in healthy subjects from families with low HDL cholesterol
    C Alagona
    University of Helsinki, Helsinki, Finland
    Eur J Clin Invest 33:457-63. 2003
    ..Cardiovascular disease is characterized by increased intima-media thickness (IMT) and arterial stiffness, but the effect of low HDL on these measurements has not been reported...
  23. ncbi request reprint Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy
    Jussi Sutinen
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Finland
    AIDS 16:2183-93. 2002
    ..To determine liver fat content in patients with highly active antiretroviral therapy (HAART)-associated lipodystrophy...
  24. ncbi request reprint Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects
    Anna Kotronen
    Division of Diabetes, University of Helsinki, Helsinki, Finland
    Diabetes Care 31:165-9. 2008
    ....
  25. ncbi request reprint Postprandial lipemia associates with liver fat content
    Niina Matikainen
    Department of Medicine, University of Helsinki, P O Box 700, FIN 00029 Helsinki, Finland
    J Clin Endocrinol Metab 92:3052-9. 2007
    ..Postprandial lipemia and low adiponectin represent novel risk factors for vascular disease. This study aimed to determine whether liver fat content and adiponectin are predictors of postprandial triglyceride (TG)-rich lipoproteins (TRL)...
  26. pmc Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver
    Anna Kotronen
    Department of Medicine, Division of Diabetes, Helsinki, Finland
    Diabetes 58:203-8. 2009
    ..To determine whether 1) hepatic ceramide and diacylglycerol concentrations, 2) SCD1 activity, and 3) hepatic lipogenic index are increased in the human nonalcoholic fatty liver...
  27. doi request reprint Long-TE 1H MRS suggests that liver fat is more saturated than subcutaneous and visceral fat
    Jesper Lundbom
    Department of Medicine, Division of Cardiology, University of Helsinki, Helsinki, Finland
    NMR Biomed 24:238-45. 2011
    ..The results suggest that liver fat is more saturated than subcutaneous or visceral adipose tissue, which may be attributed to differences in de novo lipogenesis...
  28. ncbi request reprint Insulin resistance, arterial stiffness and wave reflection
    Hannele Yki-Jarvinen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Adv Cardiol 44:252-60. 2007
    ..In insulin-resistant subjects, this effect of insulin is blunted implying that insulin resistance involves also large arteries. This may provide one mechanism linking insulin resistance and cardiovascular disease...
  29. ncbi request reprint Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins
    Kirsi Hannele Pietiläinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Am J Physiol Endocrinol Metab 288:E768-74. 2005
    ..55, P = 0.015) but not liver (r = -0.20, P = 0.20) fat. We conclude that acquired obesity is associated with increases in intra-abdominal and liver fat and insulin resistance, independent of genetic factors...
  30. ncbi request reprint Arterial stiffness in HIV-infected patients receiving highly active antiretroviral therapy
    Ksenia Sevastianova
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland
    Antivir Ther 10:925-35. 2005
    ..011) were identified as independent factors predicting AgI(HR). Prolonged antiretroviral treatment, thus, delineates as a risk factor for systemic arterial stiffness and the associated cardiovascular mortality...
  31. doi request reprint Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum
    Anna Kotronen
    Department of Medicine, Division of Diabetes, Helsinki, Finland
    Obesity (Silver Spring) 18:937-44. 2010
    ..89, P = 0.012) and Delta6 (18:3[n-6]/18:2, r = 1.0, P < 0.001) desaturase activities. We conclude that the human liver contains higher concentrations of ceramides and saturated free fatty acids than either SCfat or IAfat...
  32. doi request reprint Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts
    Anna Kotronen
    Division of Diabetes, Department of Medicine, University of Helsinki, FIN 00029 Helsinki, Finland
    Eur J Endocrinol 160:593-602. 2009
    ..We investigated whether polymorphisms in candidate genes involved in lipid metabolism and type 2 diabetes are related to liver fat content...
  33. ncbi request reprint Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, 00029 Helsinki, Finland
    J Clin Endocrinol Metab 88:4924-31. 2003
    ....
  34. ncbi request reprint Liver fat in the metabolic syndrome
    Anna Kotronen
    Department of Medicine, Division of Diabetes, The Finnish Twin Cohort Study, University of Helsinki, FIN 00029 Helsinki, Finland
    J Clin Endocrinol Metab 92:3490-7. 2007
    ..The amount of liver fat in subjects with and without the metabolic syndrome has not been determined. It is unknown which clinically available markers best reflect liver fat content...
  35. doi request reprint Nonalcoholic fatty liver disease: detection of elevated nicotinamide adenine dinucleotide phosphate with in vivo 3.0-T 31P MR spectroscopy with proton decoupling
    Ksenia Sevastianova
    Department of Medicine, Division of Diabetes, University of Helsinki, PO Box 340, Helsinki 00029 HUCH, Finland
    Radiology 256:466-73. 2010
    ....
  36. doi request reprint Long-term effects of fenofibrate on carotid intima-media thickness and augmentation index in subjects with type 2 diabetes mellitus
    Anne Hiukka
    Department of Medicine, University of Helsinki, Helsinki University Central Hospital and Biomedicum, Helsinki, Finland
    J Am Coll Cardiol 52:2190-7. 2008
    ..The aim of this substudy was to ascertain whether long-term treatment with fenofibrate reduces surrogate measures of atherosclerosis, biomarkers of inflammation, and endothelial activation in patients with type 2 diabetes...
  37. doi request reprint Characterizing human adipose tissue lipids by long echo time 1H-MRS in vivo at 1.5 Tesla: validation by gas chromatography
    Jesper Lundbom
    Department of Medicine, Division of Cardiology, University of Helsinki, Helsinki, Finland
    NMR Biomed 23:466-72. 2010
    ..569, p = 0.017, n = 17), but serum lipid levels showed no apparent relation to SAT FA composition. We conclude that long TE (1)H-MRS provides a robust non-invasive method for characterizing adipose tissue triglycerides in vivo...
  38. ncbi request reprint Arterial stiffness and insulin resistance
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Semin Vasc Med 2:157-64. 2002
    ..These data suggest that the inability of insulin to normally diminish arterial stiffness could provide a mechanistic link between insulin resistance and systolic hypertension...
  39. doi request reprint Gene expression in human NAFLD
    Dario Greco
    Institute of Biotechnology, University of Helsinki, Finland
    Am J Physiol Gastrointest Liver Physiol 294:G1281-7. 2008
    ..The data show that multiple changes in gene expression characterize simple steatosis...
  40. ncbi request reprint Metabolic syndrome aggravates the increased endothelial activation and low-grade inflammation in subjects with familial low HDL
    Aino Soro-Paavonen
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland
    Ann Med 38:229-38. 2006
    ..Inhibition of cytokine-induced expression of adhesion molecules is one of the atheroprotective mechanisms of high-density lipoprotein (HDL)...
  41. ncbi request reprint Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity
    Maria Kolak
    Atherosclerosis Research Unit, Department of Medicine, King Gustaf V Research Institute, Karolinska Institutet, Stockholm, Sweden
    Diabetes 56:1960-8. 2007
    ..We sought to determine whether adipose tissue is inflamed in individuals with increased liver fat (LFAT) independently of obesity...
  42. ncbi request reprint Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia
    Martin Adiels
    Department of Mathematical Sciences, Chalmers University of Technology, Goteborg, Sweden
    Arterioscler Thromb Vasc Biol 25:1697-703. 2005
    ..We sought to compare the synthesis and metabolism of VLDL1 and VLDL2 in patients with type 2 diabetes mellitus (DM2) and nondiabetic subjects...
  43. ncbi request reprint Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity
    Deborah J Wake
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Scotland, UK
    Clin Endocrinol (Oxf) 66:440-6. 2007
    ..We aimed to test associations between body fat or fat distribution and mRNA transcript levels for androgen and oestrogen receptors and for enzymes metabolizing sex steroids in adipose tissue...
  44. ncbi request reprint The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans
    Ruth Andrew
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
    Diabetes 54:1364-70. 2005
    ..Thus, in addition to free fatty acids and adipokines, the portal vein delivers cortisol to the liver, and inhibition of 11HSD1 in visceral adipose tissue may indeed be valuable in ameliorating insulin resistance in obesity...
  45. ncbi request reprint PROactive in patients with type 2 diabetes and previous myocardial infarction: swinging the sword of Damocles?
    Jukka Westerbacka
    J Am Coll Cardiol 49:1781-2. 2007