Research Topics
Species | Erkki VuoriSummaryAffiliation: University of Helsinki Country: Finland Publications
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Detail Information
Publications
Abuse liability of buprenorphine-naloxone tablets in untreated IV drug usersHannu Alho
National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
Drug Alcohol Depend 88:75-8. 2007..Its street price was less than half that of buprenorphine alone. The buprenorphine+naloxone combination appears to be a feasible tool, along with easier access to addiction treatment, for decreasing IV abuse of buprenorphine...- Death following ingestion of MDMA (ecstasy) and moclobemideErkki Vuori
Department of Forensic Medicine, University of Helsinki, Finland
Addiction 98:365-8. 2003..Warnings are needed against misinformed attempts to potentiate the pharmacological effects of illicit drugs... 
Comparison of fatal poisonings by prescription opioidsMargareeta Häkkinen
University of Helsinki, Hjelt Institute, Department of Forensic Medicine, PO Box 40 Kytösuontie 11, FI 00014 Helsinki, Finland
Forensic Sci Int 222:327-31. 2012..35 mg/l) was not different from that in other causes of death (0.30 mg/l). Sedative drugs and/or alcohol were very frequently found in fatal poisonings involving these prescription opioids...- Quantification of drugs in plasma without primary reference standards by liquid chromatography-chemiluminescence nitrogen detection: application to tramadol metabolite ratiosSuvi Ojanperä
Department of Forensic Medicine, University of Helsinki, Helsinki, Finland
Ther Drug Monit 29:423-8. 2007..This experiment suggests that a recovery-corrected LC-CLND analysis produces sufficiently accurate results to be useful in a clinical context, particularly in instances in which reference standards are not readily accessible... - Adverse interaction of warfarin and paracetamol: evidence from a post-mortem studyTerhi Launiainen
Department of Forensic Medicine, University of Helsinki, Helsinki, Finland
Eur J Clin Pharmacol 66:97-103. 2010..Another purpose was to obtain facts related to the questioned safety of warfarin-paracetamol and warfarin-tramadol combinations... - CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsiesAnna Koski
Laboratory of Toxicology, Department of Forensic Medicine, P O Box 40, FI 00014 University of Helsinki, Finland
Forensic Sci Int 158:177-83. 2006..This result demonstrates the feasibility of postmortem pharmacogenetic analysis and supports the dominant role of genes in drug metabolism... - Fatal venlafaxine poisonings are associated with a high prevalence of drug interactionsTerhi Launiainen
Department of Forensic Medicine, University of Helsinki, P O Box 40, FI 00014, Helsinki, Finland
Int J Legal Med 125:349-58. 2011..In conclusion, the high suicide potential of VEN in combination with the high prevalence of drugs causing adverse interactions could be the reason for the observed high FTI... - An epidemic of fatal 3-methylfentanyl poisoning in EstoniaIlkka Ojanpera
Department of Forensic Medicine, University of Helsinki, P O Box 40, 00014, Helsinki, Finland
Int J Legal Med 122:395-400. 2008..9 microg/l) was more than ten times lower than the mean fentanyl concentration in fentanyl-related fatalities. Concomitant use of other drugs involved alcohol, amphetamines, benzodiazepines, and cannabis, but very rarely other opioids... - A fatal doxepin poisoning associated with a defective CYP2D6 genotypeAnna Koski
Department of Forensic Medicine, University of Helsinki, Helsinki, Finland
Am J Forensic Med Pathol 28:259-61. 2007..Our case strongly emphasizes that a pharmacogenetic analysis in postmortem forensic setting may reveal new insight to the cause or manner of death... - Elevated formic acid concentrations in putrefied post-mortem blood and urine samplesJenni Viinamäki
Hjelt Institute, Department of Forensic Medicine, University of Helsinki, Helsinki, Finland
Forensic Sci Int 208:42-6. 2011..Poor correlation was shown between blood and urine concentrations of FA. Poor correlations were also shown, in both blood and urine, between methanol and FA concentrations... - Benzodiazepines and alcohol are associated with cases of fatal buprenorphine poisoningMargareeta Häkkinen
Department of Forensic Medicine, University of Helsinki, Hjelt Institute, PO Box 40, Kytosuontie 11, Helsinki, 00014, Finland
Eur J Clin Pharmacol 68:301-9. 2012..In Finland, buprenorphine is the most important abused opioid causing fatal poisonings... - Blood levels of 3-methylfentanyl in 3 fatal poisoning casesIlkka Ojanpera
Department of Forensic Medicine, University of Helsinki, Helsinki, Finland
Am J Forensic Med Pathol 27:328-31. 2006..5 microg/L). These values are significantly lower than the levels reported for alpha-methylfentanyl and fentanyl in fatal poisonings. Repeated seizures of fentanyl and its analogs have been reported in Europe close to the Russian border... - Newer antidepressants: evaluation of fatal toxicity index and interaction with alcohol based on Finnish postmortem dataAnna Koski
Laboratory of Toxicology, Department of Forensic Medicine, P O Box 40, 00014 University of Helsinki, Finland
Int J Legal Med 119:344-8. 2005..The SSRIs appear to present a low risk of fatal poisoning when taken alone or in combination with alcohol, whereas venlafaxine is associated with an elevated risk... - Screening for basic drugs in hair of drug addicts by liquid chromatography/time-of-flight mass spectrometryAnna Pelander
Department of Forensic Medicine, University of Helsinki, Helsinki, Finland
Ther Drug Monit 30:717-24. 2008..5 and 0.4 mDa, respectively. Cutoff values for tramadol and methamphetamine in hair were 100 and 200 pg/mg, respectively. The method proved to be a simple and straightforward tool for comprehensive screening of basic drugs in hair... - Application of accurate mass measurement to urine drug screeningLkka Ojanperä
Department of Forensic Medicine, University of Helsinki, P O Box 40, FIN 00014, Helsinki, Finland
J Anal Toxicol 29:34-40. 2005..In contrast to ordinary techniques requiring primary reference standards, the formula-based databases can be updated instantly with fresh numeric data from scientific literature and authority sources... - Under-recording of ethanol intoxication and poisoning in cause-of-death data: causes and consequencesRaimo A Lahti
Hjelt Institute, Department of Forensic Medicine, 00014 University of Helsinki, Finland
Forensic Sci Int 212:121-5. 2011.... - Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/time-of-flight mass spectrometrySuvi Ojanperä
Department of Forensic Medicine, University of Helsinki, Helsinki, Finland
Rapid Commun Mass Spectrom 20:1161-7. 2006..The results show that isotopic pattern matching by SigmaFit is a powerful means of identification in addition to accurate mass measurement... - Prevalence of adverse drug combinations in a large post-mortem toxicology databaseTerhi Launiainen
Department of Forensic Medicine, University of Helsinki, P O Box 40, 00014, Helsinki, Finland
Int J Legal Med 123:109-15. 2009..In one third of the possible ADI cases, a forensic pathologist had noted the studied compounds as an underlying or contributing cause of death, although the agents' specific role in ADIs was rarely recognised... 
Infant botulism acquired from household dust presenting as sudden infant death syndromeMari Nevas
Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, P O Box 66, 00014 Helsinki University, Finland
J Clin Microbiol 43:511-3. 2005....- Headspace in-tube extraction gas chromatography-mass spectrometry for the analysis of hydroxylic methyl-derivatized and volatile organic compounds in blood and urineIlpo Rasanen
Department of Forensic Medicine, Kytosuontie 11, University of Helsinki, Finland
J Anal Toxicol 34:113-21. 2010..The ITEX method described here was more sensitive for analysis of volatile organic compounds than the corresponding static headspace analysis as demonstrated for 11 representative compounds... - Alcohol tax cuts and increase in alcohol-positive sudden deaths: a time-series intervention analysisAnna Koski
Department of Forensic Medicine, University of Helsinki, Finland
Addiction 102:362-8. 2007.... - Post-mortem SNP analysis of CYP2D6 gene reveals correlation between genotype and opioid drug (tramadol) metabolite ratios in bloodAntti Levo
Laboratory of Forensic Biology, Department of Forensic Medicine, P O Box 40, 00014, University of Helsinki, Finland
Forensic Sci Int 135:9-15. 2003..The results also suggest that genetic factors play, in general, a dominant role over other factors in the metabolism of individual drugs... - Analysis of street drugs in seized material without primary reference standardsSuvi Laks
Department of Forensic Medicine, University of Helsinki, P.O. Box 40, FIN-00014 Helsinki, Finland
Anal Chem 76:7375-9. 2004..Results suggest that the present combination of LC/TOFMS and LC/CLND offers a simple solution for the analysis of scheduled and designer drugs in seized material, independent of the availability of primary reference standards... - Interaction of alcohol and drugs in fatal poisoningsAnna Koski
Laboratory of Toxicology, Department of Forensic Medicine, FIN 00014, University of Helsinki, Finland
Hum Exp Toxicol 22:281-7. 2003..The other drugs had relatively low FTIs. The results reflect not only the acute toxicity of a given drug-alcohol combination but also the manners of use and abuse of these drugs... - Performance of immunoassays in screening for opiates, cannabinoids and amphetamines in post-mortem bloodYukiko Hino
Department of Forensic Medicine, University of Helsinki, PO Box 40, FIN-00014, Helsinki, Finland
Forensic Sci Int 131:148-55. 2003..The modified EMIT immunoassay system presented here seems to be useful for screening of drugs of abuse in post-mortem blood samples, especially when urine is not available... - Screening for basic drugs in 2-mL urine samples by dual-plate overpressured layer chromatography and comparison with gas chromatography-mass spectrometryAnna Pelander
Department of Forensic Medicine, PO Box 40, FIN 00014 University of Helsinki, Finland
J Anal Toxicol 27:226-32. 2003..The OPLC method thus provides an alternative for current planar and column liquid chromatographic drug screening methods with the possibility of lowering detection limits by using a larger sample size...