Sari Voutilainen

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. pmc Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Kuopio ischaemic heart disease risk factor study
    Sari Voutilainen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    PLoS ONE 2:e181. 2007
  2. ncbi Carotenoids and cardiovascular health
    Sari Voutilainen
    Research Institute of Public Health and Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 83:1265-71. 2006
  3. ncbi Serum folate and homocysteine and the incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Sari Voutilainen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Am J Clin Nutr 80:317-23. 2004
  4. ncbi Association between depressive symptoms and serum concentrations of homocysteine in men: a population study
    Tommi Tolmunen
    Department of Psychiatry, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 80:1574-8. 2004
  5. doi Intake of fruit, berries, and vegetables and risk of type 2 diabetes in Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Jaakko Mursu
    Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Am J Clin Nutr 99:328-33. 2014
  6. ncbi The effects of coffee consumption on lipid peroxidation and plasma total homocysteine concentrations: a clinical trial
    Jaakko Mursu
    Research Institute of Public Health, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Free Radic Biol Med 38:527-34. 2005
  7. ncbi Serum homocysteine, folate and risk of stroke: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study
    Jyrki K Virtanen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Eur J Cardiovasc Prev Rehabil 12:369-75. 2005
  8. ncbi Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland
    Jyrki K Virtanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Arterioscler Thromb Vasc Biol 25:228-33. 2005
  9. doi Flavonoid intake and the risk of ischaemic stroke and CVD mortality in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Jaakko Mursu
    Research Unit of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, PO Box 1627, Kuopio 70211, Finland
    Br J Nutr 100:890-5. 2008
  10. doi Intake of flavonoids and risk of cancer in Finnish men: The Kuopio Ischaemic Heart Disease Risk Factor Study
    Jaakko Mursu
    Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Int J Cancer 123:660-3. 2008

Detail Information

Publications50

  1. pmc Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Kuopio ischaemic heart disease risk factor study
    Sari Voutilainen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    PLoS ONE 2:e181. 2007
    ..Many genetic factors play a role in folate-homocysteine metabolism, like functional polymorphism (Val108Met) in the Catechol-O-methyltransferase (COMT) gene...
  2. ncbi Carotenoids and cardiovascular health
    Sari Voutilainen
    Research Institute of Public Health and Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 83:1265-71. 2006
    ..Currently, the consumption of carotenoids in pharmaceutical forms for the treatment or prevention of heart diseases cannot be recommended...
  3. ncbi Serum folate and homocysteine and the incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Sari Voutilainen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Am J Clin Nutr 80:317-23. 2004
    ....
  4. ncbi Association between depressive symptoms and serum concentrations of homocysteine in men: a population study
    Tommi Tolmunen
    Department of Psychiatry, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 80:1574-8. 2004
    ..Results of studies of the association between blood concentrations of homocysteine and depression in general populations and among psychiatric patients are inconsistent...
  5. doi Intake of fruit, berries, and vegetables and risk of type 2 diabetes in Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Jaakko Mursu
    Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Am J Clin Nutr 99:328-33. 2014
    ..Although higher intakes of fruit, berries, and vegetables (FBV) have been associated with reduced risk of type 2 diabetes (T2D) in some observational studies, the evidence is limited and inconclusive...
  6. ncbi The effects of coffee consumption on lipid peroxidation and plasma total homocysteine concentrations: a clinical trial
    Jaakko Mursu
    Research Institute of Public Health, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Free Radic Biol Med 38:527-34. 2005
    ..In conclusion, the consumption of filtered coffee does not have any detectable effects on lipid peroxidation in healthy nonsmoking men. The effect of coffee consumption on tHcy concentrations needs further investigation...
  7. ncbi Serum homocysteine, folate and risk of stroke: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study
    Jyrki K Virtanen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Eur J Cardiovasc Prev Rehabil 12:369-75. 2005
    ..Homocysteine and folate have been suggested to have opposite effects on the risk of stroke, although the results are controversial...
  8. ncbi Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland
    Jyrki K Virtanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Arterioscler Thromb Vasc Biol 25:228-33. 2005
    ..We investigated the effects of high mercury content in hair on the risk of acute coronary events and cardiovascular and all-cause mortality in men from eastern Finland...
  9. doi Flavonoid intake and the risk of ischaemic stroke and CVD mortality in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Jaakko Mursu
    Research Unit of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, PO Box 1627, Kuopio 70211, Finland
    Br J Nutr 100:890-5. 2008
    ..54 (95% CI 0.32, 0.92) and 0.65 (95% CI 0.40, 1.05), respectively. The present results suggest that high intakes of flavonoids may be associated with decreased risk of ischaemic stroke and possibly with reduced CVD mortality...
  10. doi Intake of flavonoids and risk of cancer in Finnish men: The Kuopio Ischaemic Heart Disease Risk Factor Study
    Jaakko Mursu
    Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Int J Cancer 123:660-3. 2008
    ..No association between flavonoid intake and risk of prostate or colorectal cancer were found. We conclude that high intake of flavonoids is associated with decreased risk of lung cancer in middle-aged Finnish smoking men...
  11. ncbi The intake of flavonoids and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Jaakko Mursu
    The Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Br J Nutr 98:814-8. 2007
    ..There was a trend for an inverse association between intake of flavonols and mean CCA-IMT (P = 0.055). We conclude that high intake of flavonoids is associated with decreased carotid atherosclerosis in middle-aged Finnish men...
  12. ncbi Polyphenol-rich phloem enhances the resistance of total serum lipids to oxidation in men
    Jaakko Mursu
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    J Agric Food Chem 53:3017-22. 2005
    ..in a dose-dependent manner. Our results suggest that polyphenols may inhibit lipid peroxidation in the hydrophilic fraction of serum...
  13. ncbi High dietary methionine intake increases the risk of acute coronary events in middle-aged men
    Jyrki K Virtanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Nutr Metab Cardiovasc Dis 16:113-20. 2006
    ..To date, the effects of dietary intake of methionine, the key amino acid in homocysteine metabolism, on CVD have not been studied. Our aim was to examine the effects of dietary methionine intake on the risk of acute coronary events...
  14. pmc Catechol-o-methyltransferase gene polymorphism modifies the effect of coffee intake on incidence of acute coronary events
    Pertti Happonen
    Department of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    PLoS ONE 1:e117. 2006
    ....
  15. ncbi Low intake of fruits, berries and vegetables is associated with excess mortality in men: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study
    Tiina H Rissanen
    Research Institute of Public Health, University of Kuopio, Finland
    J Nutr 133:199-204. 2003
    ..Consequently, the findings of this work indicate that diets that are rich in plant-derived foods can promote longevity...
  16. ncbi Effects of astaxanthin supplementation on lipid peroxidation
    Jouni Karppi
    Research Institute of Public Health, University of Kuopio, P O Box 1627, FI 70211 Kuopio, Finland
    Int J Vitam Nutr Res 77:3-11. 2007
    ..The present study suggests that intestinal absorption of astaxanthin delivered as capsules is adequate, and well tolerated. Supplementation with astaxanthin may decrease in vivo oxidation of fatty acids in healthy men...
  17. ncbi Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Tiina H Rissanen
    Research Institute of Public Health, Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 77:133-8. 2003
    ..Lycopene is one of the major carotenoids in the Western diet and is probably one of the protective factors in a vegetable-rich diet...
  18. doi Coffee, tea and caffeine intake and the risk of severe depression in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Anu Ruusunen
    Institute of Public Health and Clinical Nutrition, Kuopio Campus, University of Eastern Finland, 70211 Kuopio, Finland
    Public Health Nutr 13:1215-20. 2010
    ..Only a few cross-sectional studies have assessed the association between coffee, tea and caffeine and the risk of depression. Our aim was to determine the association in a population-based cohort study...
  19. doi Dietary intake and urinary excretion of lignans in Finnish men
    Tarja Nurmi
    Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, PO Box 1627, FI 70211 Kuopio, Finland
    Br J Nutr 103:677-85. 2010
    ..Although the assessed intake of lignans corresponded well with the urinary excretion of lignans, the enterolactone production in the human body depended more on the dietary sources of lignans than the absolute intake of lignans...
  20. ncbi Dietary folate and the risk of depression in Finnish middle-aged men. A prospective follow-up study
    Tommi Tolmunen
    Department of Psychiatry, University of Kuopio, Kuopio, Finland
    Psychother Psychosom 73:334-9. 2004
    ..Several cross-sectional studies have focused on the low blood folate levels of depressive patients. Nevertheless, no prospective studies have been published on the association between dietary folate and depression...
  21. doi Serum polyunsaturated fatty acids are not associated with the risk of severe depression in middle-aged Finnish men: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study
    Anu Ruusunen
    Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
    Eur J Nutr 50:89-96. 2011
    ..The aim of this study is to investigate whether serum n - 3 polyunsaturated fatty acids (PUFAs) or n - 6 to n - 3 ratio is associated with risk of severe depression in middle-aged Finnish men...
  22. ncbi Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study
    Riitta M Salonen
    Research Institute of Public Health, University of Kuopio, Finland
    Circulation 107:947-53. 2003
    ..This article examines the 6-year effect of supplementation on common carotid artery (CCA) intima-media thickness (IMT)...
  23. doi Serum long-chain n-3 polyunsaturated fatty acids, methylmercury and blood pressure in an older population
    Jyrki K Virtanen
    University of Eastern Finland, Institute of Public Health and Clinical Nutrition, Kuopio, Finland
    Hypertens Res 35:1000-4. 2012
    ..These results suggest that higher serum long-chain n-3 PUFA concentration has a modest inverse association with blood pressure in older men and women...
  24. pmc Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study
    Jyrki K Virtanen
    University of Eastern Finland, Institute of Public Health and Clinical Nutrition, Kuopio, Finland
    PLoS ONE 7:e41046. 2012
    ..It is also a major source of methylmercury, which was associated with increased risk of CVD in this study population. Impact of interaction between long-chain n-3 PUFA and methylmercury on the SCD risk is unknown...
  25. ncbi Dietary zinc intake and the risk of depression in middle-aged men: a 20-year prospective follow-up study
    Soili M Lehto
    Department of Psychiatry, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    J Affect Disord 150:682-5. 2013
    ..This study examined the association between dietary zinc intake and depression in a prospective setting in initially depression-free men during a 20-year follow-up...
  26. doi Body iron stores and the risk of type 2 diabetes in middle-aged men
    Alex Aregbesola
    Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Yliopistonranta 1C, PO Box 1627, FI70211 Kuopio, Finland
    Eur J Endocrinol 169:247-53. 2013
    ..We investigated the risk of type 2 diabetes mellitus (T2DM) over a wide range of body iron stores...
  27. pmc Elevated depressive symptoms and compositional changes in LDL particles in middle-aged men
    Soili M Lehto
    Department of Psychiatry, Kuopio University Hospital, 70210, Kuopio, Finland
    Eur J Epidemiol 25:403-9. 2010
    ..Our findings suggest that greater small-particle LDL levels are not associated with depression, and are thus unlikely to underlie the association between cardiovascular risk and depression...
  28. ncbi Risk of cardiovascular disease-related and all-cause death according to serum concentrations of enterolactone: Kuopio Ischaemic Heart Disease Risk Factor Study
    Meri Vanharanta
    Research Institute of Public Health, University of Kuopio, Harjulantie 1B, 70210 Kuopio, Finland
    Arch Intern Med 163:1099-104. 2003
    ..Owing to its phenolic structure, enterolactone and its plant lignan precursors, which are converted by intestinal bacteria to enterolactone, are potential antioxidants...
  29. ncbi Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans
    Jaakko Mursu
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Free Radic Biol Med 37:1351-9. 2004
    ..Cocoa polyphenols may increase the concentration of HDL cholesterol, whereas chocolate fatty acids may modify the fatty acid composition of LDL and make it more resistant to oxidative damage...
  30. ncbi Lycopene, atherosclerosis, and coronary heart disease
    Tiina Rissanen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland 70211
    Exp Biol Med (Maywood) 227:900-7. 2002
    ..We conclude that circulating levels of lycopene, a biomarker of tomato-rich food, may play a role in early stages of atherogenesis and may have clinical and public health relevance...
  31. ncbi Mercury as a risk factor for cardiovascular diseases
    Jyrki K Virtanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    J Nutr Biochem 18:75-85. 2007
    ..There are several plausible mechanisms to explain the association; these are discussed in this review. We also review the epidemiological studies that have investigated the association between mercury and CVD...
  32. ncbi Dietary folate and depressive symptoms are associated in middle-aged Finnish men
    Tommi Tolmunen
    Department of Psychiatry, University of Kuopio, Finland
    J Nutr 133:3233-6. 2003
    ..46, 95% CI = 1.01-2.12, P = 0.044). There were no associations between the intake of cobalamin, pyridoxine or riboflavin, and depression. These results indicate that nutrition may have a role in the prevention of depression...
  33. ncbi Arginine intake, blood pressure, and the incidence of acute coronary events in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Birgitta Venho
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 76:359-64. 2002
    ..Evidence suggests that dietary supplementation of L-arginine, the precursor of nitric oxide, may protect arteries against atherosclerosis...
  34. ncbi Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study
    David E Laaksonen
    Department of Physiology, University of Kuopio, Kuopio, Finland
    Int J Cancer 111:444-50. 2004
    ....
  35. doi Serum long-chain n-3 polyunsaturated fatty acids and risk of hospital diagnosis of atrial fibrillation in men
    Jyrki K Virtanen
    Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Circulation 120:2315-21. 2009
    ..We tested this hypothesis by studying the association between the serum long-chain n-3 PUFAs eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid and risk of AF in men...
  36. doi Serum 25-hydroxyvitamin D3 and the risk of pneumonia in an ageing general population
    Alex Aregbesola
    Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Yliopistonranta 1C, P O Box 1627, Kuopio, North Savo FI70211, Finland
    J Epidemiol Community Health 67:533-6. 2013
    ..We therefore investigated the effect of serum 25-hydroxyvitamin D₃ (25(OH)D₃) on the risk of incident hospitalised pneumonia in an ageing general population in eastern Finland...
  37. doi Association of serum 25-hydroxyvitamin D with type 2 diabetes and markers of insulin resistance in a general older population in Finland
    Anne Riina Hurskainen
    The Institute of Public Health and Clinical Nutrition, University of Eastern Finland, PO Box 1627, 70211 Kuopio, Finland
    Diabetes Metab Res Rev 28:418-23. 2012
    ..Our aim was to study the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D status, and glucose homeostasis and type 2 diabetes in a general population sample in Eastern Finland...
  38. doi Psychosocial problems in childhood and later alcohol consumption: a life course approach with historical information
    Janne Leino
    Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Scand J Public Health 39:749-56. 2011
    ..Childhood psychosocial problems have been associated with poor alcohol habits in adulthood. The purpose of this study was to investigate further the association in men by using information from historical health records...
  39. ncbi Liquid chromatography method for plant and mammalian lignans in human urine
    Tarja Nurmi
    Research Institute of Public Health, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    J Chromatogr B Analyt Technol Biomed Life Sci 798:101-10. 2003
    ..e. sample with very high concentrations of mammalian lignans. The method was found to be a useful tool for studies on plant lignan intake and the activity of micro flora in the metabolism of plant lignans...
  40. doi Metabolism of berry anthocyanins to phenolic acids in humans
    Tarja Nurmi
    Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    J Agric Food Chem 57:2274-81. 2009
    ..Although anthocyanins were partly fragmented to phenolic acids, still a large part of metabolites remained unknown...
  41. ncbi Coffee drinking is dose-dependently related to the risk of acute coronary events in middle-aged men
    Pertti Happonen
    Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland
    J Nutr 134:2381-6. 2004
    ..In conclusion, heavy coffee consumption increases the short-term risk of acute myocardial infarction or coronary death, independent of the brewing method or currently recognized risk factors for CHD...
  42. pmc Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation
    Carsten Carlberg
    School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 8:e71042. 2013
    ..These biomarkers allow the classification of subjects into those, who might benefit from a vitamin D3 supplementation, and others who do not. ..
  43. pmc Alcohol consumption and dietary patterns: the FinDrink study
    Timothy O Fawehinmi
    Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 7:e38607. 2012
    ..Further studies on the relationship between alcohol consumption and dietary habits are needed to plan a comprehensive dietary intervention programs in future...
  44. ncbi Association between low serum enterolactone and increased plasma F2-isoprostanes, a measure of lipid peroxidation
    Meri Vanharanta
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Atherosclerosis 160:465-9. 2002
    ..Our present data suggest that low serum enterolactone concentration is associated with enhanced in vivo lipid peroxidation in men...
  45. doi Twelve-year trend in treatment seeking for buprenorphine abuse in Finland
    Hanna Uosukainen
    School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland
    Drug Alcohol Depend 127:207-14. 2013
    ..The objective of this study was to examine the trend in characteristics of clients seeking treatment for buprenorphine abuse and compare them to those seeking treatment for heroin and amphetamine abuse...
  46. ncbi Consumption of juice fortified with oregano extract markedly increases excretion of phenolic acids but lacks short- and long-term effects on lipid peroxidation in healthy nonsmoking men
    Anna Nurmi
    Division of Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, Finland
    J Agric Food Chem 54:5790-6. 2006
    ....
  47. ncbi Risks and benefits of fish intake
    Tomi Pekka Tuomainen
    JAMA 297:585-6; author reply 586. 2007
  48. ncbi Ingestion of oregano extract increases excretion of urinary phenolic metabolites in humans
    Anna Nurmi
    Division of Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, Finland
    J Agric Food Chem 54:6916-23. 2006
    ..The main metabolite, p-hydroxybenzoic acid, was excreted rapidly. The results show that constituents of oregano extract and, in particular, their metabolites may contribute to the dietary intake of phenolic antioxidants...
  49. ncbi Coffee intake and the incidence of hypertension
    Sari Voutilainen
    Am J Clin Nutr 86:1248; author reply 1249. 2007
  50. ncbi Coffee and sweetened beverage consumption and the risk of type 2 diabetes mellitus: the atherosclerosis risk in communities study
    Nina P Paynter
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 164:1075-84. 2006
    ..In summary, increased coffee consumption was significantly associated with a decreased risk of diagnosed type 2 diabetes mellitus in community-based US adults...