M Vihinen

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. pmc Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death
    Yue Mei Fan
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland
    Thromb J 6:17. 2008
  2. pmc Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals
    Kirsi M Kuusisto
    Institute of Biomedical Technology, University of Tampere, Biokatu 8, Tampere, 33520, Finland
    Breast Cancer Res 13:R20. 2011
  3. pmc Spectrum of disease-causing mutations in protein secondary structures
    Sofia Khan
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    BMC Struct Biol 7:56. 2007
  4. pmc Distribution of immunodeficiency fact files with XML--from Web to WAP
    Jouni Väliaho
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    BMC Med Inform Decis Mak 5:21. 2005
  5. pmc Immunome knowledge base (IKB): an integrated service for immunome research
    Csaba Ortutay
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    BMC Immunol 10:3. 2009
  6. pmc Prediction of disease-related mutations affecting protein localization
    Kirsti Laurila
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    BMC Genomics 10:122. 2009
  7. pmc NMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene
    Henna Mattila
    Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
    BMC Cancer 11:327. 2011
  8. pmc A statistical score for assessing the quality of multiple sequence alignments
    Virpi Ahola
    Biotechnology and Food Research, MTT Agrifood Research Finland, Jokioinen, Finland
    BMC Bioinformatics 7:484. 2006
  9. pmc Dynamic covariation between gene expression and proteome characteristics
    Mansour Taghavi Azar Sharabiani
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    BMC Bioinformatics 6:215. 2005
  10. pmc PROlocalizer: integrated web service for protein subcellular localization prediction
    Kirsti Laurila
    Department of Signal Processing, Tampere University of Technology, Tampere, Finland
    Amino Acids 40:975-80. 2011

Detail Information

Publications63

  1. pmc Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death
    Yue Mei Fan
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland
    Thromb J 6:17. 2008
    ....
  2. pmc Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals
    Kirsi M Kuusisto
    Institute of Biomedical Technology, University of Tampere, Biokatu 8, Tampere, 33520, Finland
    Breast Cancer Res 13:R20. 2011
    ..We aimed to analyze additional mutations in HBC-associated genes and to define the sensitivity of our current BRCA1/2 mutation analysis protocol used in genetic counseling...
  3. pmc Spectrum of disease-causing mutations in protein secondary structures
    Sofia Khan
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    BMC Struct Biol 7:56. 2007
    ..Further, the effect of a mutation is also dependent on the sequence and structure context of the alteration...
  4. pmc Distribution of immunodeficiency fact files with XML--from Web to WAP
    Jouni Väliaho
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    BMC Med Inform Decis Mak 5:21. 2005
    ..A XML-based language enables creation of open source databases for storage, maintenance and delivery for different platforms...
  5. pmc Immunome knowledge base (IKB): an integrated service for immunome research
    Csaba Ortutay
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    BMC Immunol 10:3. 2009
    ..However, these data are scattered into several databases and literature and therefore integration is needed...
  6. pmc Prediction of disease-related mutations affecting protein localization
    Kirsti Laurila
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    BMC Genomics 10:122. 2009
    ....
  7. pmc NMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene
    Henna Mattila
    Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
    BMC Cancer 11:327. 2011
    ..Several predisposition loci for hereditary prostate cancer (HPC) have been suggested, including HPCX1 at Xq27-q28, but due to the complex structure of the region, the susceptibility gene has not yet been identified...
  8. pmc A statistical score for assessing the quality of multiple sequence alignments
    Virpi Ahola
    Biotechnology and Food Research, MTT Agrifood Research Finland, Jokioinen, Finland
    BMC Bioinformatics 7:484. 2006
    ..Although the automatic construction of a multiple sequence alignment for a set of remotely related sequences cause a very challenging and error-prone task, many downstream analyses still rely heavily on the accuracy of the alignments...
  9. pmc Dynamic covariation between gene expression and proteome characteristics
    Mansour Taghavi Azar Sharabiani
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    BMC Bioinformatics 6:215. 2005
    ..Since the majority of genes encode proteins, we investigated possible correlations between protein parameters and gene expression patterns to identify proteome-wide characteristics indicative of trends common to expressed proteins...
  10. pmc PROlocalizer: integrated web service for protein subcellular localization prediction
    Kirsti Laurila
    Department of Signal Processing, Tampere University of Technology, Tampere, Finland
    Amino Acids 40:975-80. 2011
    ..The method allows the submission of a number of proteins and mutations and generates a detailed informative document of the prediction and obtained results. PROlocalizer is available at http://bioinf.uta.fi/PROlocalizer/ ...
  11. ncbi Signal transduction-related bioinformatics services
    Mauno Vihinen
    Institute of Medical Technology, University of Tampere, Finland
    Brief Bioinform 4:325-31. 2003
    ..This has resulted in large body of publications and Internet services. This paper describes open-access databases and software aiming at presenting the kind of data available and how to perform bioinformatics analyses...
  12. ncbi Bioinformatics in proteomics
    M Vihinen
    Institute of Medical Technology, University of Tampere, Finland
    Biomol Eng 18:241-8. 2001
    ..The significance of informatics in proteomics will gradually increase because of the advent of high-throughput methods relying on powerful data analysis...
  13. ncbi Mutations of the human BTK gene coding for bruton tyrosine kinase in X-linked agammaglobulinemia
    M Vihinen
    Institute of Medical Technology, University of Tampere, Finland
    Hum Mutat 13:280-5. 1999
    ..The putative structural implications of all the missense mutations are provided in the database. BTKbase is available at http://www.uta.fi/imt/bioinfo...
  14. doi Guidelines for establishing locus specific databases
    Mauno Vihinen
    Institute of Biomedical Technology, University of Tampere, Finland
    Hum Mutat 33:298-305. 2012
    ..These resources are becoming ever more important and new curators are essential to ensure that we will have expertly curated databases for all disease-related genes in the near future...
  15. ncbi Molecular characterization of the immune system: emergence of proteins, processes, and domains
    Csaba Ortutay
    Institute of Medical Technology, University of Tampere, 33014, Tampere, Finland
    Immunogenetics 59:333-48. 2007
    ..Immunome genes were found to have three types of emergence in independent studies of their ontologies, domains, and functions...
  16. ncbi cDNA microarray analysis of gene expression in coeliac disease jejunal biopsy samples
    K Juuti-Uusitalo
    Paediatric Research Centre, Tampere University Hospital, University of Tampere, FIN 33014 Tampere, Finland
    J Autoimmun 22:249-65. 2004
    ..The method holds promise in exploring the pathogenetic mechanisms in the small bowel and may reveal new target genes for the therapy of coeliac disease...
  17. ncbi On preprocessing of protein sequences for neural network prediction of polyproline type II secondary structures
    M Siermala
    Department of Computer and Information Sciences, 33014 University of Tampere, Finland
    Comput Biol Med 31:385-98. 2001
    ..The problem is very difficult because of the great similarity of the two classes present in the classification. Nevertheless, neural networks were able to recognize and predict about 75% of secondary structures...
  18. ncbi The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein
    J Pitkanen
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33101 Tampere, Finland
    J Biol Chem 275:16802-9. 2000
    ..We suggest that the transcriptional transactivation properties of AIRE together with its interaction with CBP might be important in its function as disease-causing mutations almost totally abolish the activation effect...
  19. ncbi On approximate string matching of unique oligonucleotides
    H Hyyrö
    Department of Computer and Information Sciences, 33014 University of Tampere, Finland
    Stud Health Technol Inform 84:960-4. 2001
    ..We tested several approximate string matching algorithms and furthermore developed one for DNA data. Run times of the algorithms are important, since the amount of data is very large...
  20. ncbi Physicochemical feature-based classification of amino acid mutations
    Bairong Shen
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    Protein Eng Des Sel 21:37-44. 2008
    ..Different kernel functions, attributes and window sizes were optimized. An average accuracy of 80% was obtained in cross-validation experiments...
  21. ncbi Bioinformatic analysis of protein structure-function relationships: case study of leukocyte elastase (ELA2) missense mutations
    Janita Thusberg
    Institute of Medical Technology, University of Tampere, Finland
    Hum Mutat 27:1230-43. 2006
    ....
  22. pmc Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase
    Mika Hilvo
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, 33520 Tampere, Finland
    Biochem J 392:83-92. 2005
    ..Both specific and non-specific chaperones increase the production of active enzyme. The results suggest that CA XV is the first member of the alpha-CA gene family that is expressed in several species, but not in humans and chimpanzees...
  23. pmc PseudoGeneQuest - service for identification of different pseudogene types in the human genome
    Csaba Ortutay
    Institute of Medical Technology, University of Tampere, FI 33014 Tampere, Finland
    BMC Bioinformatics 9:299. 2008
    ..PseudoGeneQuest is an online tool to search the human genome for a given query sequence and to identify different types of pseudogenes as well as novel genes and gene fragments...
  24. ncbi Immunity genes and their orthologs: a multi-species database
    Kathryn Rannikko
    Bioinformatics Research Group, Institute of Medical Technology, FI 33014, University of Tampere, Finland
    Int Immunol 19:1361-70. 2007
    ..All the immunity genes and their evidence of immune function, orthologs and ortholog groups have been combined into an open access database -- ImmunomeBase, which is publicly available from (http://bioinf.uta.fi/ImmunomeBase)...
  25. pmc Identification of candidate disease genes by integrating Gene Ontologies and protein-interaction networks: case study of primary immunodeficiencies
    Csaba Ortutay
    Institute of Medical Technology, FI 33014 University of Tampere and Tampere University Hospital, FI 33520 Tampere, Finland
    Nucleic Acids Res 37:622-8. 2009
    ..The method can be generalized for any disease group with sufficient information...
  26. ncbi RankViaContact: ranking and visualization of amino acid contacts
    Bairong Shen
    Institute of Medical Technology, University of Tampere, FIN 33014 and Research Unit, Tampere University Hospital, FIN 33520 Tampere, Finland
    Bioinformatics 19:2161-2. 2003
    ..The program can be used to design stabilizing mutations, to analyze residue-residue contacts and to study the consequences of mutations...
  27. doi Performance of protein stability predictors
    Sofia Khan
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    Hum Mutat 31:675-84. 2010
    ..However, at best, the predictions were only moderately accurate ( approximately 60%) and significantly better tools would be needed for routine analysis of mutation effects...
  28. ncbi BioWAP, mobile Internet service for bioinformatics
    P Riikonen
    Institute of Medical Technology, FIN-33014 University of Tampere, Finland
    Bioinformatics 17:855-6. 2001
    ..AVAILABILITY: The BioWAP service starting page can be browsed with any WAP terminal from http://bioinf.uta.fi/wml/welcome.wml...
  29. pmc IDR: the ImmunoDeficiency Resource
    Jouni Väliaho
    Institute of Medical Technology, FIN 33014 University of Tampere, Finland
    Nucleic Acids Res 30:232-4. 2002
    ..The fact files written by the IDML can be used to present data in different contexts and platforms. All the information in the IDR is validated by expert curators...
  30. ncbi KinMutBase: a registry of disease-causing mutations in protein kinase domains
    Csaba Ortutay
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    Hum Mutat 25:435-42. 2005
    ..CpG containing codons, especially for arginine, constitute the majority of mutational hotspots. There are certain clear differences in mutation patterns and types between PSKs and PTKs...
  31. ncbi Interaction between Btk TH and SH3 domain
    Michael P Okoh
    Institute of Medical Technology, FIN 33014 University of Tampere, Finland
    Biopolymers 63:325-34. 2002
    ..The intra- or intermolecular interaction between the TH and SH3 domain might have regulatory function also in the other Tec family members...
  32. ncbi Mobile access to biological databases on the Internet
    Pentti Riikonen
    Institute of Medical Technology, University of Tampere, Tampere, FIN 33014 Finland
    IEEE Trans Biomed Eng 49:1477-9. 2002
    ..e. the applications that are not WAP or Internet based. The BioWAP service can be browsed with any WAP terminal...
  33. ncbi Conservation and covariance in PH domain sequences: physicochemical profile and information theoretical analysis of XLA-causing mutations in the Btk PH domain
    Bairong Shen
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    Protein Eng Des Sel 17:267-76. 2004
    ..Together with additional structural analyses, all the XLA mutations that were analyzed could be explained at the molecular level. The method developed here is applicable to the design of mutations for protein engineering...
  34. doi Pathogenic or not? And if so, then how? Studying the effects of missense mutations using bioinformatics methods
    Janita Thusberg
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    Hum Mutat 30:703-14. 2009
    ..We discuss the applicability of these methods in the analysis of genes, proteins, and diseases to reveal protein structure-function relationships, which is essential to gain insights into disease genotype-phenotype correlations...
  35. ncbi Identification of novel transcription factor-like gene from human intestinal cells
    K Lindfors
    Institute of Medical Technology, Tampere, FIN 33014, Finland
    Biochem Biophys Res Commun 276:660-6. 2000
    ..Human AATF-mRNA was expressed at high levels in human brain, heart, thymus, kidney, and placenta while in skeletal muscle and colon the expression was lower. The gene was mapped to chromosome 17q11.2-q12...
  36. ncbi Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family
    U Aapola
    Institute of Medical Technology, University of Tampere, Finland
    Genomics 65:293-8. 2000
    ..Expression of the DNMT3L mRNA was not detectable by Northern blotting; however, RT-PCR amplification revealed that it is expressed at low levels in several tissues including testis, ovary, and thymus...
  37. ncbi Immunodeficiency mutation databases (IDbases)
    Hilkka Piirilä
    Institute of Medical Technology, University of Tampere, Finland
    Hum Mutat 27:1200-8. 2006
    ..Arginine is the most mutated as well as the most abundant mutant amino acid...
  38. doi Bioinformatics services related to diagnosis of primary immunodeficiencies
    Crina Samarghitean
    Institute of Medical Technology, University of Tampere, Finland
    Curr Opin Allergy Clin Immunol 9:531-6. 2009
    ..Patient information has been collected in different patient registries. Several software tools have been developed in order to build the databases, expert systems and other information systems useful in diagnosis or prediction...
  39. ncbi Structural basis of ICF-causing mutations in the methyltransferase domain of DNMT3B
    Ilkka Lappalainen
    Institute of Medical Technology, FIN 33014 University of Tampere, Tampere, Finland
    Protein Eng 15:1005-14. 2002
    ..The structural principles of the pathogenic mutations based on the modelled structure and the analysis of chi angle rotation changes of mutated side chains are discussed...
  40. ncbi Online registry of genetic and clinical immunodeficiency diagnostic laboratories, IDdiagnostics
    Crina Samarghitean
    Institute of Medical Technology, FIN 33014 University of Tampere, Finland
    J Clin Immunol 24:53-61. 2004
    ..Both the services are freely available and regularly updated. The services aim at increasing the awareness of IDs and helping to obtain exact and early diagnosis...
  41. ncbi Immunome: a reference set of genes and proteins for systems biology of the human immune system
    Csaba Ortutay
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    Cell Immunol 244:87-9. 2006
    ..The reference set and the categories are freely available in the immunome database at http://bioinf.uta.fi/Immunome/...
  42. ncbi Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family
    Jonna Lehtonen
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    J Biol Chem 279:2719-27. 2004
    ..In conclusion, the predicted amino acid sequence, structural model, distribution, and activity data suggest that CA XIII represents a novel enzyme, which may play important physiological roles in several organs...
  43. ncbi SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase
    A Manninen
    Institute of Medical Technology, University of Tampere, Tampere, FIN 33101, Finland
    Virology 250:273-82. 1998
    ..Molecular modeling suggests that these residues are involved in formation of an adjacent binding surface for NAK or another critical component of the NAK/Nef complex...
  44. doi Phylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5
    Csaba Ortutay
    Institute of Medical Technology, FI 33014 University of Tampere, Finland
    Adv Genet 64:51-80. 2008
    ..It is conserved in choanoflagellates and interestingly exists also in nematodes, which do not express TFKs, suggesting a broader function in addition to Btk regulation. The related SH3BP5-like protein is not found in Nematodes...
  45. ncbi Profiling genetic variation along the androgen biosynthesis and metabolism pathways implicates several single nucleotide polymorphisms and their combinations as prostate cancer risk factors
    Nina Mononen
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere FIN 33014, Finland
    Cancer Res 66:743-7. 2006
    ....
  46. ncbi BTKbase: the mutation database for X-linked agammaglobulinemia
    Jouni Väliaho
    Institute of Medical Technology, University of Tampere, Finland
    Hum Mutat 27:1209-17. 2006
    ..The structural consequences of the mutations in all the domains have been studied based on crystallographic and nuclear magnetic resonance (NMR) structures as well as computer-aided molecular modeling...
  47. doi Systematic classification of primary immunodeficiencies based on clinical, pathological, and laboratory parameters
    Crina Samarghitean
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    J Immunol 183:7569-75. 2009
    ..The method can be applied to any group of diseases...
  48. ncbi APECED-causing mutations in AIRE reveal the functional domains of the protein
    Maria Halonen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mutat 23:245-57. 2004
    ....
  49. ncbi Efficient estimation of emission probabilities in profile hidden Markov models
    Virpi Ahola
    Department of Statistics, FIN 20014 University of Turku, Finland
    Bioinformatics 19:2359-68. 2003
    ..For this reason, the number of estimated emission parameters is often enormous. Focusing the analysis on conserved residues only should increase the accuracy of sequence database search...
  50. ncbi Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling
    Jessica M Lindvall
    Clinical Research Center, Karolinska Institutet, Huddinge, Sweden
    Immunol Rev 203:200-15. 2005
    ..We conclusively demonstrate that for the R28C-missense mutant (Xid), there is no biologically relevant residual activity or any dominant negative effect versus other proteins...
  51. doi Human Proteinpedia enables sharing of human protein data
    Suresh Mathivanan
    Nat Biotechnol 26:164-7. 2008
  52. ncbi Fast iterative gene clustering based on information theoretic criteria for selecting the cluster structure
    Ciprian Doru Giurcăneanu
    Institute of Signal Processing, Tampere University of Technology, P O Box 553, FIN 33101 Tampere, Finland
    J Comput Biol 11:660-82. 2004
    ..The proposed method is applied to B-cell differentiation data, and the resulting clusters are compared with those found by self-organizing maps (SOM)...
  53. ncbi PhenCode: connecting ENCODE data with mutations and phenotype
    Belinda Giardine
    Center for Comparative Genomics and Bioinformatics, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Hum Mutat 28:554-62. 2007
    ..We present several examples illustrating the power of these connections for exploring phenotypes associated with functional elements, and for identifying genomic data that could help to explain clinical phenotypes...
  54. ncbi On exact string matching of unique oligonucleotides
    Heikki Hyyrö
    Department of Computer Sciences, 33014 University of Tampere, Tampere, Finland
    Comput Biol Med 35:173-81. 2005
    ..e. in respect of theoretical time complexity, these algorithms do not actually differ essentially from each other...
  55. ncbi Structure-function analysis of PrsA reveals roles for the parvulin-like and flanking N- and C-terminal domains in protein folding and secretion in Bacillus subtilis
    Marika Vitikainen
    Vaccine Development Laboratory, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Biol Chem 279:19302-14. 2004
    ..Our results indicate that PrsA is a PPIase, but the essential role in vivo seems to depend on some non-PPIase activity of both the parvulin-like and flanking domains...
  56. pmc Genome-wide selection of unique and valid oligonucleotides
    Heikki Hyyrö
    Department of Computer Sciences, FI 33014 University of Tampere, Finland
    Nucleic Acids Res 33:e115. 2005
    ..The flanking regions in eukaryotes were clearly underrepresented among suitable oligonucleotides. In addition to distributions within genes, the effects on codon and amino acid usage were also studied...
  57. ncbi Novel insertions of Bruton tyrosine kinase in patients with X-linked agammaglobulinemia
    Michael P Okoh
    Institute of Medical Technology, FIN 33014 University of Tampere, Finland
    Hum Mutat 20:480-1. 2002
    ..In the intron 4 there is a substitution of two bases. Carrier detection was performed in four families. In one case the mutation was found to be de novo...
  58. doi Model-based prediction of sequence alignment quality
    Virpi Ahola
    Biotechnology and Food Research, MTT Agrifood Research Finland, FI 31600 Jokioinen, Finland
    Bioinformatics 24:2165-71. 2008
    ..Since the success of the sequence analysis is highly dependent on the reliability of alignments, measures for assessing the quality of alignments are highly requisite...
  59. doi Genome wide analysis of pathogenic SH2 domain mutations
    Ilkka Lappalainen
    Department of Biological and Environmental Sciences, Division of Biochemistry, FI 00014 University of Helsinki, Finland
    Proteins 72:779-92. 2008
    ..The majority of the mutations affect positions essential for phosphotyrosine ligand binding and specificity. The structural basis of the SH2 domain diseases was elucidated based on the bioinformatic analysis...
  60. ncbi Identification of differentially expressed genes after PPM1D silencing in breast cancer
    Jenita Pärssinen
    Laboratory of Cancer Genetics, Tampere University Hospital, FI 33014 University of Tampere, Finland
    Cancer Lett 259:61-70. 2008
    ..Overall, our findings suggest that PPM1D contributes to breast cancer associated phenotypic characteristics by directly or indirectly affecting several important cellular signaling pathways...
  61. pmc Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
    Pipsa Saharinen
    Haartman Institute, Department of Virology, University of Helsinki, Helsinki FIN 00014, Finland
    Mol Biol Cell 14:1448-59. 2003
    ..Together, the results provide evidence for autoinhibition of a Jak family kinase and identify JH2 regions important for autoregulation of Jak2...
  62. pmc High-precision mapping of protein protein interfaces: an integrated genetic strategy combining en masse mutagenesis and DNA-level parallel analysis on a yeast two-hybrid platform
    Maria Pajunen
    Program in Cellular Biotechnology, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Nucleic Acids Res 35:e103. 2007
    ..We demonstrate the feasibility of the methodology by mapping the region in human JFC1 that interacts with Rab8A, and we show that the association is mediated by the Slp homology domain 1...
  63. ncbi Probing the alpha-complementing domain of E. coli beta-galactosidase with use of an insertional pentapeptide mutagenesis strategy based on Mu in vitro DNA transposition
    Eini Poussu
    Program in Cellular Biotechnology, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Proteins 54:681-92. 2004
    ..Six percent of the mutant proteins exhibited temperature sensitivity, in general suggesting the method's usefulness for generation of conditional phenotypes. The method should be applicable to any cloned protein-encoding gene...