S J Vainio

Summary

Affiliation: University of Oulu
Country: Finland

Publications

  1. doi Coordination of kidney organogenesis by Wnt signaling
    Kimmo Halt
    The Centre of Excellence in Cell Extracellular Matrix Research, Oulu, Finland
    Pediatr Nephrol 29:737-44. 2014
  2. pmc A secreted BMP antagonist, Cer1, fine tunes the spatial organization of the ureteric bud tree during mouse kidney development
    Lijun Chi
    Laboratory of Developmental Biology, Department of Medical Biochemistry and Molecular Biology, Center for Cell Matrix Research, Institute of Biomedicine Oulu, Biocenter Oulu, University of Oulu, Oulu, Finland
    PLoS ONE 6:e27676. 2011
  3. ncbi Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimüllerian hormone expression during oocyte maturation in the female follicle
    Renata Prunskaite-Hyyryläinen
    1Laboratory of Developmental Biology, Department of Medical Biochemistry and Molecular Biology, University of Oulu and Biocenter Oulu, Aapistie 5, P O Box 5000, FIN 90220, Oulu, Finland
    FASEB J 28:1568-81. 2014
  4. ncbi How the developing mammalian kidney assembles its thousands of nephrons: Fgfs as stemness signals
    Seppo Vainio
    Biocenter Oulu, Laboratory of Developmental Biology and Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, Oulu Center for Cell Matrix Research, University of Oulu, P O Box 5000, Oulu FIN 90014, Finland
    Dev Cell 22:1125-6. 2012
  5. ncbi Wnts as kidney tubule inducing factors
    S J Vainio
    Biocenter Oulu and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, Finland
    Int J Dev Biol 43:419-23. 1999
  6. ncbi Nephrogenesis regulated by Wnt signaling
    Seppo J Vainio
    Biocenter and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, PO Box 3000, Oulu, FIN 90014, Finland
    J Nephrol 16:279-85. 2003
  7. ncbi A road to kidney tubules via the Wnt pathway
    S J Vainio
    University of Oulu, Department of Biochemistry, Linnanmaa, Finland
    Pediatr Nephrol 15:151-6. 2000
  8. ncbi Coordinating early kidney development: lessons from gene targeting
    Seppo Vainio
    Biocenter Oulu and Department of Biochemistry, Linnanmaa, Faculties of Science and Medicine, University of Oulu, P O Box 3000, FIN 90014, Finland
    Nat Rev Genet 3:533-43. 2002
  9. ncbi Patterning parameters associated with the branching of the ureteric bud regulated by epithelial-mesenchymal interactions
    Yanfeng Lin
    Biocenter Oulu and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, Finland
    Int J Dev Biol 47:3-13. 2003
  10. ncbi Induced repatterning of type XVIII collagen associates with ectopic Sonic hedgehog and lung surfactant C gene expression and changes in epithelial epigenesis in the ureteric bud
    Seppo Vainio
    Biocenter Oulu, University of Oulu, Oulu, Finland
    J Am Soc Nephrol 14:S3-8. 2003

Collaborators

  • Matti Kinnunen
  • Claude Perreault
  • Jose Antonio Belo
  • Yuji Yokouchi
  • Jamie Davies
  • Kimmo Halt
  • P Neubauer
  • VESA M KAARTINEN
  • Ildikó Loikkanen
  • Beatrix Fahnert
  • Petri Itäranta
  • Jingdong Shan
  • Lijun Chi
  • Renata Prunskaite-Hyyryläinen
  • Antti Railo
  • Tiina Jokela
  • Yanfeng Lin
  • Hellevi Peltoketo
  • Shaobing Zhang
  • Ilya Skovorodkin
  • Antti M Salo
  • Ilkka Pietilä
  • Juha Tuukkanen
  • Kalle Savolainen
  • Ilkka Miinalainen
  • Krista M Heinonen
  • Bairong Shen
  • Wenying Yan
  • Kenjiro Katsu
  • Yu Liu
  • Ulla Saarela
  • Shelagh Anthony
  • Ana Marisa Salgueiro
  • Florence Naillat
  • Keijo Viiri
  • Jussi Vuoristo
  • Pekka Kilpeläinen
  • Antti Pajunen
  • Raili Myllyla
  • Laura Sipilä
  • Raija Sormunen
  • Mikael Niku
  • Heli Ruotsalainen
  • Tiina Seppänen
  • J Kalervo Hiltunen
  • Mika Ilves
  • Werner Schmitz
  • Ernst Conzelmann
  • Reetta Vuolteenaho
  • Tiina J Kotti
  • Raija T Sormunen
  • Teuvo I Savolainen
  • Taina Pihlajaniemi
  • Giulietta Roël
  • Olivier Destree
  • Juha Peräsaari

Detail Information

Publications27

  1. doi Coordination of kidney organogenesis by Wnt signaling
    Kimmo Halt
    The Centre of Excellence in Cell Extracellular Matrix Research, Oulu, Finland
    Pediatr Nephrol 29:737-44. 2014
    ..Wnt-mediated signaling regulates several critical aspects of kidney development from the early inductive stages to later steps of tubular epithelial maturation. ..
  2. pmc A secreted BMP antagonist, Cer1, fine tunes the spatial organization of the ureteric bud tree during mouse kidney development
    Lijun Chi
    Laboratory of Developmental Biology, Department of Medical Biochemistry and Molecular Biology, Center for Cell Matrix Research, Institute of Biomedicine Oulu, Biocenter Oulu, University of Oulu, Oulu, Finland
    PLoS ONE 6:e27676. 2011
    ....
  3. ncbi Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimüllerian hormone expression during oocyte maturation in the female follicle
    Renata Prunskaite-Hyyryläinen
    1Laboratory of Developmental Biology, Department of Medical Biochemistry and Molecular Biology, University of Oulu and Biocenter Oulu, Aapistie 5, P O Box 5000, FIN 90220, Oulu, Finland
    FASEB J 28:1568-81. 2014
    ..Thus, Wnt4 signaling is necessary during maturation of the ovarian follicles, where it coordinates expression of Amh, cell survival, and polarized organization of the follicular cells...
  4. ncbi How the developing mammalian kidney assembles its thousands of nephrons: Fgfs as stemness signals
    Seppo Vainio
    Biocenter Oulu, Laboratory of Developmental Biology and Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, Oulu Center for Cell Matrix Research, University of Oulu, P O Box 5000, Oulu FIN 90014, Finland
    Dev Cell 22:1125-6. 2012
    ..These Fgfs serve as survival and nephron-forming competence signals for purified Six2+ cells that represent the progenitors that normally go on to generate nephrons...
  5. ncbi Wnts as kidney tubule inducing factors
    S J Vainio
    Biocenter Oulu and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, Finland
    Int J Dev Biol 43:419-23. 1999
    ..Here, we will review evidence suggesting that secreted signaling molecules from the Wnt gene family mediate kidney tubule induction...
  6. ncbi Nephrogenesis regulated by Wnt signaling
    Seppo J Vainio
    Biocenter and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, PO Box 3000, Oulu, FIN 90014, Finland
    J Nephrol 16:279-85. 2003
    ..The varied role of Wnt signaling in the developing kidney is discussed...
  7. ncbi A road to kidney tubules via the Wnt pathway
    S J Vainio
    University of Oulu, Department of Biochemistry, Linnanmaa, Finland
    Pediatr Nephrol 15:151-6. 2000
    ..Taken together, the data provide evidence of an essential role for Wnt signal transmission and transduction pathways in the induction of kidney tubules, and the findings have paved the way for detailed molecular studies...
  8. ncbi Coordinating early kidney development: lessons from gene targeting
    Seppo Vainio
    Biocenter Oulu and Department of Biochemistry, Linnanmaa, Faculties of Science and Medicine, University of Oulu, P O Box 3000, FIN 90014, Finland
    Nat Rev Genet 3:533-43. 2002
    ..Although our understanding of how the kidney is assembled is still limited, these studies are beginning to provide insights into the genetic and cellular interactions that regulate early organogenesis...
  9. ncbi Patterning parameters associated with the branching of the ureteric bud regulated by epithelial-mesenchymal interactions
    Yanfeng Lin
    Biocenter Oulu and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, Finland
    Int J Dev Biol 47:3-13. 2003
    ....
  10. ncbi Induced repatterning of type XVIII collagen associates with ectopic Sonic hedgehog and lung surfactant C gene expression and changes in epithelial epigenesis in the ureteric bud
    Seppo Vainio
    Biocenter Oulu, University of Oulu, Oulu, Finland
    J Am Soc Nephrol 14:S3-8. 2003
    ....
  11. ncbi In vitro studies toward noninvasive glucose monitoring with optical coherence tomography
    Matti Kinnunen
    Optoelectronics and Measurement Techniques Laboratory and Infotech Oulu, University of Finland
    Appl Opt 45:2251-60. 2006
    ..This change is much larger than the change in 2% Intralipid (2.1%/30 mM) and in 5% Intralipid (0.86%/30 mM). Hence the results show that OCT has potential to monitor glucose-induced changes in tissues in vitro...
  12. ncbi Expression of cytosolic acetyl-CoA synthetase gene is developmentally regulated
    Ildikó Loikkanen
    Department of Biochemistry, University of Oulu, P O Box 3000, FIN 90014 Oulu, Finland
    Mech Dev 115:139-41. 2002
    ..In the kidneys AceCS1 transcripts appear in a subset of the renal tubules at E16.5 and remains in these structures in newborns. Hence, expression of AceCS1 is developmentally regulated suggesting a role for AceCS1 during embryogenesis...
  13. doi Detecting glucose-induced changes in in vitro and in vivo experiments with optical coherence tomography
    Matti Kinnunen
    University of Oulu, Optoelectronics and Measurement Techniques Laboratory and Infotech Oulu, Department of Electrical and Information Engineering, P O Box 4500, FIN 90014 Oulu, Finland
    J Biomed Opt 13:021111. 2008
    ..In comparison with tissue, the effect of glucose is the smallest in Intralipid. The results increase the value of using cultured tissue in developing optical sensing techniques...
  14. ncbi Murine Wnt-1 with an internal c-myc tag recombinantly produced in Escherichia coli can induce intracellular signaling of the canonical Wnt pathway in eukaryotic cells
    Beatrix Fahnert
    Bioprocess Engineering Laboratory, Department of Process and Environmental Engineering, University of Oulu, P O Box 4300, FIN 90014 Oulu, Finland
    J Biol Chem 279:47520-7. 2004
    ..Thus, this approach could make recombinant murine Wnt-1 available as a good starting point for other Wnts needed, for example, for maintaining and differentiating stem cells, organ restoration therapy, and tissue engineering...
  15. ncbi Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes
    Ildikó Loikkanen
    Department of Biochemistry, University of Oulu, PO Box 3000, FIN 90014 Oulu, Finland
    Differentiation 73:303-12. 2005
    ..We propose that ODC and polyamines have an important role in kidney organogenesis, being involved in the regulation of the expression of genes implicated in epithelial-mesenchymal tissue interactions...
  16. ncbi Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro
    Petri Itäranta
    Biocenter Oulu, Department of Biochemistry, University of Oulu, Linnanmaa 90570 Oulu, Finland
    Genesis 32:259-68. 2002
    ..Wnt-6 also induces a secondary axis in early Xenopus embryos. We conclude that Wnt-6 is a candidate for the ureter epithelium-derived signal that leads to activation of kidney tubulogenesis via Wnt-4...
  17. ncbi The lysyl hydroxylase isoforms are widely expressed during mouse embryogenesis, but obtain tissue- and cell-specific patterns in the adult
    Antti M Salo
    Department of Biochemistry and Biocenter Oulu, University of Oulu, PO Box 3000, FI 90014 University of Oulu, Finland
    Matrix Biol 25:475-83. 2006
    ..The results reveal a specific regulation for the expression of LH isoforms as well as for alternative splicing of LH2 during embryogenesis and in different tissues...
  18. ncbi Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development
    Lijun Chi
    Biocenter Oulu and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, PO Box 3000, FIN 90014 Oulu, Finland
    Development 131:3345-56. 2004
    ..Together, these data suggest that Spry genes contribute to reciprocal epithelial-mesenchymal and stromal signalling controlling ureteric branching, which involves the coordination of Ffg/Wnt11/Gdnf pathways...
  19. ncbi Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney
    Petri Itäranta
    Biocenter Oulu, Department of Medical Biochemistry and Molecular Biology, Laboratory of Developmental Biology, University of Oulu, Aapistie 5A, P O Box 5000, University of Oulu, FIN 90220, Finland
    Dev Biol 293:473-83. 2006
    ..Thus, besides being critical for regulating mesenchymal to epithelial transformation in the cortical region in nephrogenesis, Wnt-4 signaling regulates the fate of smooth muscle cells in the developing medullary region...
  20. doi Genomic response to Wnt signalling is highly context-dependent--evidence from DNA microarray and chromatin immunoprecipitation screens of Wnt/TCF targets
    Antti Railo
    Oulu Centre for Cell Matrix Research, Biocenter Oulu, Laboratory of Developmental Biology and Department of Medical Biochemistry and Molecular Biology, FIN 90014, University of Oulu, P O Box 5000, Finland
    Exp Cell Res 315:2690-704. 2009
    ..Taken together, our approaches give an insight into the complex context-dependent nature of Wnt pathway transcriptional responses and identify Disabled-2 as a potential new direct target for Wnt signalling...
  21. doi Mapping of the fate of cell lineages generated from cells that express the Wnt4 gene by time-lapse during kidney development
    Jingdong Shan
    Oulu Center for Cell Matrix Research, Biocenter Oulu, Laboratory of Developmental Biology, Institute of Biomedicine, Department of Medical Biochemistry and Molecular Biology, University of Oulu, P O Box 5000, Aapistie 5, FIN 90014, Oulu, Finland
    Differentiation 79:57-64. 2010
    ..The Wnt4(EGFPCre) allele provides a useful new tool for conditional mutagenesis and provides the first time-lapse-based map of the fate of nephron precursor cells...
  22. ncbi The embryonic aorta-gonad-mesonephros region as a generator of haematopoietic stem cells
    Ilkka Pietilä
    Department of Medical Biochemistry and Molecular Biology, Biocenter Oulu, University of Oulu, Oulu, Finland
    APMIS 113:804-12. 2005
    ..We will here discuss the contribution of the AGM to definitive haematopoiesis in mammals and review some of the cell-cell interactions and associated signalling systems involved in the development of AGM stem cells...
  23. doi Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse
    Jingdong Shan
    Oulu Center for Cell Matrix Research, Biocenter Oulu, Laboratory of Developmental Biology, Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland
    Genesis 47:782-8. 2009
    ..All in all, the floxed Wnt4 allele serves as a useful tool for studying the roles of Wnt4 signaling during the life cycle...
  24. doi Lumbo-sacral neural crest derivatives fate mapped with the aid of Wnt-1 promoter integrate but are not essential to kidney development
    Petri Itäranta
    Oulu Center of Cell Matrix Research, Biocenter Oulu, Laboratory of Developmental Biology and Institute of Biomedicine, University of Oulu, Aapistie 5A, PO Box 5000, FIN 90220 Oulu, Finland
    Differentiation 77:199-208. 2009
    ....
  25. ncbi Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis
    Lijun Chi
    Department of Biochemistry, University of Oulu, Finland
    Endocrinology 147:3777-88. 2006
    ..Based on these data, we propose that the Sprouty proteins are involved normally in mediating the sexually dimorphic signaling of FGF9 and controlling cell migration from the mesonephros during testis development...
  26. ncbi Conditional tamoxifen Cre induced mutagenesis in the embryonic kidney in organ culture
    Tiina Jokela
    Department of Medical Biochemistry and Molecular Biology, Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland
    Genesis 45:757-61. 2007
    ..Our results indicate that the inducible ER(Tm) Cre/loxP system indeed provides an effective way of conditionally mutagenizing genes in kidney organ culture and tissue conjugates...
  27. ncbi A mouse model for alpha-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids
    Kalle Savolainen
    Department of Biochemistry, Biocenter Oulu, University of Oulu, FIN 90014, Finland
    Hum Mol Genet 13:955-65. 2004
    ..Based upon our mouse model, we propose elimination of phytol from the diet of patients suffering from Amacr deficiency...