Antti Vaheri

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi Proliferation and motility of HaCaT keratinocyte derivatives is enhanced by fibroblast nemosis
    Kati Räsänen
    Haartman Institute, POB 21, FI 00014 University of Helsinki, Finland
    Exp Cell Res 316:1739-47. 2010
  2. ncbi Hantavirus infections in Europe and their impact on public health
    Antti Vaheri
    Department of Virology, Haartman Institute, and Research Programs Unit, Infection Biology, University of Helsinki, Helsinki, Finland
    Rev Med Virol 23:35-49. 2013
  3. ncbi Hantaviruses and TNF-alpha act synergistically to induce ERK1/2 inactivation in Vero E6 cells
    Tomas Strandin
    Department of Virology, Haartman Institute, P, O, Box 21, FI 00014, University of Helsinki, Finland
    Virol J 5:110. 2008
  4. ncbi Phylogenetic evidence for the distinction of Saaremaa and Dobrava hantaviruses
    Tarja Sironen
    Department of Virology, Haartman Institute, Haartmaninkatu 3, FIN 00014 University of Helsinki, Finland
    Virol J 2:90. 2005
  5. ncbi Young male patients are at elevated risk of developing serious central nervous system complications during acute Puumala hantavirus infection
    Timo Hautala
    Department of Internal Medicine, Oulu University Hospital, Oulu, Finland
    BMC Infect Dis 11:217. 2011
  6. ncbi The ezrin protein family: membrane-cytoskeleton interactions and disease associations
    A Vaheri
    Haartman Institute, University of Helsinki, Finland
    Curr Opin Cell Biol 9:659-66. 1997
  7. ncbi How to diagnose hantavirus infections and detect them in rodents and insectivores
    Antti Vaheri
    Department of Virology, Haartman Institute, FI 00014, University of Helsinki, Finland
    Rev Med Virol 18:277-88. 2008
  8. ncbi Oligomerization of Hantavirus N protein: C-terminal alpha-helices interact to form a shared hydrophobic space
    Pasi Kaukinen
    Department of Virology, Haartman Institute, P O Box 21, FI 00014 University of Helsinki, Finland
    J Virol 78:13669-77. 2004
  9. ncbi Nemosis, a novel way of fibroblast activation, in inflammation and cancer
    Antti Vaheri
    Haartman Institute, University of Helsinki, Finland
    Exp Cell Res 315:1633-8. 2009
  10. ncbi Tissue plasminogen activator as a key effector in neurobiology and neuropathology
    T Teesalu
    Haartman Institute, POB 21, FIN 00014 University of Helsinki, Helsinki, Finland
    Biochem Soc Trans 30:183-9. 2002

Detail Information

Publications104 found, 100 shown here

  1. ncbi Proliferation and motility of HaCaT keratinocyte derivatives is enhanced by fibroblast nemosis
    Kati Räsänen
    Haartman Institute, POB 21, FI 00014 University of Helsinki, Finland
    Exp Cell Res 316:1739-47. 2010
    ....
  2. ncbi Hantavirus infections in Europe and their impact on public health
    Antti Vaheri
    Department of Virology, Haartman Institute, and Research Programs Unit, Infection Biology, University of Helsinki, Helsinki, Finland
    Rev Med Virol 23:35-49. 2013
    ..No vaccine or specific therapy is in general use in Europe. We conclude that hantaviruses have a significant impact on public health in Europe...
  3. ncbi Hantaviruses and TNF-alpha act synergistically to induce ERK1/2 inactivation in Vero E6 cells
    Tomas Strandin
    Department of Virology, Haartman Institute, P, O, Box 21, FI 00014, University of Helsinki, Finland
    Virol J 5:110. 2008
    ..Since TNF-alpha is involved in the pathogenesis of hantavirus-caused hemorrhagic fever with renal syndrome (HFRS) we investigated its effects on HFRS-causing hantavirus-infected cells...
  4. ncbi Phylogenetic evidence for the distinction of Saaremaa and Dobrava hantaviruses
    Tarja Sironen
    Department of Virology, Haartman Institute, Haartmaninkatu 3, FIN 00014 University of Helsinki, Finland
    Virol J 2:90. 2005
    ..0-3.7 MYA that is very close to the values obtained earlier...
  5. ncbi Young male patients are at elevated risk of developing serious central nervous system complications during acute Puumala hantavirus infection
    Timo Hautala
    Department of Internal Medicine, Oulu University Hospital, Oulu, Finland
    BMC Infect Dis 11:217. 2011
    ....
  6. ncbi The ezrin protein family: membrane-cytoskeleton interactions and disease associations
    A Vaheri
    Haartman Institute, University of Helsinki, Finland
    Curr Opin Cell Biol 9:659-66. 1997
    ..Merlin is a tumor suppressor that is involved in tumorigenesis of schwannomas and meningiomas. Merlin has the same overall protein structure as the other proteins in the subfamily but may have partially distinct functions...
  7. ncbi How to diagnose hantavirus infections and detect them in rodents and insectivores
    Antti Vaheri
    Department of Virology, Haartman Institute, FI 00014, University of Helsinki, Finland
    Rev Med Virol 18:277-88. 2008
    ..Hantaviruses are prime examples of emerging and re-emerging infections and it seems likely that many new hantaviruses will be detected in the near future...
  8. ncbi Oligomerization of Hantavirus N protein: C-terminal alpha-helices interact to form a shared hydrophobic space
    Pasi Kaukinen
    Department of Virology, Haartman Institute, P O Box 21, FI 00014 University of Helsinki, Finland
    J Virol 78:13669-77. 2004
    ..N protein trimerization was supported by three-dimensional reconstruction of the N protein by electron microscopy after negative staining. Finally, we discuss how N protein trimerization could occur...
  9. ncbi Nemosis, a novel way of fibroblast activation, in inflammation and cancer
    Antti Vaheri
    Haartman Institute, University of Helsinki, Finland
    Exp Cell Res 315:1633-8. 2009
    ..In summary, our results suggest that this kind of fibroblast activation (nemosis) may be involved in pathological conditions such as inflammation and cancer...
  10. ncbi Tissue plasminogen activator as a key effector in neurobiology and neuropathology
    T Teesalu
    Haartman Institute, POB 21, FIN 00014 University of Helsinki, Helsinki, Finland
    Biochem Soc Trans 30:183-9. 2002
    ....
  11. ncbi Genetic analysis of hantaviruses carried by Myodes and Microtus rodents in Buryatia
    Angelina Plyusnina
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    Virol J 5:4. 2008
    ..glareolus and Muju virus associated with M. regulus, (ii) confirm that M. fortis is the natural host for VLAV, and (iii) suggest M. oeconomus as an alternative host for VLAV...
  12. ncbi Prevalence and protein specificity of human antibodies to Inkoo virus infection
    Niina Putkuri
    Department of Virology, Haartman Institute, P O Box 21 Haartmaninkatu 3, FI 00014 University of Helsinki, Helsinki, Finland
    Clin Vaccine Immunol 14:1555-62. 2007
    ..N protein seems to be the optimal antigen for the serodiagnosis of acute infection, and the Gc protein could be appropriate for the serosurveillance of INKV...
  13. ncbi The cytoplasmic tail of hantavirus Gn glycoprotein interacts with RNA
    Tomas Strandin
    Peptide and Protein Laboratory, Infection Biology Research Program, Haartman Institute, PO Box 21, FI 00014, University of Helsinki, Finland
    Virology 418:12-20. 2011
    ..We conclude that recognition of the RNP complex by the Gn-CT could be mediated by interactions with both genomic RNA and the N protein. This would provide the required selectivity for the genome packaging of hantaviruses...
  14. ncbi Tick-borne encephalitis virus in ticks in Finland, Russian Karelia and Buryatia
    Anu E Jaaskelainen
    Infection Biology Research Program, Department of Virology, Haartman Institute, FI 00014 University of Helsinki, Finland
    J Gen Virol 91:2706-12. 2010
    ..TBEV E and NS3 gene sequences obtained showed a variability of 0-4 % within European-subtype strains, 2-9 % for Siberian-subtype strains and 3-13 % for Far Eastern-subtype strains...
  15. ncbi Distribution of Puumala hantavirus in Denmark: analysis of bank voles (Clethrionomys glareolus) from Fyn and Jutland
    Tarja Sironen
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Vector Borne Zoonotic Dis 2:37-45. 2002
    ..Our data confirmed the circulation of PUUV in both the southeastern and western parts of the island, known to have the highest numbers of human NE cases...
  16. ncbi Saaremaa hantavirus in Denmark
    Kirill Nemirov
    Department of Virology, Haartman Institute, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, FIN-00014 Helsinki, Finland
    J Clin Virol 30:254-7. 2004
    ..We also analyzed serum samples from a patient from Lolland with a history of hantavirus-like infection, probably caused by SAAV. Thus, in addition to Puumala virus, SAAV can impose a threat for the human health in Denmark...
  17. ncbi Identification of Seoul hantavirus in Rattus norvegicus in Indonesia
    Angelina Plyusnina
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    Scand J Infect Dis 36:356-9. 2004
    ..Partial M segment sequence was recovered from the lung tissue of Rattus norvegicus trapped in central Jakarta. The sequence belongs to SEOV genotype and is most closely related to the strain B-1 from Japan...
  18. ncbi Diagnostics of Pogosta disease: antigenic properties and evaluation of Sindbis virus IgM and IgG enzyme immunoassays
    Tytti Manni
    Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, Finland
    Vector Borne Zoonotic Dis 8:303-11. 2008
    ..Both E1 and E2 glycoproteins of SINV were shown to be recognized by IgM and IgG antibodies early in infection...
  19. ncbi Serological microarray for detection of HSV-1, HSV-2, VZV, and CMV antibodies
    Anne J Jääskeläinen
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    J Virol Methods 160:167-71. 2009
    ..The serological microarray showed potential for screening purposes. The microarray based analyses were easy to perform, and HSV-1, HSV-2, VZV, and CMV antibodies could be detected on the same microarray...
  20. ncbi Mutational analysis of positively charged amino acid residues of Uukuniemi phlebovirus nucleocapsid protein
    Anna Katz
    Research Programs Unit, Infection Biology Research Program, Department of Virology, Haartman Institute, PO Box 21, University of Helsinki, 00014 Helsinki, Finland
    Virus Res 167:118-23. 2012
    ..In the 3D-model of UUKV N protein, five of the affected residues, R61, R64, R73, R98 and R115, were located either within or in close proximity to the central cavity that could potentially bind RNA...
  21. ncbi Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter
    Kirsi M Jääskeläinen
    Department of Virology, Haartman Institute, FIN 00014 University of Helsinki, Finland
    J Med Virol 79:1527-36. 2007
    ..The findings may explain why the NSs ORF has been preserved in the genome of most hantaviruses during their long evolution and why hantavirus-infected cells secrete relatively low levels of IFNs...
  22. ncbi Degradation and aggresome formation of the Gn tail of the apathogenic Tula hantavirus
    Hao Wang
    Department of Virology, Haartman Institute, PO Box 21, FIN 00014 University of Helsinki, Finland
    J Gen Virol 90:2995-3001. 2009
    ..We conclude that degradation upon aggregation of Gn tails, which may represent a general cellular response to misfolded protein used by hantaviruses to control maturation of virions, is unrelated to pathogenicity...
  23. ncbi Characterization of a novel flavivirus from mosquitoes in northern europe that is related to mosquito-borne flaviviruses of the tropics
    Eili Huhtamo
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    J Virol 83:9532-40. 2009
    ..Despite the biological properties preferring replication in mosquito cells, the genetic relatedness of LAMV to viruses associated with vertebrate hosts warrants a search for disease associations...
  24. ncbi Nemosis of fibroblasts is inhibited by benign HaCaT keratinocytes but promoted by malignant HaCaT cells
    Kati Räsänen
    Haartman Institute, POB 21, FI 00014 University of Helsinki, Finland
    Mol Oncol 2:340-8. 2008
    ..In collagen co-cultures benign keratinocytes caused a nemosis-inhibiting effect on fibroblast spheroids by inhibiting COX-2 induction, while with malignant keratinocytes myofibroblastic differentiation of fibroblasts was seen...
  25. ncbi Oligomerization of hantavirus nucleocapsid protein: analysis of the N-terminal coiled-coil domain
    Agne Alminaite
    Department of Virology, Haartman Institute, P.O. Box 21, FIN-00014 University of Helsinki, Helsinki, Finland
    J Virol 80:9073-81. 2006
    ..Our alignments of the N-terminal domain of the hantaviral N proteins suggest the coiled-coil structure, and hence the mode of N-protein oligomerization, is conserved among hantaviruses...
  26. ncbi Orthomyxo-, paramyxo- and flavivirus infections in wild waterfowl in Finland
    Erika Lindh
    Department of Virology, Haartman Institute, Faculty of Medicine, P, O, Box 21, FI 00014 University of Helsinki, Finland
    Virol J 5:35. 2008
    ....
  27. ncbi Tula hantavirus L protein is a 250 kDa perinuclear membrane-associated protein
    Sami K J Kukkonen
    Department of Virology, Haartman Institute, PO Box 21, FIN 00014 University of Helsinki, Finland
    J Gen Virol 85:1181-9. 2004
    ..L-EGFP localized in the perinuclear region where it had partial co-localization with the Golgi matrix protein GM130 and the TULV nucleocapsid protein...
  28. ncbi Pathology of Puumala hantavirus infection in macaques
    Tarja Sironen
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    PLoS ONE 3:e3035. 2008
    ....
  29. ncbi Sindbis virus infection in resident birds, migratory birds, and humans, Finland
    Satu Kurkela
    Department of Virology, Faculty of Medicine, Haartman Institute at the University of Helsinki, Haartmaninkatu 3, Helsinki, Finland
    Emerg Infect Dis 14:41-7. 2008
    ..Among 2,529 persons, the age-standardized seroprevalence (1999-2003) was 5.2%; seroprevalence and incidence (1995-2003) were highest in North Karelia (eastern Finland). Grouse may contribute to the epidemiology of SINV in humans...
  30. ncbi Interaction between hantaviral nucleocapsid protein and the cytoplasmic tail of surface glycoprotein Gn
    Hao Wang
    Department of Virology, Infection Biology Research Program, Haartman Institute, University of Helsinki, Finland
    Virus Res 151:205-12. 2010
    ....
  31. ncbi Co-circulation of three pathogenic hantaviruses: Puumala, Dobrava, and Saaremaa in Hungary
    Angelina Plyusnina
    Department of Virology, Infection Biology Research Program, Haartman Institute, University of Helsinki, Helsinki, Finland
    J Med Virol 81:2045-52. 2009
    ..This study confirms that multiple hantaviruses can co-circulate in the same locality and can be maintained side-by-side in different rodent species...
  32. ncbi Genetic characterization of new Dobrava hantavirus isolate from Greece
    Kirill Nemirov
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    J Med Virol 69:408-16. 2003
    ....
  33. ncbi Non-covalent interaction between nucleocapsid protein of Tula hantavirus and small ubiquitin-related modifier-1, SUMO-1
    Pasi Kaukinen
    Department of Virology, Haartman Institute, PO Box 21, University of Helsinki, FIN 00014, Helsinki, Finland
    Virus Res 92:37-45. 2003
    ..By using a pepscan assay, two basic amino acid stretches in the N-terminal part of SUMO-1 were shown to be involved in the interaction...
  34. ncbi Tick-borne encephalitis virus in wild rodents in winter, Finland, 2008-2009
    Elina Tonteri
    University of Helsinki, Helsinki, Finland
    Emerg Infect Dis 17:72-5. 2011
    ..Persistence in rodent reservoirs may contribute to virus overwintering...
  35. ncbi Complete coding sequence and molecular epidemiological analysis of Sindbis virus isolates from mosquitoes and humans, Finland
    Jussi Sane
    Infection Biology Research Program, Department of Virology, Haartman Institute, Faculty of Medicine, PO Box 21, FI 00014 University of Helsinki, Helsinki, Finland
    J Gen Virol 93:1984-90. 2012
    ..Phylogenetic analyses further indicate that SINV has a local circulation in endemic regions in Northern Europe and no novel strains are frequently being introduced...
  36. ncbi Cell-cell contact activation of fibroblasts increases the expression of matrix metalloproteinases
    Vappu Sirén
    Haartman Institute, University of Helsinki, Finland
    Ann Med 38:212-20. 2006
    ..On the surface of the decomposing spheroids, activation of the major extracellular proteolytic cascade, plasminogen activation, associated with surface exposure of alpha-enolase, took place...
  37. ncbi Rate of evolution and molecular epidemiology of tick-borne encephalitis virus in Europe, including two isolations from the same focus 44 years apart
    Nathalie Y Uzcategui
    Infection Biology Research Program, Department of Virology, Haartman Institute, PO Box 21, FI 00014 University of Helsinki, Helsinki, Finland
    J Gen Virol 93:786-96. 2012
    ..The measurements from the natural rate of evolution correlated with the estimates done by phylogenetic programs, demonstrating their robustness...
  38. ncbi Tula hantavirus isolate with the full-length ORF for nonstructural protein NSs survives for more consequent passages in interferon-competent cells than the isolate having truncated NSs ORF
    Kirsi M Jääskeläinen
    Department of Virology, Haartman Institute, PO Box 21, FIN 00014 University of Helsinki, Helsinki, Finland
    Virol J 5:3. 2008
    ..The two isolates differ in the length of the open reading frame (ORF) encoding the nonstructural protein NSs, which has previously been shown to inhibit IFN response in infected cells...
  39. ncbi Oligomerization of Uukuniemi virus nucleocapsid protein
    Anna Katz
    Department of Virology, Infection Biology Research Program, Haartman Institute, PO Box 21, University of Helsinki, Helsinki, Finland
    Virol J 7:187. 2010
    ..The aim was to locate the domains involved in the N protein oligomerization and study the process in detail...
  40. ncbi Oligomerization of hantaviral nucleocapsid protein: charged residues in the N-terminal coiled-coil domain contribute to intermolecular interactions
    Agne Alminaite
    Department of Virology, Haartman Institute, PO Box 21, FIN 00014 University of Helsinki, Finland
    J Gen Virol 89:2167-74. 2008
    ..It is hypothesized that the tips of the coiled-coils are the first to come into direct contact and thus to initiate tight packing of the three structures...
  41. ncbi TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benign, not in malignant keratinocytes
    Kati Räsänen
    Haartman Institute, POB 21, FI 00014 University of Helsinki, Finland
    J Dermatol Sci 58:97-104. 2010
    ..Cancer-related inflammation, mediated by prostaglandins, has been proposed as a critical mechanism in conversion of benign cells to malignant...
  42. ncbi Alcohol, smoking and human papillomavirus in laryngeal carcinoma: a Nordic prospective multicenter study
    Walter J Koskinen
    Department of Virology, Haartman Institute, University of Helsinki, Haartmaninkatu 3, P O Box 21, 00014 Helsinki, Finland
    J Cancer Res Clin Oncol 133:673-8. 2007
    ..Moreover risk factors such as smoking, alcohol abuse, chronic laryngitis and gastroesophageal reflux disease (GERD) were evaluated..
  43. ncbi Differences in the nemosis response of normal and cancer-associated fibroblasts from patients with oral squamous cell carcinoma
    Kati Räsänen
    Haartman Institute, University of Helsinki, Helsinki, Finland
    PLoS ONE 4:e6879. 2009
    ..Here we used paired normal skin fibroblasts and cancer-associated fibroblasts (CAF) and primary and recurrent oral squamous cell carcinoma (SCC) cells to study the nemosis response...
  44. ncbi Detection of rhinovirus RNA in middle turbinate of patients with common colds by in situ hybridization
    Anne Pitkaranta
    Department of Otorhinolaryngology, University Hospital of Helsinki, Helsinki, Finland
    J Med Virol 70:319-23. 2003
    ..However, in situ hybridization procedure appeared to be an interesting methodology to investigate the physiopathology of respiratory tract infection by rhinoviruses...
  45. ncbi Lymphatic vessel density in vocal cord carcinomas assessed with LYVE-1 receptor expression
    Walter J Koskinen
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    Radiother Oncol 77:172-5. 2005
    ..We investigated whether the lymphatic vessel density (LVD) of vocal cord carcinomas differs from that of other head and neck carcinomas...
  46. ncbi Adaptation of Puumala hantavirus to cell culture is associated with point mutations in the coding region of the L segment and in the noncoding regions of the S segment
    Kirill Nemirov
    Department of Virology, Haartman Institute, FIN-00014 University of Helsinki, Finland
    J Virol 77:8793-800. 2003
    ..However, the spectrum of the S segment quasispecies appeared to be changing, suggesting that, after the initial adaptation (passages 1 to 11), the viral population is still being driven by selection for variants with higher fitness...
  47. ncbi Tula hantavirus NSs protein accumulates in the perinuclear area in infected and transfected cells
    Jussi Oskari Virtanen
    Infection Biology Research Program, Department of Virology, Haartman Institute, University of Helsinki, PO Box 21, Haartmaninkatu 3, 00014 Helsinki, Finland
    Arch Virol 155:117-21. 2010
    ....
  48. ncbi Improved multiplex-PCR and microarray for herpesvirus detection from CSF
    Anne J Jääskeläinen
    Department of Virology, Haartman Institute, FIN 00014 University of Helsinki, Finland
    J Clin Virol 42:172-5. 2008
    ..A multiplex-PCR and microarray-based method was designed for detection of eight herpesviruses from clinical specimens...
  49. ncbi Human herpesvirus-6 and -7 DNA in cerebrospinal fluid of facial palsy patients
    Mervi Kanerva
    Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Otolaryngol 128:460-4. 2008
    ..HHV-6 or -7 DNA was revealed in 10% of the CSF samples tested from 70 immunocompetent adolescents and adults; a highly unusual result. How these findings are associated with the diseases they accompany remains to be defined...
  50. ncbi Quasispecies dynamics and fixation of a synonymous mutation in hantavirus transmission
    Tarja Sironen
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    J Gen Virol 89:1309-13. 2008
    ..An elementary step of virus microevolution was apparent, as one synonymous mutation (A759G) repeatedly became fixed in the viral RNA quasispecies populations in the recipient animals...
  51. ncbi Tula hantavirus infection of Vero E6 cells induces apoptosis involving caspase 8 activation
    Xiao-Dong Li
    Department of Virology, Haartman Institute, University of Helsinki, POB 21, FIN-00014, Finland
    J Gen Virol 85:3261-8. 2004
    ..Taken together, these results suggest that TULV replication initiates a typical apoptotic programme involving caspase 8 activation...
  52. ncbi Plasminogen activators and their inhibitor gene expression in cutaneous NF1-related neurofibromas
    Vappu Sirén
    Haartman Institute, University of Helsinki, P O Box 21, 00014, Helsinki, Finland
    Arch Dermatol Res 297:421-4. 2006
    ..Large extent of tumor cells of Schwann cell origin and prominent expression levels of uPA, tPA and PAI-1 indicated that these cells are responsible for the main source of PA components in cutaneous NF1-related neurofibromas...
  53. ncbi Clinical and laboratory manifestations of Sindbis virus infection: prospective study, Finland, 2002-2003
    Satu Kurkela
    Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, Finland
    J Infect Dis 191:1820-9. 2005
    ..The most notable finding was that, in 50% of the patients, joint symptoms lasted for >12 months...
  54. ncbi Tula hantavirus triggers pro-apoptotic signals of ER stress in Vero E6 cells
    Xiao Dong Li
    Department of Virology, Haartman Institute, PO Box 21, FIN 00014, University of Helsinki, Finland
    Virology 333:180-9. 2005
    ..Taken together, we have identified involvement of ER stress-mediated death program in Tula virus-infected Vero E6 cells which provides a new approach to understand the mechanisms in hantavirus-induced apoptosis...
  55. ncbi Complement activation in Puumala hantavirus infection correlates with disease severity
    Jussi Sane
    Infection Biology Research Program, Department of Virology, Haartman Institute, University of Helsinki, Finland
    Ann Med 44:468-75. 2012
    ..Their pathogenesis is currently poorly understood. We have studied the role of the complement system in the pathogenesis of Puumala (PUUV) hantavirus infection...
  56. ncbi Clinical Sindbis alphavirus infection is associated with HLA-DRB1*01 allele and production of autoantibodies
    Jussi Sane
    Infection Biology Research Program, Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, Finland
    Clin Infect Dis 55:358-63. 2012
    ..The aim of this study was to investigate the role of genetic factors in the susceptibility and outcome of SINV infection and to elucidate the association between SINV infection and autoimmunity...
  57. ncbi Hantavirus structure--molecular interactions behind the scene
    Jussi Hepojoki
    Infection Biology Research Program, Peptide and Protein Laboratory, Department of Virology, Haartman Institute, University of Helsinki, Finland
    J Gen Virol 93:1631-44. 2012
    ..We attempt to summarize recent results on the virion structure and to suggest mechanisms on how the assembly is driven. We also compare hantaviruses to other bunyaviruses with known structure...
  58. ncbi Orthopox virus infections in Eurasian wild rodents
    Paula M Kinnunen
    Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland
    Vector Borne Zoonotic Dis 11:1133-40. 2011
    ..Results from three real-time PCR methods were highly concordant. This study extends the geographic range and wildlife species diversity in which OPV (or CPXV) viruses are naturally circulating...
  59. ncbi Old World hantaviruses do not produce detectable amounts of dsRNA in infected cells and the 5' termini of their genomic RNAs are monophosphorylated
    Hao Wang
    Department of Virology, Infection Biology Research Program, Haartman Institute, University of Helsinki, Helsinki, Finland
    J Gen Virol 92:1199-204. 2011
    ....
  60. ncbi Clustering of fibroblasts induces proinflammatory chemokine secretion promoting leukocyte migration
    Anna Enzerink
    Haartman Institute, University of Helsinki, P O Box 21, FIN 00014 Helsinki, Finland
    Mol Immunol 46:1787-95. 2009
    ....
  61. ncbi Formation and activation of fibroblast spheroids depend on fibronectin-integrin interaction
    Pertteli Salmenperä
    Haartman Institute, POB 21, FIN 00014 University of Helsinki, Finland
    Exp Cell Res 314:3444-52. 2008
    ..Our results present a new mechanism of fibroblast activation, which is initiated by interaction of FN with its integrin receptors...
  62. ncbi Human papillomavirus type 16 in head and neck carcinogenesis
    Renwei Chen
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    Rev Med Virol 15:351-63. 2005
    ..HPV-immortalised human tonsillar epithelial cell lines may provide an in vitro model to study co-factors for the HPV-associated tonsillar cancers and to test the effects of anti-viral and anti-tumour agents...
  63. ncbi Improvement of binding of Puumala virus neutralization site resembling peptide with a second-generation phage library
    Tuomas Heiskanen
    Department of Virology, Haartman Institute, P O Box 21, FIN 00014 University of Helsinki, Finland
    Protein Eng 16:443-50. 2003
    ....
  64. ncbi Molecular epidemiology of dengue virus strains from Finnish travelers
    Eili Huhtamo
    Department of Virology, Haartman Institute, University of Helsinki, Haartmaninkatu 3, Helsinki, Finland
    Emerg Infect Dis 14:80-3. 2008
    ..The analysis of DENV isolated from travelers contributes to the global picture of strain distribution and circulation. The isolates included all serotypes, including a DENV-2 isolate from Ghana...
  65. ncbi Siberian subtype tickborne encephalitis virus, Finland
    Anu E Jaaskelainen
    Haartman Institute, University of Helsinki, Helsinki, Finland
    Emerg Infect Dis 12:1568-71. 2006
    ..Thus I. persulcatus and the Siberian TBEV are reported in a focus considerably northwest of their previously known range in eastern Europe and Siberia...
  66. ncbi Search for Herpesviruses in cerebrospinal fluid of facial palsy patients by PCR
    Mervi Kanerva
    Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Otolaryngol 127:775-9. 2007
    ..The role of human herpesvirus 6 (HHV-6) in this disorder and the significance of a positive HHV-6 DNA finding in the central nervous system need further investigation...
  67. ncbi Diagnosis of tick-borne encephalitis by a mu-capture immunoglobulin M-enzyme immunoassay based on secreted recombinant antigen produced in insect cells
    Anu Jääskeläinen
    Department of Virology, Haartman Institute, Faculty of Veterinary Medicine, FIN 00014 University of Helsinki, Finland
    J Clin Microbiol 41:4336-42. 2003
    ..93. The antigen was also suitable for IgG antibody detection in an immunofluorescent assay format. This is the first time that secreted, fully antigenic E protein has been produced in insect cells for this arthropod-borne flavivirus...
  68. ncbi Detection of human orthopoxvirus infections and differentiation of smallpox virus with real-time PCR
    Niina Putkuri
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    J Med Virol 81:146-52. 2009
    ..Amplification of variola virus sequences could be distinguished from other OPVs by melting curve analysis. We also demonstrated the applicability of the assay in human cases of cowpox and vaccinia virus infections...
  69. ncbi Presence of DNA of human papillomavirus 16 but no other types in tumor-free tonsillar tissue
    Renwei Chen
    Department of Virology, Haartman Institute, Haartmaninkatu 3, P O Box 21, 00014 University of Helsinki, Helsinki, Finland
    J Clin Microbiol 43:1408-10. 2005
    ..3% (13 of 206) in tonsillitis or hypertrophic tonsillar tissues and 0.6% (1 of 174) in exfoliated cells from normal tonsils. HPV-16 was the only type detected in tonsillar tissues, but it did not appear to lead to L1 antibody production...
  70. ncbi Co-localization of human herpes virus 6 and tissue plasminogen activator in multiple sclerosis brain tissue
    Jussi Oskari Virtanen
    Haartman Institute, Department of Virology, University of Helsinki, Finland
    Med Sci Monit 11:BR84-7. 2005
    ..CONCLUSIONS: At the cellular level, HHV-6 and plasminogen activation seem to co-localize in MS...
  71. ncbi Mapping of the regions involved in homotypic interactions of Tula hantavirus N protein
    Pasi Kaukinen
    Department of Virology, Haartman Institute, FIN 00014 University of Helsinki, Finland
    J Virol 77:10910-6. 2003
    ..Furthermore, our data suggested a tail-to-tail and head-to-head binding scheme for the N proteins...
  72. ncbi Inactivation of hantaviruses by N-ethylmaleimide preserves virion integrity
    Tomas Strandin
    Peptide and Protein Laboratory, Infection Biology Research Program, Haartman Institute, University of Helsinki, Helsinki, Finland
    J Gen Virol 92:1189-98. 2011
    ..In contrast to hantaviruses, NEM did not abolish Uukuniemi phlebovirus infectivity to the same extent. This indicates differences in the use of free thiols in virus entry among members of the family Bunyaviridae...
  73. ncbi Regulation of ezrin localization by Rac1 and PIPK in human epithelial cells
    Eeva Auvinen
    Department of Virology, Haartman Institute, University of Helsinki, and HUSLAB Clinical Microbiology, Helsinki University Central Hospital, Helsinki, Finland
    Exp Cell Res 313:824-33. 2007
    ..This localization required the activity of Rac1 and phosphatidylinositol-4-phosphate 5-kinase and involved RhoA. We suggest that localization of ezrin in adherens junctions is regulated by Rac in a manner involving PIPK...
  74. ncbi Prevalence and physical status of human papillomavirus in squamous cell carcinomas of the head and neck
    Walter J Koskinen
    Department of Virology, Haartman Institute, University of Helsinki and HUCH Laboratory Diagnostics, Helsinki, Finland
    Int J Cancer 107:401-6. 2003
    ..Patients with episomal viral DNA were more frequently found to have large (T3-T4) tumors at diagnosis than were those with integrated or mixed forms...
  75. ncbi Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system
    Tambet Teesalu
    Haartman Institute, University of Helsinki and HUCH Laboratory Diagnostics, Finland
    Thromb Haemost 92:358-68. 2004
    ..Our analysis documents a detailed map of expression of tPA and its inhibitor in the human CNS and is compatible with the view that tPA is a key player in CNS physiology and pathology...
  76. ncbi Studies on TBE epidemiology in Finland (and Lithuania)
    Xiuqi Han
    Haartman Institute, University of Helsinki, Finland
    Int J Med Microbiol 291:48-9. 2002
  77. ncbi Phylogenetic evidence for host switching in the evolution of hantaviruses carried by Apodemus mice
    Kirill Nemirov
    Department of Virology, Haartman Institute, University of Helsinki, PO Box 21, FIN 00014, Helsinki, Finland
    Virus Res 90:207-15. 2002
    ..5 MYA). Taken together with other proposed cases of host switching, our observations suggest that these events might not be exceptional in the hantavirus evolution...
  78. ncbi Intracerebral Borna disease virus infection of bank voles leading to peripheral spread and reverse transcription of viral RNA
    Paula Maria Kinnunen
    Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
    PLoS ONE 6:e23622. 2011
    ..This first experimental bornavirus infection in wild mammals confirms the recent findings regarding bornavirus DNA, and suggests that bank voles are capable of bornavirus transmission...
  79. ncbi Activation of fibroblasts in cancer stroma
    Kati Räsänen
    Haartman Institute, University of Helsinki, Finland
    Exp Cell Res 316:2713-22. 2010
    ..In this review we focus mainly on carcinomas and discuss the recent findings regarding the role of activated fibroblasts in driving tumor progression...
  80. ncbi Human papillomavirus in larynx
    Leena Maija Aaltonen
    Department of Otorhinolaryngology Head and Neck Surgery, Helsinki University Central Hospital, Finland
    Laryngoscope 112:700-7. 2002
    ..The core of the present clinical and basic research knowledge of laryngeal human papillomavirus (HPV) infection is described...
  81. ncbi Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system
    Mikaela Grönholm
    Neuroscience Program, Biomedicum Helsinki, University of Helsinki and Helsinki University Central Hospital, PB 63, Haartmaninkatu 8, 00014 Helsinki, Finland
    Mol Cell Neurosci 28:683-93. 2005
    ..The widespread expression of merlin in brain and its association with protein kinase A suggest a role for merlin in brain biology...
  82. ncbi Ezrin in primary cutaneous melanoma
    Suvi Ilmonen
    Department of Plastic Surgery, Helsinki University Hospital, Helsinki, Finland
    Mod Pathol 18:503-10. 2005
    ..Ezrin expression correlates with tumor thickness and level of invasion suggesting an association between ezrin expression and tumor progression...
  83. ncbi Multiplex-PCR and oligonucleotide microarray for detection of eight different herpesviruses from clinical specimens
    Anne J Jääskeläinen
    Department of Virology, Haartman Institute, PO Box 21, University of Helsinki, FIN 00014 Helsinki, Finland
    J Clin Virol 37:83-90. 2006
    ..Human herpesviruses cause clinically important diseases, e.g. infections of the central nervous system. New diagnostic tools are required for rapid and reliable detection of these viruses...
  84. ncbi Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A
    Mikaela Grönholm
    Biomedicum Helsinki, Department of Pathology, Neuroscience Center, Institute of Biotechnology, University of Helsinki and Helsinki University Central Hospital, 00014 Helsinki, Finland
    J Biol Chem 278:41167-72. 2003
    ..These results identify merlin as the first neuronal binding partner for PKA-RIbeta and suggest a novel function for merlin in connecting neuronal cytoskeleton to PKA signaling...
  85. ncbi Serological evidence for Borna disease virus infection in humans, wild rodents and other vertebrates in Finland
    Paula M Kinnunen
    Division of Microbiology and Epidemiology, Faculty of Veterinary Medicine, P O Box 66, 00014 University of Helsinki, Finland
    J Clin Virol 38:64-9. 2007
    ..BDV infection may lead to meningoencephalomyelitis in animals. An association with human neuropsychiatric diseases has been reported, but the causal relationship between BDV and human disease remains unclear...
  86. ncbi High concentrations of plasminogen activator inhibitor-1 in lungs of preterm infants with respiratory distress syndrome
    Katariina Cederqvist
    Department of Pediatrics, University of Helsinki, Helsinki, Finland
    Pediatrics 117:1226-34. 2006
    ..We studied levels of major plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA) in lungs of preterm infants with RDS...
  87. ncbi Ezrin is a substrate for Lck in T cells
    Matti Autero
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland
    FEBS Lett 535:82-6. 2003
    ..Lck phosphorylated ezrin in vitro, and the major phosphotyrosine was identified as Y145. These results identify ezrin as the first cytoskeletal substrate for Lck...
  88. ncbi Viral zoonoses in Europe
    Hannimari Kallio-Kokko
    Haartman Institute, Department of Virology, University of Helsinki, POB 21, 00014 Helsinki, Finland
    FEMS Microbiol Rev 29:1051-77. 2005
    ..Infections by several of these viruses may lead to high mortality and also attract attention because they are potential bio-weapons. This review will focus on zoonotic virus infections occurring in Europe...
  89. ncbi Acute central nervous system complications in varicella zoster virus infections
    Marjaleena Koskiniemi
    Department of Virology, Haartman Institute, Helenski University, Finland
    J Clin Virol 25:293-301. 2002
    ..In a previous multicenter study on central nervous system (CNS) viral infections varicella zoster virus (VZV) appeared the most frequent etiologic agent and appeared often without rash...
  90. ncbi Transfection-mediated generation of functionally competent Tula hantavirus with recombinant S RNA segment
    Alexander Plyusnin
    Haartman Institute, Department of Virology, FIN 00014 University of Helsinki, Finland
    EMBO J 21:1497-503. 2002
    ..This provides the first example of a negative-sense RNA virus constructed using homologous recombination...
  91. ncbi Bone marrow mesenchymal stem cells undergo nemosis and induce keratinocyte wound healing utilizing the HGF/c-Met/PI3K pathway
    Matti Peura
    Institute of Biomedicine, Pharmacology, Biomedicum, University of Helsinki, Helsinki, Finland
    Wound Repair Regen 17:569-77. 2009
    ..We conclude that nemosis of BMSCs can induce keratinocyte in vitro scratch-wound healing, and that in this effect signaling via HGF/c-Met is involved...
  92. ncbi Quality control measures for the serological diagnosis of hantavirus infections
    Stefan S Biel
    Robert Koch-Institut, Nordufer 20, 13353 Berlin, Germany
    J Clin Virol 28:248-56. 2003
    ..CONCLUSIONS: The results presented here prove the importance of quality measures also for viruses only rarely suspected, like hantavirus, and they clearly demonstrate the need for improvement of the existing test systems...
  93. ncbi Plasminogen activators and their inhibitors in human saliva and salivary gland tissue
    Oskari J Virtanen
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    Eur J Oral Sci 114:22-6. 2006
    ..The tPA activity in saliva suggests an active proteolysis. Plasminogen activator inhibitor 2 was found to be the main inhibitor of PAs in saliva...
  94. ncbi Endemic hantavirus infection impairs the winter survival of its rodent host
    Eva R Kallio
    Department of Biological and Environmental Science, P O Box 35, FIN 40014, University of Jyvaiskyla, Finland
    Ecology 88:1911-6. 2007
    ..Our results provide the first evidence for a significant effect of PUUV on host survival suggesting that hantaviruses, and endemic pathogens in general, deserve even more attention in studies of host population dynamics...
  95. ncbi Generation of recombinant vaccinia viruses expressing Puumala virus proteins and use in isolating cytotoxic T cells specific for Puumala virus
    Masanori Terajima
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Virus Res 84:67-77. 2002
    ..An HLA-A24-restricted CTL line recognizing the G2 protein was isolated and its 9-mer epitope was determined...
  96. ncbi Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx
    Xiao Dong Li
    Department of Virology, Haartman Institute and HUCH Laboratory Diagnostics, PO Box 21, Haartmaninkatu 3, FIN 00014 University of Helsinki, Finland
    J Gen Virol 83:759-66. 2002
    ..These data suggest a direct link between host cell machinery and a hantavirus structural component...
  97. ncbi Urokinase, tissue-type plasminogen activator and plasminogen activator inhibitor-1 expression in severely stenosed and occluded vein grafts with thrombosis
    Vappu Sirén
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Blood Coagul Fibrinolysis 14:369-77. 2003
    ..We conclude that fibrinolytic system is upregulated at sites of graft stenosis, and local proteolytic degradation of the graft wall associates with thrombus formation...
  98. ncbi Diagnostic rapid tests for acute hantavirus infections: specific tests for Hantaan, Dobrava and Puumala viruses versus a hantavirus combination test
    Helena Hujakka
    Department of Chemistry, University of Kuopio, PO Box 1627, FIN 70211, Kuopio, Finland
    J Virol Methods 108:117-22. 2003
    ..Nevertheless, the specific one-antigen tests were markedly more sensitive than the combination test. However, if optimized, a combination test would be suitable for regions where several hantaviruses circulate...
  99. ncbi Hantavirus infections in Spain: analysis of sera from the general population and from patients with pneumonia, renal disease and hepatitis
    Lourdes Lledó
    Departamento de Microbiologia y Parasitologia, Facultad de Medicina, Universidad de Alcala, Madrid, Spain
    J Clin Virol 27:296-307. 2003
    ..There are only a few reports available on hantavirus infections from Spain. Although the results of these earlier studies indicated the presence of hantavirus infections, no confirmative or serotype-specific analyses have been performed...
  100. ncbi Association between the DQA MHC class II gene and Puumala virus infection in Myodes glareolus, the bank vole
    Julie Deter
    Centre de Biologie et de Gestion et des Populations, Département INRA EFPA 1062, Campus International de Baillarguet, CS 30016, 34988 Montferrier sur Lez, France
    Infect Genet Evol 8:450-8. 2008
    ..Other datasets are now required to confirm these results and to test whether the associations vary in space and/or time...
  101. ncbi Induction of hepatocyte growth factor/scatter factor by fibroblast clustering directly promotes tumor cell invasiveness
    Esko Kankuri
    Institute of Biomedicine, Pharmacology, Haartman Institute, University of Helsinki, Finland
    Cancer Res 65:9914-22. 2005
    ..Our results thus provide the first evidence that aggravated progression of tumors with necrotic foci may involve paracrine reciprocal signaling leading to stromal activation by direct cell-cell contact (i.e., nemosis)...