Pavel Uvarov

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2
    Pavel Uvarov
    Neuroscience Center, Viikinkaari 4, University of Helsinki, Finland
    J Biol Chem 282:30570-6. 2007
  2. pmc Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain
    Pavel Uvarov
    Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, Finland
    J Biol Chem 284:13696-704. 2009
  3. doi request reprint Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription
    Anastasia Ludwig
    Institute of Biotechnology, University of Helsinki, Viikki Biocenter, Viikinkaari 9, FIN 00014, Helsinki, Finland
    J Neurosci 31:644-9. 2011
  4. pmc Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neurons
    Anastasia Ludwig
    Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, Finland
    Neural Plast 2011:1-8. 2011
  5. ncbi request reprint Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4
    Pavel Uvarov
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 26:13463-73. 2006
  6. doi request reprint Role of upstream stimulating factors in the transcriptional regulation of the neuron-specific K-Cl cotransporter KCC2
    Marika Markkanen
    Neuroscience Center, Viikinkaari 4, 00014 University of Helsinki, Finland
    Brain Res 1236:8-15. 2008
  7. ncbi request reprint Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS
    Marika Markkanen
    Department of Anatomy, Institute of Biomedicine, University of Helsinki, FI 00014, Helsinki, Finland
    J Comp Neurol 522:1897-914. 2014
  8. pmc Origin and loss of nested LRRTM/α-catenin genes during vertebrate evolution
    Pavel Uvarov
    Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland
    PLoS ONE 9:e89910. 2014
  9. ncbi request reprint Neuronal K+/Cl- co-transporter (KCC2) transgenes lacking neurone restrictive silencer element recapitulate CNS neurone-specific expression and developmental up-regulation of endogenous KCC2 gene
    Pavel Uvarov
    Neuroscience Centre, 00014 University of Helsinki, Helsinki, Finland
    J Neurochem 95:1144-55. 2005

Collaborators

Detail Information

Publications9

  1. ncbi request reprint A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2
    Pavel Uvarov
    Neuroscience Center, Viikinkaari 4, University of Helsinki, Finland
    J Biol Chem 282:30570-6. 2007
    ....
  2. pmc Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain
    Pavel Uvarov
    Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, Finland
    J Biol Chem 284:13696-704. 2009
    ..Consistent with this, native gel analysis shows that a substantial part of endogenous KCC2 isoforms in the neonatal brain constitute dimers...
  3. doi request reprint Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription
    Anastasia Ludwig
    Institute of Biotechnology, University of Helsinki, Viikki Biocenter, Viikinkaari 9, FIN 00014, Helsinki, Finland
    J Neurosci 31:644-9. 2011
    ..These results indicate that Egr4 is an important component in the mechanism of BDNF-dependent KCC2 gene regulation via the ERK1/2 pathway in immature neurons...
  4. pmc Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neurons
    Anastasia Ludwig
    Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, Finland
    Neural Plast 2011:1-8. 2011
    ..These results show that Egr4 is an important component in the mechanism for trophic factor-mediated upregulation of KCC2 in immature neurons involving the activation of specific intracellular pathways common to BDNF and Neurturin...
  5. ncbi request reprint Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4
    Pavel Uvarov
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 26:13463-73. 2006
    ..Together, the results indicate an important role for Egr4 in the developmental upregulation of KCC2 gene expression...
  6. doi request reprint Role of upstream stimulating factors in the transcriptional regulation of the neuron-specific K-Cl cotransporter KCC2
    Marika Markkanen
    Neuroscience Center, Viikinkaari 4, 00014 University of Helsinki, Finland
    Brain Res 1236:8-15. 2008
    ..The results suggest that binding of USF proteins to the E-boxKCC2b may contribute to the upregulation of KCC2b gene expression in developing brain...
  7. ncbi request reprint Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS
    Marika Markkanen
    Department of Anatomy, Institute of Biomedicine, University of Helsinki, FI 00014, Helsinki, Finland
    J Comp Neurol 522:1897-914. 2014
    ..The results, together with those of previous studies, suggest that KCC2a and KCC2b have overlapping roles in neonatal neurons but presumably different roles in mature neurons...
  8. pmc Origin and loss of nested LRRTM/α-catenin genes during vertebrate evolution
    Pavel Uvarov
    Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland
    PLoS ONE 9:e89910. 2014
    ..We identified several other protein-coding nested gene structures of which either the host or the nested gene has presumably been lost in the frog or chicken lineages. Interestingly, majority of these nested genes comprise LRR domains. ..
  9. ncbi request reprint Neuronal K+/Cl- co-transporter (KCC2) transgenes lacking neurone restrictive silencer element recapitulate CNS neurone-specific expression and developmental up-regulation of endogenous KCC2 gene
    Pavel Uvarov
    Neuroscience Centre, 00014 University of Helsinki, Helsinki, Finland
    J Neurochem 95:1144-55. 2005
    ..Thus, developmental up-regulation of the KCC2 gene does not require NRSE(KCC2) and the 1.4-kb KCC2 promoter is largely sufficient for neurone-specific expression of KCC2...