Matti Uusitupa

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. pmc Short-term LDL cholesterol-lowering efficacy of plant stanol esters
    Maarit Hallikainen
    Department of Clinical Nutrition, University of Kuopio, Finland
    BMC Cardiovasc Disord 2:14. 2002
  2. ncbi request reprint Long-term improvement in insulin sensitivity by changing lifestyles of people with impaired glucose tolerance: 4-year results from the Finnish Diabetes Prevention Study
    Matti Uusitupa
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Diabetes 52:2532-8. 2003
  3. ncbi request reprint [Permanent changes in insulin resistance by changes in life style among subjects with impaired glucose tolerance]
    Matti Uusitupa
    Kliinisen ravitsemustieteen laitos ja Elintarvikkeiden terveysvaikutusten tutkimuskeskus, Kuopion yliopisto
    Duodecim 120:1495-7. 2004
  4. pmc Ten-year mortality and cardiovascular morbidity in the Finnish Diabetes Prevention Study--secondary analysis of the randomized trial
    Matti Uusitupa
    School of Public Health and Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    PLoS ONE 4:e5656. 2009
  5. ncbi request reprint Gene-diet interaction in relation to the prevention of obesity and type 2 diabetes: evidence from the Finnish Diabetes Prevention Study
    Matti Uusitupa
    Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Nutr Metab Cardiovasc Dis 15:225-33. 2005
  6. doi request reprint Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention
    Tuomas O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio 70211, Finland
    Metabolism 57:428-36. 2008
  7. doi request reprint Gene expression of FTO in human subcutaneous adipose tissue, peripheral blood mononuclear cells and adipocyte cell line
    Tiina Lappalainen
    Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Eastern Finland, Kuopio, Finland
    J Nutrigenet Nutrigenomics 3:37-45. 2010
  8. ncbi request reprint Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome
    Petteri Kallio
    Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Finland
    Am J Clin Nutr 87:1497-503. 2008
  9. ncbi request reprint SNPs in PPARG associate with type 2 diabetes and interact with physical activity
    Tuomas O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Med Sci Sports Exerc 40:25-33. 2008
  10. doi request reprint The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study
    Tiina J Lappalainen
    School of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    Obesity (Silver Spring) 17:832-6. 2009

Detail Information

Publications91

  1. pmc Short-term LDL cholesterol-lowering efficacy of plant stanol esters
    Maarit Hallikainen
    Department of Clinical Nutrition, University of Kuopio, Finland
    BMC Cardiovasc Disord 2:14. 2002
    ..Therefore, we investigated the time in days needed to obtain the full cholesterol-lowering effect of stanol esters in hypercholesterolemic subjects...
  2. ncbi request reprint Long-term improvement in insulin sensitivity by changing lifestyles of people with impaired glucose tolerance: 4-year results from the Finnish Diabetes Prevention Study
    Matti Uusitupa
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Diabetes 52:2532-8. 2003
    ..In conclusion, Si markedly improved by weight reduction during the 4-year follow-up of individuals with IGT. Insulin secretion remained constant for years in individuals with IGT who were able to lose weight...
  3. ncbi request reprint [Permanent changes in insulin resistance by changes in life style among subjects with impaired glucose tolerance]
    Matti Uusitupa
    Kliinisen ravitsemustieteen laitos ja Elintarvikkeiden terveysvaikutusten tutkimuskeskus, Kuopion yliopisto
    Duodecim 120:1495-7. 2004
  4. pmc Ten-year mortality and cardiovascular morbidity in the Finnish Diabetes Prevention Study--secondary analysis of the randomized trial
    Matti Uusitupa
    School of Public Health and Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    PLoS ONE 4:e5656. 2009
    ..Furthermore, we compared these results with a population-based cohort comprising individuals of varying glucose tolerance states...
  5. ncbi request reprint Gene-diet interaction in relation to the prevention of obesity and type 2 diabetes: evidence from the Finnish Diabetes Prevention Study
    Matti Uusitupa
    Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Nutr Metab Cardiovasc Dis 15:225-33. 2005
    ..This review deals with selected genes examined so far in the DPS...
  6. doi request reprint Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention
    Tuomas O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio 70211, Finland
    Metabolism 57:428-36. 2008
    ..In conclusion, genetic variation may modify the magnitude of the beneficial effects of PA on characteristics of the metabolic syndrome in persons with IGT...
  7. doi request reprint Gene expression of FTO in human subcutaneous adipose tissue, peripheral blood mononuclear cells and adipocyte cell line
    Tiina Lappalainen
    Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Eastern Finland, Kuopio, Finland
    J Nutrigenet Nutrigenomics 3:37-45. 2010
    ..We also investigated if mRNA levels of FTO in adipose tissue correlated with the adiposity or inflammatory markers and mRNA levels of genes involved in the response to hypoxia (HIF-1a) and cell death(HMGB1)...
  8. ncbi request reprint Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome
    Petteri Kallio
    Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Finland
    Am J Clin Nutr 87:1497-503. 2008
    ..Inflammation may be a mechanism by which high postprandial insulin and glucose responses increase the risk of type 2 diabetes mellitus...
  9. ncbi request reprint SNPs in PPARG associate with type 2 diabetes and interact with physical activity
    Tuomas O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Med Sci Sports Exerc 40:25-33. 2008
    ....
  10. doi request reprint The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study
    Tiina J Lappalainen
    School of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    Obesity (Silver Spring) 17:832-6. 2009
    ..Based on the results from the DPS, it is unlikely that the common variant of the FTO gene affects the success of lifestyle modification on weight loss...
  11. pmc Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study
    Titta Salopuro
    University of Kuopio, Department of Clinical Nutrition and Food and Health Research Center, Kuopio, Finland
    BMC Med Genet 10:94. 2009
    ..2 +/- 4.5 kg/m2, age: 55 +/- 7 years) for whom DNA was available were randomized to either an intensified diet and physical activity group or to a conventional care control group...
  12. ncbi request reprint Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study
    Olli Laukkanen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes 54:2256-60. 2005
    ..56 [1.78-17.39], P = 0.003) but not in the intervention group. We conclude that the SNPs of SLC2A2 predict the conversion to diabetes in obese subjects with IGT...
  13. doi request reprint Genetic predisposition to obesity and lifestyle factors--the combined analyses of twenty-six known BMI- and fourteen known waist:hip ratio (WHR)-associated variants in the Finnish Diabetes Prevention Study
    Tiina Jääskeläinen
    Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, PO Box 1627, FI 70211 Kuopio, Finland
    Br J Nutr 110:1856-65. 2013
    ..In addition, these findings suggest that the association between the BMI-related genetic variants and obesity could be modulated by the diet...
  14. doi request reprint The genetic variation of the tenomodulin gene (TNMD) is associated with serum levels of systemic immune mediators--the Finnish Diabetes Prevention Study
    Anna Maija Tolppanen
    Department of Clinical Nutrition and Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Genet Med 10:536-44. 2008
    ..Our objective was to investigate the genetic associations of the single nucleotide polymorphisms of the TNMD gene with the serum levels of systemic immune mediators...
  15. pmc Sleep duration, lifestyle intervention, and incidence of type 2 diabetes in impaired glucose tolerance: The Finnish Diabetes Prevention Study
    Henri Tuomilehto
    Department of Otorhinolaryngology, Kuopio University Hospital, and University of Kuopio, Kuopio, Finland
    Diabetes Care 32:1965-71. 2009
    ....
  16. pmc Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study
    Niina Siitonen
    Department of Clinical Nutrition and Food and Health Research Centre, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    BMC Med Genet 12:5. 2011
    ..Moreover, we investigated whether ADIPOQ gene variants modify the effect of lifestyle changes on these traits...
  17. doi request reprint The activation of the inflammatory cytokines in overweight patients with mild obstructive sleep apnoea
    Johanna Sahlman
    Department of Otorhinolaryngology, Institute of Clinical Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    J Sleep Res 19:341-8. 2010
    ..Mild OSA was found to be associated not only with the activation of the pro-inflammatory, but also with the anti-inflammatory systems...
  18. ncbi request reprint Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study
    Anna Maija Tolppanen
    Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Obesity (Silver Spring) 15:1082-8. 2007
    ..191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men...
  19. doi request reprint Long-term repeatability of measures of early insulin secretion derived from an intravenous glucose tolerance test and conversion from impaired glucose tolerance to diabetes
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Ann Med 40:303-11. 2008
    ..We assessed the long-term repeatability of the acute insulin response (AIR) and sensitivity index (S(I)) derived from the frequently sampled intravenous glucose tolerance test (FSIGT)...
  20. pmc Insulin secretion and its determinants in the progression of impaired glucose tolerance to type 2 diabetes in impaired glucose-tolerant individuals: the Finnish Diabetes Prevention Study
    Vanessa D F de Mello
    Institute of Public Health and Clinical Nutrition, Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Diabetes Care 35:211-7. 2012
    ....
  21. pmc Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance
    Ursula Mager
    Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    PLoS ONE 3:e2941. 2008
    ..Ghrelin may influence the development of obesity through its role in the control of energy balance, food intake, and regulation of body weight. The effects of ghrelin are mediated via the growth hormone secretagogue receptor (GHSR)...
  22. ncbi request reprint Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study
    David E Laaksonen
    Department of Clinical Nutrition and Food and Health Research Center, University of Kuopio, P O Box 1627, Kuopio, Finland
    Diabetes 54:158-65. 2005
    ..34, 0.19-0.62) was the most strongly associated with incident diabetes. Thus increasing physical activity may substantially reduce the incidence of type 2 diabetes in high-risk individuals...
  23. doi request reprint Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndrome
    Ursula Mager
    Department of Clinical Nutrition, School of Public Health and Clinical Nutrition, Food and Health Research Centre, University of Kuopio PO Box 1627, FIN 70211 Kuopio, Finland
    Eur J Endocrinol 158:499-510. 2008
    ..We examined the expression of ghrelin and ghrelin receptors in peripheral blood mononuclear cells (PBMCs) and evaluated the effect of weight loss or exercise on plasma ghrelin concentrations in subjects with the metabolic syndrome...
  24. ncbi request reprint Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study
    Olli Laukkanen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 89:6286-90. 2004
    ..2 gene...
  25. doi request reprint Effect of weight loss on cytokine messenger RNA expression in peripheral blood mononuclear cells of obese subjects with the metabolic syndrome
    Vanessa D F de Mello
    School of Public Health and Clinical Nutrition, Food and Health Research Centre, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Metabolism 57:192-9. 2008
    ....
  26. ncbi request reprint Serum uric acid as a harbinger of metabolic outcome in subjects with impaired glucose tolerance: the Finnish Diabetes Prevention Study
    Leo Niskanen
    Department of Medicine, Kuopio University Hospital, Bld nro 5, FIN 70210, Kuopio, Finland
    Diabetes Care 29:709-11. 2006
  27. doi request reprint Association of the fat mass and obesity-associated (FTO) gene variant (rs9939609) with dietary intake in the Finnish Diabetes Prevention Study
    Tiina Lappalainen
    Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, PO Box 1627, FI 70211 Kuopio, Finland
    Br J Nutr 108:1859-65. 2012
    ....
  28. ncbi request reprint Physical activity, diet, and incident diabetes in relation to an ADRA2B polymorphism
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Med Sci Sports Exerc 39:227-32. 2007
    ..We assessed the associations of leisure-time physical activity (LTPA), dietary changes, and weight loss on the risk of type 2 diabetes according to the 12Glu9 polymorphism in 481 participants of the Finnish Diabetes Prevention Study...
  29. doi request reprint Sustained improvement in mild obstructive sleep apnea after a diet- and physical activity-based lifestyle intervention: postinterventional follow-up
    Henri Tuomilehto
    Institute of Clinical Medicine, Otorhinolaryngology, Kuopio University Hospital, and University of Eastern Finland, Kuopio, Finland
    Am J Clin Nutr 92:688-96. 2010
    ..Weight-reduction programs have been observed to represent effective treatment of overweight patients with OSA. However, it is not known whether beneficial changes remain after the end of the intervention...
  30. ncbi request reprint Refinement of the 22q12-q13 breast cancer--associated region: evidence of TMPRSS6 as a candidate gene in an eastern Finnish population
    Jaana M Hartikainen
    Department of Pathology, University of Kuopio, Finland
    Clin Cancer Res 12:1454-62. 2006
    ..041) provides further evidence for breast cancer risk factor locating on 22q12-q13, possibly being TMPRSS6. Our results suggest that matriptase-2 gene is associated with breast cancer risk in the Eastern Finnish population...
  31. doi request reprint Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population
    Kai Kaarniranta
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland
    Neurosci Lett 513:233-7. 2012
    ..4%. Distribution of proportion of cases/controls between alleles revealed an additive genetic model. Our findings reveal that rs10753929 ADIPOR1 variant is a novel candidate for AMD genetic risk factor in Finnish population...
  32. pmc Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study
    Niina Siitonen
    Department of Clinical Nutrition and Food and Health Research Centre, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Cardiovasc Diabetol 10:83. 2011
    ....
  33. ncbi request reprint Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: the FUNGENUT Study
    Petteri Kallio
    Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 85:1417-27. 2007
    ..Diets rich in whole-grain cereals and foods with a low glycemic index may protect against type 2 diabetes, but the underlying molecular mechanisms are unknown...
  34. pmc Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration
    Anna Maija Tolppanen
    Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    Mol Vis 15:762-70. 2009
    ..Associations of single nucleotide polymorphisms of TNMD with the prevalence of age-related macular degeneration (AMD) were examined...
  35. pmc Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes
    Maija Vaittinen
    Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Diabetes 62:3747-50. 2013
    ..To conclude, CPPED1 is a novel molecule involved in AT biology, and CPPED1 is involved in glucose uptake in adipocytes. ..
  36. doi request reprint The effect of fatty or lean fish intake on inflammatory gene expression in peripheral blood mononuclear cells of patients with coronary heart disease
    Vanessa D F de Mello
    Department of Clinical Nutrition Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    Eur J Nutr 48:447-55. 2009
    ..Little is known about the effect of fish consumption on gene expression of inflammation-related genes in immune cells in coronary heart disease (CHD)...
  37. ncbi request reprint Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study
    Agata Kubaszek
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Diabetes 52:1872-6. 2003
    ..Furthermore, this polymorphism seems to have a gene-gene interaction with the C-174C genotype of the IL-6 gene...
  38. doi request reprint Lifestyle intervention with weight reduction: first-line treatment in mild obstructive sleep apnea
    Henri P I Tuomilehto
    Department of Otorhinolaryngology, Institute of Clinical Medicine, University of Kuopio, Kuopio University Hospital, P O Box 1777, FIN 70211 Kuopio, Finland
    Am J Respir Crit Care Med 179:320-7. 2009
    ..Obesity is the most important risk factor for obstructive sleep apnea (OSA). However, although included in clinical guidelines, no randomized controlled studies have been performed on the effects of weight reduction on mild OSA...
  39. pmc Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study
    Ursula Schwab
    School of Public Health and Clinical Nutrition, Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    PLoS ONE 3:e2630. 2008
    ..The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-week intervention...
  40. pmc Whole grain products, fish and bilberries alter glucose and lipid metabolism in a randomized, controlled trial: the Sysdimet study
    Maria Lankinen
    VTT Technical Research Centre of Finland, Kuopio, Finland
    PLoS ONE 6:e22646. 2011
    ..Herein we investigated the effects of low-insulin-response grain products, fatty fish, and berries on glucose metabolism and plasma lipidomic profiles in persons with impaired glucose metabolism...
  41. ncbi request reprint Costs of a self-selected, health-promoting diet among the participants of the Finnish Diabetes Prevention Study
    Anne Mari Ottelin
    Department of Public Health and Clinical Nutrition, Food and Health Research Centre, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Diabetes Care 30:1275-7. 2007
  42. ncbi request reprint Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes
    Katariina Sivenius
    Department of Clinical Nutrition, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Diabetes Care 27:2021-6. 2004
    ....
  43. doi request reprint Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort
    Anna Maija Tolppanen
    Department of Clinical Nutrition and Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Neurobiol Aging 32:546.e7-9. 2011
    ..47, p=0.019, false discovery rate 10.4%). According to these results the sequence variation of TNMD is not associated with AD, but might modify the effect of APOE ε4-allele in women...
  44. ncbi request reprint Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome
    Maarit Hallikainen
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Clin Chim Acta 383:126-32. 2007
    ..The purpose of this study was to investigate whether cholesterol metabolism is associated with serum adipokines and inflammatory markers...
  45. ncbi request reprint Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans
    Ursula Schwab
    Department of Clinical Nutrition, University of Kuopio, Finland
    J Nutr 136:34-8. 2006
    ..In conclusion, a single dose of orally administered betaine had an acute and dose-dependent effect on serum betaine concentration and resulted in lowered plasma tHcy concentrations within 2 h in healthy subjects...
  46. doi request reprint Tenomodulin gene and obesity-related phenotypes
    Anna Maija Tolppanen
    Department of Clinical Nutrition and Food and Health Research Centre, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Ann Med 42:265-75. 2010
    ..In this review, the potential mechanisms that could link TNMD with the pathogenesis of obesity and related disorders are discussed...
  47. doi request reprint Gene expression of peripheral blood mononuclear cells as a tool in dietary intervention studies: What do we know so far?
    Vanessa Derenji Ferreira de Mello
    Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Mol Nutr Food Res 56:1160-72. 2012
    ..Use of microarray technology in larger well-designed dietary intervention studies is still needed for exploring PBMC potential in the field of nutrigenomics...
  48. ncbi request reprint Epidemiology and treatment of the metabolic syndrome
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Ann Med 36:332-46. 2004
    ..In the meantime, efforts to curb obesity and overweight, increase physical activity and improve compliance with current dietary recommendations should continue...
  49. ncbi request reprint A deletion in the alpha2B-adrenergic receptor gene and autonomic nervous function in central obesity
    Katariina Sivenius
    Department of Clinical Nutrition, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Obes Res 11:962-70. 2003
    ..Because autonomic nervous function participates in the regulation of energy metabolism, there could be a link between this polymorphism and autonomic nervous function...
  50. doi request reprint Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes
    Yuvaraj Mahendran
    Institute of Clinical Sciences, Internal Medicine YM, HC, JV, As, JK, and ML, the Institute of Biomedicine Physiology JÅ, and the Institute of Public Health and Clinical Nutrition MU and US, University of Eastern Finland, Kuopio, Finland, and the Research Unit MU and the Department of Medicine HC, JK, and ML, Kuopio University Hospital, Kuopio, Finland
    Am J Clin Nutr 99:79-85. 2014
    ..The significance of erythrocyte membrane fatty acids (EMFAs) and their ratios to predict hyperglycemia and incident type 2 diabetes is unclear...
  51. ncbi request reprint An autosome-wide scan for linkage disequilibrium-based association in sporadic breast cancer cases in eastern Finland: three candidate regions found
    Jaana M Hartikainen
    Department of Pathology and Forensic Medicine, University of Kuopio, P O Box 1627, FI 70211 Kuopio, Finland
    Cancer Epidemiol Biomarkers Prev 14:75-80. 2005
    ..003-0.021). Our results suggest breast cancer-associated regions on 3p26, 11q23, and 22q13.1 in an eastern Finnish population...
  52. ncbi request reprint Anthropometry, bioelectrical impedance and dual-energy X-ray absorptiometry in the assessment of body composition in elderly Finnish women
    Irja Haapala
    Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland
    Clin Physiol Funct Imaging 22:383-91. 2002
    ..These results indicate that BIA prediction equations, chosen with care, can improve the performance of equations based upon anthropometric measurements alone in the assessment of body composition in elderly women...
  53. ncbi request reprint Treatment improves serotonin transporter binding and reduces binge eating
    Liisa I Tammela
    Department of Clinical Nutrition, University of Kuopio and Kuopio University Hospital, 70211 Kuopio, Finland
    Psychopharmacology (Berl) 170:89-93. 2003
    ..Serotonin (5-HT) is involved in the control of eating behaviour by inhibiting food intake. Obese women with binge-eating disorder (OB-BED) were recently found to have reduced 5-HT transporter binding...
  54. ncbi request reprint [Nutrigenomics-key for identification of molecular effects of nutritional factors]
    Marjukka Kolehmainen
    Kuopion yliopiston kliinisen ravitsemustieteen laitos, Elintarvikkeiden terveysvaikutusten tutkimuskeskus, Kuopio
    Duodecim 121:2139-41. 2005
  55. pmc Dietary fat in relation to erythrocyte fatty acid composition in men
    Markus Takkunen
    Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P O Box 1627, 70211, Kuopio, Finland
    Lipids 48:1093-102. 2013
    ..Yet, all main sources of dietary fat were related with EMFA. The dietary effect on the nervonic acid proportion was confirmed...
  56. pmc Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation
    Carsten Carlberg
    School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 8:e71042. 2013
    ..These biomarkers allow the classification of subjects into those, who might benefit from a vitamin D3 supplementation, and others who do not. ..
  57. ncbi request reprint The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism
    Jussi Pihlajamaki
    Departments of Medicine and Clinical Nutrition, University of Kuopio, Kuopio, Finland and the Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    Metabolism 52:643-6. 2003
    ..003). In conclusion, the Leu7Pro polymorphism of the NPY gene associates with alterations in FFA metabolism but does not have an impact on insulin sensitivity, insulin secretion, or glucose metabolism...
  58. pmc History of medically treated diabetes and risk of Alzheimer disease in a nationwide case-control study
    Anna Maija Tolppanen
    Institute of Clinical Medicine, Neurology, University of Kuopio, Kuopio, Finland
    Diabetes Care 36:2015-9. 2013
    ..We investigated whether individuals with AD were more likely to have a history of diabetes than matched controls from the general aged population...
  59. ncbi request reprint Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects
    Ursula Schwab
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 76:961-7. 2002
    ..It is involved in homocysteine metabolism as an alternative methyl donor and is used in the treatment of homocystinuria in humans. In pigs, betaine decreases the amount of adipose tissue...
  60. ncbi request reprint The effect of intensified diet counseling on the diet of hypertensive subjects in primary health care: a 2-year open randomized controlled trial of lifestyle intervention against hypertension in eastern Finland
    Maarit Korhonen
    Department of Clinical Nutrition, University of Kuopio, Finland
    Prev Med 36:8-16. 2003
    ..Diet is an essential part of the nonpharmacological management of hypertension. The aim of this study was to investigate in a primary health care setting the effect of intensified diet counseling on the diet of hypertensive subjects...
  61. ncbi request reprint Long-term results, late complications and quality of life in a series of adjustable gastric banding
    Tarja Martikainen
    Division of Clinical Nutrition, Kuopio University Hospital, University of Kuopio, Finland
    Obes Surg 14:648-54. 2004
    ..Adjustable gastric banding is currently the most common bariatric operation. This study is a retrospective analysis of the Finnish experience with this procedure over the last 10 years...
  62. ncbi request reprint No observed local immunological response at cell level after five years of oats in adult coeliac disease
    Tarja Kemppainen
    Department of Clinical Nutrition, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Scand J Gastroenterol 42:54-9. 2007
    ..The objective of the present study was to clarify its applicability by analysing local cellular immunological responses after 5 years' consumption of oats by adult coeliac patients...
  63. ncbi request reprint Iris transluminance in type 2 diabetes
    Raija Voutilainen-Kaunisto
    Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland
    Acta Ophthalmol Scand 80:64-8. 2002
    ..Cross-sectional analysis of iris transluminance in type 2 diabetic patients compared with control subjects, all followed in a cohort study...
  64. ncbi request reprint [Brain imaging in eating disorders and obesity reseach]
    Leila Karhunen
    Kuopion yliopisto, kliinisen ravitsemustieteen laitos, PL 1627, 70211 Kuopio
    Duodecim 119:859-65. 2003
  65. ncbi request reprint Combined COMT and GST genotypes and hormone replacement therapy associated breast cancer risk
    Katja Mitrunen
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenetics 12:67-72. 2002
    ..84-45.0) of breast cancer in this study group. These results suggest that the use of HRT could substantially increase the risk of breast cancer among women with specific combinations of the at-risk genotypes of COMT and GST genes...
  66. doi request reprint NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer
    Rainer Fagerholm
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, FI 00029 Helsinki, Finland
    Nat Genet 40:844-53. 2008
    ....
  67. ncbi request reprint Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults
    Ilkka Vauhkonen
    Department of Medicine, Kuopio University Hospital, Finland
    Eur J Endocrinol 153:265-73. 2005
    ..We set out to assess whether hyperproinsulinaemia is an early finding in latent autoimmune diabetes in adults (LADA)...
  68. ncbi request reprint NAT2 slow acetylator genotype as an important modifier of breast cancer risk
    Pia Sillanpää
    Finnish Institute of Occupational Health, Helsinki, Finland
    Int J Cancer 114:579-84. 2005
    ..60; 95% CI, 1.07-2.39). Our results therefore suggest that NAT2 slow acetylator genotype may be an important modifier of environmentally induced breast cancer risk in Finnish women...
  69. ncbi request reprint [Liposuction as treatment of diabetes--is it an effective treatment?]
    Matti Uusitupa
    Duodecim 120:2355; author reply 2356. 2004
  70. ncbi request reprint Comparative evaluation of simple indices of insulin resistance
    Olga Vaccaro
    Department of Clinical and Experimental Medicine, Federico II University of Naples, Italy
    Metabolism 53:1522-6. 2004
    ..The novel indices QUICKI and R-QUICKI do not perform better than HOMA and fasting insulin as surrogate measures of insulin resistance or means for the identification of people with MS in the general population...
  71. ncbi request reprint Prevalence of the metabolic syndrome and its components: findings from a Finnish general population sample and the Diabetes Prevention Study cohort
    Pirjo Ilanne-Parikka
    The Diabetes Center, Kirjoniementie 15, FIN 33680 Tampere, Finland
    Diabetes Care 27:2135-40. 2004
    ..To assess the prevalence of the metabolic syndrome (MetS) in two independent Finnish study cohorts...
  72. ncbi request reprint [Inherited combined hyperlipidemia (FKH)--revealing the genetic etiology is getting closer]
    Matti Uusitupa
    Duodecim 120:1193-4. 2004
  73. ncbi request reprint Interactions between peroxisome proliferator-activated receptor-gamma 2 gene polymorphisms and size at birth on blood pressure and the use of antihypertensive medication
    Hilkka Ylihärsilä
    National Public Health Institute, Helsinki, University of Helsinki, Finland
    J Hypertens 22:1283-7. 2004
    ..We examined whether the association between small body size at birth and adult blood pressure is modulated by PPAR-gamma 2 gene polymorphism, and whether the use of any class of antihypertensive medication is related to birth size...
  74. ncbi request reprint The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study
    Boryana Todorova
    Department of Medicine, University of Kuopio, 70210 Kuopio
    J Clin Endocrinol Metab 89:2019-23. 2004
    ..001). We conclude that the G-250G genotype of the LIPC gene is a risk factor for type 2 diabetes. Therefore, genes regulating lipid and lipoprotein metabolism may be potential candidate genes for type 2 diabetes...
  75. ncbi request reprint Vitamin D receptor gene polymorphism as an important modifier of positive family history related breast cancer risk
    Pia Sillanpää
    Department of Occupational Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland
    Pharmacogenetics 14:239-45. 2004
    ..In conclusion, our results suggest that the VDR ApaI genotype may be an important modifier of individual breast cancer risk among Finnish women, especially if they have a positive family history of breast cancer...
  76. ncbi request reprint The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity
    Jaana Lindström
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 26:3230-6. 2003
    ..To describe the 1) lifestyle intervention used in the Finnish Diabetes Prevention Study, 2) short- and long-term changes in diet and exercise behavior, and 3) effect of the intervention on glucose and lipid metabolism...
  77. ncbi request reprint Prevention of diabetes mellitus in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study: results from a randomized clinical trial
    Jaana Lindström
    National Public Health Institute, Department of Epidemiology, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
    J Am Soc Nephrol 14:S108-13. 2003
    ..In conclusion, the DPS is the first controlled trial demonstrating that type 2 diabetes can be prevented by changes in lifestyle in high-risk subjects...
  78. ncbi request reprint Sulfotransferase 1A1 genotype as a potential modifier of breast cancer risk among premenopausal women
    Pia Sillanpää
    Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenet Genomics 15:749-52. 2005
    ..09-0.63) compared to women with two SULT1A1*1 alleles. Our results suggest that the SULT1A1 genotype is not an important risk factor for breast cancer in general, but may modify the risk among premenopausaul women with high parity...
  79. ncbi request reprint Dietary (n-3) fatty acids reduce plasma F2-isoprostanes but not prostaglandin F2alpha in healthy humans
    Cecilia Nälsén
    The KANWU Study Group at Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Sweden
    J Nutr 136:1222-8. 2006
    ..We conclude that supplementation with (n-3) fatty acids decreases nonenzymatic free radical-catalyzed isoprostane formation, but does not affect cyclooxygenase-mediated prostaglandin formation...
  80. doi request reprint Lifestyle intervention, diabetes, and cardiovascular disease
    Jaana Lindström
    Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, FIN 00300 Helsinki, Finland
    Lancet 371:1731-3. 2008
  81. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment...
  82. doi request reprint Measurement of blood glucose: comparison between different types of specimens
    Bendix Carstensen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Ann Clin Biochem 45:140-8. 2008
    ..To provide conversion formulae between measurements based on different specimens in use in epidemiological studies and clinical practice, and to evaluate the relative precision for the different methods...
  83. doi request reprint Determinants for the effectiveness of lifestyle intervention in the Finnish Diabetes Prevention Study
    Jaana Lindström
    Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Diabetes Care 31:857-62. 2008
    ..We investigated whether and to what extent risk factors for type 2 diabetes and other baseline characteristics of the study participants modified the effectiveness of the lifestyle intervention...
  84. doi request reprint Effect of lifestyle intervention on the occurrence of metabolic syndrome and its components in the Finnish Diabetes Prevention Study
    Pirjo Ilanne-Parikka
    Diabetes Center, Finnish Diabetes Association, Tampere, Finland
    Diabetes Care 31:805-7. 2008
    ..The aim of this secondary analysis of the Finnish Diabetes Prevention Study was to assess the effects of lifestyle intervention on metabolic syndrome and its components...
  85. ncbi request reprint Lifestyle intervention to prevent diabetes in men and women with impaired glucose tolerance is cost-effective
    Peter Lindgren
    Karolinska Institutet, Stockholm, Sweden
    Int J Technol Assess Health Care 23:177-83. 2007
    ..As such, a program is demanding in terms of resources; it is necessary to assess whether it would be money well spent. This determination was the purpose of this study...
  86. pmc XRCC1 and XPD genetic polymorphisms, smoking and breast cancer risk in a Finnish case-control study
    Katja Metsola
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    Breast Cancer Res 7:R987-97. 2005
    ..In this study, we evaluated if polymorphisms in DNA repair genes XRCC1 (Arg280His, Arg399Gln) and XPD (Lys751Gln) modify individual breast cancer risk, with emphasis on tobacco smoking...
  87. ncbi request reprint Fish oil, insulin sensitivity, insulin secretion and glucose tolerance in healthy people: is there any effect of fish oil supplementation in relation to the type of background diet and habitual dietary intake of n-6 and n-3 fatty acids?
    Rosalba Giacco
    Institute of Food Science, Italian National Research Council, Avellino, Italy
    Nutr Metab Cardiovasc Dis 17:572-80. 2007
    ....
  88. ncbi request reprint Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study
    Jaana Lindström
    Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Lancet 368:1673-9. 2006
    ..In the extended follow-up of the Finnish Diabetes Prevention Study, we assessed the extent to which the originally-achieved lifestyle changes and risk reduction remain after discontinuation of active counselling...
  89. ncbi request reprint CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population
    Pia Sillanpää
    Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, Helsinki, Finland
    Breast Cancer Res Treat 104:287-97. 2007
    ..Our results suggest that the CYP1B1 polymorphism may be an important modifier of breast cancer risk in Finnish Caucasian women who have been exposed to tobacco smoke and/or carry the NAT2 slow acetylator genotype...
  90. ncbi request reprint Systemic immune mediators and lifestyle changes in the prevention of type 2 diabetes: results from the Finnish Diabetes Prevention Study
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes 55:2340-6. 2006
    ..088). Thus, systemic concentrations of immune mediators appear to be associated with the progression to type 2 diabetes and the prevention of type 2 diabetes by lifestyle changes...
  91. ncbi request reprint The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth
    Johan G Eriksson
    Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Diabetes 51:2321-4. 2002
    ..We suggest that these findings reflect gene-environment interaction...