Olavi Ukkola

Summary

Affiliation: University of Oulu
Country: Finland

Publications

  1. doi request reprint Total testosterone levels, metabolic parameters, cardiac remodeling and exercise capacity in coronary artery disease patients with different stages of glucose tolerance
    Olavi Ukkola
    Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu and Clinical Research Center of Oulu University Hospital, Finland
    Ann Med 45:206-12. 2013
  2. doi request reprint Ghrelin and its promoter variant associated with cardiac hypertrophy
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, Institute of Clinical Medicine, University of Oulu, and Clinical Research Center, Oulu University Hospital, Oulu, Finland
    J Hum Hypertens 26:452-7. 2012
  3. doi request reprint Genetic variants of ghrelin in metabolic disorders
    Olavi Ukkola
    Department of Internal Medicine and Biocenter Oulu, Institute of Clinical Medicine, University of Oulu, Oulu, Finland
    Peptides 32:2319-22. 2011
  4. ncbi request reprint Ghrelin and metabolic disorders
    Olavi Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    Curr Protein Pept Sci 10:2-7. 2009
  5. ncbi request reprint Operative risk factors in the metabolic syndrome: is it lipids and high blood pressure or are there direct vascular effects of insulin resistance and obesity?
    Olavi Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Kajaanintie 50 P O Box 5000, Oulu, FIN 90014, Finland
    Curr Cardiol Rep 8:427-32. 2006
  6. ncbi request reprint Preproghrelin Leu72Met polymorphism in patients with type 2 diabetes mellitus
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    J Intern Med 254:391-4. 2003
  7. doi request reprint Interactions between ghrelin, leptin and IGF-I affect metabolic syndrome and early atherosclerosis
    Olavi Ukkola
    Department of Internal Medicine, University of Oulu, Finland
    Ann Med 40:465-73. 2008
  8. ncbi request reprint Peripheral regulation of food intake: new insights
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    J Endocrinol Invest 27:96-8. 2004
  9. doi request reprint ApoE phenotype is associated with inflammatory markers in middle-aged subjects
    O Ukkola
    Department of Internal Medicine, Biocenter Oulu, Oulu, Finland
    Inflamm Res 58:54-9. 2009
  10. ncbi request reprint [Does inhibition of tyrosine phosphatase 1B protect from obesity and type 2 diabetes?]
    Olavi Ukkola
    Oulun yliopisto, sisätautien klinikka ja Biocenter Oulu PL 5000, 90014 Oulu
    Duodecim 118:1857-62. 2002

Collaborators

Detail Information

Publications90

  1. doi request reprint Total testosterone levels, metabolic parameters, cardiac remodeling and exercise capacity in coronary artery disease patients with different stages of glucose tolerance
    Olavi Ukkola
    Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu and Clinical Research Center of Oulu University Hospital, Finland
    Ann Med 45:206-12. 2013
    ..The correlation between total testosterone levels, exercise capacity, and metabolic and echocardiographic parameters was studied in 1097 male subjects with coronary artery disease (CAD) and different stages of glucose tolerance...
  2. doi request reprint Ghrelin and its promoter variant associated with cardiac hypertrophy
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, Institute of Clinical Medicine, University of Oulu, and Clinical Research Center, Oulu University Hospital, Oulu, Finland
    J Hum Hypertens 26:452-7. 2012
    ..The effects of the SNP seem not to be mediated through its effects on ghrelin plasma levels...
  3. doi request reprint Genetic variants of ghrelin in metabolic disorders
    Olavi Ukkola
    Department of Internal Medicine and Biocenter Oulu, Institute of Clinical Medicine, University of Oulu, Oulu, Finland
    Peptides 32:2319-22. 2011
    ..We therefore conclude that more studies on variants of ghrelin gene are needed to perform in different populations to get deeper understanding on the relationship of ghrelin gene and its variants to obesity...
  4. ncbi request reprint Ghrelin and metabolic disorders
    Olavi Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    Curr Protein Pept Sci 10:2-7. 2009
    ..Antagonism of ghrelin function to treat diabetes is thus a fascinating idea. This review concentrates on recent findings on the orexigenic peptide ghrelin and its derivatives in metabolic disorders with emphasis put on human studies...
  5. ncbi request reprint Operative risk factors in the metabolic syndrome: is it lipids and high blood pressure or are there direct vascular effects of insulin resistance and obesity?
    Olavi Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Kajaanintie 50 P O Box 5000, Oulu, FIN 90014, Finland
    Curr Cardiol Rep 8:427-32. 2006
    ..The role of traditional versus novel adipose tissue-related risk factors in the background of atherosclerosis in the metabolic syndrome are discussed...
  6. ncbi request reprint Preproghrelin Leu72Met polymorphism in patients with type 2 diabetes mellitus
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    J Intern Med 254:391-4. 2003
    ..The association between the Leu72Met polymorphism of the preproghrelin gene and diabetic complications was examined in patients with type 2 diabetes mellitus...
  7. doi request reprint Interactions between ghrelin, leptin and IGF-I affect metabolic syndrome and early atherosclerosis
    Olavi Ukkola
    Department of Internal Medicine, University of Oulu, Finland
    Ann Med 40:465-73. 2008
    ..High leptin and low ghrelin are associated with the metabolic syndrome (MS)...
  8. ncbi request reprint Peripheral regulation of food intake: new insights
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    J Endocrinol Invest 27:96-8. 2004
    ..In this review old and new peripheral signals and their interaction in the control of food intake are briefly discussed...
  9. doi request reprint ApoE phenotype is associated with inflammatory markers in middle-aged subjects
    O Ukkola
    Department of Internal Medicine, Biocenter Oulu, Oulu, Finland
    Inflamm Res 58:54-9. 2009
    ..Apolipoprotein (apo) E phenotype has been associated with inflammation markers. The determinants of these associations and the relationship between novel inflammation marker, resistin, and apoE phenotype are studied here...
  10. ncbi request reprint [Does inhibition of tyrosine phosphatase 1B protect from obesity and type 2 diabetes?]
    Olavi Ukkola
    Oulun yliopisto, sisätautien klinikka ja Biocenter Oulu PL 5000, 90014 Oulu
    Duodecim 118:1857-62. 2002
  11. doi request reprint Genetic variants at the resistin locus are associated with the plasma resistin concentration and cardiovascular risk factors
    Olavi Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Finland
    Regul Pept 149:56-9. 2008
    ..To examine the relation of the single nucleotide polymorphisms (SNPs) of the resistin gene on the plasma resistin concentration and cardiovascular risk factors...
  12. ncbi request reprint Leptin and high-sensitivity C-reactive protein and their interaction in the metabolic syndrome in middle-aged subjects
    Olavi Ukkola
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Metabolism 56:1221-7. 2007
    ..The study suggests sex-specific interplay between metabolic and inflammatory markers in the pathogenesis of MS...
  13. ncbi request reprint [Cachexia]
    Olavi Ukkola
    Oulun yliopisto, sisãtautien klinikka, Biocenter Oulu
    Duodecim 121:985-92. 2005
  14. ncbi request reprint Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    Eur J Clin Nutr 61:1102-5. 2007
    ....
  15. ncbi request reprint Ghrelin and the metabolic balance
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Finland
    J Endocrinol Invest 28:849-52. 2005
    ..Future studies will reveal which of the two forms of ghrelin, the acylated or non-acylated forms, dominates and determines the net influence on energy balance...
  16. ncbi request reprint Role of candidate genes in the lipid responses to intensified treatment in Type 2 diabetes
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    J Endocrinol Invest 28:871-5. 2005
    ..To identify genetic factors related to individual differences in lipid responses to intensified treatment in Type 2 diabetes. Design and..
  17. ncbi request reprint Low plasma ghrelin concentration is an indicator of the metabolic syndrome
    Olavi Ukkola
    Department of Internal Medicine, University of Oulu, Finland
    Ann Med 38:274-9. 2006
    ..Low ghrelin concentration has been associated with several features of metabolic syndrome (MS), but the relationship between ghrelin concentration and MS as a cluster of metabolic aberrations has not yet been studied...
  18. doi request reprint Non-dipping pattern in ambulatory blood pressure monitoring is associated with metabolic abnormalities in a random sample of middle-aged subjects
    Olavi Ukkola
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, and Clinical Research Center, Oulu University Hospital, Oulu, Finland
    Hypertens Res 32:1022-7. 2009
    ..It is also associated with several other metabolic abnormalities. Whether non-dipping pattern is causally related to these metabolic aberrations remains to be explored in a future prospective follow-up of this cohort...
  19. doi request reprint Gastric bypass and glucose metabolism
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    Intern Med J 39:502-5. 2009
    ..In this paper, a short review of the topic is presented and a suggestion of the improvement of glucose metabolism is made based on the current published work...
  20. doi request reprint High serum fasting peptide YY (3-36) is associated with obesity-associated insulin resistance and type 2 diabetes
    Olavi H Ukkola
    Institute of Clinical Medicine, Department of Internal Medicine, Finland Biocenter Oulu, University of Oulu and Clinical Research Center of Oulu University Hospital, Finland
    Regul Pept 170:38-42. 2011
    ..Although high PYY(3-36) is strongly linked to obesity and associated insulin resistance, the relation between PYY(3-36) and type 2 diabetes is independent of body fatness...
  21. ncbi request reprint [Ghrelin--peptide hormone that increases appetite. It opens new possibilities for the research on energy metabolism]
    Olavi Ukkola
    Biocenter Oulu, Uleåborgs universitet, Kajaanintie 50 PB 5000, FIN 900 14 Uleåborg, Finland
    Lakartidningen 99:2152-3. 2002
    ..In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin might participate in meal initiation and may signal to the hypothalamus when an increase in metabolic efficiency is needed...
  22. ncbi request reprint Protein tyrosine phosphatase 1B: a new target for the treatment of obesity and associated co-morbidities
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    J Intern Med 251:467-75. 2002
    ..The objective of this paper is to review the current evidence of PTP1B in the pathophysiology of obesity, type 2 diabetes and cancer as well as in the treatment of these disorders...
  23. doi request reprint Ghrelin in Type 2 diabetes mellitus and metabolic syndrome
    Olavi Ukkola
    Department of Internal Medicine and Biocenter, University of Oulu, Oulu, Finland
    Mol Cell Endocrinol 340:26-8. 2011
    ..Whether ghrelin has a role in the development metabolic syndrome and the associated diseases, is not known. This review will report the evidence for the role of ghrelin in the clustering of the components of the metabolic syndrome...
  24. ncbi request reprint Ghrelin, growth and obesity
    Olavi Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Finland
    Ann Med 34:102-8. 2002
    ..Furthermore, ghrelin might be involved in the growth of some neoplasms. In conclusion, ghrelin, a new somatotrophic, orexigenic and adipogenic peptide hormone, links the regulatory systems for growth and energy balance...
  25. ncbi request reprint Adiponectin: a link between excess adiposity and associated comorbidities?
    Olavi Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Kajaanintie 50 P O Box 5000, 90220 Oulu, Finland
    J Mol Med (Berl) 80:696-702. 2002
    ..The evidence of an association between adiponectin and the metabolic and cardiovascular complications of obesity is growing all the time...
  26. ncbi request reprint Resistin - a mediator of obesity-associated insulin resistance or an innocent bystander?
    Olavi Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Kajaanintie 50 PO Box 5000, FIN 90220 Oulu, Finland
    Eur J Endocrinol 147:571-4. 2002
    ..In conclusion, resistin is a fascinating new hormone for which a definite role in metabolism will be revealed in the near future...
  27. ncbi request reprint [The hormonal regulation of eating]
    Olavi Ukkola
    Oulun yliopiston sisätautien klinikka ja Biocenter Oulu PL 5000, 90014 Oulu
    Duodecim 119:381-7; quiz 387, 423. 2003
  28. doi request reprint High plasma immunoglobulin (Ig) A and low IgG antibody titers to oxidized low-density lipoprotein are associated with markers of glucose metabolism
    Maritta Sämpi
    Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu and Clinical Research Center of Oulu University Hospital, Oulu, Finland
    J Clin Endocrinol Metab 95:2467-75. 2010
    ..Plasma oxidized low-density lipoprotein (OxLDL) is known to be associated with obesity, metabolic syndrome, and diabetes...
  29. ncbi request reprint High plasma resistin level is associated with enhanced highly sensitive C-reactive protein and leukocytes
    Anne Kunnari
    Clinical Research Center Department of Internal Medicine, P O Box 5000, 90014 Oulu University, Oulu, Finland
    J Clin Endocrinol Metab 91:2755-60. 2006
    ..In humans, inflammatory cells seem to be the major source of resistin. The aim of this study was to find out whether plasma resistin concentration associates with carotid artery atherosclerosis and the risk factors of atherosclerosis...
  30. doi request reprint Plasma lipid levels and body weight altered by intrauterine growth restriction and postnatal fructose diet in adult rats
    Elina Malo
    Department of Internal Medicine, Institute of Clinical Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland
    Pediatr Res 73:155-62. 2013
    ..The effects of IUGR, postnatal fructose diet, and their interaction on the lipid profile and adiposity were studied in adult rats...
  31. doi request reprint Adiponectin induced placental cell apoptosis could be mediated via the ADIPOR1-receptor in pre-eclampsia with IUGR
    Jouko Jarvenpaa
    Department of Obstetrics and Gynecology, Oulu University Hospital, University of Oulu, Finland
    J Perinat Med 37:257-62. 2009
    ..Our aim was to study the expression of adiponectin, leptin, their receptor genes and apoptosis in severely PE and normal placentas...
  32. ncbi request reprint Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes
    Seppo M Pöykkö
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    Diabetes 52:2546-53. 2003
    ..Therefore, it might have some role in the etiology of type 2 diabetes and the regulation of BP. The ghrelin Arg51Gln mutation is associated with low plasma ghrelin concentrations...
  33. doi request reprint Nondipping pattern and carotid atherosclerosis in a middle-aged population: OPERA Study
    Riitta Liisa Vasunta
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland
    Am J Hypertens 25:60-6. 2012
    ..The relationship between the dipping pattern and atherosclerosis is not clear. The night-time systolic blood pressure (SBP) determines the dipping status...
  34. doi request reprint Fasting plasma total ghrelin concentrations in monozygotic twins discordant for obesity
    Piia Leskelä
    Department of Internal Medicine and Biocenter Oulu, Clinical Research Center Oulu, University of Oulu, Oulu University Hospital, P O Box 5000, FIN 90014, Finland
    Metabolism 58:174-9. 2009
    ..The ghrelin gene may thus play a role in the regulation of variability of body weight, such that Leu72 allele carriers are more prone to weight variability in response to environmental factors...
  35. doi request reprint Estrogen replacement therapy decreases plasma adiponectin but not resistin in postmenopausal women
    Anne Kunnari
    Department of Internal Medicine, Biocenter Oulu, University of Oulu, Clinical Research Center, Oulu University Hospital, 90220 Oulu, Finland
    Metabolism 57:1509-15. 2008
    ..407, P = .011). The results show that peroral ERT can decrease plasma adiponectin levels. However, ERT does not seem to influence plasma resistin concentrations...
  36. doi request reprint Low serum adiponectin level as a predictor of impaired glucose regulation and type 2 diabetes mellitus in a middle-aged Finnish population
    Kirsti Jalovaara
    Institute of Health Sciences, University of Oulu, Box 5000, FIN 90014 Oulu, Finland
    Metabolism 57:1130-4. 2008
    ..Our findings support the hypothesis that adiponectin may play a role in the pathogenesis of abnormal glucose metabolism...
  37. doi request reprint Comparison of family history of sudden cardiac death in nonischemic and ischemic heart disease
    Eeva Hookana
    Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu, Oulu, Finland
    Circ Arrhythm Electrophysiol 5:757-61. 2012
    ..The purpose of this study was to determine whether nonischemic SCD has a similar familial background, which would be evidence of a genetic predisposition...
  38. ncbi request reprint IGF-I concentrations are positively associated with carotid artery atherosclerosis in women
    Mirella Hietaniemi
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Finland
    Ann Med 37:373-82. 2005
    ..In addition, the T1169A polymorphism in the GH1 gene has been associated with IGF-I levels...
  39. ncbi request reprint Estrogen replacement therapy increases plasma ghrelin levels
    Eija Kellokoski
    Clinical Research Center, Department of Internal Medicine and Biocenter Oulu, University of Oulu, P O Box 5000, FIN 90014 Oulu, Finland
    J Clin Endocrinol Metab 90:2954-63. 2005
    ..As a conclusion, estrogen replacement therapy increased active plasma ghrelin levels, particularly PE therapy. Additional studies are needed to determine the possible underlying mechanisms...
  40. doi request reprint Leptin receptor Arg109 homozygotes display decreased total mortality as well as lower incidence of cardiovascular disease and related death
    Meiju Aijälä
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland Electronic address
    Gene 534:88-92. 2014
    ..In conclusion, the Arg109Arg genotype of LEPR seems to be protective from cardiovascular events and death and this phenomenon seems to be independent of the traditional risk factors for atherosclerosis...
  41. doi request reprint Increased daily sodium intake is an independent dietary indicator of the metabolic syndrome in middle-aged subjects
    Juha Pekka Räisänen
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, and Clinical Research Center, Oulu University Hospital, Oulu, Finland
    Ann Med 44:627-34. 2012
    ....
  42. doi request reprint Ghrelin vaccination decreases plasma MCP-1 level in LDLR(-/-)-mice
    Eija Kellokoski
    Department of Internal Medicine, Institute of Clinical Medicine, Biocenter Oulu, Finland
    Peptides 30:2292-300. 2009
    ..Ghrelin vaccination decreases plasma MCP-1 levels even though no effects on developing signs of atherosclerosis or weight gain in mice were observed...
  43. doi request reprint Gene expression profiles in fetal and neonatal rat offspring of energy-restricted dams
    Mirella Hietaniemi
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland
    J Nutrigenet Nutrigenomics 2:173-83. 2009
    ..The aim of this study was to explore changes in gene expression related to maternal energy restriction during pregnancy in rat fetuses and in neonatal rat offspring...
  44. ncbi request reprint Apolipoprotein E polymorphism affects carotid artery atherosclerosis in smoking hypertensive men
    Jarkko Karvonen
    Department of Internal Medicine, University of Oulu, PO Box 5000, FIN 90014, Finland
    J Hypertens 20:2371-8. 2002
    ..The objective was to investigate whether there is some gene-environment interaction between smoking and apoE polymorphism. DESIGN Cross-sectional case-control study...
  45. ncbi request reprint Sequencing analysis of the ghrelin receptor (growth hormone secretagogue receptor type 1a) gene
    Johanna Vartiainen
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, PO Box 5000, 90014 Oulu, Finland
    Eur J Endocrinol 150:457-63. 2004
    ..We hypothesised that there might be functional sequential variations in the GHS-R1a gene affecting phenotypes linked to the GH/insulin-like growth factor-I (IGF-I)-axis...
  46. doi request reprint Plasma adiponectin--an independent indicator of liver fat accumulation
    Pauliina Pisto
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, Finland
    Metabolism 60:1515-20. 2011
    ..Whether low adiponectin levels predict to liver fat accumulation remains to be explored in a future prospective follow-up of this cohort...
  47. doi request reprint Plasma interleukin-5 levels are related to antibodies binding to oxidized low-density lipoprotein and to decreased subclinical atherosclerosis
    Maritta Sämpi
    Department of Internal Medicine, Biocenter Oulu, Oulu, Finland
    J Am Coll Cardiol 52:1370-8. 2008
    ..This study's aim was to assess the role of interleukin (IL)-5 in modulating the levels of antibodies binding to oxidized low-density lipoprotein (OxLDL) in human atherosclerosis...
  48. doi request reprint Plasma IgA antibody levels to malondialdehyde acetaldehyde-adducts are associated with inflammatory mediators, obesity and type 2 diabetes
    Lauri Vehkala
    Department of Medical Microbiology and Immunology, Institute of Diagnostics, University of Oulu, Finland and Medical Research Center, Oulu, Finland
    Ann Med 45:501-10. 2013
    ..Our aim was to investigate the associations between plasma IgA antibodies to MAA-LDL, inflammatory markers, adipokines, obesity, and T2D...
  49. doi request reprint Plasma adiponectin levels are associated with left ventricular hypertrophy in a random sample of middle-aged subjects
    Tero Pääkkö
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, and Clinical Research Center, Oulu University Hospital, Oulu, Finland
    Ann Med 42:131-7. 2010
    ..We evaluated the association between plasma adiponectin concentrations and echocardiographic measurements, including left ventricular mass index (LVMI), in 933 middle-aged subjects consisting of 453 hypertensives and 480 controls...
  50. doi request reprint Resistin is an indicator of the metabolic syndrome according to five different definitions in the Finnish Health 2000 survey
    Elina Malo
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    Metab Syndr Relat Disord 9:203-10. 2011
    ..We examined the association of resistin with metabolic syndrome and its components in a population-based cohort...
  51. doi request reprint Glomerular filtration rate is related to carotid intima-media thickness in middle-aged adults
    Helena Kastarinen
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Finland
    Nephrol Dial Transplant 24:2767-72. 2009
    ..Severe renal dysfunction is associated with increased cardiovascular risk. The aim of this study was to investigate the association between renal function and carotid intima-media thickness (cIMT) in a middle-aged population-based cohort...
  52. ncbi request reprint Sequencing analysis of ghrelin gene 5' flanking region: relations between the sequence variants, fasting plasma total ghrelin concentrations, and body mass index
    Johanna Vartiainen
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, P O Box 5000, 90014 Oulu, Finland
    Metabolism 55:1420-5. 2006
    ..However, SNP-501 A>C genotype distribution seems to be different in subjects having the highest compared with those with the lowest ghrelin levels, and the SNP may be associated with BMI and waist circumference...
  53. doi request reprint The effect of energy restriction during pregnancy on obesity-related peptide hormones in rat offspring
    Mirella Hietaniemi
    Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Finland
    Peptides 30:705-9. 2009
    ..The observed changes may predispose to insulin resistance and significantly increase the risk of developing cardiovascular disease in later life...
  54. ncbi request reprint Tyrosine phosphatase 1B and leptin receptor genes and their interaction in type 2 diabetes
    M Santaniemi
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    J Intern Med 256:48-55. 2004
    ..Furthermore, the association of the polymorphisms and PTP1B and leptin receptor (LepR) gene-gene interactions with complications of type 2 diabetes were examined in type 2 diabetic patients...
  55. pmc Long telomeres in blood leukocytes are associated with a high risk of ascending aortic aneurysm
    Tuija J Huusko
    Institute of Clinical Medicine, Department of Internal Medicine, Clinical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
    PLoS ONE 7:e50828. 2012
    ..Further studies will be needed to confirm if this change in telomere length can serve as a tool for assessing the risk of ascending aortic aneurysm...
  56. doi request reprint Adiponectin concentration in plasma is associated with muscle fiber size in healthy middle-aged men
    Pauliina Pisto
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, and Clinical Research Center, Oulu University Hospital, Oulu, Finland
    Scand J Clin Lab Invest 72:395-402. 2012
    ..Skeletal muscle fiber characteristics are related to overweight. In addition, a correlation was observed between low adiponectin and large muscle fiber size and this was not dependent on the amount of total fatness...
  57. doi request reprint Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis
    Meiju Saukko
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland
    Metab Syndr Relat Disord 8:425-30. 2010
    ..The aim of this study was to characterize two polymorphisms of LEPR, Lys109Arg (rs1137100) and Gln223Arg (rs1137101), as risk factors for early atherosclerosis. This connection has not been studied before...
  58. ncbi request reprint Low plasma adiponectin concentration is an indicator of the metabolic syndrome
    Merja Santaniemi
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, PO Box 5000, 90014 Oulu, Finland
    Eur J Endocrinol 155:745-50. 2006
    ..We wanted to investigate the role of adiponectin as a biomarker of metabolic syndrome (MS) and see how the plasma adiponectin levels relate to new criteria of MS proposed by the International Diabetes Federation...
  59. doi request reprint Occupational burnout, eating behavior, and weight among working women
    Nina J Nevanperä
    Finnish Institute of Occupational Health, Oulu, Finland
    Am J Clin Nutr 95:934-43. 2012
    ..Studies on the effect of occupational burnout (exhaustive fatigue, cynicism, and lost occupational self-respect caused by chronic work stress) on eating behavior are lacking...
  60. doi request reprint Glomerular filtration rate is related to dipping pattern in ambulatory blood pressure monitoring--a cross-sectional population-based study
    H Kastarinen
    Department of Internal Medicine and Biocenter Oulu, Institute of Clinical Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland
    J Hum Hypertens 24:247-53. 2010
    ..18 to 4.63) and OR, 2.01 (95% CI, 1.06 to 3.83), respectively). This study showed that even a minor deterioration in renal function is associated with increased risk of non-dipping pattern in ABPM in a random middle-aged population...
  61. doi request reprint Serum ghrelin and the prediction of the development of impaired glucose regulation and Type 2 diabetes in middle-aged subjects
    J Vartiainen
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, Clinical Research Center, Oulu University Hospital, 311A, P O Box 5000, FIN 90014, Oulu, Finland
    J Endocrinol Invest 33:496-500. 2010
    ..Ghrelin is a peptide hormone which has been shown to associate with obesity, hypertension and Type 2 diabetes (T2DM) in cross-sectional studies...
  62. doi request reprint The effect of a short-term hypocaloric diet on liver gene expression and metabolic risk factors in obese women
    M Hietaniemi
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Nutr Metab Cardiovasc Dis 19:177-83. 2009
    ..However, the liver also plays a central role in maintaining energy balance. We wanted to study the effects of a hypocaloric diet on overall hepatic gene expression and metabolic risk factors...
  63. ncbi request reprint Lack of association between polymorphisms of catalase, copper-zinc superoxide dismutase (SOD), extracellular SOD and endothelial nitric oxide synthase genes and macroangiopathy in patients with type 2 diabetes mellitus
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Finland
    J Intern Med 249:451-9. 2001
    ..The prevalence of the missense Glu298Asp variant of the endothelial nitric oxide synthase (eNOS) gene and its association with macroangiopathy were also determined...
  64. ncbi request reprint The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes
    S M Pöykkö
    Department of Internal Medicine, University of Oulu, P O Box 5000, 90014 Oulu, Finland
    Diabetologia 48:309-16. 2005
    ..The aims of this study were to clarify the association between ghrelin and IGF-I concentrations in a large cohort and to characterize whether obesity, insulin resistance and type 2 diabetes affect this association...
  65. ncbi request reprint Two variants in the resistin gene and the response to long-term overfeeding
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    Eur J Clin Nutr 58:654-9. 2004
    ..To investigate the role of resistin gene variants on the adiposity and metabolic changes observed in response to a 100-day overfeeding protocol conducted with 12 pairs of monozygotic twins...
  66. ncbi request reprint Ghrelin Arg51Gln mutation is a risk factor for Type 2 diabetes and hypertension in a random sample of middle-aged subjects
    S Pöykkö
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Finland
    Diabetologia 46:455-8. 2003
    ....
  67. doi request reprint Plasma adiponectin concentration is associated with ambulatory daytime systolic blood pressure but not with the dipping status
    R L Vasunta
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    J Hum Hypertens 24:545-51. 2010
    ..The plasma high adiponectin concentration is independently associated with low daytime systolic ABP value. The mechanisms may include effects on endothelial function and the sympathetic nervous system...
  68. ncbi request reprint Resistin polymorphisms are associated with cerebrovascular disease in Finnish Type 2 diabetic patients
    A Kunnari
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    Diabet Med 22:583-9. 2005
    ..Resistin has been found to increase insulin resistance, a key feature in Type 2 diabetes. The aim of this study was to investigate whether resistin polymorphisms are associated with Type 2 diabetes and its clinical characteristics...
  69. ncbi request reprint Adiponectin concentration and insulin indicators following overfeeding in identical twins
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    J Endocrinol Invest 31:132-7. 2008
    ..Low adiponectin levels have been associated with high body mass index, low insulin sensitivity, and diabetes...
  70. ncbi request reprint Genetic variation at the adipsin locus and response to long-term overfeeding
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    Eur J Clin Nutr 57:1073-8. 2003
    ..The role of adipsin and adipsin Hinc II polymorphisms on the metabolic and body composition changes in response to overfeeding was studied...
  71. doi request reprint Leptin and lipid metabolism in chronic kidney failure
    H Kastarinen
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    Scand J Clin Lab Invest 69:401-8. 2009
    ..The aim of this study was to investigate the relationship between leptin and the lipoprotein profile in non-dialyzed patients with chronic kidney disease (CKD)...
  72. ncbi request reprint Plasma ghrelin concentrations are positively associated with carotid artery atherosclerosis in males
    S M Pöykkö
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    J Intern Med 260:43-52. 2006
    ..We, therefore, characterized the association between ghrelin concentration and carotid artery intima-media thickness (IMT) in a population-based cohort of 1024 middle-aged (40-60 years) men and women...
  73. ncbi request reprint Altered expression of angiogenesis-related placental genes in pre-eclampsia associated with intrauterine growth restriction
    Jouko Jarvenpaa
    Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland
    Gynecol Endocrinol 23:351-5. 2007
    ..In an attempt to identify novel factors, we performed a gene expression profiling study of placental tissue from women with and without pre-eclampsia...
  74. doi request reprint Effects of low-dose liquorice alone or in combination with hydrochlorothiazide on the plasma potassium in healthy volunteers
    Janne Hukkanen
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Blood Press 18:192-5. 2009
    ..The evaluation of liquorice consumption habits is warranted when initiating thiazide medications to avoid the excessive risk of hypokalaemia associated with the combined use of low-dose liquorice and thiazide diuretics...
  75. doi request reprint Early atherosclerosis and IgG2 to bacteria are associated with FcgammaRIIa genotype in non-smokers
    M Sämpi
    University of Oulu, Oulu, Finland
    Eur J Clin Invest 39:517-26. 2009
    ..Human FcgammaRIIa receptor (CD32) plays a crucial role in the phagocytosis of IgG(2) ICs and a functional point mutation 131His/Arg diminishes IgG(2) binding to the receptor...
  76. ncbi request reprint A genomewide linkage scan for abdominal subcutaneous and visceral fat in black and white families: The HERITAGE Family Study
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 51:848-55. 2002
    ..Additional work in an independent sample is needed to verify the linkages for baseline AVF as well as the response measures...
  77. ncbi request reprint Adiponectin polymorphisms, adiposity and insulin metabolism: HERITAGE family study and Oulu diabetic study
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge 70808 4124, USA
    Ann Med 37:141-50. 2005
    ..Adiponectin is an adipocytokine with lowered blood levels in obesity and Type 2 diabetes mellitus. We sought to define the specific effects of different alleles of the gene encoding adiponectin...
  78. ncbi request reprint Skeletal muscle characteristics predict body fat gain in response to overfeeding in never-obese young men
    Guang Sun
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Metabolism 51:451-6. 2002
    ..43 to 0.53, and account for 18% to 28% of the variance in the response to overfeeding. The results suggest that an elevated skeletal muscle oxidative capacity plays a protective role in the response to long-term positive energy balance...
  79. ncbi request reprint Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Obes Res 13:829-34. 2005
    ..Gene-gene interactions between the PTPN1 and leptin receptor genes contributed to the phenotypic variability of insulin sensitivity. The PTPN1 Pro387Leu variant was associated with lower glucose tolerance...
  80. ncbi request reprint Na+-K+-ATPase alpha 2-gene and skeletal muscle characteristics in response to long-term overfeeding
    Olavi Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    J Appl Physiol (1985) 94:1870-4. 2003
    ..3-kb(-) subjects with overfeeding, suggesting more unfavorable metabolic changes compared with the 3.3-kb(+) subjects...
  81. ncbi request reprint Role of ghrelin polymorphisms in obesity based on three different studies
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 10:782-91. 2002
    ..Associations between preproghrelin DNA variants and obesity-related phenotypes were studied in 3004 subjects from the Québec Family Study (QFS), the HERITAGE Family Study (HERITAGE), and the Swedish Obese Subjects (SOS) Study...
  82. ncbi request reprint Mutations in the adiponectin gene in lean and obese subjects from the Swedish obese subjects cohort
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808 4124, USA
    Metabolism 52:881-4. 2003
    ..In conclusion, adiponectin DNA sequence variations might play a role in the complications of morbid obesity and should be further investigated...
  83. ncbi request reprint Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort
    Peter Jacobson
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 87:4442-6. 2002
    ..In conclusion, our results do not support the prevailing notion that sequence variation in the melanocortin 4 receptor gene is a frequent cause of human obesity...
  84. ncbi request reprint [Ghrelin, growth and obesity]
    Olavi Ukkola
    Duodecim 118:133-5. 2002
  85. ncbi request reprint Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study
    Timo A Lakka
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
    Diabetes 53:1603-8. 2004
    ..Similar interaction was observed in blacks (P = 0.046). Variations in the LEP and LEPR genes are associated with the magnitude of the effects of regular exercise on glucose homeostasis in nondiabetic individuals...
  86. ncbi request reprint Polymorphisms in exon 3 of the proopiomelanocortin gene in relation to serum leptin, salivary cortisol, and obesity in Swedish men
    Roland Rosmond
    Department of Internal Medicine, Research Centre for Endocrinology and Metabolism, Goteborg University, Grona Straket 8, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Metabolism 51:642-4. 2002
    ..This association might reflect variations in melanocortin expression and/or activity, because exon 3 contains, among others, the coding sequences for melanocortins...
  87. pmc Cardiovascular and lifestyle risk factors in lumbar radicular pain or clinically defined sciatica: a systematic review
    Rahman Shiri
    Musculoskeletal Disorders, Finnish Institute of Occupational Health, Topeliuksenkatu 41a A, 00250, Helsinki, Finland
    Eur Spine J 16:2043-54. 2007
    ..However, more prospective studies are needed in order to further clarify these associations and the mechanisms of action...
  88. ncbi request reprint Risk factors of atherosclerosis and shoulder pain--is there an association? A systematic review
    Eira Viikari-Juntura
    Musculoskeletal Centre, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 00250 Helsinki, Finland
    Eur J Pain 12:412-26. 2008
    ..Shoulder pain is prevalent and a common cause of disability at work and daily activities. Some studies suggest an association between risk factors of atherosclerosis and shoulder pain and disorders...
  89. ncbi request reprint A genome-wide linkage scan for steroids and SHBG levels in black and white families: the HERITAGE Family Study
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisianan State University, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 87:3708-20. 2002
    ..3. Several genes encoding enzymes of the steroid biosynthesis pathways but also other potential candidate genes were located in the vicinity of the genomic regions showing evidence of linkage in this genomic scan...
  90. ncbi request reprint Temporal changes in cardiovascular autonomic regulation in type II diabetic patients: association with coronary risk variables and progression of coronary artery disease
    Vesa Jokinen
    Division of Cardiology, University of Oulu, Finland corrected
    Ann Med 35:216-23. 2003
    ....