Research Topics
| M UhariSummaryAffiliation: University of Oulu Country: Finland Publications
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Detail Information
Publications
Xylitol-supplemented nutrition enhances bacterial killing and prolongs survival of rats in experimental pneumococcal sepsisMarjo Renko
Department of Paediatrics, University of Oulu, Oulu, Finland
BMC Microbiol 8:45. 2008..Xylitol has antiadhesive effects on Streptococcus pneumoniae and inhibits its growth, and has also been found to be effective in preventing acute otitis media and has been used in intensive care as a valuable source of energy...
Experiences of using an interactive audience response system in lecturesMatti Uhari
The Department of Paediatrics, University of Oulu, FIN 90014 University of Oulu, Finland
BMC Med Educ 3:12. 2003..Lectures are good for presenting information and providing explanations, but because they lack active participation they have been neglected...
[Research of psychotherapy is clinical research]Matti Uhari
OYS:n lastentautien klinikka, Oulun yliopisto
Duodecim 120:2617-8. 2004
[Using characteristic numbers to estimate the usefulness of laboratory tests for diagnosis]Matti Uhari
Oulun yliopiston lastentautien klinikka PL 5000, 90014 Oulun yliopisto
Duodecim 120:935-41. 2004
[Use of pad gives accuracy to the diagnosis of urinary tract infections in children]Matti Uhari
OYS:n lastentautien klinikka, Oulun yliopisto
Duodecim 122:579-84. 2006
Xylitol in preventing acute otitis mediaM Uhari
Department of Paediatrics, University of Oulu, FIN 90220 Oulu, Finland
Vaccine 19:S144-7. 2000..Xylitol appears to be an attractive alternative to prevent acute otitis media. A more practical frequency of doses should be found before its use can be widely recommended...
An open randomized controlled trial of infection prevention in child day-care centersM Uhari
Department of Pediatrics, University of Oulu, Finland
Pediatr Infect Dis J 18:672-7. 1999..Child care outside the home increases children's infections substantially. We have to evaluate the possibilities for reducing the transmission of infections by an infection prevention program...
Adverse reactions in children during long-term antimicrobial therapyM Uhari
Department of Pediatrics, University of Oulu, Finland
Pediatr Infect Dis J 15:404-8. 1996..It is difficult to obtain reliable date on the rate of adverse reactions caused by drugs in general use. Yet it would be important to compile data on adverse reactions to long-term antimicrobial therapy...
Effect of xylitol on growth of Streptococcus pneumoniae in the presence of fructose and sorbitolT Tapiainen
Department of Pediatrics, University of Oulu, Oulu, Finland
Antimicrob Agents Chemother 45:166-9. 2001..Thus, it seems that xylitol is the only commercially used sugar substitute proven to have an antimicrobial effect on pneumococci...
Serum concentrations of interferon-gamma and intercellular adhesion molecule-1 eight years after an early respiratory syncytial virus infectionH Juntti
Department of Paediatrics, University of Oulu, Finland
Clin Exp Allergy 35:59-63. 2005..Respiratory syncytial virus (RSV) infection may influence the development of recurrent wheezing and atopy, but the mechanisms are unclear...
Costs arising from otitis mediaM Niemela
Department of Paediatrics, University of Oulu, Finland
Acta Paediatr 88:553-6. 1999..OM leads to considerable expenses and even expensive preventive measures would be cost-effective...
Symptoms of acute otitis mediaT Kontiokari
Department of Pediatrics, University of Oulu, Finland
Pediatr Infect Dis J 17:676-9. 1998..The symptoms related to acute otitis media, however, are considered nonspecific...
Cardiac troponin-I as a screening tool for myocarditis in children hospitalized for viral infectionM Renko
Department of Paediatrics, University of Oulu, Oulu, Finland
Acta Paediatr 99:283-5. 2010..We hypothesized that screening all children who are hospitalized for an acute infection with troponin-I (TnI) would reveal myocarditis cases and performed a prospective screening study...
Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in womenT Kontiokari
Department of Pediatrics, University of Oulu, Oulu, FIN 90220, Finland
BMJ 322:1571. 2001..To determine whether recurrences of urinary tract infection can be prevented with cranberry-lingonberry juice or with Lactobacillus GG drink. Design: Open, randomised controlled 12 month follow up trial...
Hospital-associated infections in children: a prospective post-discharge follow-up survey in three different paediatric hospitalsS Kinnula
Department of Pediatrics, University of Oulu, Finland
J Hosp Infect 80:17-24. 2012..Reported viral hospital-associated infection (HAI) frequencies have ranged from 1% to 24% between paediatric wards and hospitals. Reasons for this variation remain unclear...
Nasopharyngeal dimensions in magnetic resonance imaging and the risk of acute otitis mediaM Renko
Department of Pediatrics, University of Oulu, Oulu, Finland
J Laryngol Otol 121:853-6. 2007..We evaluate here the association of nasopharyngeal dimensions in magnetic resonance imaging (MRI) with the occurrence of AOM in otherwise healthy children...
Biofilm formation and virulence of uropathogenic Escherichia coli in urine after consumption of cranberry-lingonberry juiceT Tapiainen
Department of Pediatrics, University of Oulu, P O Box 5000, 90014, Oulu, Finland
Eur J Clin Microbiol Infect Dis 31:655-62. 2012..04). It appears that the effect of CLJ in preventing UTIs is not explained by mechanisms that reduce biofilm formation or the expression of selected virulence genes of Escherichia coli in urine...
Post-discharge follow-up of hospital-associated infections in paediatric patients with conventional questionnaires and electronic surveillanceS Kinnula
Department of Paediatrics, University of Oulu, Finland
J Hosp Infect 80:13-6. 2012..Viral infections are common causes of hospital-associated infections (HAIs) in paediatric patients, with most of these infections only becoming evident after discharge...
Diet, serum fatty acids, and atopic diseases in childhoodT Dunder
Department of Pediatrics, University of Oulu, Oulu, Finland
Allergy 56:425-8. 2001..Differences supporting these dietary findings were similarly found in the serum fatty acid data. CONCLUSION: The diet of the atopic children differed from that of the nonatopic children in the consumption of polyunsaturated fat...
Xylitol concentrations in the saliva of children after chewing xylitol gum or consuming a xylitol mixtureT Tapiainen
Department of Paediatrics, University of Oulu, Finland
Eur J Clin Microbiol Infect Dis 21:53-5. 2002..A schedule with the same single doses given less frequently could be clinically effective in preventing otitis media...
Quantitative analysis of the effect of xylitol on pneumococcal nasal colonisation in ratsT Kontiokari
Department of Paediatrics, University of Oulu, Finland
FEMS Microbiol Lett 178:313-7. 1999..Neither the mean colony-forming unit counts nor the PCR counts differed statistically significant between the xylitol and control groups. Thus, we found that xylitol had no significant effect on pneumococcal mucosal colonisation...
Dietary factors protecting women from urinary tract infectionTero Kontiokari
Department of Pediatrics, University of Oulu, Oulu, Finland
Am J Clin Nutr 77:600-4. 2003..7; 95% CI: 1.16, 6.2). CONCLUSION: Dietary habits seem to be an important risk factor for UTI recurrence in fertile women, and dietary guidance could be a first step toward prevention...
Mixed bacterial-viral infections in septic children with leukemiaMinna Koskenvuo
Department of Pediatrics, Turku University Hospital, Turku, Finland
Pediatr Infect Dis J 26:1133-6. 2007..Febrile infections in children with leukemia are common. The occurrence of possible mixed bacterial-viral infections is unknown...
Insulin and blood pressure among healthy children. Cardiovascular risk in young FinnsL Taittonen
Department of Pediatrics, University of Oulu, Finland
Am J Hypertens 9:194-9. 1996..However, insulin does not enhance the rise in blood pressure...
Middle ear effusion among children diagnosed and treated actively for acute otitis mediaT Kontiokari
Department of Paediatrics, University of Oulu, Finland
Eur J Pediatr 157:731-4. 1998..2% and that of otitis media with effusion 3.9%. CONCLUSION: We conclude that active diagnosis and treatment of acute otitis media practically eliminates such middle ear effusion that could cause significant hearing impairment...
Occurrence of vesicoureteral reflux in childrenM Venhola
Department of Paediatrics, University Hospital, Oulu, Finland
Acta Paediatr 99:1875-8. 2010..The reported low occurrence of vesicoureteral reflux in the general population seems implausible. We wanted to test the hypothesis that reflux is more common and more independent of urinary-tract infection than has previously been thought...
Preventive treatment for recurrent febrile seizuresH Rantala
Department of Paediatrics, University of Oulu, Finland
Ann Med 32:177-80. 2000..The number of febrile episodes is the only risk factor that can be influenced by preventive measures. The time being, we can reassure parents on the benign nature of febrile seizures...
Biofilm formation by Escherichia coli isolated from patients with urinary tract infectionsJ Salo
Department of Pediatrics, Oulu University Hospital, Finland
Clin Nephrol 71:501-7. 2009..We wanted to find out whether Escherichia coli (E. coli) strains isolated from UTI patients differ in their ability to form biofilms and whether this ability is associated with the clinical presentation of UTI...
Angiotensin converting enzyme gene insertion/deletion polymorphism, angiotensinogen gene polymorphisms, family history of hypertension, and childhood blood pressureL Taittonen
Department of Pediatrics, University of Oulu, Finland
Am J Hypertens 12:858-66. 1999..Although the common genetic variation of ACE may influence blood pressure in male children and adolescents, our data do not suggest a role for the common variation of the angiotensinogen gene as a BP regulator during childhood...
Subjects with allergic rhinitis show signs of more severely impaired paranasal sinus functioning during viral colds than nonallergic subjectsO-P Alho
Department of Otorhinolaryngology, University of Oulu, Finland
Allergy 58:767-71. 2003..These changes indicate impaired sinus functioning and may increase the risk of bacterial sinusitis...
Cross-sectional survey of paranasal sinus magnetic resonance imaging findings in schoolchildrenA Kristo
Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
Acta Paediatr 92:34-6. 2003..Sinus image abnormalities are common among children examined for indications other than sinus disease. The purpose of this study was to determine the frequency of sinus abnormalities among otherwise healthy children attending school...
Lymphocyte and mast cell counts are increased in the nasal mucosa in symptomatic natural coldsO P Alho
Department of Otorhinolaryngology, University of Oulu and the Microbiology Laboratory of Oulu University Hospital, Oulu, Finland
Clin Exp Immunol 131:138-42. 2003..005 and P = 0.04, respectively). Contrary to the earlier experimental studies, we found that viruses cause accumulation of T and B lymphocytes and mast cells during the first days of a symptomatic naturally acquired respiratory infection...
Cytokine responses in cord blood predict the severity of later respiratory syncytial virus infectionHanna Juntti
Department of Paediatrics, University of Oulu, PO Box 5000, University of Oulu, Oulu FI 90014, Finland
J Allergy Clin Immunol 124:52-58.e1-2. 2009..It has been claimed that an early respiratory syncytial virus (RSV) infection can induce asthma and recurrent wheezing...
Meta-analysis of the significance of asymptomatic bacteriuria in diabetesMarjo Renko
Department of Pediatrics, University of Oulu, Oulu, Finland
Diabetes Care 34:230-5. 2011..To evaluate whether asymptomatic bacteriuria (ASB) is more common in patients with diabetes than among control subjects. In addition, we wanted to clarify the clinical significance of ASB in patients with diabetes...
Vesicoureteral reflux in children with suspected and proven urinary tract infectionAnnukka Hannula
Department of Paediatrics, University of Oulu, Oulu, Finland
Pediatr Nephrol 25:1463-9. 2010..This challenges the recommendations of routine VCUG after UTI...
Consumption of asthma medication after RS-virus epidemic--a population based surveyTeija Dunder
Department of Pediatrics, University of Oulu, Oulu, Finland
Pediatr Allergy Immunol 18:105-9. 2007..5% vs. 20.3% for consumption and 4.8% vs. 4.9% for reimbursement. These differences were insignificant. In conclusion exposure to a RSV epidemic in infancy does not increase the consumption of asthma medicines at the population level...
Infections in child day care centers and later development of asthma, allergic rhinitis, and atopic dermatitis: prospective follow-up survey 12 years after controlled randomized hygiene interventionTeija Dunder
Department of Pediatrics, University of Oulu, PO Box 5000, FIN 90014 Oulu, Finland
Arch Pediatr Adolesc Med 161:972-7. 2007..To evaluate the effect of successful prevention of common infections in child day care centers on the later development of allergic diseases...
Safety of alcohol hand gel use among children and personnel at a child day care centerSohvi Kinnula
Department of Pediatrics, University of Oulu, Oulu, Finland
Am J Infect Control 37:318-21. 2009..Alcohol hand gels (AHG) have been used by children in child day care centers (CDCCs) to prevent the transmission of microbes. Because parents and personnel have been concerned about the safety of AHGs, we conducted a trial to assess this...
Biofilm formation by Streptococcus pneumoniae isolates from paediatric patientsTerhi Tapiainen
Department of Pediatrics, University of Oulu, and Laboratory of Microbiology, Oulu University Hospital, Oulu, Finland
APMIS 118:255-60. 2010..We conclude that the clinical presentation of pneumococcal disease did not differ in relation to biofilm formation in vitro, even though there was marked variation between the clinical isolates and serotypes...
An outbreak of holarctica-type tularemia in pediatric patientsUlla Jounio
Department of Pediatrics, University of Oulu, Oulu, Finland
Pediatr Infect Dis J 29:160-2. 2010..Holarctica-type tularemia is endemic in the Northern Hemisphere. Despite recurrent epidemics tularemia is not well known in children and the pediatric cases are often misdiagnosed...
Timing of rhinosinusitis complications in childrenAila Kristo
Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
Pediatr Infect Dis J 28:769-71. 2009..One reason for this recommendation is to prevent the complications of sinus infection. We wanted to find out whether there is any evidence to support this...
[The care of obstructive bronchitis]Teija Dunder
OYS:n lasten ja nuorten klinikka
Duodecim 122:459-61. 2006
Dietary factors affecting susceptibility to urinary tract infectionTero Kontiokari
Department of Pediatrics, University of Oulu, P O Box 5000, 90014 Oulu, Finland
Pediatr Nephrol 19:378-83. 2004..However, there is no reason to expect that children would be different from adults in this respect. In this review, we discuss the dietary factors affecting the susceptibility to UTI...
Peer consultation as a method for promoting problem-based learning during a paediatrics courseMarjo Renko
Department of Pediatrics, University of Oulu, Finland
Med Teach 24:408-11. 2002..These experiences suggest that the model of peer consultation adds new flavour, increasing enthusiasm in problem-based learning...
[Infant mortality in Finland during the years of 1969-1996]Marjo Kallunki
Oulun yliopiston lastentautien klinikka
Duodecim 120:2100-7. 2004
Xylitol administered only during respiratory infections failed to prevent acute otitis mediaTerhi Tapiainen
Department of Pediatrics, University of Oulu, Oulu, Finland
Pediatrics 109:E19. 2002..As regular administration of xylitol had been effective in preventing acute otitis media (AOM) in children, we tested whether xylitol administered only at times of acute respiratory infection (ARI) reduces the occurrence of AOM...
Paranasal sinus findings in children during respiratory infection evaluated with magnetic resonance imagingAila Kristo
Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
Pediatrics 111:e586-9. 2003..The main objective of this study was to evaluate the frequency and spontaneous resolution of paranasal sinus abnormalities in children with acute respiratory infection using magnetic resonance imaging (MRI)...
Cranberry juice and bacterial colonization in children--a placebo-controlled randomized trialTero Kontiokari
Department of Pediatrics, University of Oulu, P O Box 5000, FIN 90014, Finland
Clin Nutr 24:1065-72. 2005..We were interested in studying cranberry juice in children since many children with recurrent UTI need long-term antimicrobial prophylaxis and would benefit from an alternative...
Cefuroxime axetil versus placebo for children with acute respiratory infection and imaging evidence of sinusitis: a randomized, controlled trialAila Kristo
Department of Otolaryngology, University of Oulu, Oulu, Finland
Acta Paediatr 94:1208-13. 2005..To evaluate the efficacy of antibiotic treatment in children who presented in medical care with respiratory infection and had imaging evidence of sinusitis...
Nasal middle meatal specimen bacteriology as a predictor of the course of acute respiratory infection in childrenAila Kristo
Departments of Otorhinolaryngology, PO Box 5000, University of Oulu, Oulu FIN 90014, Finland
Pediatr Infect Dis J 25:108-12. 2006....
Disappearance of middle ear effusion in acute otitis media monitored daily with tympanometryMarjo Renko
Department of Paediatrics, University of Oulu, Oulu, Finland
Acta Paediatr 95:359-63. 2006..Disappearance of middle ear effusion is one of the most important outcomes in the treatment of acute otitis media (AOM)...
Association of an early respiratory syncytial virus infection and atopic allergyH Juntti
Department of Pediatrics, University of Oulu, PO Box 5000, FIN-90014 Oulu, Finland
Allergy 58:878-84. 2003..This finding might explain why there is less atopic sensitization in countries with a greater probability of acquiring RSV infection at an early age...
Pacifier as a risk factor for acute otitis media: A randomized, controlled trial of parental counselingM Niemela
Department of Pediatrics, Division of Phoniatrics, University of Oulu, Oulu, Finland
Pediatrics 106:483-8. 2000..To evaluate the association between pacifier use and the increased occurrence of acute otitis media (AOM) in an intervention trial...
Clinical guidelines and hospital discharges of children with acute urinary tract infectionsM Nuutinen
Department of Pediatrics, University of Oulu, Finland
Pediatr Nephrol 13:45-9. 1999..According to our data, valid clinical guidelines are effective in changing clinical practice...
Recurrence and follow-up after urinary tract infection under the age of 1 yearM Nuutinen
Department of Pediatrics, University of Oulu, P O Box 5000, 90401 Oulu, Finland
Pediatr Nephrol 16:69-72. 2001..Since the vast majority of UTI recurrences occur within 6 months of the first UTI, routine follow-up for 6 months seems to be sufficient after symptomatic UTI in children with grade 3-5 VUR...
The common cold in patients with a history of recurrent sinusitis: increased symptoms and radiologic sinusitislike findingsO P Alho
Department of Otorhinolaryngology, University of Oulu, Finland
J Fam Pract 50:26-31. 2001..We evaluated whether the symptoms and signs and radiologic findings during a common cold are similar in patients who have and have not suffered from recurrent sinusitis...
Hospital-associated infections during and after care in a paediatric infectious disease wardS E Kinnula
Department of Paediatrics, University of Oulu, Oulu, Finland
J Hosp Infect 68:334-40. 2008..Eight percent of the patients in our ward, where alcohol hand gel is actively used and single rooms are common, developed an HAI. Eighty percent of the HAIs appeared at home, which emphasises the importance of post-discharge follow-up...
Trends in childhood mortality from 1969 to 2004 in FinlandMarjo Lantto
Department of Paediatrics, University of Oulu, Finland
Acta Paediatr 97:1024-9. 2008..The aim was to evaluate the trends in childhood mortality in Finland from 1969 to 2004. We especially wanted to find out whether the decline in mortality is continuous and whether there are still deaths that could be prevented...
Ultrastructure of Streptococcus pneumoniae after exposure to xylitolTerhi Tapiainen
Department of Pediatrics, University of Oulu, PO Box 5000, FIN-90014, Oulu
J Antimicrob Chemother 54:225-8. 2004..The observed changes in the polysaccharide capsule and the cell wall of pneumococci could affect the adherence and virulence of pneumococci, explaining the good clinical efficacy of xylitol in the prevention of acute otitis media...
Failure of xylitol given three times a day for preventing acute otitis mediaOuti Hautalahti
Department of Pediatrics, University of Oulu, Oulu, Finland
Pediatr Infect Dis J 26:423-7. 2007..To find a more convenient dosing regimen, we tested whether xylitol administered 3 times a day reduces the occurrence of AOM...
A randomized, controlled trial of tonsillectomy in periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndromeM Renko
Department of Pediatrics, University of Oulu, Finland
J Pediatr 151:289-92. 2007..We carried out a prospective, randomized, controlled trial to clarify the effect of tonsillectomy on the clinical course of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome...
Antipyretic agents for preventing recurrences of febrile seizures: randomized controlled trialTeemu Strengell
Department of Pediatrics, University of Oulu, Oulu, Finland
Arch Pediatr Adolesc Med 163:799-804. 2009..To evaluate the efficacy of different antipyretic agents and their highest recommended doses for preventing febrile seizures...
Efficacy of five days' barbiturate anesthesia in the treatment of intractable epilepsies in childrenH Rantala
Department of Pediatrics, University of Oulu, Finland
Epilepsia 40:1775-9. 1999..To analyze the efficacy of barbiturate anesthesia in the treatment of intractable epilepsies in childhood...
Febrile seizures and mesial temporal sclerosis: No association in a long-term follow-up studyR Tarkka
Department of Pediatrics, University of Oulu, Finland
Neurology 60:215-8. 2003..CONCLUSION: The occurrence of MTS following even prolonged febrile seizures is an uncommon event, confirming the good clinical outcome of febrile seizures...
Adenoidectomy versus chemoprophylaxis and placebo for recurrent acute otitis media in children aged under 2 years: randomised controlled trialPetri Koivunen
University of Oulu, PO Box 5000, FIN 90014, Finland
BMJ 328:487. 2004..To evaluate the efficacy of adenoidectomy compared with long term chemoprophylaxis and placebo in the prevention of recurrent acute otitis media in children aged between 10 months and 2 years...
Meta-analysis of vesicoureteral reflux and urinary tract infection in childrenMika Venhola
Department of Pediatrics, Oulu University Hospital, Oulu, Finland
Scand J Urol Nephrol 40:98-102. 2006..We evaluated the efficacy of medical and surgical treatment of vesicoureteral reflux (VUR) in children by means of a meta-analysis, using the recurrence of urinary tract infections (UTIs), renal growth and renal scarring as endpoints...
Respiratory viral infections in children with leukemiaMinna Koskenvuo
Department of Pediatrics, Turku University Hospital, Turku, Finland
Pediatr Infect Dis J 27:974-80. 2008..Respiratory viruses occur frequently in the community and are a common cause of fever in children. Data on respiratory viral infections in children with cancer are limited...
Dynamics of gut colonization and source of intestinal flora in healthy newborn infantsTerhi Tapiainen
Department of Pediatrics, University of Oulu, Oulu, Finland
APMIS 114:812-7. 2006..The effect of the maternal flora on the initial gut colonization may be less than expected as the fecal flora of infants started to resemble both the fecal flora of the mother as well as that of the first nurse...
Evaluation of decision rules for identifying serious consequences of traumatic head injuries in pediatric patientsSanna Klemetti
Department of Pediatrics, University of Oulu, Oulu 90014, Finland
Pediatr Emerg Care 25:811-5. 2009..We evaluated the existing decision rules and developed our own decision rule for use with pediatric patients having head injuries to see how good they are for identifying serious complications...
Risk factors for croup in children with recurrent respiratory infections: a case-control studyHannele Pruikkonen
Department of Pediatrics, University of Oulu, Oulu, Finland
Paediatr Perinat Epidemiol 23:153-9. 2009..5 (95% CI 0.2, 1.0, P = 0.04). Family history appeared to be an exceptionally strong predictive factor for croup and its recurrence. In this patient series prone to respiratory infections recurrence of croup was common...
Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns StudyOlli T Raitakari
Department of Clinical Physiology and PET Centre, University of Turku, Turku
JAMA 290:2277-83. 2003..Exposure to cardiovascular risk factors during childhood and adolescence may be associated with the development of atherosclerosis later in life...
Recent advances in otitis media. 1. Epidemiology, natural history, and risk factorsKathleen A Daly
Department of Otolaryngology, University of Minnesota, Minneapolis, USA
Ann Otol Rhinol Laryngol Suppl 194:8-15. 2005
