Jaakko Tuomilehto

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. doi request reprint Comparison of definitions of metabolic syndrome in relation to the risk of developing stroke and coronary heart disease in Finnish and Swedish cohorts
    Qing Qiao
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Stroke 40:337-43. 2009
  2. pmc High prevalence of obesity, central obesity and abnormal glucose tolerance in the middle-aged Finnish population
    Timo E Saaristo
    Finnish Diabetes Association, Tampere, Finland
    BMC Public Health 8:423. 2008
  3. ncbi request reprint Modeling of primary prevention of the development of type 2 diabetes
    Jaakko Tuomilehto
    Department of Public Health University of Helsinki, Helsinki, Finland
    Przegl Lek 63:3-6. 2006
  4. pmc Nonpharmacologic therapy and exercise in the prevention of type 2 diabetes
    Jaakko Tuomilehto
    Department of Public Health, University of Helsinki, Helsinki, Finland, South Ostrobothnia Central Hospital, Seinajoki, Finland
    Diabetes Care 32:S189-93. 2009
  5. pmc Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range
    Feng Ning
    Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
    Cardiovasc Diabetol 11:76. 2012
  6. doi request reprint Serum uric acid and components of the metabolic syndrome in non-diabetic populations in Mauritian Indians and Creoles and in Chinese in Qingdao, China
    Hairong Nan
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Metab Syndr Relat Disord 6:47-57. 2008
  7. ncbi request reprint Determinants for the effectiveness of lifestyle intervention in the Finnish Diabetes Prevention Study
    Jaana Lindström
    Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Diabetes Care 31:857-62. 2008
  8. pmc Hyperglycemia and stroke mortality: comparison between fasting and 2-h glucose criteria
    Marjukka Hyvärinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Diabetes Care 32:348-54. 2009
  9. ncbi request reprint Distinct ethnic differences in lipid profiles across glucose categories
    Lei Zhang
    Department of Public Health, University of Helsinki, PL41, Mannerheimintie 172, FIN 00014 Helsinki, Finland
    J Clin Endocrinol Metab 95:1793-801. 2010
  10. ncbi request reprint Leisure time, occupational, and commuting physical activity and the risk of stroke
    Gang Hu
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Stroke 36:1994-9. 2005

Collaborators

Detail Information

Publications120 found, 100 shown here

  1. doi request reprint Comparison of definitions of metabolic syndrome in relation to the risk of developing stroke and coronary heart disease in Finnish and Swedish cohorts
    Qing Qiao
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Stroke 40:337-43. 2009
    ..The purpose of this study was to compare definitions of metabolic syndrome with regard to their prediction of stroke and coronary heart disease incidence...
  2. pmc High prevalence of obesity, central obesity and abnormal glucose tolerance in the middle-aged Finnish population
    Timo E Saaristo
    Finnish Diabetes Association, Tampere, Finland
    BMC Public Health 8:423. 2008
    ....
  3. ncbi request reprint Modeling of primary prevention of the development of type 2 diabetes
    Jaakko Tuomilehto
    Department of Public Health University of Helsinki, Helsinki, Finland
    Przegl Lek 63:3-6. 2006
  4. pmc Nonpharmacologic therapy and exercise in the prevention of type 2 diabetes
    Jaakko Tuomilehto
    Department of Public Health, University of Helsinki, Helsinki, Finland, South Ostrobothnia Central Hospital, Seinajoki, Finland
    Diabetes Care 32:S189-93. 2009
    ..To review the current knowledge about nonpharmacologic approaches in the prevention and early treatment of type 2 diabetes...
  5. pmc Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range
    Feng Ning
    Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
    Cardiovasc Diabetol 11:76. 2012
    ..This is further investigated regarding to the first events of coronary heart disease (CHD) and ischemic stroke (IS)...
  6. doi request reprint Serum uric acid and components of the metabolic syndrome in non-diabetic populations in Mauritian Indians and Creoles and in Chinese in Qingdao, China
    Hairong Nan
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Metab Syndr Relat Disord 6:47-57. 2008
    ..To assess the association of serum uric acid (UA) with components of metabolic syndrome (MetS) in different ethnic groups...
  7. ncbi request reprint Determinants for the effectiveness of lifestyle intervention in the Finnish Diabetes Prevention Study
    Jaana Lindström
    Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Diabetes Care 31:857-62. 2008
    ..We investigated whether and to what extent risk factors for type 2 diabetes and other baseline characteristics of the study participants modified the effectiveness of the lifestyle intervention...
  8. pmc Hyperglycemia and stroke mortality: comparison between fasting and 2-h glucose criteria
    Marjukka Hyvärinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Diabetes Care 32:348-54. 2009
    ..We investigated stroke mortality in individuals in different categories of glycemia and compared hazard ratios (HRs) corresponding to a 1-SD increase in 2-h plasma glucose and fasting plasma glucose (FPG) criteria...
  9. ncbi request reprint Distinct ethnic differences in lipid profiles across glucose categories
    Lei Zhang
    Department of Public Health, University of Helsinki, PL41, Mannerheimintie 172, FIN 00014 Helsinki, Finland
    J Clin Endocrinol Metab 95:1793-801. 2010
    ..Dyslipidemia coexists with hyperglycemia. However, little is known about the ethnic differences in lipid profiles at comparable glucose tolerance status...
  10. ncbi request reprint Leisure time, occupational, and commuting physical activity and the risk of stroke
    Gang Hu
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Stroke 36:1994-9. 2005
    ..We assessed the relationship of different types of physical activity with total and type-specific stroke risk...
  11. doi request reprint Comparison of body mass index with waist circumference, waist-to-hip ratio, and waist-to-stature ratio as a predictor of hypertension incidence in Mauritius
    Regzedmaa Nyamdorj
    Department of Public Health, University of Helsinki, Helsinki, Finland
    J Hypertens 26:866-70. 2008
    ..Comparison of BMI with waist circumference, waist-to-hip ratio (WHR), and waist-to-stature ratio (WSR) as a predictor of hypertension incidence...
  12. doi request reprint Hyperglycemia and incidence of ischemic and hemorrhagic stroke-comparison between fasting and 2-hour glucose criteria
    Marjukka Hyvärinen
    Department of Public Health, University of Helsinki, PL 41, Mannerheimintie 172, Helsinki, Finland
    Stroke 40:1633-7. 2009
    ..We examined the impact of hyperglycemia on ischemic and hemorrhagic stroke incidence comparing criteria based on fasting plasma glucose (FPG) and 2-hour plasma glucose (2-hour PG)...
  13. ncbi request reprint The validity of the Finnish Diabetes Risk Score for the prediction of the incidence of coronary heart disease and stroke, and total mortality
    Karri Silventoinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Eur J Cardiovasc Prev Rehabil 12:451-8. 2005
    ....
  14. pmc Leukocyte telomere length in the Finnish Diabetes Prevention Study
    Iiris Hovatta
    Research Programs Unit, Molecular Neurology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    PLoS ONE 7:e34948. 2012
    ..TL had no substantial role in worsening of glucose tolerance in people with IGT. Our study confirms that leukocyte TL can increase with time even in obese people with impaired glucose metabolism...
  15. doi request reprint Perinatal risk factors in young adult-onset type 1 and type 2 diabetes - a population-based case-control study
    Niina Lammi
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Acta Obstet Gynecol Scand 88:468-674. 2009
    ..To examine the effects of the size of the mother and the newborn, including placental weight and gestational age at delivery, on the risk for young adult-onset type 1 diabetes (T1DM) and type 2 diabetes (T2DM)...
  16. doi request reprint BMI compared with central obesity indicators as a predictor of diabetes incidence in Mauritius
    Regzedmaa Nyamdorj
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Obesity (Silver Spring) 17:342-8. 2009
    ..05). The relation of BMI with the development of diabetes was as strong as that for indicators of central obesity in this study population...
  17. pmc Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes
    Niina Sandholm
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Helsinki, Finland
    J Am Soc Nephrol 24:1537-43. 2013
    ..004). Overall, these results suggest that rs4972593 is a sex-specific genetic variant associated with ESRD in patients with type 1 diabetes and may underlie the sex-specific protection against ESRD. ..
  18. doi request reprint The impact of dyslipidaemia on incidence of coronary heart disease in Finns and Swedes with different categories of glucose tolerance
    Lei Zhang
    Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
    Diabetes Res Clin Pract 91:406-12. 2011
    ..The association of dyslipidaemia with incidence of coronary heart disease (CHD) has not been well studied in people with different glucose categories...
  19. ncbi request reprint The impact of dyslipidaemia on cardiovascular mortality in individuals without a prior history of diabetes in the DECODE Study
    Lei Zhang
    Department of Public Health, University of Helsinki, Mannerheimintie 172, Helsinki, Finland
    Atherosclerosis 206:298-302. 2009
    ..To evaluate the impact of dyslipidaemia on cardiovascular disease (CVD) mortality in relation to fasting (FPG) and 2-h (2hPG) plasma glucose levels in individuals without a prior history of diabetes...
  20. ncbi request reprint Coffee consumption and the incidence of antihypertensive drug treatment in Finnish men and women
    Gang Hu
    Department of Health Promotion and Chronic Diseases Prevention, National Public Health Institute, Helsinki, Finland
    Am J Clin Nutr 86:457-64. 2007
    ..Only 2 prospective studies have previously investigated the association between coffee consumption and incident hypertension, and the findings are equivocal...
  21. ncbi request reprint The difference between acute coronary heart disease and ischaemic stroke risk with regard to gender and age in Finnish and Swedish populations
    Marjukka Hyvärinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Int J Stroke 5:152-6. 2010
    ..We studied the age and gender difference between acute coronary heart disease and ischaemic stroke risk and examined the extent to which such a difference may be explained by known risk factors...
  22. ncbi request reprint Genetic random effects model for family data with long-term survivors: analysis of diabetic nephropathy in type 1 diabetes
    Janne Pitkäniemi
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Genet Epidemiol 31:697-708. 2007
    ..According to the variance components estimated a substantial familial variation in the susceptibility to DN exist among families, while time to DN is less influenced by shared familial factors...
  23. ncbi request reprint Occupational, commuting, and leisure-time physical activity in relation to total and cardiovascular mortality among Finnish subjects with type 2 diabetes
    Gang Hu
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Circulation 110:666-73. 2004
    ..Some previous studies have assessed the association between leisure-time physical activity and mortality among patients with diabetes, but the potential effect of occupational and commuting physical activity remains uncertain...
  24. ncbi request reprint The diabetes-cardiovascular risk paradox: results from a Finnish population-based prospective study
    Noel C Barengo
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Eur Heart J 29:1889-95. 2008
    ..To assess changes in coronary heart disease (CHD) event rates and CHD mortality rates among diabetic and non-diabetic individuals between two large study cohorts with baseline assessments 10 years apart and followed up for 10 years...
  25. doi request reprint Socio-economic differences in dysglycemia and lifestyle-related risk factors in the Finnish middle-aged population
    Katja Wikström
    Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    Eur J Public Health 21:768-74. 2011
    ....
  26. doi request reprint Joint effects of coffee consumption and serum gamma-glutamyltransferase on the risk of liver cancer
    Gang Hu
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Hepatology 48:129-36. 2008
    ..A combination of very low coffee consumption and high level of serum GGT was associated with nearly nine-fold increased risk...
  27. doi request reprint Development and validation of a risk-score model for subjects with impaired glucose tolerance for the assessment of the risk of type 2 diabetes mellitus-The STOP-NIDDM risk-score
    Jaakko Tuomilehto
    Department of Public Health, University of Helsinki, Finland
    Diabetes Res Clin Pract 87:267-74. 2010
    ..To develop a risk-score model, based on available clinical data to assess absolute risk of type 2 diabetes among people with impaired glucose tolerance (IGT)...
  28. ncbi request reprint Serum uric acid, plasma glucose and diabetes
    - Hairong Nan
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Diab Vasc Dis Res 7:40-6. 2010
    ..UA may serve as a potential biomarker of deterioration in glucose metabolism, but its clinical implication need to be further studied...
  29. ncbi request reprint The impact of history of hypertension and type 2 diabetes at baseline on the incidence of stroke and stroke mortality
    Gang Hu
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Stroke 36:2538-43. 2005
    ..We evaluated prospectively the joint association of history of hypertension and type 2 diabetes on the incidence of stroke and stroke mortality...
  30. ncbi request reprint Occupational, commuting, and leisure-time physical activity in relation to cardiovascular mortality among finnish subjects with hypertension
    Gang Hu
    Department of Health Promotion and Prevention of Chronic Diseases, National Public Health Institute, Helsinki, Finland
    Am J Hypertens 20:1242-50. 2007
    ..The purpose of this study was to determine the association of occupational, commuting, and leisure-time physical activity on cardiovascular mortality among hypertensive patients...
  31. ncbi request reprint The likelihood of diabetes based on the proposed definitions for impaired fasting glucose
    Weiguo Gao
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Diabetes Res Clin Pract 79:151-5. 2008
    ..6-6.0 mmol/l than in those with FPG of 6.1-6.9 mmol/l. The clinical and social implication of labelling more individuals with impaired fasting glucose needs to be further studied...
  32. ncbi request reprint The validity of the Finnish Hospital Discharge Register and Causes of Death Register data on coronary heart disease
    Pia Pajunen
    National Public Health Institute, Helsinki, Finland
    Eur J Cardiovasc Prev Rehabil 12:132-7. 2005
    ....
  33. ncbi request reprint The gender-specific impact of diabetes and myocardial infarction at baseline and during follow-up on mortality from all causes and coronary heart disease
    Gang Hu
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    J Am Coll Cardiol 45:1413-8. 2005
    ..The goal of this study is to compare the magnitude of diabetes and myocardial infarction (MI) at baseline and during follow-up on cause-specific and all-cause mortality...
  34. ncbi request reprint Type 2 diabetes and the risk of Parkinson's disease
    Gang Hu
    Department of Health Promotion and Chronic Diseases Prevention, National Public Health Institute, Helsinki, Finland
    Diabetes Care 30:842-7. 2007
    ..To evaluate whether type 2 diabetes at baseline is a risk factor for Parkinson's disease...
  35. ncbi request reprint Assessing the preprandial glucose target: 100 mg/dL versus 110 mg/dL
    Jaakko Tuomilehto
    University of Helsinki, Finland
    Endocr Pract 12:67-70. 2006
    ..To assess the potential value of lowering the impaired fasting glucose (IFG) cut point from 110 mg/dL to 100 mg/dL...
  36. ncbi request reprint Exercise, genetics and prevention of type 2 diabetes
    Gang Hu
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Essays Biochem 42:177-92. 2006
    ....
  37. doi request reprint Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study
    Valma Harjutsalo
    Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Lancet 371:1777-82. 2008
    ..Our aim was to assess the temporal trend in type 1 diabetes incidence since 2000 in Finnish children aged younger than 15 years and to predict the number of cases of type 1 diabetes in the future...
  38. ncbi request reprint Coffee and tea consumption and the risk of Parkinson's disease
    Gang Hu
    Department of Health Promotion and Chronic Diseases Prevention, National Public Health Institute, Helsinki, Finland
    Mov Disord 22:2242-8. 2007
    ..41 (95% CI 0.20-0.83). These results suggest that coffee drinking is associated with a lower risk of PD. More tea drinking is associated with a lower risk of PD...
  39. pmc A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland
    Qing Qiao
    Department of Public Health, University of Helsinki, Finland
    BMC Genet 8:84. 2007
    ....
  40. doi request reprint The validity of heart failure diagnoses obtained from administrative registers
    Markku Mahonen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Eur J Prev Cardiol 20:254-9. 2013
    ..Population-based administrative registers could be used for identifying heart failure (HF) cases. However, the validity of the classification obtained from administrative registers is not known...
  41. doi request reprint Body fat measured by a near-infrared interactance device as a predictor of cardiovascular events: the FINRISK'92 cohort
    Pia Pajunen
    Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    Obesity (Silver Spring) 19:848-52. 2011
    ....
  42. ncbi request reprint Prevention of diabetes mellitus in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study: results from a randomized clinical trial
    Jaana Lindström
    National Public Health Institute, Department of Epidemiology, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
    J Am Soc Nephrol 14:S108-13. 2003
    ..In conclusion, the DPS is the first controlled trial demonstrating that type 2 diabetes can be prevented by changes in lifestyle in high-risk subjects...
  43. ncbi request reprint Lifestyle strategies for weight control: experience from the Finnish Diabetes Prevention Study
    Jaana Lindström
    National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
    Proc Nutr Soc 64:81-8. 2005
    ..Most importantly, lifestyle changes do not have to be extreme. If the population would adopt a lifestyle in line with the official nutrition recommendations, the obesity and diabetes trend could at least be stabilised...
  44. pmc Cardiovascular disease mortality in Europeans in relation to fasting and 2-h plasma glucose levels within a normoglycemic range
    Feng Ning
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Diabetes Care 33:2211-6. 2010
    ..To study mortality in relation to fasting plasma glucose (FPG) and 2-h plasma glucose levels within the normoglycemic range...
  45. pmc Association of Serum 25-Hydroxyvitamin D with Lifestyle Factors and Metabolic and Cardiovascular Disease Markers: Population-Based Cross-Sectional Study (FIN-D2D)
    Maija E Miettinen
    Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 9:e100235. 2014
    ..Our aim was to determine lifestyle and clinical factors that are associated with 25OHD level and to investigate connection of 25OHD level with metabolic and cardiovascular disease markers...
  46. doi request reprint Coffee consumption and risk of gastric and pancreatic cancer--a prospective cohort study
    Siamak Bidel
    Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland
    Int J Cancer 132:1651-9. 2013
    ..19) and 0.82 (95% CI, 0.38-1.76) (P for trend = 0.95) for the combined population of men and women, respectively. We did not find a significant association between coffee consumption and the risk of gastric and/or pancreatic cancers...
  47. ncbi request reprint The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity
    Jaana Lindström
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 26:3230-6. 2003
    ..To describe the 1) lifestyle intervention used in the Finnish Diabetes Prevention Study, 2) short- and long-term changes in diet and exercise behavior, and 3) effect of the intervention on glucose and lipid metabolism...
  48. doi request reprint The effects of awareness, treatment and control of hypertension on future stroke incidence in a community-based population study in Finland
    Noel C Barengo
    Department of Public Health, University of Helsinki, Helsinki, Finland
    J Hypertens 27:1459-65. 2009
    ..To investigate whether there are differences in stroke risk among hypertensive men and women by awareness, treatment and blood pressure control status at baseline...
  49. ncbi request reprint Metabolic syndrome and cardiovascular disease
    Qing Qiao
    Department of the Public Health, University of Helsinki, PL41, Mannerheimintie 172, FIN 00014 Helsinki, Finland
    Ann Clin Biochem 44:232-63. 2007
    ..Pharmacological and surgical therapies for obesity are effective in selected patients. In this article we discuss the definitions, prevalence, pathogenesis and management of the metabolic syndrome in relation to cardiovascular risk...
  50. doi request reprint Serum uric acid and incident diabetes in Mauritian Indian and Creole populations
    Hairong Nan
    Department of Public Health, University of Helsinki, Helsinki, Finland Diabetes Unit, National Public Health Institute, Helsinki, Finland
    Diabetes Res Clin Pract 80:321-7. 2008
    ..To investigate the predictive value of serum uric acid (UA) for the development of diabetes in Asian Indians and Creoles living in Mauritius...
  51. pmc The impact of diabetes on coronary heart disease differs from that on ischaemic stroke with regard to the gender
    Marjukka Hyvärinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Cardiovasc Diabetol 8:17. 2009
    ..To study the diabetes related CVD risk between men and women of different ages...
  52. doi request reprint Menopause in women with type 1 diabetes
    Lena Sjöberg
    Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland
    Menopause 18:158-63. 2011
    ..Our objective was to study age at menopause and the factors associated with it in a large population-based group of Finnish women with childhood-onset type 1 diabetes...
  53. ncbi request reprint Post-challenge hyperglycaemia rather than fasting hyperglycaemia is an independent risk factor of cardiovascular disease events
    Weiguo Gao
    Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki, Finland
    Clin Lab 50:609-15. 2004
    ..To recognize that post-challenge hyperglycaemia is an important risk factor for cardiovascular disease may be of a significant preventive importance...
  54. pmc Full likelihood analysis of genetic risk with variable age at onset disease--combining population-based registry data and demographic information
    Janne Pitkäniemi
    Department of Public Health, University of Helsinki, Helsinki, Finland
    PLoS ONE 4:e6836. 2009
    ..Both of these approaches lead to a substantial loss of valuable data...
  55. ncbi request reprint Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes
    Niina Sandholm
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Diabetologia 57:1143-53. 2014
    ..Our aim was to estimate the heritability and to detect genetic variation associated with elevated AER in patients with type 1 diabetes...
  56. pmc Non-alcoholic and alcoholic fatty liver disease - two diseases of affluence associated with the metabolic syndrome and type 2 diabetes: the FIN-D2D survey
    Anna Kotronen
    Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
    BMC Public Health 10:237. 2010
    ..We aimed at assessing the prevalences of NAFLD and AFLD, and to examine to what extent these conditions are associated with MetS and abnormal glucose tolerance...
  57. ncbi request reprint Joint effects of history of hypertension at baseline and type 2 diabetes at baseline and during follow-up on the risk of coronary heart disease
    Gang Hu
    Department of Health Promotion and Chronic Diseases Prevention, National Public Health Institute, Helsinki, Finland
    Eur Heart J 28:3059-66. 2007
    ..To evaluate the joint associations of history of hypertension at baseline and type 2 diabetes at baseline and during follow-up on the incidence of coronary heart disease (CHD) and CHD mortality...
  58. ncbi request reprint How should the clinician most effectively prevent type 2 diabetes in the obese person at high risk?
    Peter E H Schwarz
    Department of Public Health, University of Helsinki, Mannerheimintie 172, 00300 Helsinki, Finland
    Curr Diab Rep 7:353-62. 2007
    ..The implementation of managed prevention concepts will realistically help to improve the ability to prevent T2D in the public health framework...
  59. ncbi request reprint The metabolic syndrome and cardiovascular risk
    Gang Hu
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Curr Diabetes Rev 1:137-43. 2005
    ....
  60. ncbi request reprint Educational inequalities in the metabolic syndrome and coronary heart disease among middle-aged men and women
    Karri Silventoinen
    Department of Public Health, University of Helsinki, PO Box 41, Mannerheimintie 172, FIN 00014, Finland
    Int J Epidemiol 34:327-34. 2005
    ..We investigated this question in a prospective study of middle-aged men and women...
  61. ncbi request reprint The diabetes risk score: a practical tool to predict type 2 diabetes risk
    Jaana Lindström
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 26:725-31. 2003
    ..Interventions to prevent type 2 diabetes should be directed toward individuals at increased risk for the disease. To identify such individuals without laboratory tests, we developed the Diabetes Risk Score...
  62. ncbi request reprint Body mass index and cancer incidence: the FINRISK study
    Xin Song
    Department of Public Health, Hjelt Institute, University of Helsinki, Mannerheimintie 172, PL41, 00014, Helsinki, Finland
    Eur J Epidemiol 29:477-87. 2014
    ..High BMI in women was associated with an increased overall cancer risk in never smokers but a reduced risk in smokers. Elevated BMI was associated with an increased risk of incidence of cancers of certain sites. ..
  63. ncbi request reprint Joint effect of family history of diabetes with obesity on prevalence of type 2 diabetes mellitus among Chinese and Finnish men and women
    Feng Ning
    Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland Electronic address
    Can J Diabetes 37:65-71. 2013
    ..To study joint effect of family history of diabetes (FHD) with obesity on prevalence of type 2 diabetes mellitus in the Chinese and in the Finns...
  64. ncbi request reprint Predictive properties of impaired glucose tolerance for cardiovascular risk are not explained by the development of overt diabetes during follow-up
    Qing Qiao
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 26:2910-4. 2003
    ....
  65. ncbi request reprint Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women
    Jaakko Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    JAMA 291:1213-9. 2004
    ..Only a few studies of coffee consumption and diabetes mellitus (DM) have been reported, even though coffee is the most consumed beverage in the world...
  66. ncbi request reprint Headache and the risk of stroke: a prospective observational cohort study among 35,056 Finnish men and women
    Pekka Jousilahti
    Department of Public Health, University of Helsinki, and the National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Arch Intern Med 163:1058-62. 2003
    ..Previous studies have shown an increased risk of stroke among patients with migraine. However, very few data are available on the possible association between chronic unspecified headache and the risk of stroke...
  67. ncbi request reprint Class I and II HLA genes are associated with susceptibility and age at onset in Finnish families with type 1 diabetes
    Janne Pitkäniemi
    Department of Public Health, School of Medicine, University of Helsinki, Helsinki, Finland
    Hum Hered 57:69-79. 2004
    ....
  68. ncbi request reprint Genetic and environmental effects on fasting and postchallenge plasma glucose and serum insulin values in Finnish twins
    Shuichi Katoh
    Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki, Finland
    J Clin Endocrinol Metab 90:2642-7. 2005
    ..81). In conclusion, additive genetic effects are important for the insulin secretion, whereas nonshared environmental effects contribute strongly to peripheral insulin resistance...
  69. ncbi request reprint Cumulative incidence of type 1 diabetes in 10,168 siblings of Finnish young-onset type 1 diabetic patients
    Valma Harjutsalo
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Diabetes 54:563-9. 2005
    ..This large prospective family study of type 1 diabetes in siblings of childhood-onset diabetic patients provides reliable empirical estimates for the sibling recurrence risk...
  70. ncbi request reprint Do trends in population levels of blood pressure and other cardiovascular risk factors explain trends in stroke event rates? Comparisons of 15 populations in 9 countries within the WHO MONICA Stroke Project. World Health Organization Monitoring of Trends
    Hanna Tolonen
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Stroke 33:2367-75. 2002
    ..To what extent variations in stroke trends between populations can be attributed to differences in classic cardiovascular risk factor trends is unknown...
  71. ncbi request reprint Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study
    Valma Hyttinen
    National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
    Diabetes 52:1052-5. 2003
    ..In conclusion, these nationwide twin data demonstrated high genetic liability for type 1 diabetes. Early-onset diabetes increases the risk in cotwins. However, the majority of affected MZ twin pairs remain discordant for type 1 diabetes...
  72. ncbi request reprint Diabetes associated with a low serum uric acid level in a general Chinese population
    Hairong Nan
    Qingdao Diabetes Epidemiology Study Group, Qingdao Endocrine and Diabetes Institute, Qingdao, China
    Diabetes Res Clin Pract 76:68-74. 2007
    ..This was investigated in a general Chinese population...
  73. ncbi request reprint The prevalence of hyperuricemia in a population of the coastal city of Qingdao, China
    Hairong Nan
    Qingdao Diabetes Epidemiology Study Group, Qingdao Endocrine and Diabetes Institute, Qingdao, China
    J Rheumatol 33:1346-50. 2006
    ..Hyperuricemia and gout have shown an increase worldwide. Data are lacking for the prevalence of hyperuricemia and gout and their correlates in China. We studied the occurrence of these conditions in Chinese adults in the city of Qingdao...
  74. ncbi request reprint Counterpoint: Evidence-based prevention of type 2 diabetes: the power of lifestyle management
    Jaakko Tuomilehto
    Department of Public Health, University of Helsinki, Mannerheimintie 172, 00300 Helsinki, Finland
    Diabetes Care 30:435-8. 2007
  75. ncbi request reprint Systemic exposure to Porphyromonas gingivalis predicts incident stroke
    Pirkko J Pussinen
    Institute of Dentistry, University of Helsinki, PO Box 63, FI 00014 Helsinki, Finland
    Atherosclerosis 193:222-8. 2007
    ..31 (1.31-8.40, p=0.012) for stroke. No association between antibody levels to Actinobacillus actinomycetemcomitans and stroke was found. The results suggest that the systemic exposure to P. gingivalis may predispose to incident stroke...
  76. ncbi request reprint Adenoidectomy during early life and the risk of asthma
    Petri S Mattila
    Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland
    Pediatr Allergy Immunol 14:358-62. 2003
    ..The observed association between an adenoidectomy and asthma may be explained by an underlying factor predisposing to both recurrent otitis media and asthma...
  77. ncbi request reprint Combination therapy with valsartan/hydrochlorothiazide at doses up to 320/25 mg improves blood pressure levels in patients with hypertension inadequately controlled by valsartan 320 mg monotherapy
    Jaakko Tuomilehto
    Department of Public Health, University of Helsinki, Mannerheimintie 172, FIN 00300, Helsinki, Finland
    Blood Press Suppl 1:15-23. 2008
    ..d.), Val/hydrochlorothiazide (HCTZ) 320/12.5 mg o.d. and Val/HCTZ 320/25 mg o.d. in patients with hypertension not adequately controlled by Val monotherapy...
  78. ncbi request reprint Geographical variation in the incidence of acute myocardial infarction in eastern Finland--a Bayesian perspective
    Maarit Viik-Kajander
    National Public Health Institute, Helsinki, Finland
    Ann Med 35:43-50. 2003
    ..We undertook this study to estimate the geographical distribution of Acute Myocardial Infarction (AMI) incidence in the high-risk province of North Karelia and in the province of Kuopio...
  79. ncbi request reprint Impact of age on cardiovascular risk: implications for cardiovascular disease management
    Jaakko Tuomilehto
    National Public Health Institute, University of Helsinki, Mannerheiminite 166, 00300 Helsinki, Finland
    Atheroscler Suppl 5:9-17. 2004
    ..This review also focuses on how these conditions can be optimally managed and whether treatment outcomes are affected by age. The current status of research is assessed and issues which remain to be resolved are highlighted...
  80. ncbi request reprint Do microbes have a causal role in type 1 diabetes?
    Niina Lammi
    Niina Lammi, National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Med Sci Monit 11:RA63-9. 2005
    ..Proving a causal role between microbial infections and T1DM appears difficult. Despite intensive research, a final conclusion concerning the causal role of microbes in the pathogenesis of T1DM has not been made...
  81. ncbi request reprint Predisposition to atopic symptoms to inhaled antigens may protect from childhood type 1 diabetes
    Petri S Mattila
    Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland
    Diabetes Care 25:865-8. 2002
    ..The main outcome measures were self-reported physician-diagnosed asthma and atopic symptoms to animal dust and pollen...
  82. ncbi request reprint Point: a glucose tolerance test is important for clinical practice
    Jaakko Tuomilehto
    Department of Public Health, University of Helsinki, and the Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki, Finland
    Diabetes Care 25:1880-2. 2002
  83. ncbi request reprint Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation
    Gang Hu
    Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Arch Intern Med 164:892-6. 2004
    ..Sedentary lifestyle, obesity, and impaired glucose regulation are associated with the risk of type 2 diabetes. However, the joint associations of these risk factors are not known...
  84. ncbi request reprint Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe Trial
    Jan A Staessen
    J Hypertens 22:847-57. 2004
    ....
  85. ncbi request reprint Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women
    Gang Hu
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Arch Intern Med 164:1066-76. 2004
    ..This study examined the age- and sex-specific prevalence of the metabolic syndrome and its association with all-cause and cardiovascular mortality in nondiabetic European men and women...
  86. ncbi request reprint Blood pressure, smoking, and the incidence of lung cancer in hypertensive men in North Karelia, Finland
    Annamarja Lindgren
    Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland
    Am J Epidemiol 158:442-7. 2003
    ..05, 1.17) for smokers and 1.04 (95% confidence interval: 0.95, 1.14) for nonsmokers. These findings suggest that high blood pressure levels are associated with increased risk of lung cancer in smoking, hypertensive men...
  87. ncbi request reprint Tracking of systolic blood pressure during childhood: a 15-year follow-up population-based family study in eastern Finland
    Ricardo M Fuentes
    Department of Public Health and General Practice, Faculty of Medicine, University of Kuopio, Kuopio, Finland
    J Hypertens 20:195-202. 2002
    ..To investigate the tracking of systolic arterial blood pressure (SBP) during childhood...
  88. ncbi request reprint The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    Hanna Maaria Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    JAMA 288:2709-16. 2002
    ..Despite its high prevalence, little is known of the prospective association of the metabolic syndrome with cardiovascular and overall mortality...
  89. ncbi request reprint Preferential transmission of type 1 diabetes from parents to offspring: fact or artifact?
    Sun Wei Guo
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Genet Epidemiol 23:323-34. 2002
    ....
  90. ncbi request reprint Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States
    Katharina Wolf-Maier
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Ill 60153, USA
    JAMA 289:2363-9. 2003
    ..Geographic variations in cardiovascular disease (CVD) and associated risk factors have been recognized worldwide. However, little attention has been directed to potential differences in hypertension between Europe and North America...
  91. ncbi request reprint Twenty-five-year trends in physical activity of 30- to 59-year-old populations in eastern Finland
    Noel C Barengo
    Department of Public Health and General Practice, University of Kuopio, PL 1627, 70211 Kuopio, Finland
    Med Sci Sports Exerc 34:1302-7. 2002
    ..The purpose of this study was to determine the 25-yr trends in leisure-time physical activity (LTPA), occupational activity (OPA), and commuting activity (CA) in the middle-aged population...
  92. ncbi request reprint Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study
    Virpi I Lindi
    Department of Clinical Nutrition, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 51:2581-6. 2002
    ..However, beneficial changes in diet, increases in physical activity, and weight loss may reverse, to some extent, the diabetogenic impact of the Ala12 allele, possibly due to an improved insulin sensitivity...
  93. ncbi request reprint Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c
    Qing Qiao
    Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Clin Epidemiol 57:590-6. 2004
    ..To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality...
  94. ncbi request reprint [Permanent changes in insulin resistance by changes in life style among subjects with impaired glucose tolerance]
    Matti Uusitupa
    Kliinisen ravitsemustieteen laitos ja Elintarvikkeiden terveysvaikutusten tutkimuskeskus, Kuopion yliopisto
    Duodecim 120:1495-7. 2004
  95. ncbi request reprint Prevalence of the metabolic syndrome and its components: findings from a Finnish general population sample and the Diabetes Prevention Study cohort
    Pirjo Ilanne-Parikka
    The Diabetes Center, Kirjoniementie 15, FIN 33680 Tampere, Finland
    Diabetes Care 27:2135-40. 2004
    ..To assess the prevalence of the metabolic syndrome (MetS) in two independent Finnish study cohorts...
  96. ncbi request reprint Disorders of glucose metabolism in acute stroke patients: an underrecognized problem
    Karl Matz
    Department of Neurology, Donauklinikum and Neurosciences Centre, Donau Universität, Hauptstrasse 2, A 3400 Maria Gugging, Austria
    Diabetes Care 29:792-7. 2006
    ..To determine the prevalence of disturbances in glucose metabolism in patients with acute stroke...
  97. ncbi request reprint Six year incidence and progression of diabetic retinopathy: results from the Mauritius diabetes complication study
    Robyn J Tapp
    Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    Diabetes Res Clin Pract 73:298-303. 2006
    ..To determine the incidence, progression and risk factors for diabetic retinopathy in the multiethnic population of Mauritius...
  98. ncbi request reprint How well does the metabolic syndrome defined by five definitions predict incident diabetes and incident coronary heart disease in a Chinese population?
    Jian Jun Wang
    Department of Medicine, University of Kuopio, P O Box 1627, FIN 70210 Kuopio, Finland
    Atherosclerosis 192:161-8. 2007
    ..None of the five definitions predicted either incident CHD alone (177 cases) or total incident CHD (236 cases). In conclusion, the MetS defined by the current definitions appears to be more effective at predicting incident diabetes...
  99. ncbi request reprint Twenty-five-year trends in lifestyle and socioeconomic characteristics in Eastern Finland
    Noel C Barengo
    Department of Public Health and General Practice, University of Kuopio, Finland
    Scand J Public Health 34:437-44. 2006
    ..This study aimed at assessing whether the lifestyle and the socioeconomic profile of people with either low total physical activity (TPA) or high TPA changed during 1972-97...
  100. ncbi request reprint Sleep duration is associated with an increased risk for the prevalence of type 2 diabetes in middle-aged women - The FIN-D2D survey
    Henri Tuomilehto
    Department of Otorhinolaryngology, Kuopio University Hospital, and University of Kuopio, Finland
    Sleep Med 9:221-7. 2008
    ..To examine the association between sleep duration with type 2 diabetes and abnormal glucose tolerance among middle-aged men and women in Finland...