P Tuohimaa

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. ncbi The role of sex steroids in forming anxiety states in female mice
    A Yu Galeeva
    I P Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St Petersburg, Russia
    Neurosci Behav Physiol 33:415-20. 2003
  2. ncbi Involvement of nuclear progesterone receptors in the formation of anxiety in female mice
    A Yu Galeeva
    I P Pavlov Institute of Physiology, Russian Academy of Sciences, St Petersburg, Russia
    Neurosci Behav Physiol 37:843-8. 2007
  3. ncbi Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries
    Pentti Tuohimaa
    Medical School, University of Tampere, Tampere, Finland
    Int J Cancer 108:104-8. 2004
  4. ncbi Calcidiol and prostate cancer
    P Tuohimaa
    Medical School, University of Tampere, Department of Clinical Chemistry, Tampere University Hospital, 33014 Turku, Finland
    J Steroid Biochem Mol Biol 93:183-90. 2005
  5. ncbi Interaction of factors related to the metabolic syndrome and vitamin D on risk of prostate cancer
    Pentti Tuohimaa
    Medical School, University of Tampere, Department of Clinical Chemistry, Tampere University Hospital, Finland
    Cancer Epidemiol Biomarkers Prev 16:302-7. 2007
  6. ncbi Optimal serum calcidiol concentration for cancer prevention
    P Tuohimaa
    Medical School, 33520 University of Tampere, Tampere, Finland
    Anticancer Res 32:373-81. 2012
  7. ncbi Vitamin D and prostate cancer
    P Tuohimaa
    Medical School, University of Tampere, 33014, Tampere, Finland
    J Steroid Biochem Mol Biol 76:125-34. 2001
  8. doi Vitamin D, aging, and cancer
    Pentti Tuohimaa
    The Department of Anatomy, Medical School, University of Tampere and Department of Medical Chemistry, Tampere University Hospital, Tampere, Finland
    Nutr Rev 66:S147-52. 2008
  9. ncbi Vitamin D and aging
    Pentti Tuohimaa
    Medical School, 33014 University of Tampere, Finland
    J Steroid Biochem Mol Biol 114:78-84. 2009
  10. doi Vitamin D, nervous system and aging
    P Tuohimaa
    Medical School, University of Tampere, 33014 Tampere, Finland
    Psychoneuroendocrinology 34:S278-86. 2009

Detail Information

Publications87

  1. ncbi The role of sex steroids in forming anxiety states in female mice
    A Yu Galeeva
    I P Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St Petersburg, Russia
    Neurosci Behav Physiol 33:415-20. 2003
    ..Thus, the data obtained here suggest that the genomic effects of sex steroids are important, as they appear to be involved in non-sexual forms of behavior, particularly the level of anxiety...
  2. ncbi Involvement of nuclear progesterone receptors in the formation of anxiety in female mice
    A Yu Galeeva
    I P Pavlov Institute of Physiology, Russian Academy of Sciences, St Petersburg, Russia
    Neurosci Behav Physiol 37:843-8. 2007
    ..Prior blockade of progesterone receptors using mifepristone led to a maximal reduction in the level of anxiety, which was also evidence for a role for the genomic mechanisms of action of progesterone in controlling anxiety in females...
  3. ncbi Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries
    Pentti Tuohimaa
    Medical School, University of Tampere, Tampere, Finland
    Int J Cancer 108:104-8. 2004
    ..It is recommended that vitamin D deficiency be supplemented, but too high vitamin D serum level might also enhance cancer development...
  4. ncbi Calcidiol and prostate cancer
    P Tuohimaa
    Medical School, University of Tampere, Department of Clinical Chemistry, Tampere University Hospital, 33014 Turku, Finland
    J Steroid Biochem Mol Biol 93:183-90. 2005
    ..Several mechanisms may mediate the action of Vitamin D in the prostate. This is a review of some recent studies on the role of (1) Vitamin D metabolism, (2) growth factors and (3) fatty acid metabolism...
  5. ncbi Interaction of factors related to the metabolic syndrome and vitamin D on risk of prostate cancer
    Pentti Tuohimaa
    Medical School, University of Tampere, Department of Clinical Chemistry, Tampere University Hospital, Finland
    Cancer Epidemiol Biomarkers Prev 16:302-7. 2007
    ..Factors related to the metabolic syndrome and low levels of vitamin D have been implicated as risk factors for prostate cancer. Insofar, no studies have assessed their joint effects on prostate cancer risk...
  6. ncbi Optimal serum calcidiol concentration for cancer prevention
    P Tuohimaa
    Medical School, 33520 University of Tampere, Tampere, Finland
    Anticancer Res 32:373-81. 2012
    ..In these cells, calcidiol and calcitriol act synergistically, therefore fluctuations of the serum calcidiol concentration may define the hormonal activity and cancer development...
  7. ncbi Vitamin D and prostate cancer
    P Tuohimaa
    Medical School, University of Tampere, 33014, Tampere, Finland
    J Steroid Biochem Mol Biol 76:125-34. 2001
    ..Based on these studies, a putative model for VD action on cell proliferation and differentiation is presented...
  8. doi Vitamin D, aging, and cancer
    Pentti Tuohimaa
    The Department of Anatomy, Medical School, University of Tampere and Department of Medical Chemistry, Tampere University Hospital, Tampere, Finland
    Nutr Rev 66:S147-52. 2008
    ..Therefore, the chronic diseases and cancers related to aging might be prevented by an optimal concentration of serum calcidiol, which remains to be determined...
  9. ncbi Vitamin D and aging
    Pentti Tuohimaa
    Medical School, 33014 University of Tampere, Finland
    J Steroid Biochem Mol Biol 114:78-84. 2009
    ....
  10. doi Vitamin D, nervous system and aging
    P Tuohimaa
    Medical School, University of Tampere, 33014 Tampere, Finland
    Psychoneuroendocrinology 34:S278-86. 2009
    ..Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS...
  11. doi Niacin in the prevention of atherosclerosis: Significance of vasodilatation
    P Tuohimaa
    Medical School, University of Tampere and Department of Clinical Chemistry, Tampere University Hospital, 33014 Tampere, Finland
    Med Hypotheses 75:397-400. 2010
    ....
  12. doi 25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand
    Yan Ru Lou
    Department of Anatomy, Medical School, University of Tampere, Tampere, FIN 33014, Finland
    J Steroid Biochem Mol Biol 118:162-70. 2010
    ..In conclusion, 25-hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand with gene regulatory and anti-proliferative properties...
  13. ncbi The role of Vitamin D3 metabolism in prostate cancer
    Y R Lou
    Department of Anatomy, Medical School, SF 33014 University of Tampere, Finland
    J Steroid Biochem Mol Biol 92:317-25. 2004
    ..2004)]) and phytoestrogens may modulate the expression of Vitamin D metabolizing enzymes. In summary, the local metabolism of hormonal Vitamin D seems to play an important role in the development and progression of prostate cancer...
  14. ncbi Vitamin D induced up-regulation of keratinocyte growth factor (FGF-7/KGF) in MCF-7 human breast cancer cells
    A Lyakhovich
    Tampere University Medical School, Tampere, 33101, Finland
    Biochem Biophys Res Commun 273:675-80. 2000
    ..This is the first demonstration of vitamin D regulation of FGF-7 expression and its possible involvement in mediating growth and differentiation by vitamin D...
  15. ncbi Localization of 1,25-dihydroxyvitamin D3 receptor (VDR) expression in human prostate
    M Kivineva
    Graduate School of Steroid Research, Department of Anatomy, University of Tampere, Finland
    J Steroid Biochem Mol Biol 66:121-7. 1998
    ..This suggests that effects of 1,25-dihydroxyvitamin D3 are mediated through VDR in these cells. Moreover our result indicates that there are strong variations in VDR expression between prostatic samples...
  16. ncbi Progesterone receptor in chicken bursa of Fabricius and thymus: evidence for expression in B-lymphocytes
    S Pasanen
    Department of Anatomy and Graduate School of Steroid Research, Medical School, University of Tampere, Finland
    Mol Cell Endocrinol 141:119-28. 1998
    ..Expression of PR in B-lymphocytes, macrophages and plasma cells in the chicken is documented for the first time and suggests evidence for direct action of progesterone on immune responses...
  17. ncbi Distribution of progesterone receptor in chicken: novel target organs for progesterone and estrogen action
    S Pasanen
    Department of Anatomy, Medical School, University of Tampere, Finland
    Mol Cell Endocrinol 135:79-91. 1997
    ..These results suggest that progesterone and estrogen may have physiological effects on many organs outside the genital tract not previously known as steroid-target tissues...
  18. ncbi Inhibin A and B in peri- and postmenopause
    S L Ala-Fossi
    Department of Obstetrics and Gynecology, Tampere University Hospital, Finland
    Maturitas 30:273-81. 1998
    ..The aim of the study was to investigate the origin of inhibin A and B during the last years of the reproductive age and after menopause by measuring their levels in the ovarian and peripheral venous blood...
  19. ncbi Increased anxiety in mice lacking vitamin D receptor gene
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, FIN 33014 Tampere, Finland
    Neuroreport 15:1271-4. 2004
    ..These studies suggest that vitamin D and its receptors are an important factor in the brain, whose imbalance may significantly affect emotional behaviour...
  20. ncbi Evidence for enhanced ubiquitin-mediated proteolysis of the chicken progesterone receptor by progesterone
    H Syvala
    Institute of Medical Technology, University of Tampere, Finland
    Life Sci 63:1505-12. 1998
    ..Our data suggest that ligand-induced down-regulation of PR involves enhanced degradation of receptor protein by ubiquitin-proteasome system in vivo...
  21. ncbi Identification of a nuclear localization signal in activin/inhibin betaA subunit; intranuclear betaA in rat spermatogenic cells
    M Bläuer
    Molecular Endocrinology Research Unit and Graduate School of Steroid Research, Department of Anatomy, Medical School, University of Tampere, Tampere, Finland
    Biol Reprod 60:588-93. 1999
    ..According to our immunohistochemical data, betaA may play a significant role in the regulation of nuclear functions during meiosis and spermiogenesis...
  22. ncbi Progesterone receptor concentration differences in the chick oviduct cells and apparent down-regulation by ligand. A semiquantitative immunohistochemical study
    A Pekki
    Department of Biomedical Sciences, University of Tampere, Finland
    J Steroid Biochem 34:351-4. 1989
    ..This technique allows for histological identification of biochemical events that should help lead to the understanding of the role of PR changes in a variety of experimental situations...
  23. ncbi Impaired motor performance in mice lacking neurosteroid vitamin D receptors
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    Brain Res Bull 64:25-9. 2004
    ..This study confirms the important role of the vitamin D system in motor functions and suggests that animal genetic models targeting the vitamin D/VDR system may be a useful tool to study vitamin D-related motor/behavioural disorders...
  24. ncbi Pharmacological modulation of anxiety-related behaviors in the murine Suok test
    A V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere, Finland
    Brain Res Bull 74:45-50. 2007
    ..Overall, the results of this study confirm the potential utility of both murine Suok tests, especially when used in selected "sensitive" mouse strains, for high-throughput screening of potential anxiotropic drugs...
  25. ncbi The vitamin D neuroendocrine system as a target for novel neurotropic drugs
    A V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere, Finland
    CNS Neurol Disord Drug Targets 5:363-71. 2006
    ..Here we review the important role of the vitamin D neuroendocrine system in the brain, and outline perspectives for the search for novel neurotropic drugs to treat various vitamin D-related dysfunctions...
  26. ncbi Analysis of mouse plus-maze behavior modulated by ovarian steroids
    A Galeeva
    Department of Anatomy, Tampere University Medical School, P O Box 607, FIN 33101 Tampere, Finland
    Behav Brain Res 119:41-7. 2001
    ..Our data suggest that sex steroid hormones play an important role in induction of anxiety. Furthermore, this action might be partially mediated through the classical steroid receptors...
  27. doi Heliotherapy improves vitamin D balance and atopic dermatitis
    K Vähävihu
    Department of Dermatology, Paijat Hame Central Hospital, Lahti, Finland
    Br J Dermatol 158:1323-8. 2008
    ..Vitamin D insufficiency during winter is common in the Nordic countries. Heliotherapy (HT) may heal atopic dermatitis (AD) but its effect on vitamin D balance has not been examined...
  28. ncbi Correlation between serum inhibin B and other indicators of the ovarian function
    H Tinkanen
    Department of Obstetrics and Gynecology, Tampere University Hospital, FIN-33521, Tampere, Finland
    Eur J Obstet Gynecol Reprod Biol 94:109-13. 2001
    ..CONCLUSION: The number of small follicles reflect the inhibin B production of the ovaries. BMI being as strong predictive factor of inhibin B levels as FSH could in part explain the impaired likelihood of conceiving in obese patients...
  29. doi Narrowband ultraviolet B course improves vitamin D balance in women in winter
    K Vähävihu
    Department of Dermatology, Paijat Hame Central Hospital, Lahti, Finland
    Br J Dermatol 162:848-53. 2010
    ..Vitamin D insufficiency is common in winter in the Nordic countries...
  30. ncbi Aberrant nest building and prolactin secretion in vitamin D receptor mutant mice
    Tiina Keisala
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    J Steroid Biochem Mol Biol 104:269-73. 2007
    ....
  31. ncbi Influence of paternal genotypes on F1 behaviors: lessons from several mouse strains
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere, Finland
    Behav Brain Res 177:45-50. 2007
    ..Our results imply complex interplay between parental genotypes in anxiety, activity, grooming, aggression and barbering of their F1 progeny, further confirming the utility of F1 hybrids in behavioral neurogenetics...
  32. doi Spore film dosimeters are feasible for UV dose monitoring during heliotherapy
    Katja Vähävihu
    Department of Dermatology, Paijat Hame Central Hospital, Lahti, Finland
    Photochem Photobiol 86:1174-8. 2010
    ..The increase in serum 25(OH)D correlated with the UV-B dose received. The patients complied well to use the dosimeters. We conclude spore films to be a feasible and reliable personal UV dosimeter in vivo in field conditions...
  33. ncbi Regulation of cholesterol 25-hydroxylase expression by vitamin D3 metabolites in human prostate stromal cells
    Jing Huan Wang
    Department of Anatomy, Medical School, 33014 University of Tampere, Tampere, Finland
    Biochem Biophys Res Commun 345:720-5. 2006
    ..Our data suggest that ch25h could be a vitamin D3 target gene and may partly mediate anti-proliferative action of vitamin D3 in human primary prostate stromal cells...
  34. ncbi Androgen enhances the antiproliferative activity of vitamin D3 by suppressing 24-hydroxylase expression in LNCaP cells
    Yan Ru Lou
    Department of Anatomy, Medical School, University of Tampere, and Department of Clinical Chemistry, Tampere University Hospital, FIN 33014, Finland
    J Steroid Biochem Mol Biol 99:44-9. 2006
    ..The combined use of androgen and Vitamin D3 metabolites could be a promising treatment for prostate cancer...
  35. ncbi Temporal stability of novelty exploration in mice exposed to different open field tests
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere, Finland
    Behav Processes 72:104-12. 2006
    ..These results suggest that mice are characterised by stability of temporal organization of their exploration in different OF novelty situations...
  36. ncbi Behavioural anomalies in mice evoked by "Tokyo" disruption of the Vitamin D receptor gene
    Allan V Kalueff
    Medical School, University of Tampere, Finland
    Neurosci Res 54:254-60. 2006
    ..Taken together, these findings confirm the important role postulated for the VDR in the regulation of behaviour, and suggest the mice lacking functional VDR may be a useful tool to model different brain disorders...
  37. ncbi Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells
    Yan Ru Lou
    Department of Anatomy Medical School, FIN 33014 University of Tampere, Finland
    Biochem Biophys Res Commun 338:1973-81. 2005
    ..Our data suggest that ATRA suppresses 24-hydroxylase expression through RARalpha-dependent signaling pathway and can enhance vitamin D action in suppression of cell growth...
  38. doi Premature aging in vitamin D receptor mutant mice
    Tiina Keisala
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    J Steroid Biochem Mol Biol 115:91-7. 2009
    ....
  39. ncbi Neophobia, sensory and cognitive functions, and hedonic responses in vitamin D receptor mutant mice
    Anna Minasyan
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    J Steroid Biochem Mol Biol 104:274-80. 2007
    ....
  40. ncbi An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men
    Ilkka Laaksi
    Department of Cell Biology and Anatomy, Medical School, University of Tampere, Tampere, Finland
    Am J Clin Nutr 86:714-7. 2007
    ..The data suggest that differences in the ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection...
  41. doi The effects of storage time and sampling season on the stability of serum 25-hydroxy vitamin D and androstenedione
    Calypse Agborsangaya
    University of Tampere, Tampere, Finland
    Nutr Cancer 62:51-7. 2010
    ..Stored serum samples can be used to study disease associations with both hormones. However, sampling season needs to be taken into account for 25-OHD by considering matching and stratification and, if possible, serial sampling...
  42. ncbi Regulation of 17beta-hydroxysteroid dehydrogenase type 2, type 4 and type 5 by calcitriol, LXR agonist and 5alpha-dihydrotestosterone in human prostate cancer cells
    Jing Huan Wang
    Department of Anatomy, Medical School, 33014 University of Tampere, Tampere, Finland
    J Steroid Biochem Mol Biol 107:100-5. 2007
    ..The regulation of HSD17B2, HSD17B4 and HSD17B5 by ligands of LXR and VDR as well as AR in prostate cancer cells suggests a complex interaction of these signaling systems in the prostate...
  43. doi Serum 25-hydroxyvitamin D at pregnancy and risk of breast cancer in a prospective study
    Calypse B Agborsangaya
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Eur J Cancer 46:467-70. 2010
    ..In a longitudinal study, we evaluated the association between vitamin D levels at pregnancy over time with the risk of breast cancer, and pregnancy-associated breast cancer...
  44. doi Serum 25-hydroxyvitamin D and the risk of ovarian cancer
    Adetunji T Toriola
    National Institute for Health and Welfare, Finland
    Eur J Cancer 46:364-9. 2010
    ..In this study, we sought to determine the risk of developing ovarian cancer according to serum 25-hydroxyvitamin D (25-OHD) concentrations assessed on average 5 years before the diagnosis...
  45. doi Serum cholesterol and expression of ApoAI, LXRbeta and SREBP2 in vitamin D receptor knock-out mice
    Jing Huan Wang
    Department of Anatomy, Medical School, University of Tampere, Medisiinarinkatu 3, Tampere, Finland
    J Steroid Biochem Mol Biol 113:222-6. 2009
    ..Although VDR seems to regulate some of the genes involved in cholesterol metabolism, its role in the regulation of serum cholesterol seems to be minimal...
  46. doi Vestibular dysfunction in vitamin D receptor mutant mice
    Anna Minasyan
    Department of Anatomy, Medical School, University of Tampere, Finland
    J Steroid Biochem Mol Biol 114:161-6. 2009
    ..These data suggest that VDR deficiency in mice is associated with decreased balance function, and may be relevant to poorer balance/posture control in humans with low levels of vitamin D...
  47. ncbi Regulation of aromatase and 5alpha-reductase by 25-hydroxyvitamin D(3), 1alpha,25-dihydroxyvitamin D(3), dexamethasone and progesterone in prostate cancer cells
    Yan Ru Lou
    Department of Anatomy, Medical School, University of Tampere, FIN 33014 Tampere, Finland
    J Steroid Biochem Mol Biol 94:151-7. 2005
    ..The expression of 5alpha-reductase type I mRNA was not regulated by 1alpha,25-(OH)(2)D(3) and no expression of 5alpha-reductase type II was detected in LNCaP...
  48. ncbi Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    Neurosci Lett 394:69-73. 2006
    ..Our findings suggest that VDRs modulate seizure susceptibility in mice, and that the Vitamin D/VDR endocrine system may be involved in the pathogenesis of epilepsy...
  49. ncbi HDLG5/KIAA0583, encoding a MAGUK-family protein, is a primary progesterone target gene in breast cancer cells
    Sami Purmonen
    Department of Cell Biology, Medical School, University of Tampere, Tampere, Finland
    Int J Cancer 102:1-6. 2002
    ..The Dlg has a well-established role in cell growth control and maintenance of cell adhesion and cell polarity. Domain profile analysis revealed that hDlg5 has 2 additional PDZ domains than previously reported...
  50. ncbi Role of 24-hydroxylase in vitamin D3 growth response of OVCAR-3 ovarian cancer cells
    Susanna Miettinen
    Department of Cell Biology, Medical School, University of Tampere, Tampere, Finland
    Int J Cancer 108:367-73. 2004
    ..The possible mitogenic effects of vitamin D should be considered when evaluating treatment of ovarian cancer with vitamin D...
  51. ncbi Grooming analysis algorithm for neurobehavioural stress research
    Allan V Kalueff
    Medical School Anatomy Department and University Hospital, University of Tampere, Tampere 33014, Finland
    Brain Res Brain Res Protoc 13:151-8. 2004
    ..The protocol can be a useful tool in neurobehavioural stress research including modelling stress-evoked states, pharmacological screening of potential antistress drugs or behavioural phenotyping of genetically modified animals...
  52. ncbi 25-hydroxyvitamin D3 is an active hormone in human primary prostatic stromal cells
    Yan Ru Lou
    Department of Anatomy, Medical School, FIN 33014, University of Tampere, Finland
    FASEB J 18:332-4. 2004
    ..Altogether our results suggest that 25OHD3 at a high but physiological concentration acts as an active hormone with respect to vitamin D3 responsive gene regulation and suppression of cell proliferation...
  53. ncbi Expression of progesterone receptor isoforms A and B is differentially regulated by estrogen in different breast cancer cell lines
    Annika Vienonen
    Tampere Graduate School of Biomedicine, Medical School, FIN 33014, University of Tampere, Finland
    J Steroid Biochem Mol Biol 80:307-13. 2002
    ..This is the first report describing that in different breast cancer cell lines the expression of PR-A and PR-B is regulated by E(2) in a distinct way...
  54. ncbi Calcitriol-induced prostate-derived factor: autocrine control of prostate cancer cell growth
    Nadja Nazarova
    Department of Anatomy, Medical School, University of Tampere, Tampere, Finland
    Int J Cancer 112:951-8. 2004
    ..This is a new link between calcitriol and growth factors of TGF-beta superfamily in the control of prostate cell growth...
  55. ncbi Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells
    Tytti M Ahola
    Department of Cell Biology, Medical School, 33014 University of Tampere, Finland
    Eur J Biochem 269:2485-90. 2002
    ..These data demonstrate a new progestin target gene, the expression of which correlates with growth inhibition...
  56. ncbi Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells
    Shengjun Qiao
    Department of Anatomy, Medical School, University of Tampere, 33014 Tampere, Finland
    FEBS Lett 577:451-4. 2004
    ....
  57. ncbi 5alpha-dihydrotestosterone inhibits 1alpha,25-dihydroxyvitamin D3-induced expression of CYP24 in human prostate cancer cells
    Yan Ru Lou
    Department of Anatomy, Medical School, University of Tampere, Finland
    Prostate 63:222-30. 2005
    ..A cross-talk between 1alpha,25-dihydroxyvitamin D(3) [1alpha,25-(OH)(2)D(3)] and 5alpha-dihydrotestosterone (DHT) in the growth inhibition has been demonstrated, but the mechanism is unknown...
  58. ncbi The role of long-chain fatty-acid-CoA ligase 3 in vitamin D3 and androgen control of prostate cancer LNCaP cell growth
    Shengjun Qiao
    Department of Anatomy, Medical School, University of Tampere, 33014, Tampere, Finland
    Biochem Biophys Res Commun 319:358-68. 2004
    ....
  59. ncbi Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells
    Shengjun Qiao
    Department of Anatomy, Medical School, 33014 University of Tampere, Tampere, Finland
    J Steroid Biochem Mol Biol 85:1-8. 2003
    ..The findings suggest that FAS is involved in the antiproliferative effect of 1alpha,25(OH)(2)D(3) in presence of androgens on prostate cancer LNCaP cells...
  60. ncbi Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-alpha) in prostate cancer cells
    Olga Golovko
    Department of Anatomy, Medical School, University of Tampere, FIN 33014, Tampere, Finland
    Life Sci 77:562-77. 2005
    ..Therefore a cooperation of vitamin D and TNF-alpha may play an important role in the control of cell growth in prostate cancer...
  61. ncbi A20 gene expression is regulated by TNF, Vitamin D and androgen in prostate cancer cells
    Olga Golovko
    Department of Anatomy, Medical School, University of Tampere, FIN 33014 Tampere, Finland
    J Steroid Biochem Mol Biol 94:197-202. 2005
    ..We conclude that A20 may be involved in the regulation of cell proliferation by TNF, Vitamin D, and androgen in prostate cancer...
  62. ncbi Calcitriol inhibits growth response to Platelet-Derived Growth Factor-BB in human prostate cells
    Nadja Nazarova
    Department of Anatomy, Medical School, University of Tampere, 33014 Tampere, Finland
    J Steroid Biochem Mol Biol 94:189-96. 2005
    ..Calcitriol does not affect PDGFRalpha and PDGF-B mRNA expression. We suggest that inhibition of PDGFRbeta expression by calcitriol might reduce responsiveness of prostate cells to mitogenic action of PDGF-BB...
  63. ncbi Localization of glucocorticoid receptor interacting protein 1 in murine tissues using two novel polyclonal antibodies
    R Puustinen
    Department of Cell Biology, Medical School, University of Tampere, FIN 33014, Tampere, Finland
    Eur J Endocrinol 145:323-33. 2001
    ..The aim of this study was to investigate GRIP1 expression in various murine tissues and whether the protein is nuclear, cytoplasmic, or both...
  64. ncbi Contrasting grooming phenotypes in three mouse strains markedly different in anxiety and activity (129S1, BALB/c and NMRI)
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    Behav Brain Res 160:1-10. 2005
    ..We suggest that ethological analysis of mouse grooming, such as that reported here, may be a useful tool in neurobehavioural research...
  65. ncbi Distribution of progesterone receptor in female mouse tissues
    N Uotinen
    Medical School, University of Tampere, Tampere, FIN 33101, Finland
    Gen Comp Endocrinol 115:429-41. 1999
    ..These results suggest cell-specific progesterone actions in the urinary tract, skin, and gastrointestinal organs, on the immune functions, and on the regulation of local blood flow...
  66. ncbi Hair barbering in mice: implications for neurobehavioural research
    A V Kalueff
    Department of Anatomy of the Medical School, University of Tampere, Tampere 33014, Finland
    Behav Processes 71:8-15. 2006
    ..We suggest that barbering may be an important complex multi-domain behaviour sensitive to various manipulations, and represent a useful index in neurobehavioural research...
  67. ncbi The role of hair in swimming of laboratory mice: implications for behavioural studies in animals with abnormal hair
    A V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    Lab Anim 39:370-6. 2005
    ..Our results indicate that hair condition is not an important factor in the forced swim test for this mouse strain, and suggest that this test may have wider utility for behavioural analyses of mice with abnormal hair...
  68. ncbi Immunolocalization of retinoic acid receptors in rat, mouse and human ovary and uterus
    Y H Zhuang
    Department of Biomedical Sciences, University of Tampere, Finland
    J Steroid Biochem Mol Biol 48:61-8. 1994
    ..In the rat ovary, positive reaction was found in the nuclei of germinal epithelial, follicular and stromal cells...
  69. ncbi Antiproliferative action of vitamin D
    Timo Ylikomi
    Graduate School of Biomedicine, Department of Cell Biology, 33014 University of Tampere, Finland
    Vitam Horm 64:357-406. 2002
    ..In the present review we discuss the mechanisms whereby vitamin D regulates cell proliferation and whether it could be used in prevention and treatment of hyperproliferative disorders like cancers...
  70. ncbi Abnormal behavioral organization of grooming in mice lacking the vitamin D receptor gene
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere, Finland
    J Neurogenet 19:1-24. 2005
    ..Our results suggest that a neurosteroid vitamin D and VDR may play an important role in controlling sequencing of grooming in mice, and further confirm the important role of the vitamin D system and VDR in the regulation of behavior...
  71. doi Progressive hearing loss in mice with a mutated vitamin D receptor gene
    Jing Zou
    Department of Otolaryngology, School of Medicine, University of Tampere, Tampere, Finland
    Audiol Neurootol 13:219-30. 2008
    ..Hormonal forms of vitamin D regulate transcription by binding with the high-affinity vitamin D receptor (VDR)...
  72. ncbi Increased grooming behavior in mice lacking vitamin D receptors
    A V Kalueff
    Department of Anatomy, Medical School, Tampere University, 33014, Finland
    Physiol Behav 82:405-9. 2004
    ..In general, our results confirm the role of vitamin D and VDR in the regulation of behavior, including grooming, and suggest that increased grooming behavioral phenotype may be associated with genetic ablation of VDR in mutant mice...
  73. ncbi Inhibin A, B and pro-alphaC in serum and peritoneal fluid in postmenopausal patients with ovarian tumors
    S L Ala-Fossi
    Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland
    Eur J Endocrinol 142:334-9. 2000
    ..To compare serum and peritoneal fluid concentrations of inhibin A, B, and pro-alphaC in women with ovarian tumors...
  74. ncbi Cell type-specific induction of cyclin D and cyclin-dependent kinase inhibitor p27(kip1) expression by estrogen in rat endometrium
    Y H Zhuang
    Department of Cell Biology, Tampere University Medical School, 33014, Tampere, Finland
    J Steroid Biochem Mol Biol 78:193-9. 2001
    ....
  75. pmc Heat shock protein 90 and the nuclear transport of progesterone receptor
    M Haverinen
    Department of Cell Biology, Graduate School of Biosciences, University of Tampere, Finland
    Cell Stress Chaperones 6:256-62. 2001
    ..Thus, the role of Hsp90 in PR action is likely to reside in the Hsp90-assisted chaperoning process of PR preceding nuclear transport of the receptor...
  76. ncbi Anticonvulsant effects of 1,25-dihydroxyvitamin D in chemically induced seizures in mice
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    Brain Res Bull 67:156-60. 2005
    ..Our findings show that Vitamin D plays a direct anticonvulsant role in the brain and suggest that the Vitamin D endocrine system may represent a new target for the development of anticonvulsant drugs...
  77. doi The regular and light-dark Suok tests of anxiety and sensorimotor integration: utility for behavioral characterization in laboratory rodents
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    Nat Protoc 3:129-36. 2008
    ....
  78. ncbi Behavioural characterization in rats using the elevated alley Suok test
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    Behav Brain Res 165:52-7. 2005
    ..This new behavioural paradigm may be widely used in neurobehavioural stress research, including modelling of stress-evoked states and pharmacological screening of psychotropic drugs...
  79. ncbi The Suok ("ropewalking") murine test of anxiety
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere, 33014 Finland
    Brain Res Brain Res Protoc 14:87-99. 2005
    ....
  80. ncbi Neurosteroid hormone vitamin D and its utility in clinical nutrition
    Allan V Kalueff
    Medical School, University of Tampere, Tampere, Finland
    Curr Opin Clin Nutr Metab Care 10:12-9. 2007
    ..We also outline perspectives for the use of vitamin D in clinical nutrition to prevent or treat various brain disorders...
  81. ncbi Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: vitamin D as a possible explanation
    Pentti Tuohimaa
    Medical School, Department of Clinical Chemistry, University of Tampere, Tampere University Hospital, Tampere 33014, Finland
    Eur J Cancer 43:1701-12. 2007
    ..The aim of this study was to assess whether patients with skin cancer have an altered risk of developing other cancers...
  82. ncbi Experimental modeling of anxiety and depression
    Allan V Kalueff
    Medical School, Tampere University Hospital, University of Tampere, Tampere 33014, Finland
    Acta Neurobiol Exp (Wars) 64:439-48. 2004
    ..We take an interdisciplinary approach and review the existing experimental models of anxiety and depression in order to promote further understanding of neurobiological aspects of anxiety and depression...
  83. ncbi Mouse grooming microstructure is a reliable anxiety marker bidirectionally sensitive to GABAergic drugs
    Allan V Kalueff
    Medical School of the University of Tampere, Tampere University Hospital, Tampere 33014, Finland
    Eur J Pharmacol 508:147-53. 2005
    ..Our study also confirms that detailed ethological analyses of grooming microstructure can be a useful tool in behavioural pharmacology of anxiety...
  84. ncbi Suppression of immunoreactive macrophages in atheromatous lesions of rabbits by clodronate
    Ritva Ylitalo
    Department of Pharmacological Sciences, University of Tampere, Medical School, Finland
    Pharmacol Toxicol 90:139-43. 2002
    ..The results suggest that clodronate suppresses the appearance of cholesterol-phagocyting macrophages in arterial walls during atherogenesis...
  85. ncbi Contrasting grooming phenotypes in C57Bl/6 and 129S1/SvImJ mice
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    Brain Res 1028:75-82. 2004
    ....
  86. ncbi Association between serum 25(OH)D concentrations and bone stress fractures in Finnish young men
    Juha Petri Ruohola
    Research Institute of Military Medicine, Helsinki, Finland
    J Bone Miner Res 21:1483-8. 2006
    ..The average serum 25(OH)D concentration was significantly lower in the group with fracture, suggesting a relationship between vitamin D and fatigue bone stress fracture...
  87. ncbi Activin B in patients with granulosa cell tumors: serum levels in comparison to inhibin
    Kimmo K Vihko
    Department of Obstetrics and Gynecology, Turku University Central Hospital, Finland
    Acta Obstet Gynecol Scand 82:570-4. 2003
    ..In the ovary, activins and inhibins are primarily synthesized by granulosa cells. Serum inhibin measurements have been used for the follow-up of patients with granulosa-cell tumors (GCT) after surgery...