Mark Tummers

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. pmc The dynamic interest in topics within the biomedical scientific community
    Frederic Michon
    Institute of Biotechnology, Developmental Biology Program, University of Helsinki, Helsinki, Finland
    PLoS ONE 4:e6544. 2009
  2. doi request reprint The importance of signal pathway modulation in all aspects of tooth development
    Mark Tummers
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Exp Zool B Mol Dev Evol 312:309-19. 2009
  3. doi request reprint Observations on continuously growing roots of the sloth and the K14-Eda transgenic mice indicate that epithelial stem cells can give rise to both the ameloblast and root epithelium cell lineage creating distinct tooth patterns
    Mark Tummers
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Evol Dev 10:187-95. 2008
  4. ncbi request reprint Modulation of epithelial cell fate of the root in vitro
    M Tummers
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, PO Box 56, FIN 00014, Helsinki, Finland
    J Dent Res 86:1063-7. 2007
  5. ncbi request reprint Root or crown: a developmental choice orchestrated by the differential regulation of the epithelial stem cell niche in the tooth of two rodent species
    Mark Tummers
    Institute of Biotechnology, Viikki Biocenter, FIN 00014 University of Helsinki, Finland
    Development 130:1049-57. 2003
  6. doi request reprint Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs
    Frederic Michon
    Institute of Biotechnology, Developmental Biology Program, PO Box 56, University of Helsinki, FIN 00014, Helsinki, Finland
    Dev Biol 340:355-68. 2010
  7. pmc Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors
    Emma Juuri
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Cell 23:317-28. 2012
  8. ncbi request reprint Sostdc1 defines the size and number of skin appendage placodes
    Katja Närhi
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Dev Biol 364:149-61. 2012
  9. ncbi request reprint p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation
    Johanna Laurikkala
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 133:1553-63. 2006
  10. doi request reprint Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction
    Pauliina M Munne
    Developmental Biology Program, Institute of Biotechnology, PO Box 56, University of Helsinki, FIN 00014, Helsinki, Finland
    Development 136:393-402. 2009

Collaborators

Detail Information

Publications15

  1. pmc The dynamic interest in topics within the biomedical scientific community
    Frederic Michon
    Institute of Biotechnology, Developmental Biology Program, University of Helsinki, Helsinki, Finland
    PLoS ONE 4:e6544. 2009
    ..In conclusion, the longtail distribution is the foundation of the scientific output of the scientific community and can be used to examine different aspects of science practice...
  2. doi request reprint The importance of signal pathway modulation in all aspects of tooth development
    Mark Tummers
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Exp Zool B Mol Dev Evol 312:309-19. 2009
    ..All these findings support the hypothesis that the diversity of tooth types and dental patterns may have resulted from tinkering with the conserved signal pathways, organized into complex networks, during evolution...
  3. doi request reprint Observations on continuously growing roots of the sloth and the K14-Eda transgenic mice indicate that epithelial stem cells can give rise to both the ameloblast and root epithelium cell lineage creating distinct tooth patterns
    Mark Tummers
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Evol Dev 10:187-95. 2008
    ..ERM, can be regulated independently from the regulation of stem cell maintenance. This developmental flexibility may underlie the developmental and evolutionary diversity in tooth patterning...
  4. ncbi request reprint Modulation of epithelial cell fate of the root in vitro
    M Tummers
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, PO Box 56, FIN 00014, Helsinki, Finland
    J Dent Res 86:1063-7. 2007
    ..We conclude that the fate of the epithelium is regulated by external cues influenced by culture conditions, and that the molar has the intrinsic capacity to grow continuously...
  5. ncbi request reprint Root or crown: a developmental choice orchestrated by the differential regulation of the epithelial stem cell niche in the tooth of two rodent species
    Mark Tummers
    Institute of Biotechnology, Viikki Biocenter, FIN 00014 University of Helsinki, Finland
    Development 130:1049-57. 2003
    ..The regulation of the epithelial stem cell niche seems to be flexible allowing for the existence of different tooth types, such as continuously growing teeth, and high and low crowned molars...
  6. doi request reprint Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs
    Frederic Michon
    Institute of Biotechnology, Developmental Biology Program, PO Box 56, University of Helsinki, FIN 00014, Helsinki, Finland
    Dev Biol 340:355-68. 2010
    ..Based on our findings we suggest that miRNAs modulate tooth morphogenesis largely by fine tuning conserved signaling networks and that miRNAs may have played important roles during tooth evolution...
  7. pmc Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors
    Emma Juuri
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Cell 23:317-28. 2012
    ..The identification of Sox2 as a marker for the dental epithelial stem cells will facilitate further studies on their lineage segregation and differentiation during tooth renewal...
  8. ncbi request reprint Sostdc1 defines the size and number of skin appendage placodes
    Katja Närhi
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Dev Biol 364:149-61. 2012
    ..Our data suggest that functions of Sostdc1 can be largely attributed to its ability to attenuate Wnt/β-catenin signaling...
  9. ncbi request reprint p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation
    Johanna Laurikkala
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 133:1553-63. 2006
    ..We also demonstrate that BMP2, BMP7 and FGF10 are potent inducers of p63 in cultured tissue explants. Hence, we suggest that p63 regulates the morphogenesis of surface ectoderm and its derivatives via multiple signalling pathways...
  10. doi request reprint Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction
    Pauliina M Munne
    Developmental Biology Program, Institute of Biotechnology, PO Box 56, University of Helsinki, FIN 00014, Helsinki, Finland
    Development 136:393-402. 2009
    ..Considering the role of mesenchyme in tooth induction and the design of tissue engineering protocols, our work may have uncovered how delicate control of tissue quantities alone influences the outcome between induction and inhibition...
  11. ncbi request reprint Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth
    Tuija Mustonen
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki FIN 00014, Finland
    Dev Biol 248:281-93. 2002
    ..We conclude that Lunatic fringe may play a role in boundary formation of the enamel knot and that Notch-signaling in the dental epithelium is regulated by mesenchymal FGFs and BMP...
  12. ncbi request reprint Stem cells and tissue engineering: prospects for regenerating tissues in dental practice
    Irma Thesleff
    Developmental Biology Research Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki, Finland
    Med Princ Pract 12:43-50. 2003
    ..This information is already being used for the generation of dentoalveolar tissues in vitro and in vivo. Could we perhaps grow new enamel, dentine, periodontal ligament, bone, or even whole new teeth for our patients in the future?..
  13. doi request reprint The role of the dental lamina in mammalian tooth replacement
    Elina Järvinen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki, Finland
    J Exp Zool B Mol Dev Evol 312:281-91. 2009
    ..We suggest that the reactivation of a competent dental lamina is pivotal for the replacement tooth formation...
  14. ncbi request reprint Expression of bone morphogenetic proteins and Msx genes during root formation
    T Yamashiro
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, PO Box 56, FIN 00014 University of Helsinki, Finland
    J Dent Res 82:172-6. 2003
    ..Msx2 expression continued in the epithelial cell rests of Malassez, and the nearby cementoblasts intensely expressed Bmp3, which may regulate some functions of the fragmented epithelium...
  15. doi request reprint Novel Golgi protein, GoPro49, is a specific dental follicle marker
    M S Takatalo
    University of Helsinki, Department of Biological and Environmental Sciences, Division of Biochemistry, P O Box 56 Viikinkaari 5D, University of Helsinki FIN 00014, Finland
    J Dent Res 88:534-8. 2009
    ..Abbreviations: Bsp1, bone sialoprotein 1; GoPro49, Golgi protein 49 kDa; E16, embryonic day 16; HERS, Hertwig's epithelial root sheath; PDL, periodontal ligament; dpn, day post-natal...