J Toppari

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. doi request reprint Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection
    Jorma Toppari
    Departments of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, Turku, Finland
    Birth Defects Res A Clin Mol Teratol 88:910-9. 2010
  2. ncbi request reprint Cryptorchidism --disease or symptom?
    Jorma Toppari
    Departments of Physiology and Pediatrics, University of Turku, Turku, Findland Electronic address
    Ann Endocrinol (Paris) 75:72-6. 2014
  3. doi request reprint Carcinoma in situ -from clinical observation to a paradigm shift for testicular carcinogenesis
    Jorma Toppari
    Department of Physiology, University of Turku, Turku, Finland
    Int J Dev Biol 57:221-3. 2013
  4. ncbi request reprint Luteinizing hormone in testicular descent
    Jorma Toppari
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Mol Cell Endocrinol 269:34-7. 2007
  5. ncbi request reprint Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registry-based data
    J Toppari
    Departments of Paediatrics and Physiology, University of Turku, Finland
    Hum Reprod Update 7:282-6. 2001
  6. doi request reprint Trends in puberty timing in humans and environmental modifiers
    Jorma Toppari
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Mol Cell Endocrinol 324:39-44. 2010
  7. ncbi request reprint The role of retinoblastoma protein family in the control of germ cell proliferation, differentiation and survival
    Jorma Toppari
    Department of Paediatrics, University of Turku, FIN 20520 Turku, Finland
    APMIS 111:245-51; discussion 251. 2003
  8. ncbi request reprint Changes in male reproductive health and effects of endocrine disruptors in Scandinavian countries
    Jorma Toppari
    Department of Pediatrics, University of Turku, Turku, Finland
    Cad Saude Publica 18:413-20. 2002
  9. doi request reprint Environmental endocrine disrupters
    J Toppari
    Department of Physiology, University of Turku, Turku, Finland
    Sex Dev 2:260-7. 2008
  10. ncbi request reprint Physiology and disorders of testicular descent
    Jorma Toppari
    Departments of Pediatrics and Physiology, University of Turku, Finland
    Endocr Dev 5:104-9. 2003

Detail Information

Publications106 found, 100 shown here

  1. doi request reprint Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection
    Jorma Toppari
    Departments of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, Turku, Finland
    Birth Defects Res A Clin Mol Teratol 88:910-9. 2010
    ..Despite progress in identification of endocrine-disrupting substances, we are still far from knowing all the risk factors for these birth defects, and advice for prevention must be based on precautionary principles...
  2. ncbi request reprint Cryptorchidism --disease or symptom?
    Jorma Toppari
    Departments of Physiology and Pediatrics, University of Turku, Turku, Findland Electronic address
    Ann Endocrinol (Paris) 75:72-6. 2014
    ..In searching the genetic and environmental reasons for these diseases, it is useful to consider their connection with each other. ..
  3. doi request reprint Carcinoma in situ -from clinical observation to a paradigm shift for testicular carcinogenesis
    Jorma Toppari
    Department of Physiology, University of Turku, Turku, Finland
    Int J Dev Biol 57:221-3. 2013
    ..These are the key findings of Niels E. Skakkebaek that changed our view of testicular tumourigenesis during the last fifty years. These and other findings are discussed in this interview-based review of testicular germ cell cancer...
  4. ncbi request reprint Luteinizing hormone in testicular descent
    Jorma Toppari
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Mol Cell Endocrinol 269:34-7. 2007
    ..Cryptorchid boys have normal testosterone levels with slightly but significantly elevated LH levels as compared to healthy boys. This high gonadotropin drive may compensate for mild Leydig cell dysfunction in cryptorchidism...
  5. ncbi request reprint Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registry-based data
    J Toppari
    Departments of Paediatrics and Physiology, University of Turku, Finland
    Hum Reprod Update 7:282-6. 2001
    ..g. in Finland the incidence of cryptorchidism is clearly lower than in Denmark. Regional and temporal trends may help to identify environmental factors that might be associated with these disorders...
  6. doi request reprint Trends in puberty timing in humans and environmental modifiers
    Jorma Toppari
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Mol Cell Endocrinol 324:39-44. 2010
    ..g., polybrominated biphenyls) or delayed (e.g., lead) puberty. Here we shortly review the available data on recent trends in timing of puberty and the possible role of endocrine disrupters...
  7. ncbi request reprint The role of retinoblastoma protein family in the control of germ cell proliferation, differentiation and survival
    Jorma Toppari
    Department of Paediatrics, University of Turku, FIN 20520 Turku, Finland
    APMIS 111:245-51; discussion 251. 2003
    ..These proteins may also serve as markers of cell cycle status of germ cells during spermatogenesis...
  8. ncbi request reprint Changes in male reproductive health and effects of endocrine disruptors in Scandinavian countries
    Jorma Toppari
    Department of Pediatrics, University of Turku, Turku, Finland
    Cad Saude Publica 18:413-20. 2002
    ..The reasons for secular trends are unknown, but the rapid pace of the change points to environmental causes. Endocrine disrupting chemicals have been hypothesized to influence male reproductive health...
  9. doi request reprint Environmental endocrine disrupters
    J Toppari
    Department of Physiology, University of Turku, Turku, Finland
    Sex Dev 2:260-7. 2008
    ..This is also a demanding research task for endocrinologists working with disorders of sex differentiation...
  10. ncbi request reprint Physiology and disorders of testicular descent
    Jorma Toppari
    Departments of Pediatrics and Physiology, University of Turku, Finland
    Endocr Dev 5:104-9. 2003
  11. ncbi request reprint Environmental effects on hormonal regulation of testicular descent
    J Toppari
    Departments of Physiology and Paediatrics, University of Turku, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    J Steroid Biochem Mol Biol 102:184-6. 2006
    ..We hypothesize that an exposure to a mixture of chemicals with anti-androgenic or estrogenic properties (either their own activity or their effect on androgen-estrogen ratio) may be involved in cryptorchidism...
  12. ncbi request reprint Maldescendus testis
    J Toppari
    Departments of Paediatrics and Physiology, University of Turku, Finland
    Horm Res 51:261-9. 1999
    ..Although our knowledge on cryptorchidism has increased considerably during the last decades, many questions remain to be answered: Is the incidence rate increasing? What is causing maldescent? Do hormones have any role in the treatment?..
  13. ncbi request reprint The effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on testicular steroidogenesis in infantile male rats
    T E Haavisto
    Department of Biology, Laboratory of Animal Physiology, University of Turku, Turku, Finland
    Int J Androl 29:313-22. 2006
    ..The present study confirms our earlier findings in in utero TCDD-exposed foetal testis indicating that maternal TCDD exposure does not negatively influence the developmental testosterone production of foetal type Leydig cells in rats...
  14. ncbi request reprint Expression of green fluorescent protein under beta-actin promoter in living spermatogenic cells of the mouse: stage-specific regulation by FSH
    S Ventelä
    Department of Anatomy, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Int J Androl 23:236-42. 2000
    ..Techniques used in this study give us new insight to study temporal and hormonal regulation of gene products in living spermatogenic cells...
  15. ncbi request reprint Differential expression and regulation of the retinoblastoma family of proteins during testicular development and spermatogenesis: roles in the control of germ cell proliferation, differentiation and apoptosis
    W Yan
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland
    Oncogene 20:1343-56. 2001
    ....
  16. ncbi request reprint Effects of neonatal exposure to 4-tert-octylphenol, diethylstilbestrol, and flutamide on steroidogenesis in infantile rat testis
    Tiina F M Mikkilä
    Laboratory of Animal Physiology, Department of Biology, University of Turku, 20520 Turku, Finland
    Toxicol Sci 91:456-66. 2006
    ..FLU-induced changes suggest the importance of androgen receptor-mediated regulation of testosterone synthesis in the postnatal rat testis. Octylphenol appeared less effective in bringing about acute steroidogenic changes...
  17. doi request reprint Effects of maternal exposure to di-isononylphthalate (DINP) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on steroidogenesis in the fetal rat testis and adrenal gland
    A Adamsson
    Department of Physiology, University of Turku, 20520 Turku, Finland
    Reprod Toxicol 28:66-74. 2009
    ..5 rat testis and adrenal. These structural alterations can disturb the development and function of fetal testis and adrenal that may become evident later in life...
  18. ncbi request reprint Low serum inhibin B concentrations in male survivors of childhood malignancy
    P M Lähteenmäki
    Department of Paediatrics, University of Turku, Finland
    Eur J Cancer 35:612-9. 1999
    ..However, the correct cut-off level of serum inhibin B, as well as the details of inhibin B physiology during puberty, remain to be determined before semen analysis can be replaced by the measurement of inhibin B...
  19. ncbi request reprint In vivo and in vitro effects of flutamide and diethylstilbestrol on fetal testicular steroidogenesis in the rat
    N Annika Adamsson
    Department of Physiology, University of Turku, 20520 Turku, Finland
    Reprod Toxicol 25:76-83. 2008
    ..In vitro time-series experiments revealed that changes in steroidogenesis occur very fast. Experiments with FLU brought further evidence to the hypothesis that ARs have negative autocrine role in developing Leydig cells...
  20. doi request reprint A cohort effect on serum testosterone levels in Finnish men
    A Perheentupa
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Eur J Endocrinol 168:227-33. 2013
    ..e. semen quality, incidence of cryptorchidism and testicular cancer); thus, we expected no significant cohort-dependent decrease in serum testosterone...
  21. ncbi request reprint Testicular dysgenesis syndrome and the development and occurrence of male reproductive disorders
    H E Virtanen
    Department of Pediatrics, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Toxicol Appl Pharmacol 207:501-5. 2005
    ..Studies are underway to assess whether there is any exposure-outcome relation with selected chemicals (persistent organic pollutants, pesticides, phthalates) and cryptorchidism...
  22. ncbi request reprint Overexpression of Bcl-W in the testis disrupts spermatogenesis: revelation of a role of BCL-W in male germ cell cycle control
    Wei Yan
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN 20520, Turku, Finland
    Mol Endocrinol 17:1868-79. 2003
    ....
  23. ncbi request reprint Function of stem cell factor as a survival factor of spermatogonia and localization of messenger ribonucleic acid in the rat seminiferous epithelium
    H Hakovirta
    Department of Anatomy, University of Turku, Finland
    Endocrinology 140:1492-8. 1999
    ..The results of the present study suggest that SCF is a Sertoli cell-produced paracrine regulator and acts as a survival factor for spermatogonia in the adult rat seminiferous epithelium in a stage-specific manner...
  24. ncbi request reprint A common polymorphism in the human relaxin-like factor (RLF) gene: no relationship with cryptorchidism
    P Koskimies
    Department of Physiology, Turku Graduate School of Biomedical Sciences, University of Turku, Finland
    Pediatr Res 47:538-41. 2000
    ..Our results indicate that mutations in the RLF gene are not a common reason for cryptorchidism and that the common G178A polymorphism has no apparent relationship with this condition...
  25. ncbi request reprint The birth rate of hypospadias in the Turku area in Finland
    H E Virtanen
    Department of Physiology, University of Turku, Finland
    APMIS 109:96-100. 2001
    ..Due to differences in national registration systems between countries, prospective studies with equal assessment criteria are needed in order to make reliable international comparisons...
  26. ncbi request reprint Transgenic male mice expressing human hydroxysteroid dehydrogenase 2 indicate a role for the enzyme independent of its action on sex steroids
    Shen Zhongyi
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Endocrinology 148:3827-36. 2007
    ....
  27. ncbi request reprint Effects of 4-tert-octylphenol, 4-tert-butylphenol, and diethylstilbestrol on prenatal testosterone surge in the rat
    Tapio E Haavisto
    Department of Biology, Laboratory of Animal Physiology, 20014 University of, Turku, Turku, Finland
    Reprod Toxicol 17:593-605. 2003
    ..Altogether, the present in vivo and in vitro analyses confirm different effects of alkylphenols and DES on fetal rat steroidogenesis and tissue structure...
  28. doi request reprint Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis
    Leon J S Brokken
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Endocrinology 150:445-51. 2009
    ....
  29. pmc Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta
    H E Virtanen
    Departments of Physiology and Paediatrics, University of Turku, Turku, Finland
    Int J Androl 35:283-93. 2012
    ..In conclusion, no association between placenta levels of dioxins or PCBs and congenital cryptorchidism was found. Significant country differences in chemical levels were observed...
  30. ncbi request reprint The expression and regulation of Bcl-2-related ovarian killer (Bok) mRNA in the developing and adult rat testis
    J S Suominen
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland
    Eur J Endocrinol 145:771-8. 2001
    ..To study the role of Bcl-2-related ovarian killer (Bok) in the regulation of apoptosis in the testis of developing and adult rat...
  31. ncbi request reprint Stage-specific expression and phosphorylation of retinoblastoma protein (pRb) in the rat seminiferous epithelium
    W Yan
    Department of Medical Genetics and Center for Reproductive and Developmental Medicine, University of Turku, Finland
    Mol Cell Endocrinol 132:137-48. 1997
    ....
  32. doi request reprint Orexins and the regulation of the hypothalamic-pituitary-testicular axis
    M Nurmio
    Department of Physiology, University of Turku, Turku, Finland
    Acta Physiol (Oxf) 198:349-54. 2010
    ..Overall, the available data strongly suggest that, by acting at different levels of the HPG axis, orexins may operate as putative neuroendocrine and autocrine/paracrine regulators of gonadal function...
  33. ncbi request reprint Timing of peak serum cortisol values in preterm infants in low-dose and the standard ACTH tests
    R Karlsson
    Department of Pediatrics, University of Turku, Finland
    Pediatr Res 45:367-9. 1999
    ..These results are comparable with those from adults. According to this study, blood samples for the low-dose ACTH test in infants should be taken before dosing and between 30 and 40 min after dosing...
  34. ncbi request reprint Expression of the nuclear RING finger protein SNURF/RNF4 during rat testis development suggests a role in spermatid maturation
    Wei Yan
    Department of Physiology, University of Turku, FIN 20520 Turku, Finland
    Mech Dev 118:247-53. 2002
    ....
  35. ncbi request reprint In utero and lactational exposure to TCDD; steroidogenic outcomes differ in male and female rat pups
    S A Myllymäki
    Department of Biology, Laboratory of Animal Physiology, University of Turku, Finland
    Toxicol Sci 88:534-44. 2005
    ..In female pups, reduced estradiol, ovarian P450arom expression and enzyme activity levels, and elevated FSH levels may have a role in the development of ovarian dysfunction reported in TCDD-exposed females...
  36. ncbi request reprint Epidemiology and pathogenesis of cryptorchidism
    H E Virtanen
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Hum Reprod Update 14:49-58. 2008
    ..Environmental factors may also have a role in the etiology of cryptorchidism. Future studies on the gene-environment interaction will give new insights to the pathogenesis of cryptorchidism...
  37. ncbi request reprint Male reproductive health after childhood cancer
    P M Lähteenmäki
    Department of Pediatrics, Turku University Central Hospital, Turku, Finland
    Acta Paediatr 97:935-42. 2008
    ..Twenty-five male patients were investigated to elucidate the correlation of semen parameters and other related parameters in the assessment of spermatogenesis after childhood cancer treatment...
  38. ncbi request reprint Infantile 4-tert-octylphenol exposure transiently inhibits rat ovarian steroidogenesis and steroidogenic acute regulatory protein (StAR) expression
    S A Myllymäki
    Department of Biology, Laboratory of Animal Physiology, 20014 University of Turku, Finland
    Toxicol Appl Pharmacol 207:59-68. 2005
    ....
  39. ncbi request reprint Adrenocorticotropin and corticotropin-releasing hormone tests in preterm infants
    R Karlsson
    Departments of Pediatrics, University of Turku, FIN 20520 Turku, Finland
    J Clin Endocrinol Metab 85:4592-5. 2000
    ..Therefore, whether the infant is or will be under acute stress after short glucocorticoid treatment, ensuring adequate cortisol secretion with the CRH test should be considered...
  40. ncbi request reprint Survivin expression in rat testis is upregulated by stem-cell factor
    Yangyang Wang
    Department of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, Turku 20520, Finland
    Mol Cell Endocrinol 218:165-74. 2004
    ..BIRC-5/survivin protein levels were up-regulated in vitro by the paracrine, Stem-Cell Factor, that is known to regulate both proliferation and apoptosis of germ cells and Leydig cells...
  41. ncbi request reprint Circannual rhythm in the incidence of cryptorchidism in Finland
    Marko Kaleva
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Int J Androl 28:53-7. 2005
    ..We conclude that a circannual fluctuation in the incidence of cryptorchidism exists, which indicates an influence by environmental factors. The underlying reason for cyclicity affects similarly both preterm and term boys...
  42. ncbi request reprint The regulated expression of c-IAP1 and c-IAP2 during the rat seminiferous epithelial cycle plays a role in the protection of germ cells from Fas-mediated apoptosis
    Yangyang Wang
    Department of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, Turku 20520, Finland
    Mol Cell Endocrinol 245:111-20. 2005
    ..Its expression was upregulated by SCF. Inhibition of IAP activity resulted in a greater sensitivity of germ cells to Fas-mediated apoptosis. These results suggest an important role for IAPs in the regulation of spermatogenic apoptosis...
  43. ncbi request reprint Does variant luteinizing hormone (V-LH) predispose to improper testicular position in late pregnancy?
    Marko Kaleva
    Department of Physiology, University of Turku, Finland
    Pediatr Res 58:447-50. 2005
    ....
  44. ncbi request reprint Effects of in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on rat follicular steroidogenesis
    Sari A Pesonen
    Department of Biology, Laboratory of Animal Physiology, University of Turku, 20014 Turku, Finland
    Reprod Toxicol 22:521-8. 2006
    ..Furthermore, TCDD had no direct effect on immature rat ovarian steroidogenesis in vitro suggesting that the follicle culture method is not a sensitive method to study the mechanisms of TCDD action...
  45. ncbi request reprint Mild gestational diabetes as a risk factor for congenital cryptorchidism
    Helena E Virtanen
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    J Clin Endocrinol Metab 91:4862-5. 2006
    ..Cryptorchidism is the most common malformation in newborn boys. Maternal diabetes has previously been suggested to be a risk factor for this disorder in one epidemiological study...
  46. doi request reprint Functional in vitro model to examine cancer therapy cytotoxicity in maturing rat testis
    Mirja Nurmio
    Department of Physiology, University of Turku, FIN 20520 Turku, Finland
    Reprod Toxicol 27:28-34. 2009
    ..Organ culture which reduces the need of animal experimentation can be used to study the cytotoxic effects of doxorubicin on the immature testis...
  47. ncbi request reprint Inhibition of tyrosine kinases PDGFR and C-Kit by imatinib mesylate interferes with postnatal testicular development in the rat
    Mirja Nurmio
    Department of Physiology, University of Turku, FIN 20520 Turku, Finland
    Int J Androl 30:366-76; discussion 376. 2007
    ..As development of the human testis is controlled by the same mechanisms, further studies with primate and human models are needed to explore whether imatinib affects the testis in children as well...
  48. ncbi request reprint Accumulation of piRNAs in the chromatoid bodies purified by a novel isolation protocol
    Oliver Meikar
    Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland
    Exp Cell Res 316:1567-75. 2010
    ..Analysis of the CB RNA content reveals enrichment of PIWI-interacting RNAs (piRNAs), further emphasizing the role of CB as the RNA processing body...
  49. ncbi request reprint Development and descent of the testis in relation to cryptorchidism
    Helena E Virtanen
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Acta Paediatr 96:622-7. 2007
    ..Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis...
  50. ncbi request reprint Expression of the E3 SUMO-1 ligases PIASx and PIAS1 during spermatogenesis in the rat
    Wei Yan
    Departments of Physiology and Pediatrics, University of Turku, FIN 20520 Turku, Finland
    Gene Expr Patterns 3:301-8. 2003
    ..Since PIASx and PIAS1 accumulate in developing male germ cells, their regulatory functions are not only restricted to AR in Sertoli cells, but they also participate in molecular processes during meiosis...
  51. pmc Intercellular organelle traffic through cytoplasmic bridges in early spermatids of the rat: mechanisms of haploid gene product sharing
    Sami Ventelä
    Department of Anatomy, Turku Graduate School of Biomedical Science, University of Turku, FIN 20520 Turku, Finland
    Mol Biol Cell 14:2768-80. 2003
    ..Golgi-derived haploid gene products are shared between spermatids, and an active involvement of the chromatoid body in intercellular material transport between round spermatids is proposed...
  52. doi request reprint Adult reproductive functions after early postnatal inhibition by imatinib of the two receptor tyrosine kinases, c-kit and PDGFR, in the rat testis
    Mirja Nurmio
    Department of Physiology, University of Turku, FIN 20520 Turku, Finland
    Reprod Toxicol 25:442-6. 2008
    ..Our findings indicate that treatment of cancer with certain molecularly targeted drugs may have latent effects on testicular development by inhibiting specific physiological signaling pathways...
  53. pmc Differential expression of members of the E2F family of transcription factors in rodent testes
    Kame S El-Darwish
    Departments of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, FIN 20520, Turku, Finland
    Reprod Biol Endocrinol 4:63. 2006
    ..In this study, the cell-specific and stage-specific expression of members of the E2F proteins has been elucidated...
  54. ncbi request reprint In vitro effects of diethylstilbestrol, genistein, 4-tert-butylphenol, and 4-tert-octylphenol on steroidogenic activity of isolated immature rat ovarian follicles
    Sari Myllymäki
    Department of Biology, Laboratory of Animal Physiology, 20014 University of Turku, Turku, Finland
    Toxicol Appl Pharmacol 204:69-80. 2005
    ..The results indicate that isolated ovarian follicles representing intact morphological and functional units offer a sensitive model system for elucidating the female-specific reproductive effects of environmental chemicals...
  55. ncbi request reprint Retinoblastoma protein (RB) interacts with E2F3 to control terminal differentiation of Sertoli cells
    E Rotgers
    1 Department of Physiology, University of Turku, Kiinamyllynkatu 10, Turku FIN 20520, Finland 2 Department of Pediatrics, University of Turku, Kiinamyllynkatu 10, Turku FIN 20520, Finland
    Cell Death Dis 5:e1274. 2014
    ..These results point to RB as a key regulator of SC function in adult mice and that the RB/E2F3 pathway directs SC maturation, cell cycle quiescence, and RB protects SC from apoptosis. ..
  56. doi request reprint The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis
    A Adamsson
    Department of Physiology, University of Turku, Turku, Finland
    Int J Androl 32:575-85. 2009
    ..These changes can lead to impaired steroidogenesis and it may result in the maldevelopment of the testis and weaken masculinization...
  57. pmc The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis
    Fu Ping Zhang
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland
    Proc Natl Acad Sci U S A 100:13692-7. 2003
    ..Extrapolated to humans, it may indicate that only total abolition of testicular androgen action will result in consistent azoospermia, which is necessary for effective male contraception...
  58. ncbi request reprint Targeted therapy for adrenocortical tumors in transgenic mice through their LH receptor by Hecate-human chorionic gonadotropin beta conjugate
    Susanna Vuorenoja
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Endocr Relat Cancer 15:635-48. 2008
    ..Hereby, our findings support the principle that Hecate-CGbeta conjugate is able to specifically destroy tumor cells that ectopically express LHR...
  59. ncbi request reprint Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin
    Susana B Rulli
    Department of Physiology, Institute of Biomedicine, University of Turku, Finland
    Endocrinology 144:4980-90. 2003
    ....
  60. ncbi request reprint Hormonal changes in 3-month-old cryptorchid boys
    Anne Maarit Suomi
    Department of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    J Clin Endocrinol Metab 91:953-8. 2006
    ..Hormonal dysregulation has been suggested to be one of many etiological factors of cryptorchidism...
  61. ncbi request reprint Indirect Sertoli cell-mediated ablation of germ cells in mice expressing the inhibin-alpha promoter/herpes simplex virus thymidine kinase transgene
    Maarit Ahtiainen
    Department of Physiology, University of Turku, FIN 20520 Turku, Finland
    Biol Reprod 71:1545-50. 2004
    ..Thus, the model offers a new tool for studies on germ cell-Sertoli cell interactions by accurate alteration of the germ cell composition in seminiferous tubules...
  62. ncbi request reprint The effects of mono-2-ethylhexyl phathalate, adriamycin and N-ethyl-N-nitrosourea on stage-specific apoptosis and DNA synthesis in the mouse spermatogenesis
    Janne S Suominen
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN 20520, Turku, Finland
    Toxicol Lett 143:163-73. 2003
    ..We conclude that ISEL technique provides a useful method to study the stage-specific effects of chemicals on spermatogenesis...
  63. ncbi request reprint Antenatal and early postnatal dexamethasone treatment decreases cortisol secretion in preterm infants
    R Karlsson
    Department of Pediatrics, University of Turku, Turku, Finland
    Horm Res 53:170-6. 2000
    ..No effect of PCT on plasma cAMP or catecholamine concentrations was observed. The results indicate that both ACT and a short PCT can significantly suppress basal cortisol levels in preterm infants...
  64. ncbi request reprint Management of testicular cancer--16 years' experience from southwest Finland
    J Sundstrom
    Department of Anatomy, University of Turku, Finland
    Scand J Urol Nephrol 35:21-5. 2001
    ..This study investigated the outcome of testicular cancer treatment in Finland...
  65. ncbi request reprint Reassessment of sperm morphology of archival semen smears from the period 1980--1994
    A Horte
    Department of Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland
    Int J Androl 24:120-4. 2001
    ..However, there was a significant decline in the proportion of normal spermatozoa with later year of men's birth...
  66. pmc Semen quality and reproductive hormone levels in men from Southern Spain
    M F Fernandez
    Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, Granada, Spain
    Int J Androl 35:1-10. 2012
    ....
  67. ncbi request reprint Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice
    Petteri Ahtiainen
    Department of Physiology, University of Turku, FIN 20520 Turku, Finland
    Oncogene 24:7301-9. 2005
    ..Our findings demonstrate a novel intriguing difference between the fetal and adult LC populations and provide further insight into the potential tumorigenic effects of gonadotropins...
  68. doi request reprint Hecate-CGbeta conjugate and gonadotropin suppression shows two distinct mechanisms of action in the treatment of adrenocortical tumors in transgenic mice expressing Simian Virus 40 T antigen under inhibin-alpha promoter
    Susanna Vuorenoja
    Department of Physiology, University of Turku, FIN 20520 Turku, Finland
    Endocr Relat Cancer 16:549-64. 2009
    ..If extrapolated to humans, H-CGbeta-c could be considered for the treatment of gonadotropin-dependent adrenal tumors in males, whereas in females gonadotropin suppression, but not H-CGbeta-c, would work better...
  69. ncbi request reprint Regulation of acrosome formation in mice expressing green fluorescent protein as a marker
    S Ventelä
    Department of Anatomy, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Tissue Cell 32:501-7. 2000
    ..The observations suggest that microtubules have an important function during the early differentiation of the acrosomic system...
  70. ncbi request reprint Suppression of GH secretion in pituitary gigantism by continuous subcutaneous octreotide infusion in a pubertal boy
    K Nanto-Salonen
    Department of Pediatrics, University of Turku, Finland
    Acta Paediatr 88:29-33. 1999
    ..It also caused a decrease in the pituitary size in magnetic resonance images. We conclude that the efficacy of octreotide infusion in suppressing GH secretion is superior to incremental injections with the same dose...
  71. ncbi request reprint A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins
    A M Moilanen
    Department of Physiology, Institute of Biomedicine, University of Helsinki, FIN 00014 Helsinki, Finland
    J Biol Chem 274:3700-4. 1999
    ..Collectively, ARIP3 belongs to a novel nuclear protein family and is perhaps the first tissue-specific coregulator of androgen receptor...
  72. ncbi request reprint Urocanic acid isomers do not modulate intracellular calcium and cyclic AMP in human natural killer cells
    J K Laihia
    Department of Dermatology, University of Turku, Finland
    Acta Derm Venereol 81:87-91. 2001
    ..Evidently, the biochemistry of urocanic acid-mediated natural killer-cell modulation is complex, and the cellular receptor(s) and specific signal transduction pathway(s) mediating the biological effects of urocanic acid remain elusive...
  73. doi request reprint Clinical findings in prepubertal girls with inguinal hernia with special reference to the diagnosis of androgen insensitivity syndrome
    Timo Hurme
    Department of Paediatric Surgery, University Hospital, Turku, Finland
    Scand J Urol Nephrol 43:42-6. 2009
    ..However, there is a higher rate of CAIS in girls with inguinal hernia. The aim of this study was to estimate the incidence of CAIS in girls with inguinal hernia and to find a proper screening test for CAIS in these girls...
  74. ncbi request reprint Tumor necrosis factor-alpha (TNF-alpha) promotes cell survival during spermatogenesis, and this effect can be blocked by infliximab, a TNF-alpha antagonist
    Janne S Suominen
    Departments of Physiology and Pediatrics, University of Turku, Turku, Finland
    Eur J Endocrinol 151:629-40. 2004
    ..Furthermore, the effects of infliximab were studied. Infliximab is a TNF-alpha antagonist used in autoimmune disorders, such as rheumatoid arthritis and Crohn's disease...
  75. ncbi request reprint Environmental endocrine disrupters and disorders of sexual differentiation
    Jorma Toppari
    Departments of Pediatrics and Physiology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Semin Reprod Med 20:305-12. 2002
    ..It is a challenge for endocrinologists to find out whether or not these chemicals or mixtures of them are involved in any of the abnormalities of human sexual differentiation...
  76. ncbi request reprint Cryptorchidism: an indicator of testicular dysgenesis?
    Marko Kaleva
    Department of Physiology, University of Turku, 20520 Turku, Finland
    Cell Tissue Res 322:167-72. 2005
    ..Cryptorchidism may reflect foetal testicular dysgenesis that may later manifest as subfertility or testicular cancer...
  77. ncbi request reprint Gender difference in breast tissue size in infancy: correlation with serum estradiol
    Ida Maria Schmidt
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Pediatr Res 52:682-6. 2002
    ..In boys, no correlations were found. Whether the stimulation of the mammary gland in infancy represents a developmental window that is of biologic significance for breast development and pathology in adulthood remains to be defined...
  78. doi request reprint Posterior urethral valves are often associated with cryptorchidism and inguinal hernias
    Jukka Heikkilä
    Department of Pediatric Surgery, Hyvinkaa Hospital, Hyvinkaa, Finland
    J Urol 180:715-7. 2008
    ..We evaluated the incidence of cryptorchidism and inguinal hernias in patients with posterior urethral valves, and compared characteristics in patients with and without cryptorchidism or inguinal hernia...
  79. ncbi request reprint Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism
    Katrine Bay
    University Department of Growth and Reproduction, Rigshospitalet, GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:4020-7. 2007
    ..The Leydig cell hormone insulin-like factor 3 (INSL3) is important for testicular descent. Currently INSL3 levels in cord blood, in serum throughout childhood, and in relation to congenital cryptorchidism are unknown...
  80. ncbi request reprint Developmental expression and spermatogenic stage specificity of transcription factors GATA-1 and GATA-4 and their cofactors FOG-1 and FOG-2 in the mouse testis
    Ilkka Ketola
    Children s Hospital and Program for Developmental and Reproductive Biology, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland
    Eur J Endocrinol 147:397-406. 2002
    ..Therefore, we analyzed GATA-1, GATA-4, FOG-1 and FOG-2 expression in detail, from undifferentiated male urogenital ridge to adult testis...
  81. ncbi request reprint Natal and neonatal teeth in relation to environmental toxicants
    Satu Alaluusua
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    Pediatr Res 52:652-5. 2002
    ..No association was found between pollutant levels and occurrence of natal and neonatal teeth, indicating that the prevailing levels of PCDD/Fs and PCBs are likely to be below the threshold to cause perinatal eruption of teeth...
  82. ncbi request reprint [Adversive environmental hormones and reproductive health]
    Jorma Toppari
    Duodecim 118:137-8. 2002
  83. ncbi request reprint Early postnatal treatment of hypogonadotropic hypogonadism with recombinant human FSH and LH
    Katharina M Main
    University Department of Growth and Reproduction, Section 5064, National University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Eur J Endocrinol 146:75-9. 2002
    ..Patients with hypogonadotropic hypogonadism may be diagnosed shortly after birth because of micropenis and cryptorchidism, combined with subnormal LH and FSH concentrations during the postnatal period...
  84. ncbi request reprint Impact of exposure to endocrine disrupters in utero and in childhood on adult reproduction
    Ida Norgil Damgaard
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Best Pract Res Clin Endocrinol Metab 16:289-309. 2002
    ..This topic is not only relevant to basic scientists but also to clinical endocrinologists, who should also be encouraged to participate in research concerning this problem...
  85. ncbi request reprint Expression of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator messenger ribonucleic acids and proteins in rat and human testis
    Rüdiger Schultz
    Department of Developmental Biology, Tampere University, FIN 33014 Tampere, Finland
    Endocrinology 144:767-76. 2003
    ..We suggest that AHR and ARNT mediate effects by direct action on testicular cells in the rat and human testis...
  86. ncbi request reprint Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1,770 young men from the general population in five European countries
    Tina Kold Jensen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Am J Epidemiol 159:49-58. 2004
    ..Maternal smoking may have long-term implications for the reproductive health of the offspring. This is another good reason to advise pregnant women to avoid smoking...
  87. ncbi request reprint Pattern of male reproductive system effects after in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in three differentially TCDD-sensitive rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, Kuopio, Finland
    Toxicol Sci 80:101-8. 2004
    ..Thus, the intraspecies genetic differences in C-terminal transactivation domain of AHR appear to modify the sensitivity to only certain dioxin-induced male reproductive effects...
  88. ncbi request reprint Larger testes and higher inhibin B levels in Finnish than in Danish newborn boys
    Katharina M Main
    University Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 91:2732-7. 2006
    ..Recent studies showed that male reproductive health problems, such as cryptorchidism, hypospadias, testicular cancer, and low sperm quality, are more prevalent in Denmark than in Finland...
  89. pmc Paracrine regulation of mammalian oocyte maturation and male germ cell survival
    Kazuhiro Kawamura
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Proc Natl Acad Sci U S A 101:7323-8. 2004
    ....
  90. ncbi request reprint Is human fecundity declining?
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Int J Androl 29:2-11. 2006
    ..This research effort can hardly be carried out without major support from governments and granting agencies making it possible to fund collaborative projects within novel research networks of scientists...
  91. pmc Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age
    Katharina M Main
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 114:270-6. 2006
    ..We investigated whether phthalate monoester contamination of human breast milk had any influence on the postnatal surge of reproductive hormones in newborn boys as a sign of testicular dysgenesis...
  92. ncbi request reprint Adult 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and effects on male reproductive organs in three differentially TCDD-susceptible rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Sci 81:401-7. 2004
    ..The fact that the influence of resistance alleles on spermatogenesis is different from that on androgenic status indicates that the effect of TCDD on sperm numbers is not fully related to decreased serum testosterone...
  93. ncbi request reprint Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors
    Ruben Nogueiras
    Department of Physiology, University of Santiago de Compostela, C San Francisco s n, 15705, Spain
    J Cell Sci 117:3247-57. 2004
    ..These data underscore a reproductive facet of this recently cloned molecule, which may operate as a novel endocrine integrator linking energy homeostasis and reproduction...
  94. ncbi request reprint Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism
    Jaesook Roh
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Reprod Biomed Online 7:400-6. 2003
    ..These data indicate that mutations involving the human LGR8 gene do not represent a frequent cause of cryptorchidism in the Finnish population...
  95. pmc GATA-4 is required for sex steroidogenic cell development in the fetal mouse
    Malgorzata Bielinska
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Dev Dyn 236:203-13. 2007
    ..Collectively these data suggest that GATA-4 plays an integral role in the development of testicular steroidogenic cells...
  96. pmc Flame retardants in placenta and breast milk and cryptorchidism in newborn boys
    Katharina Maria Main
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 115:1519-26. 2007
    ..Polybrominated diphenyl ethers (PBDEs) are widely used in Western countries...
  97. ncbi request reprint Enantiomeric ratios as an indicator of exposure processes for persistent pollutants in human placentas
    Heqing Shen
    Institute of Ecological Chemistry, GSF National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764, Neuherberg, Germany
    Chemosphere 62:390-5. 2006
    ..This relationship appears to be important for assessing tissue- and species-specific exposure and risk and it may indicate whether net uptake or metabolic activity is dominant in exposure for the resulting exposure of the enantiomers...
  98. ncbi request reprint Transcription factor GATA-6, cell proliferation, apoptosis, and apoptosis-related proteins Bcl-2 and Bax in human fetal testis
    Ilkka Ketola
    Children s Hospital and Program for Developmental and Reproductive Biology, Biomedicum Helsinki, University of Helsinki, Finland
    J Clin Endocrinol Metab 88:1858-65. 2003
    ..Despite strong expression, GATA-6 did not correlate with apoptosis or cell proliferation and is therefore unlikely to be directly involved in these processes in the human fetal testis...
  99. ncbi request reprint Evidence for a role of glycogen synthase kinase-3 beta in rodent spermatogenesis
    Taylor B Guo
    Department of Medicine, Division of Endocrinology, Harbor UCLA Medical Center and Research and Education Institute, Torrance, California 90509, USA
    J Androl 24:332-42. 2003
    ..This work provides the basis for future studies of GSK-3 beta signaling in mammalian meiosis and spermatogenesis...
  100. ncbi request reprint Serum androgen bioactivity in cryptorchid and noncryptorchid boys during the postnatal reproductive hormone surge
    Taneli Raivio
    Biomedicum Helsinki, Institute of Biomedicine Physiology, University of Helsinki, and Helsinki University Central Hospital, FIN 00014 Helsinki, Finland
    J Clin Endocrinol Metab 88:2597-9. 2003
    ....
  101. ncbi request reprint Identification of the leukemia inhibitory factor cell targets within the rat testis
    Isabelle Dorval-Coiffec
    INSERM U 625, Groupe d Etude de la Reproduction chez l Homme et les Mammifères, Universite de Rennes I, 35042 Rennes Cedex, France
    Biol Reprod 72:602-11. 2005
    ..Taken together, our results strongly suggest that LIF has a role in the regulation of the spermatogonial cell compartment...