P Toivanen

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. pmc Normal intestinal microbiota in the aetiopathogenesis of rheumatoid arthritis
    P Toivanen
    Department of Medical Microbiology, Turku University, Finland
    Ann Rheum Dis 62:807-11. 2003
  2. ncbi request reprint From reactive arthritis to rheumatoid arthritis
    P Toivanen
    Department of Medical Microbiology, Turku Immunology Centre, Turku University, Turku, Finland
    J Autoimmun 16:369-71. 2001
  3. pmc Influence of major histocompatibility complex on bacterial composition of fecal flora
    P Toivanen
    Department of Medical Microbiology, Turku Immunology Centre, Turku University, FIN 20520 Turku, Finland
    Infect Immun 69:2372-7. 2001
  4. ncbi request reprint Reactive arthritis
    A Toivanen
    Department of Medicine, Turku University, Finland
    Curr Opin Rheumatol 12:300-5. 2000
  5. ncbi request reprint Molecular and chemical characterization of the lipopolysaccharide O-antigen and its role in the virulence of Yersinia enterocolitica serotype O:8
    L Zhang
    Turku Immunology Centre, Department of Medical Microbiology, University of Turku, Finland
    Mol Microbiol 23:63-76. 1997
  6. pmc Bacterial cell wall-induced arthritis: chemical composition and tissue distribution of four Lactobacillus strains
    E Simelyte
    Department of Medical Microbiology, Turku Immunology Centre, Turku Graduate School of Biomedical Sciences, Turku University, Turku, Finland
    Infect Immun 68:3535-40. 2000
  7. ncbi request reprint Cytokine production in arthritis susceptible and resistant rats: a study with arthritogenic and non-arthritogenic Lactobacillus cell walls
    E Simelyte
    The Turku Immunology Centre, Turku Graduate School of Biomedical Sciences, Turku University, Turku, Finland
    Scand J Immunol 53:132-8. 2001
  8. pmc Enzyme degradation and proinflammatory activity in arthritogenic and nonarthritogenic Eubacterium aerofaciens cell walls
    X Zhang
    Department of Medical Microbiology, Turku Immunology Center, University of Turku, Turku, Finland
    Infect Immun 69:7277-84. 2001
  9. pmc Human cytokine responses induced by gram-positive cell walls of normal intestinal microbiota
    T Chen
    Department of Medical Microbiology, Turku Immunology Centre, Turku University, Turku, Finland
    Clin Exp Immunol 118:261-7. 1999
  10. pmc Characterisation of Eubacterium cell wall: peptidoglycan structure determines arthritogenicity
    X Zhang
    Turku Immunology Centre, Department of Medical Microbiology, Turku University, Turku, Finland
    Ann Rheum Dis 60:269-74. 2001

Collaborators

Detail Information

Publications30

  1. pmc Normal intestinal microbiota in the aetiopathogenesis of rheumatoid arthritis
    P Toivanen
    Department of Medical Microbiology, Turku University, Finland
    Ann Rheum Dis 62:807-11. 2003
    ..In susceptible subjects, with continuous seeding of bacterial products from the gut, the synovial inflammation is followed by erosion, exposition of cartilage antigens, and self perpetuating chronic arthritis...
  2. ncbi request reprint From reactive arthritis to rheumatoid arthritis
    P Toivanen
    Department of Medical Microbiology, Turku Immunology Centre, Turku University, Turku, Finland
    J Autoimmun 16:369-71. 2001
    ..In the long-run, with continuous seeding of bacterial products from the gut, the synovial inflammation is followed by erosion, exposition of cartilage antigens, and autoimmunity...
  3. pmc Influence of major histocompatibility complex on bacterial composition of fecal flora
    P Toivanen
    Department of Medical Microbiology, Turku Immunology Centre, Turku University, FIN 20520 Turku, Finland
    Infect Immun 69:2372-7. 2001
    ..Demonstration of the genetic influence on the gastrointestinal flora opens a new approach to studying the pathogenesis of bacterially induced diseases...
  4. ncbi request reprint Reactive arthritis
    A Toivanen
    Department of Medicine, Turku University, Finland
    Curr Opin Rheumatol 12:300-5. 2000
    ..It is apparent that antibiotics have no effect on the fully developed reactive arthritis, with the exception of patients with Chlamydia-triggered ReA, who might benefit from a course of antibiotics...
  5. ncbi request reprint Molecular and chemical characterization of the lipopolysaccharide O-antigen and its role in the virulence of Yersinia enterocolitica serotype O:8
    L Zhang
    Turku Immunology Centre, Department of Medical Microbiology, University of Turku, Finland
    Mol Microbiol 23:63-76. 1997
    ..The virulence of the wild-type strain and that of the complemented strain were significantly higher (approx. 100-fold) than that of the rough mutant in an orally infected mouse model, showing that YeO8 O-antigen is a virulence factor...
  6. pmc Bacterial cell wall-induced arthritis: chemical composition and tissue distribution of four Lactobacillus strains
    E Simelyte
    Department of Medical Microbiology, Turku Immunology Centre, Turku Graduate School of Biomedical Sciences, Turku University, Turku, Finland
    Infect Immun 68:3535-40. 2000
    ..fermentum cell wall. The present results, taken together with those published previously, underline the possibility that the chemical structure of peptidoglycan is important in determining the arthritogenicity of the bacterial cell wall...
  7. ncbi request reprint Cytokine production in arthritis susceptible and resistant rats: a study with arthritogenic and non-arthritogenic Lactobacillus cell walls
    E Simelyte
    The Turku Immunology Centre, Turku Graduate School of Biomedical Sciences, Turku University, Turku, Finland
    Scand J Immunol 53:132-8. 2001
    ..Likewise, the arthritogenicity of different Lactobacillus cell walls appears not to be dependent on their capacity to stimulate cytokine production...
  8. pmc Enzyme degradation and proinflammatory activity in arthritogenic and nonarthritogenic Eubacterium aerofaciens cell walls
    X Zhang
    Department of Medical Microbiology, Turku Immunology Center, University of Turku, Turku, Finland
    Infect Immun 69:7277-84. 2001
    ..These findings indicate that the arthritogenicity of CW or a PG is not dependent on the enzyme resistance alone but also on how the PG fragments released by enzyme degradation stimulate the production of proinflammatory cytokines...
  9. pmc Human cytokine responses induced by gram-positive cell walls of normal intestinal microbiota
    T Chen
    Department of Medical Microbiology, Turku Immunology Centre, Turku University, Turku, Finland
    Clin Exp Immunol 118:261-7. 1999
    ..These findings suggest that the human cytokine responses induced by Gram-positive CW of the normal intestinal microbiota are similar to those induced by LPS or Gram-positive CW of the pathogens...
  10. pmc Characterisation of Eubacterium cell wall: peptidoglycan structure determines arthritogenicity
    X Zhang
    Turku Immunology Centre, Department of Medical Microbiology, Turku University, Turku, Finland
    Ann Rheum Dis 60:269-74. 2001
    ..To elucidate factors involved in the arthritogenicity of bacterial cell walls...
  11. pmc Construction of urease-negative mutants of Yersinia enterocolitica serotypes O:3 and o:8: role of urease in virulence and arthritogenicity
    C Gripenberg-Lerche
    Turku Immunology Center, National Public Health Institute, and Abo Academy University, Turku, Finland
    Infect Immun 68:942-7. 2000
    ..Our results indicate that urease is needed for full virulence in oral infections and that it is not an arthritogenic factor in the rat model...
  12. pmc Bacterial PCR in the diagnosis of joint infection
    J Jalava
    Department of Medical Microbiology, University of Turku, Finland
    Ann Rheum Dis 60:287-9. 2001
    ..To evaluate the value of broad range bacterial PCR in the diagnosis of joint infection and to find out if there are bacteria causing arthritis which are not cultivable by the present methods...
  13. ncbi request reprint Experimental chronic arthritis and granulomatous inflammation induced by bifidobacterium cell walls
    X Zhang
    Department of Medical Microbiology, Turku Immunology Centre, University of Turku, Turku, Finland
    Scand J Immunol 54:171-9. 2001
    ..All these in comparison to the other strain used. Such characteristics are associated with the capacity to induce chronic arthritis, but it remains open how crucial they are for the granuloma formation...
  14. pmc LcrF is the temperature-regulated activator of the yadA gene of Yersinia enterocolitica and Yersinia pseudotuberculosis
    M Skurnik
    Department of Medical Microbiology, Turku University, Finland
    J Bacteriol 174:2047-51. 1992
    ..Unlike the yop regulon, the yadA gene is not under Ca2+ regulation. Here, we show that LcrF (VirF), the temperature-regulated activator of the yop regulon, also acts as an activator for yadA...
  15. ncbi request reprint Increased expression of signaling lymphocytic activation molecule in patients with rheumatoid arthritis and its role in the regulation of cytokine production in rheumatoid synovium
    P Isomaki
    Turku Immunology Centre Department of Medical Microbiology, Turku University, Finland
    J Immunol 159:2986-93. 1997
    ..Given the fact that SLAM was recently shown to be a high affinity self ligand, our data suggest that synovial T cells may stimulate their own cytokine production through homophilic SLAM-SLAM interactions...
  16. pmc Direct amplification of rRNA genes in diagnosis of bacterial infections
    K Rantakokko-Jalava
    Department of Medical Microbiology, University of Turku, Turku, Finland
    J Clin Microbiol 38:32-9. 2000
    ....
  17. pmc Somatic serogroups, capsular types, and species of fecal Klebsiella in patients with ankylosing spondylitis
    P Toivanen
    Turku Immunology Centre, Department of Medical Microbiology, Turku University, Turku, Finland
    J Clin Microbiol 37:2808-12. 1999
    ..These findings do not indicate participation of Klebsiella in the etiopathogenesis of AS...
  18. ncbi request reprint Study of murine faecal microflora by cellular fatty acid analysis; effect of age and mouse strain
    J Vaahtovuo
    Department of Medical Microbiology, Turku Immunology Centre, Turku University, Finland
    Antonie Van Leeuwenhoek 80:35-42. 2001
    ..These results suggest that composition of the faecal flora is genetically regulated...
  19. ncbi request reprint Hydrophobic domains affect the collagen-binding specificity and surface polymerization as well as the virulence potential of the YadA protein of Yersinia enterocolitica
    A Tamm
    Department of Medical Microbiology, Turku University, Finland
    Mol Microbiol 10:995-1011. 1993
    ..This suggests that the carboxy terminus of YadA is involved in transport of the protein to the bacterial outer surface...
  20. ncbi request reprint Monoclonal antibodies against chicken Bu-1a and Bu-1b alloantigens
    T Veromaa
    Department of Medical Microbiology, Turku University, Finland
    Hybridoma 7:41-8. 1988
    ..MAbs against both allelic Bu-1 antigens are beneficial tools e.g. in typing of chicken lines and in studies on chicken B cell differentiation...
  21. ncbi request reprint A novel peripheral CD4+ CD8+ T cell population: inheritance of CD8alpha expression on CD4+ T cells
    M Luhtala
    Turku Immunology Center, Department of Medical Microbiology, Turku University, Finland
    Eur J Immunol 27:189-93. 1997
    ..The hereditary expression of CD8alpha on peripheral CD4+ T cells in chicken provides a unique model in which to study the regulation of CD4 and CD8 expression...
  22. ncbi request reprint Mononuclear cell response to enterobacteria and Gram-positive cell walls of normal intestinal microbiota in early rheumatoid arthritis and other inflammatory arthritides
    T Chen
    Department of Medical Microbiology, Turku Immunology Center, Turku University, Finland
    Clin Exp Rheumatol 20:193-200. 2002
    ..To study whether enterobacteria and Gram-positive bacterial cell walls (BCW) derivedfrom normal intestinal microbiota are involved in the etiopathogenesis of early rheumatoid arthritis (RA)...
  23. ncbi request reprint Reactive arthritis
    A Toivanen
    Departments of Medicine and Medical Microbiology, Turku University, Turku, Finland
    Isr Med Assoc J 3:681-5. 2001
    ..Despite its name, the disease should be considered as a general disorder that affects not only the joints. The prognosis is not as good as earlier believed, and relapses or chronic development are not unusual...
  24. ncbi request reprint The gene cluster directing O-antigen biosynthesis in Yersinia enterocolitica serotype 0:8: identification of the genes for mannose and galactose biosynthesis and the gene for the O-antigen polymerase
    L Zhang
    Department of Medical Microbiology, University of Turku, Finland
    Microbiology 142:277-88. 1996
    ..Also in other Yersinia spp., the locus downstream of the hemH gene is occupied by gene clusters associated with LPS biosynthesis...
  25. ncbi request reprint Detection of Salmonella infantis in synovial fluid cells of a patient with reactive arthritis
    P Ekman
    National Public Health Institute and the Department of Medical Microbiology, University of Turku, Finland
    J Rheumatol 26:2485-8. 1999
    ..This is the first report of intraarticular S. infantis antigens and potentially of Salmonella DNA in Salmonella triggered ReA...
  26. pmc Role of peptidoglycan subtypes in the pathogenesis of bacterial cell wall arthritis
    E Simelyte
    Department of Medical Microbiology, Turku Graduate School of Biomedical Sciences and Turku Immunology Centre, Turku University, Turku, Finland
    Ann Rheum Dis 62:976-82. 2003
    ..For the development of chronic bacterial CW arthritis, the structure of the bacterial peptidoglycan (PG) has been found to be decisive...
  27. pmc The putative arthritogenic cationic 19-kilodalton antigen of Yersinia enterocolitica is a urease beta-subunit
    M Skurnik
    Department of Medical Microbiology, Turku University, Finland
    Infect Immun 61:2498-504. 1993
    ..Screening of a genomic library of Y. enterocolitica O:3 with a 19-kDa-antigen-specific DNA probe allowed recombinant clones containing the entire urease operon to be obtained. These clones expressed urease activity in Escherichia coli...
  28. pmc Interleukin-15 up-regulates the expression of CD154 on synovial fluid T cells
    M Möttönen
    Turku Graduate School of Biomedical Sciences and Turku Immunology Centre, Department of Medical Microbiology, Turku, Finland
    Immunology 100:238-44. 2000
    ..Our results show that SF T cells up-regulate the expression of CD154 in the presence of IL-15, a cytokine present in the synovium of patients with RA. These results further emphasize the role of IL-15 in the pathogenesis of RA...
  29. pmc The lcrE gene is part of an operon in the lcr region of Yersinia enterocolitica O:3
    A M Viitanen
    Department of Medical Microbiology, Turku University, Finland
    J Bacteriol 172:3152-62. 1990
    ..Temperature was found to play the major role in regulation of transcription of the lcrE-containing operon of pYVO3, whereas Ca2+ concentration seemed to affect it only moderately...
  30. ncbi request reprint A vegan diet changes the intestinal flora
    P Toivanen
    Rheumatology (Oxford) 41:950-1. 2002