Research Topics
Genomes and Genes | Matti J TikkanenSummaryAffiliation: University of Helsinki Country: Finland Publications
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Publications
Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistanceM J Tikkanen
Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
Proc Natl Acad Sci U S A 95:3106-10. 1998..As only very small amounts of these substances were detected in purified LDL, modified LDL particles may have been produced in vivo by circulating isoflavonoids promoting resistance to oxidation ex vivo...
Total cardiovascular disease burden: comparing intensive with moderate statin therapy insights from the IDEAL (Incremental Decrease in End Points Through Aggressive Lipid Lowering) trialMatti J Tikkanen
Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, 00290 Helsinki, Finland
J Am Coll Cardiol 54:2353-7. 2009....
Erectile dysfunction as a risk factor for coronary heart disease: implications for preventionM J Tikkanen
Helsinki University Central Hospital, Helsinki, Finland
Int J Clin Pract 61:265-8. 2007..Men presenting with ED but no other cardiovascular symptoms provide an opportunity for the treating physician to test for asymptomatic CHD and to reduce CHD risk factors...- Dietary soy-derived isoflavone phytoestrogens. Could they have a role in coronary heart disease prevention?M J Tikkanen
Department of Medicine, Helsinki University Central Hospital, 00290 Helsinki, Finland
Biochem Pharmacol 60:1-5. 2000..Further studies are needed to assess to what extent analogous effects could be produced in vivo and whether such substances have a role in hormone replacement and coronary heart disease prevention in postmenopausal women... - Fatty acyl esterification and deesterification of 17β-estradiol in human breast subcutaneous adipose tissueFeng Wang
Folkhalsan Research Center, Biomedicum Helsinki C415, Haartmaninkatu 8, 00290 Helsinki, Finland
J Clin Endocrinol Metab 97:3349-56. 2012..Adipose tissue has an important role in peripheral estrogen synthesis. One of the metabolic pathways of estradiol (E(2)) is its conversion to lipophilic fatty acyl esters... - Comparison of efficacy and safety of atorvastatin (80 mg) to simvastatin (20 to 40 mg) in patients aged <65 versus >or=65 years with coronary heart disease (from the Incremental DEcrease through Aggressive Lipid Lowering [IDEAL] study)Matti J Tikkanen
Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
Am J Cardiol 103:577-82. 2009..The safety of atorvastatin (80 mg) and simvastatin (20 to 40 mg) was similar in patients aged <65 and >65 years with stable coronary disease... - Biochemical markers for cardiovascular disease in recently postmenopausal women with or without hot flashesPauliina Tuomikoski
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
Menopause 17:145-51. 2010..We prospectively assessed hot flash status in recently postmenopausal women and related it to a number of biochemical vascular surrogate markers for CVD... - Quantitative determination of dehydroepiandrosterone fatty acyl esters in human female adipose tissue and serum using mass spectrometric methodsFeng Wang
Institute of Clinical Medicine, Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
J Steroid Biochem Mol Biol 124:93-8. 2011..Four to ten times higher concentrations of free DHEA were quantified in adipose tissue compared to those in serum... - Are there endogenous estrone fatty acyl esters in human plasma or ovarian follicular fluid?Veera Vihma
Folkhalsan Research Center, Biomedicum Helsinki, POB 63, FIN 00014 University of Helsinki, Helsinki, Finland
J Steroid Biochem Mol Biol 127:390-5. 2011..However, previous studies on the esterification of estrone with fatty acids have yielded conflicting results, some studies reporting high nanomolar concentrations of estrone fatty acyl esters in plasma... - Estradiol fatty acid esters in adipose tissue and serum of pregnant and pre- and postmenopausal womenMaija Badeau
Department of Medicine, Helsinki University Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland
J Clin Endocrinol Metab 92:4327-31. 2007..The 17beta-estradiol fatty acid esters are hormone derivatives with long-lasting estrogenic effect. They are transported in serum lipoproteins and thought to be sequestered in adipose tissue... - Postmenopausal estrogen therapy and serum estradiol fatty acid esters in women with and without previous intrahepatic cholestasis of pregnancyVeera Vihma
Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
Ann Med 36:393-9. 2004..A history of ICP did not affect esterification of E2 during estrogen therapy... - Effect of isolated isoflavone supplementation on ABCA1-dependent cholesterol efflux potential in postmenopausal womenRobert Badeau
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
Menopause 14:293-9. 2007..In addition, various serum lipid and lipoprotein parameters were investigated. Furthermore, we separately assessed equol-producing and non-equol-producing women... - Hormonal and metabolic characteristics of premenopausal women with a history of preeclamptic pregnancyAnna Tuuri
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
Acta Obstet Gynecol Scand 89:1331-7. 2010..To investigate whether women with a history of preeclampsia have more signs of hyperandrogenism and insulin resistance in the premenopausal period than women with history of normotensive pregnancies... - Pharmacokinetics of alkylresorcinol metabolites in human urinePäivi P Söderholm
Folkhälsan Research Centre, Helsinki, Finland
Br J Nutr 106:1040-4. 2011..These results support the use of urinary DHPPA and DHBA as biomarkers of wholegrain wheat and rye and enable new potential for studying the association between wholegrain intake and diseases, even in the absence of dietary data... - Estradiol fatty acid esterification is increased in high density lipoprotein subclass 3 isolated from hypertriglyceridemic subjectsAnna Höckerstedt
Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, FIN 00290 Helsinki, Finland
Atherosclerosis 185:264-70. 2006..Thus, HDL composition regulates LCAT-facilitated E2 esterification but the in vivo role of this finding can be verified only in experiments using physiological hormone concentrations... - Fatty acid esters of steroids: synthesis and metabolism in lipoproteins and adipose tissueVeera Vihma
Institute of Clinical Medicine, Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
J Steroid Biochem Mol Biol 124:65-76. 2011..Thirdly, as a large proportion of fatty acid esterified C-19 and C-21 non-estrogenic steroids is transported in lipoproteins and as they are important precursors of androgens and estrogens, this field should be investigated further... - Lipophilic oestrogen derivatives contained in lipoprotein particlesM J Tikkanen
Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
Acta Physiol Scand 176:117-21. 2002..Because of their water-insolubility, steroid fatty acid esters are carried exclusively by circulating lipoproteins. These esters can provide antioxidant protection for lipoprotein particles... - High-density lipoprotein-associated 17beta-estradiol fatty acyl ester uptake by Fu5AH hepatoma cells: implications of the roles of scavenger receptor class B, type I and the low-density lipoprotein receptorRobert M Badeau
Department of Molecular Medicine, National Public Health Institute, and Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
Biochim Biophys Acta 1771:1329-34. 2007..HDL-E2-FAE was hydrolyzed into free E2 with the maximum at 24 h. Fu5AH cells facilitate HDL-E2 uptake by at least SR-BI and LDL receptor pathways and intracellular hydrolysis of E2-FAE into free E2 ensues... - Lecithin/cholesterol acyltransferase induces estradiol esterification in high-density lipoprotein, increasing its antioxidant potentialAnna Höckerstedt
Department of Medicine, Helsinki University Central Hospital, Finland
J Clin Endocrinol Metab 89:5088-93. 2004..Elucidation of the possible in vivo role of HDL-associated estrogen esters requires further critical studies including experiments with physiological hormone concentrations... - Dehydroepiandrosterone fatty acyl esters in high density lipoprotein: interaction with human vascular endothelial cells and vascular responses ex vivoHanna Paatela
Department of Medicine, Helsinki University Central Hospital and Folkhälsan Research Center, 00290 Helsinki, Finland
Steroids 76:376-80. 2011..In conclusion, DHEA-enriched HDL induced vasorelaxation via the SR-B1-facilitated pathway. However, this vasodilation is not likely to be attributed to rapid hydrolysis of HDL-associated DHEA esters by the vascular endothelium... - Accumulation of genistein and lipophilic genistein derivatives in lipoproteins during incubation with human plasma in vitroMaija Kaamanen
Department of Medicine, University of Helsinki, Helsinki 00014, Finland
Biochim Biophys Acta 1631:147-52. 2003..A smaller part of the latter were genistein monoesters, while part remained unidentified. Our results suggest an explanation for the increased oxidation resistance of isolated LDL during intake of soybean isoflavones... - Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteinsAnna Maria Linko-Parvinen
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, FIN 00014 Helsinki, Finland
J Nutr 137:1137-42. 2007..The plasma alkylresorcinol C17:0 to C21:0 ratio reflects intake of whole-grain wheat and rye, and the plasma total alkylresorcinol concentration appears to be a useful biomarker of whole-grain cereal intake... - Role of lysosomal acid lipase in the intracellular metabolism of LDL-transported dehydroepiandrosterone-fatty acyl estersFeng Wang
Dept of Medicine, Helsinki Univ Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland
Am J Physiol Endocrinol Metab 295:E1455-61. 2008..Although LAL contributed to the deesterification of DHEA-FAE, it was not solely responsible for the hydrolysis... - Determination of plasma genistein fatty acid esters following administration of genistein or genistein 4'7-O-dioleate in monkeysMaija Badeau
Department of Medicine, University of Helsinki, Helsinki 00014, Finland
Biochim Biophys Acta 1738:115-20. 2005..The results suggest that it may be possible to introduce intact genistein ester molecules into plasma by parenteral but not oral administration... - Effects of vitamin E on the toxicity of oxidized LDL on endothelial cells in vitro in smokers vs nonsmokers on diets rich in fishL Seppo
Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
Eur J Clin Nutr 59:1282-90. 2005.... - Differing effects of oral and transdermal hormone replacement therapy on cardiovascular risk factors in healthy postmenopausal womenTimo E Strandberg
Department of Medicine, Geriatric Clinic, University of Helsinki, PO Box 340, FIN-00029 HUS, Finland
Am J Cardiol 92:212-4. 2003 - Quantification of alkylresorcinol metabolites in urine by HPLC with coulometric electrode array detectionAnja Koskela
Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
Clin Chem 53:1380-3. 2007..Two recently identified urinary AR metabolites, 3,5-dihydroxyphenylbenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), may be useful as biomarkers of intake of whole-grain rye and wheat... - Estrogen A-ring structure and antioxidative effect on lipoproteinsMaija Badeau
Department of Medicine, University of Helsinki, 00014 Helsinki, Finland
J Steroid Biochem Mol Biol 96:271-8. 2005..Accordingly, both the presence of unsubstituted hydroxyl groups and adjacent substituents, as well as the lipophilicity of the derivatives determine the antioxidant activity of estrogen derivatives in aqueous lipoprotein solutions... - Fatty acid esterification of lipoprotein-associated estrone in human plasma and follicular fluidManna Miilunpohja
Department of Medicine, Division of Cardiology, University of Helsinki, Helsinki, Finland
J Steroid Biochem Mol Biol 100:59-66. 2006..These extremely hydrophobic estrone conjugates could, in theory, represent a storage form of this estrogen... - Quantitative determination of estradiol fatty acid esters in lipoprotein fractions in human bloodVeera Vihma
Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
J Clin Endocrinol Metab 88:2552-5. 2003..Most lipoprotein fractions contained undetectable amounts of nonesterified estradiol (< 36 pmol/liter). In conclusion, our results indicate that estradiol fatty acid esters are mostly bound by lipoproteins in blood in vivo... - Differential effects of oral and transdermal estradiol treatment on circulating estradiol fatty acid ester concentrations in postmenopausal womenVeera Vihma
Department of Medicine, University of Helsinki, 00140 Helsinki, Finland
J Clin Endocrinol Metab 88:588-93. 2003..These data raise the possibility that an increase in serum estradiol fatty acid esters may contribute to beneficial effects of oral estradiol treatment, compared with an equipotent dose of transdermal estradiol... - Is there any link between insulin resistance and inflammation in established preeclampsia?Risto Kaaja
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
Metabolism 53:1433-5. 2004..We conclude that insulin resistance and the inflammatory markers studied were not associated in established preeclampsia... - Plasma pharmacokinetics of alkylresorcinol metabolites: new candidate biomarkers for whole-grain rye and wheat intakePäivi P Söderholm
Folkhalsan Research Center, Helsinki, Finland
Am J Clin Nutr 90:1167-71. 2009..Alkylresorcinols are absorbed and thereafter metabolized to 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), which have been detected in human urine and plasma... - HDL-associated dehydroepiandrosterone fatty acyl esters: enhancement of vasodilatory effect of HDLHanna Paatela
Department of Medicine, Helsinki University Central Hospital and Folkhälsan Research Center, 00290 Helsinki, Finland
Steroids 74:814-8. 2009..We studied in isolated rat mesenteric arteries whether HDL-associated DHEA-FAE improves the vasodilatory effect of HDL... - Oxidized LDL from subjects with different dietary habits modifies atherogenic processes in endothelial and smooth muscle cellsT A Lähteenmäki
Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
Life Sci 66:455-65. 2000..In EC culture only the extensively oxidized LDLs obtained from the vegetarian diet group were able to induce PGI2 production. The LDLs did not affect basal cGMP production in either EC or VSMC culture... - Expression of low and high density lipoprotein receptor genes in human adrenalsJ Liu
Department of Pathology, PO Box 21, University of Helsinki, FIN 00014 Helsinki, Finland
Eur J Endocrinol 142:677-82. 2000..LDL rather than HDL may be used as the preferential source of cholesterol for steroidogenesis in human adult adrenocortical cells... - Proliferative effects of oxidized low-density lipoprotein on vascular smooth muscle cells: role of dietary habitsT A Lähteenmäki
Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
Life Sci 63:995-1003. 1998..The native and totally-oxidized LDL induced a significant increase in DNA synthesis, if they were obtained from the fish diet group. This study suggests an enhanced proliferative effect of partially-oxidized LDL on VSMC growth... - Lipoprotein-associated estrogensMatti J Tikkanen
Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, 00290, Helsinki, Finland
Cardiovasc Res 56:184-8. 2002..Preliminary studies suggest that diet-derived plant estrogens may also form fat-soluble derivatives which become incorporated in lipoproteins... - Accumulation of high-density lipoprotein-derived estradiol-17beta fatty acid esters in low-density lipoprotein particlesH Helisten
Department of Medicine, University of Helsinki, 00014 Helsinki, Finland
J Clin Endocrinol Metab 86:1294-300. 2001.... - LCAT facilitates transacylation of 17 beta-estradiol in the presence of HDL3 subfractionAnna Höckerstedt
Department of Medicine, Helsinki University Central Hospital, FIN 00290, Helsinki, Finland
J Lipid Res 43:392-7. 2002..However, only limited increases of radioactivity were observed in HDL(2) and LDL. In conclusion, HDL subfractions differ in their potential to regulate estradiol esterification by LCAT... - Short-term metabolic effects of isradipine and metoprolol in pre-eclampsiaH M Laivuori
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
J Hypertens 17:1189-94. 1999..To study the effects of isradipine or metoprolol on insulin sensitivity and lipid profiles as well as on blood pressure and umbilical vascular resistance in pre-eclamptic women in the third trimester of pregnancy... - Long-term maintenance of therapeutic response to lovastatin in patients with familial and non-familial hypercholesterolemia: a 3-year follow-upJ P Ojala
First Department of Medicine, University of Helsinki, Finland
Atherosclerosis 82:85-95. 1990..7 kg in mean body weight was observed in the lovastatin-only group. The ophthalmological follow-up did not reveal any cataractogenic effect attributable to treatment during the 3.8-year follow-up period... - Frequency of lipid-lowering therapy after a coronary event in Helsinki, FinlandT E Strandberg
Department of Medicine, University of Helsinki, Finland
Am J Cardiol 84:95, A8. 1999..Patients whose coronary artery disease was diagnosed before 1995 were less likely to be on lipid therapy than patients with a more recent diagnosis... - Lynestrenol induced therapeutic amenorrhea: effects of dose reduction on serum sex-hormones and lipidsK J Huovinen
Rinnekoti Institute for the Mentally Retarded, University of Helsinki, Finland
Acta Obstet Gynecol Scand 71:175-80. 1992..05). The elevation of HDL-C was probably caused by the reduced serum NET concentrations. This also resulted in an increase in serum SHBG concentration, which is regarded as an indicator of the overall estrogen/androgen ratio... - Effect of a diet based on low-fat foods enriched with nonesterified plant sterols and mineral nutrients on serum cholesterolM J Tikkanen
Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
Am J Cardiol 88:1157-62. 2001..The presence of mineral nutrients in doses recommended for blood pressure-lowering did not interfere with the cholesterol-lowering efficacy of the sterols, providing a promising approach to dietary prevention of cardiovascular diseases... - Hot flushes and biochemical markers for cardiovascular disease: a randomized trial on hormone therapyP Tuomikoski
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
Climacteric 13:457-66. 2010..We compared the responses of biochemical markers for cardiovascular diseases to HT in recently postmenopausal women with tolerable or intolerable hot flushes... - Quantitative determination of estradiol fatty acid esters in human pregnancy serum and ovarian follicular fluidV Vihma
Department of Medicine, PB 340, Helsinki University Central Hospital, 00290 Helsinki, Finland
Clin Chem 47:1256-62. 2001..0-10%) was in the esterified form. CONCLUSION: The new method provides a means to measure circulating estradiol fatty acid ester concentrations in human pregnancy serum... - Safety assessment of common foods enriched with natural nonesterified plant sterolsJ Tuomilehto
Department of Health Promotion and Chronic Disease Prevention, Division of Biochemistry, National Public Health Institute, University of Helsinki, Finland
Eur J Clin Nutr 63:684-91. 2009..To assess safety during a diet based on low-fat foods enriched with nonesterified wood-derived plant sterols and mineral nutrients related to serum phytosterol, sex hormone and fat-soluble vitamin metabolism... - Screening of the 3' two-thirds of the coding area of the apo B gene in Finnish hypercholesterolemic patients report of six new genetic variantsM Ilmonen
Department of Medicine, Helsinki University Central Hospital, Finland
Atherosclerosis 128:191-9. 1997..03 and 0.02. None of these variants seemed to explain the hyperlipidemia in these patients. A major Finnish mutation causing severe hypercholesterolemia is unlikely to exist in the 3' two-thirds of the coding area of the apo B gene... - Associations between change in C-reactive protein and serum lipids during statin treatmentT E Strandberg
Department of Medicine, University of Helsinki, Finland
Ann Med 32:579-83. 2000..The change in HDL cholesterol explained 20% of the change in CRP during statin treatment. The results are in line with previous suggestions that HDL has anti-inflammatory properties... - Endurance running ability at adolescence as a predictor of blood pressure levels and hypertension in men: a 25-year follow-up studyL Mikkelsson
Pajulahti Sports Centre, Finland
Int J Sports Med 26:448-52. 2005..83 mm Hg (95 % CI 80 to 87), age-adjusted p=0.013. High endurance type fitness in adolescence predicts low risk of hypertension and low resting diastolic blood pressure levels in adult men...