Matti J Tikkanen

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. doi request reprint Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase levels
    Matti J Tikkanen
    Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, and Folkhälsan Research Center, Helsinki, Finland Electronic address
    Int J Cardiol 168:3846-52. 2013
  2. doi request reprint Total cardiovascular disease burden: comparing intensive with moderate statin therapy insights from the IDEAL (Incremental Decrease in End Points Through Aggressive Lipid Lowering) trial
    Matti J Tikkanen
    Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, 00290 Helsinki, Finland
    J Am Coll Cardiol 54:2353-7. 2009
  3. pmc Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance
    M J Tikkanen
    Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
    Proc Natl Acad Sci U S A 95:3106-10. 1998
  4. ncbi request reprint Dietary soy-derived isoflavone phytoestrogens. Could they have a role in coronary heart disease prevention?
    M J Tikkanen
    Department of Medicine, Helsinki University Central Hospital, 00290 Helsinki, Finland
    Biochem Pharmacol 60:1-5. 2000
  5. ncbi request reprint Erectile dysfunction as a risk factor for coronary heart disease: implications for prevention
    M J Tikkanen
    Helsinki University Central Hospital, Helsinki, Finland
    Int J Clin Pract 61:265-8. 2007
  6. doi request reprint Comparison of efficacy and safety of atorvastatin (80 mg) to simvastatin (20 to 40 mg) in patients aged <65 versus >or=65 years with coronary heart disease (from the Incremental DEcrease through Aggressive Lipid Lowering [IDEAL] study)
    Matti J Tikkanen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Am J Cardiol 103:577-82. 2009
  7. doi request reprint Fatty acyl esterification and deesterification of 17β-estradiol in human breast subcutaneous adipose tissue
    Feng Wang
    Folkhalsan Research Center, Biomedicum Helsinki C415, Haartmaninkatu 8, 00290 Helsinki, Finland
    J Clin Endocrinol Metab 97:3349-56. 2012
  8. doi request reprint Biochemical markers for cardiovascular disease in recently postmenopausal women with or without hot flashes
    Pauliina Tuomikoski
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Menopause 17:145-51. 2010
  9. doi request reprint Quantitative determination of dehydroepiandrosterone fatty acyl esters in human female adipose tissue and serum using mass spectrometric methods
    Feng Wang
    Institute of Clinical Medicine, Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
    J Steroid Biochem Mol Biol 124:93-8. 2011
  10. doi request reprint Are there endogenous estrone fatty acyl esters in human plasma or ovarian follicular fluid?
    Veera Vihma
    Folkhalsan Research Center, Biomedicum Helsinki, POB 63, FIN 00014 University of Helsinki, Helsinki, Finland
    J Steroid Biochem Mol Biol 127:390-5. 2011

Collaborators

Detail Information

Publications54

  1. doi request reprint Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase levels
    Matti J Tikkanen
    Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, and Folkhälsan Research Center, Helsinki, Finland Electronic address
    Int J Cardiol 168:3846-52. 2013
    ....
  2. doi request reprint Total cardiovascular disease burden: comparing intensive with moderate statin therapy insights from the IDEAL (Incremental Decrease in End Points Through Aggressive Lipid Lowering) trial
    Matti J Tikkanen
    Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, 00290 Helsinki, Finland
    J Am Coll Cardiol 54:2353-7. 2009
    ....
  3. pmc Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance
    M J Tikkanen
    Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
    Proc Natl Acad Sci U S A 95:3106-10. 1998
    ..As only very small amounts of these substances were detected in purified LDL, modified LDL particles may have been produced in vivo by circulating isoflavonoids promoting resistance to oxidation ex vivo...
  4. ncbi request reprint Dietary soy-derived isoflavone phytoestrogens. Could they have a role in coronary heart disease prevention?
    M J Tikkanen
    Department of Medicine, Helsinki University Central Hospital, 00290 Helsinki, Finland
    Biochem Pharmacol 60:1-5. 2000
    ..Further studies are needed to assess to what extent analogous effects could be produced in vivo and whether such substances have a role in hormone replacement and coronary heart disease prevention in postmenopausal women...
  5. ncbi request reprint Erectile dysfunction as a risk factor for coronary heart disease: implications for prevention
    M J Tikkanen
    Helsinki University Central Hospital, Helsinki, Finland
    Int J Clin Pract 61:265-8. 2007
    ..Men presenting with ED but no other cardiovascular symptoms provide an opportunity for the treating physician to test for asymptomatic CHD and to reduce CHD risk factors...
  6. doi request reprint Comparison of efficacy and safety of atorvastatin (80 mg) to simvastatin (20 to 40 mg) in patients aged <65 versus >or=65 years with coronary heart disease (from the Incremental DEcrease through Aggressive Lipid Lowering [IDEAL] study)
    Matti J Tikkanen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Am J Cardiol 103:577-82. 2009
    ..The safety of atorvastatin (80 mg) and simvastatin (20 to 40 mg) was similar in patients aged <65 and >65 years with stable coronary disease...
  7. doi request reprint Fatty acyl esterification and deesterification of 17β-estradiol in human breast subcutaneous adipose tissue
    Feng Wang
    Folkhalsan Research Center, Biomedicum Helsinki C415, Haartmaninkatu 8, 00290 Helsinki, Finland
    J Clin Endocrinol Metab 97:3349-56. 2012
    ..Adipose tissue has an important role in peripheral estrogen synthesis. One of the metabolic pathways of estradiol (E(2)) is its conversion to lipophilic fatty acyl esters...
  8. doi request reprint Biochemical markers for cardiovascular disease in recently postmenopausal women with or without hot flashes
    Pauliina Tuomikoski
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Menopause 17:145-51. 2010
    ..We prospectively assessed hot flash status in recently postmenopausal women and related it to a number of biochemical vascular surrogate markers for CVD...
  9. doi request reprint Quantitative determination of dehydroepiandrosterone fatty acyl esters in human female adipose tissue and serum using mass spectrometric methods
    Feng Wang
    Institute of Clinical Medicine, Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
    J Steroid Biochem Mol Biol 124:93-8. 2011
    ..Four to ten times higher concentrations of free DHEA were quantified in adipose tissue compared to those in serum...
  10. doi request reprint Are there endogenous estrone fatty acyl esters in human plasma or ovarian follicular fluid?
    Veera Vihma
    Folkhalsan Research Center, Biomedicum Helsinki, POB 63, FIN 00014 University of Helsinki, Helsinki, Finland
    J Steroid Biochem Mol Biol 127:390-5. 2011
    ..However, previous studies on the esterification of estrone with fatty acids have yielded conflicting results, some studies reporting high nanomolar concentrations of estrone fatty acyl esters in plasma...
  11. ncbi request reprint Effect of isolated isoflavone supplementation on ABCA1-dependent cholesterol efflux potential in postmenopausal women
    Robert Badeau
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Menopause 14:293-9. 2007
    ..In addition, various serum lipid and lipoprotein parameters were investigated. Furthermore, we separately assessed equol-producing and non-equol-producing women...
  12. ncbi request reprint Postmenopausal estrogen therapy and serum estradiol fatty acid esters in women with and without previous intrahepatic cholestasis of pregnancy
    Veera Vihma
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Ann Med 36:393-9. 2004
    ..Fatty acid esters of 17beta-estradiol (E2) are estrogen metabolites associated with lipoproteins in blood...
  13. ncbi request reprint Estradiol fatty acid esters in adipose tissue and serum of pregnant and pre- and postmenopausal women
    Maija Badeau
    Department of Medicine, Helsinki University Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland
    J Clin Endocrinol Metab 92:4327-31. 2007
    ..The 17beta-estradiol fatty acid esters are hormone derivatives with long-lasting estrogenic effect. They are transported in serum lipoproteins and thought to be sequestered in adipose tissue...
  14. doi request reprint Hormonal and metabolic characteristics of premenopausal women with a history of preeclamptic pregnancy
    Anna Tuuri
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Obstet Gynecol Scand 89:1331-7. 2010
    ..To investigate whether women with a history of preeclampsia have more signs of hyperandrogenism and insulin resistance in the premenopausal period than women with history of normotensive pregnancies...
  15. doi request reprint Pharmacokinetics of alkylresorcinol metabolites in human urine
    Päivi P Söderholm
    Folkhälsan Research Centre, Helsinki, Finland
    Br J Nutr 106:1040-4. 2011
    ..These results support the use of urinary DHPPA and DHBA as biomarkers of wholegrain wheat and rye and enable new potential for studying the association between wholegrain intake and diseases, even in the absence of dietary data...
  16. doi request reprint Fatty acid esters of steroids: synthesis and metabolism in lipoproteins and adipose tissue
    Veera Vihma
    Institute of Clinical Medicine, Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
    J Steroid Biochem Mol Biol 124:65-76. 2011
    ..Thirdly, as a large proportion of fatty acid esterified C-19 and C-21 non-estrogenic steroids is transported in lipoproteins and as they are important precursors of androgens and estrogens, this field should be investigated further...
  17. ncbi request reprint Estradiol fatty acid esterification is increased in high density lipoprotein subclass 3 isolated from hypertriglyceridemic subjects
    Anna Höckerstedt
    Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, FIN 00290 Helsinki, Finland
    Atherosclerosis 185:264-70. 2006
    ..Thus, HDL composition regulates LCAT-facilitated E2 esterification but the in vivo role of this finding can be verified only in experiments using physiological hormone concentrations...
  18. ncbi request reprint Lipophilic oestrogen derivatives contained in lipoprotein particles
    M J Tikkanen
    Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Physiol Scand 176:117-21. 2002
    ..Because of their water-insolubility, steroid fatty acid esters are carried exclusively by circulating lipoproteins. These esters can provide antioxidant protection for lipoprotein particles...
  19. ncbi request reprint Fatty acid esterification of lipoprotein-associated estrone in human plasma and follicular fluid
    Manna Miilunpohja
    Department of Medicine, Division of Cardiology, University of Helsinki, Helsinki, Finland
    J Steroid Biochem Mol Biol 100:59-66. 2006
    ..These extremely hydrophobic estrone conjugates could, in theory, represent a storage form of this estrogen...
  20. ncbi request reprint Determination of plasma genistein fatty acid esters following administration of genistein or genistein 4'7-O-dioleate in monkeys
    Maija Badeau
    Department of Medicine, University of Helsinki, Helsinki 00014, Finland
    Biochim Biophys Acta 1738:115-20. 2005
    ..The results suggest that it may be possible to introduce intact genistein ester molecules into plasma by parenteral but not oral administration...
  21. ncbi request reprint High-density lipoprotein-associated 17beta-estradiol fatty acyl ester uptake by Fu5AH hepatoma cells: implications of the roles of scavenger receptor class B, type I and the low-density lipoprotein receptor
    Robert M Badeau
    Department of Molecular Medicine, National Public Health Institute, and Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Biochim Biophys Acta 1771:1329-34. 2007
    ..HDL-E2-FAE was hydrolyzed into free E2 with the maximum at 24 h. Fu5AH cells facilitate HDL-E2 uptake by at least SR-BI and LDL receptor pathways and intracellular hydrolysis of E2-FAE into free E2 ensues...
  22. doi request reprint Role of lysosomal acid lipase in the intracellular metabolism of LDL-transported dehydroepiandrosterone-fatty acyl esters
    Feng Wang
    Dept of Medicine, Helsinki Univ Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland
    Am J Physiol Endocrinol Metab 295:E1455-61. 2008
    ..Although LAL contributed to the deesterification of DHEA-FAE, it was not solely responsible for the hydrolysis...
  23. ncbi request reprint Accumulation of genistein and lipophilic genistein derivatives in lipoproteins during incubation with human plasma in vitro
    Maija Kaamanen
    Department of Medicine, University of Helsinki, Helsinki 00014, Finland
    Biochim Biophys Acta 1631:147-52. 2003
    ..A smaller part of the latter were genistein monoesters, while part remained unidentified. Our results suggest an explanation for the increased oxidation resistance of isolated LDL during intake of soybean isoflavones...
  24. ncbi request reprint Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteins
    Anna Maria Linko-Parvinen
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, FIN 00014 Helsinki, Finland
    J Nutr 137:1137-42. 2007
    ..The plasma alkylresorcinol C17:0 to C21:0 ratio reflects intake of whole-grain wheat and rye, and the plasma total alkylresorcinol concentration appears to be a useful biomarker of whole-grain cereal intake...
  25. doi request reprint Dehydroepiandrosterone fatty acyl esters in high density lipoprotein: interaction with human vascular endothelial cells and vascular responses ex vivo
    Hanna Paatela
    Department of Medicine, Helsinki University Central Hospital and Folkhälsan Research Center, 00290 Helsinki, Finland
    Steroids 76:376-80. 2011
    ..In conclusion, DHEA-enriched HDL induced vasorelaxation via the SR-B1-facilitated pathway. However, this vasodilation is not likely to be attributed to rapid hydrolysis of HDL-associated DHEA esters by the vascular endothelium...
  26. ncbi request reprint Lecithin/cholesterol acyltransferase induces estradiol esterification in high-density lipoprotein, increasing its antioxidant potential
    Anna Höckerstedt
    Department of Medicine, Helsinki University Central Hospital, Finland
    J Clin Endocrinol Metab 89:5088-93. 2004
    ..Elucidation of the possible in vivo role of HDL-associated estrogen esters requires further critical studies including experiments with physiological hormone concentrations...
  27. ncbi request reprint Effects of vitamin E on the toxicity of oxidized LDL on endothelial cells in vitro in smokers vs nonsmokers on diets rich in fish
    L Seppo
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    Eur J Clin Nutr 59:1282-90. 2005
    ....
  28. doi request reprint 17β-estradiol and estradiol fatty acyl esters and estrogen-converting enzyme expression in adipose tissue in obese men and women
    Feng Wang
    Folkhalsan Research Center, Biomedicum Helsinki C415, Haartmaninkatu 8, 00290 Helsinki, Finland
    J Clin Endocrinol Metab 98:4923-31. 2013
    ..In addition to E2, adipose tissue synthesizes E2 fatty acyl esters (E2-FAE). Objective: The aim was to compare estrogen concentrations and expression of estrogen-converting enzymes in adipose tissue between severely obese men and women...
  29. ncbi request reprint Estrogen A-ring structure and antioxidative effect on lipoproteins
    Maija Badeau
    Department of Medicine, University of Helsinki, 00014 Helsinki, Finland
    J Steroid Biochem Mol Biol 96:271-8. 2005
    ..Accordingly, both the presence of unsubstituted hydroxyl groups and adjacent substituents, as well as the lipophilicity of the derivatives determine the antioxidant activity of estrogen derivatives in aqueous lipoprotein solutions...
  30. ncbi request reprint Differing effects of oral and transdermal hormone replacement therapy on cardiovascular risk factors in healthy postmenopausal women
    Timo E Strandberg
    Department of Medicine, Geriatric Clinic, University of Helsinki, PO Box 340, FIN 00029 HUS, Finland
    Am J Cardiol 92:212-4. 2003
  31. ncbi request reprint Quantification of alkylresorcinol metabolites in urine by HPLC with coulometric electrode array detection
    Anja Koskela
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
    Clin Chem 53:1380-3. 2007
    ..Two recently identified urinary AR metabolites, 3,5-dihydroxyphenylbenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), may be useful as biomarkers of intake of whole-grain rye and wheat...
  32. ncbi request reprint Quantitative determination of estradiol fatty acid esters in lipoprotein fractions in human blood
    Veera Vihma
    Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
    J Clin Endocrinol Metab 88:2552-5. 2003
    ..Most lipoprotein fractions contained undetectable amounts of nonesterified estradiol (< 36 pmol/liter). In conclusion, our results indicate that estradiol fatty acid esters are mostly bound by lipoproteins in blood in vivo...
  33. ncbi request reprint Differential effects of oral and transdermal estradiol treatment on circulating estradiol fatty acid ester concentrations in postmenopausal women
    Veera Vihma
    Department of Medicine, University of Helsinki, 00140 Helsinki, Finland
    J Clin Endocrinol Metab 88:588-93. 2003
    ..These data raise the possibility that an increase in serum estradiol fatty acid esters may contribute to beneficial effects of oral estradiol treatment, compared with an equipotent dose of transdermal estradiol...
  34. doi request reprint HDL-associated dehydroepiandrosterone fatty acyl esters: enhancement of vasodilatory effect of HDL
    Hanna Paatela
    Department of Medicine, Helsinki University Central Hospital and Folkhälsan Research Center, 00290 Helsinki, Finland
    Steroids 74:814-8. 2009
    ..We studied in isolated rat mesenteric arteries whether HDL-associated DHEA-FAE improves the vasodilatory effect of HDL...
  35. doi request reprint Plasma pharmacokinetics of alkylresorcinol metabolites: new candidate biomarkers for whole-grain rye and wheat intake
    Päivi P Söderholm
    Folkhalsan Research Center, Helsinki, Finland
    Am J Clin Nutr 90:1167-71. 2009
    ..Alkylresorcinols are absorbed and thereafter metabolized to 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), which have been detected in human urine and plasma...
  36. ncbi request reprint Is there any link between insulin resistance and inflammation in established preeclampsia?
    Risto Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Metabolism 53:1433-5. 2004
    ..We conclude that insulin resistance and the inflammatory markers studied were not associated in established preeclampsia...
  37. ncbi request reprint Proliferative effects of oxidized low-density lipoprotein on vascular smooth muscle cells: role of dietary habits
    T A Lähteenmäki
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Life Sci 63:995-1003. 1998
    ..The native and totally-oxidized LDL induced a significant increase in DNA synthesis, if they were obtained from the fish diet group. This study suggests an enhanced proliferative effect of partially-oxidized LDL on VSMC growth...
  38. ncbi request reprint Oxidized LDL from subjects with different dietary habits modifies atherogenic processes in endothelial and smooth muscle cells
    T A Lähteenmäki
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Life Sci 66:455-65. 2000
    ..In EC culture only the extensively oxidized LDLs obtained from the vegetarian diet group were able to induce PGI2 production. The LDLs did not affect basal cGMP production in either EC or VSMC culture...
  39. ncbi request reprint Expression of low and high density lipoprotein receptor genes in human adrenals
    J Liu
    Department of Pathology, PO Box 21, University of Helsinki, FIN 00014 Helsinki, Finland
    Eur J Endocrinol 142:677-82. 2000
    ..LDL rather than HDL may be used as the preferential source of cholesterol for steroidogenesis in human adult adrenocortical cells...
  40. ncbi request reprint Lipoprotein-associated estrogens
    Matti J Tikkanen
    Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, 00290, Helsinki, Finland
    Cardiovasc Res 56:184-8. 2002
    ..Preliminary studies suggest that diet-derived plant estrogens may also form fat-soluble derivatives which become incorporated in lipoproteins...
  41. ncbi request reprint Accumulation of high-density lipoprotein-derived estradiol-17beta fatty acid esters in low-density lipoprotein particles
    H Helisten
    Department of Medicine, University of Helsinki, 00014 Helsinki, Finland
    J Clin Endocrinol Metab 86:1294-300. 2001
    ....
  42. doi request reprint Plasma alkylresorcinol metabolites as biomarkers for whole-grain intake and their association with prostate cancer: a Swedish nested case-control study
    Isabel Drake
    Authors Affiliations Research Group in Nutritional Epidemiology Diabetes and Cardiovascular Disease, Genetic Epidemiology Department of Cancer Epidemiology and Oncology and Department of Clinical Sciences in Lund, Lund University, Lund Department of Urology and Department of Clinical Sciences, Division of Urological Cancers Skåne University Hospital, Malmo, Sweden Folkhälsan Research Center, Biomedicum and Division of Clinical Chemistry, University of Helsinki and Folkhälsan Research Center, Biomedicum, Helsinki University and Central Hospital Heart and Lung Center, Helsinki, Finland
    Cancer Epidemiol Biomarkers Prev 23:73-83. 2014
    ..Observational studies have mostly found no association between self-reported whole-grain intake and prostate cancer. Plasma alkylresorcinol metabolites have been suggested as biomarkers for whole-grain intake in free-living populations...
  43. ncbi request reprint LCAT facilitates transacylation of 17 beta-estradiol in the presence of HDL3 subfraction
    Anna Höckerstedt
    Department of Medicine, Helsinki University Central Hospital, FIN 00290, Helsinki, Finland
    J Lipid Res 43:392-7. 2002
    ..However, only limited increases of radioactivity were observed in HDL(2) and LDL. In conclusion, HDL subfractions differ in their potential to regulate estradiol esterification by LCAT...
  44. ncbi request reprint Frequency of lipid-lowering therapy after a coronary event in Helsinki, Finland
    T E Strandberg
    Department of Medicine, University of Helsinki, Finland
    Am J Cardiol 84:95, A8. 1999
    ..Patients whose coronary artery disease was diagnosed before 1995 were less likely to be on lipid therapy than patients with a more recent diagnosis...
  45. ncbi request reprint Lynestrenol induced therapeutic amenorrhea: effects of dose reduction on serum sex-hormones and lipids
    K J Huovinen
    Rinnekoti Institute for the Mentally Retarded, University of Helsinki, Finland
    Acta Obstet Gynecol Scand 71:175-80. 1992
    ..05). The elevation of HDL-C was probably caused by the reduced serum NET concentrations. This also resulted in an increase in serum SHBG concentration, which is regarded as an indicator of the overall estrogen/androgen ratio...
  46. ncbi request reprint Effect of a diet based on low-fat foods enriched with nonesterified plant sterols and mineral nutrients on serum cholesterol
    M J Tikkanen
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Am J Cardiol 88:1157-62. 2001
    ..The presence of mineral nutrients in doses recommended for blood pressure-lowering did not interfere with the cholesterol-lowering efficacy of the sterols, providing a promising approach to dietary prevention of cardiovascular diseases...
  47. ncbi request reprint Long-term maintenance of therapeutic response to lovastatin in patients with familial and non-familial hypercholesterolemia: a 3-year follow-up
    J P Ojala
    First Department of Medicine, University of Helsinki, Finland
    Atherosclerosis 82:85-95. 1990
    ..7 kg in mean body weight was observed in the lovastatin-only group. The ophthalmological follow-up did not reveal any cataractogenic effect attributable to treatment during the 3.8-year follow-up period...
  48. ncbi request reprint Short-term metabolic effects of isradipine and metoprolol in pre-eclampsia
    H M Laivuori
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    J Hypertens 17:1189-94. 1999
    ..To study the effects of isradipine or metoprolol on insulin sensitivity and lipid profiles as well as on blood pressure and umbilical vascular resistance in pre-eclamptic women in the third trimester of pregnancy...
  49. ncbi request reprint Screening of the 3' two-thirds of the coding area of the apo B gene in Finnish hypercholesterolemic patients report of six new genetic variants
    M Ilmonen
    Department of Medicine, Helsinki University Central Hospital, Finland
    Atherosclerosis 128:191-9. 1997
    ..03 and 0.02. None of these variants seemed to explain the hyperlipidemia in these patients. A major Finnish mutation causing severe hypercholesterolemia is unlikely to exist in the 3' two-thirds of the coding area of the apo B gene...
  50. ncbi request reprint Quantitative determination of estradiol fatty acid esters in human pregnancy serum and ovarian follicular fluid
    V Vihma
    Department of Medicine, PB 340, Helsinki University Central Hospital, 00290 Helsinki, Finland
    Clin Chem 47:1256-62. 2001
    ..0-10%) was in the esterified form. CONCLUSION: The new method provides a means to measure circulating estradiol fatty acid ester concentrations in human pregnancy serum...
  51. doi request reprint Safety assessment of common foods enriched with natural nonesterified plant sterols
    J Tuomilehto
    Department of Health Promotion and Chronic Disease Prevention, Division of Biochemistry, National Public Health Institute, University of Helsinki, Finland
    Eur J Clin Nutr 63:684-91. 2009
    ..To assess safety during a diet based on low-fat foods enriched with nonesterified wood-derived plant sterols and mineral nutrients related to serum phytosterol, sex hormone and fat-soluble vitamin metabolism...
  52. doi request reprint Hot flushes and biochemical markers for cardiovascular disease: a randomized trial on hormone therapy
    P Tuomikoski
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    Climacteric 13:457-66. 2010
    ..We compared the responses of biochemical markers for cardiovascular diseases to HT in recently postmenopausal women with tolerable or intolerable hot flushes...
  53. ncbi request reprint Associations between change in C-reactive protein and serum lipids during statin treatment
    T E Strandberg
    Department of Medicine, University of Helsinki, Finland
    Ann Med 32:579-83. 2000
    ..The change in HDL cholesterol explained 20% of the change in CRP during statin treatment. The results are in line with previous suggestions that HDL has anti-inflammatory properties...
  54. ncbi request reprint Endurance running ability at adolescence as a predictor of blood pressure levels and hypertension in men: a 25-year follow-up study
    L Mikkelsson
    Pajulahti Sports Centre, Finland
    Int J Sports Med 26:448-52. 2005
    ..83 mm Hg (95 % CI 80 to 87), age-adjusted p=0.013. High endurance type fitness in adolescence predicts low risk of hypertension and low resting diastolic blood pressure levels in adult men...