J Tiihonen

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi Specific major mental disorders and criminality: a 26-year prospective study of the 1966 northern Finland birth cohort
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Am J Psychiatry 154:840-5. 1997
  2. ncbi Seasonal variation in the occurrence of homicide in Finland
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Finland
    Am J Psychiatry 154:1711-4. 1997
  3. ncbi Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: a fractal analysis
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Mol Psychiatry 2:463-71. 1997
  4. ncbi Reversal of cerebral asymmetry in schizophrenia measured with magnetoencephalography
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Schizophr Res 30:209-19. 1998
  5. ncbi Dopamine D(2)/D(3)-receptor and transporter densities in nucleus accumbens and amygdala of type 1 and 2 alcoholics
    E Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, FIN 70240 Kuopio, Finland
    Mol Psychiatry 6:261-7. 2001
  6. ncbi Alcoholics show altered histaminergic neurotransmission in several cortical areas--preliminary report
    K Alakärppä
    Department of Pharmacology and Toxicology, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Inflamm Res 52:S37-8. 2003
  7. ncbi Dopamine transporter and D2-receptor density in late-onset alcoholism
    E Repo
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Psychopharmacology (Berl) 147:314-8. 1999
  8. ncbi Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Mol Psychiatry 4:286-9. 1999
  9. ncbi Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography
    E Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, Finland
    Neuroimage 14:87-94. 2001
  10. ncbi Extrastriatal dopamine D 2/3 receptor density and distribution in drug-naive schizophrenic patients
    H Tuppurainen
    Department of Psychiatry, University of Kuopio, Kuopio, Finland
    Mol Psychiatry 8:453-5. 2003

Detail Information

Publications19

  1. ncbi Specific major mental disorders and criminality: a 26-year prospective study of the 1966 northern Finland birth cohort
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Am J Psychiatry 154:840-5. 1997
    ..The purpose of the study was to examine the quantitative risk of criminal behavior associated with specific mental disorders...
  2. ncbi Seasonal variation in the occurrence of homicide in Finland
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Finland
    Am J Psychiatry 154:1711-4. 1997
    ..A secondary hypothesis was that the seasonal variations in homicides and violent suicides are correlated...
  3. ncbi Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: a fractal analysis
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Mol Psychiatry 2:463-71. 1997
    ..The results are consistent with the general hypothesis that high regional heterogeneity of perfusion, metabolism and receptor density is necessary to maintain adaptation ability in the living organism...
  4. ncbi Reversal of cerebral asymmetry in schizophrenia measured with magnetoencephalography
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Schizophr Res 30:209-19. 1998
    ..The results suggest that the reversed asymmetry is associated with the higher severity of general psychopathological symptoms...
  5. ncbi Dopamine D(2)/D(3)-receptor and transporter densities in nucleus accumbens and amygdala of type 1 and 2 alcoholics
    E Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, FIN 70240 Kuopio, Finland
    Mol Psychiatry 6:261-7. 2001
    ..Our results suggest that such a reduction may result in the chronic overuse of alcohol as an attempt to stimulate DA function...
  6. ncbi Alcoholics show altered histaminergic neurotransmission in several cortical areas--preliminary report
    K Alakärppä
    Department of Pharmacology and Toxicology, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Inflamm Res 52:S37-8. 2003
  7. ncbi Dopamine transporter and D2-receptor density in late-onset alcoholism
    E Repo
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Psychopharmacology (Berl) 147:314-8. 1999
    ..Late onset type 1 alcoholism has been suggested to be associated with an underlying dopaminergic defect. Therefore, it is relevant to study both postsynaptic D2-receptor and presynaptic dopamine transporter (DAT) densities among alcoholics...
  8. ncbi Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Mol Psychiatry 4:286-9. 1999
    ..3% (95% CI 2.3-25.7%). The results indicate that the COMT polymorphism contributes significantly to the development of late-onset alcoholism...
  9. ncbi Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography
    E Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, Finland
    Neuroimage 14:87-94. 2001
    ..These data indicate that human whole hemisphere autoradiography with the analysis of binding heterogeneity may be a relevant tool to measure pathological processes in the brain...
  10. ncbi Extrastriatal dopamine D 2/3 receptor density and distribution in drug-naive schizophrenic patients
    H Tuppurainen
    Department of Psychiatry, University of Kuopio, Kuopio, Finland
    Mol Psychiatry 8:453-5. 2003
    ..86 to -0.90) and negative (r from -0.37 to -0.55) schizophrenic symptoms. These results support the previous hypothesis on dysfunction of mesocortical DA function behind the cognitive and negative symptoms in schizophrenia...
  11. ncbi Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers
    J Kauhanen
    Department of Public Health and General Practice, University of Kuopio, Finland
    Alcohol Clin Exp Res 24:135-9. 2000
    ..Previous studies have shown that type I alcoholism is more common among subjects with low activity COMT genotype (LL), compared with high activity (HH) or heterozygotic (LH) genotypes...
  12. ncbi Altered frontal lobe function suggested by source analysis of event-related potentials in impulsive violent alcoholics
    I M Tarkka
    Department of Neurology and Brain Research and Rehabilitation Center Neuron, Kuopio University Hospital, University of Kuopio, Finland
    Alcohol Alcohol 36:323-8. 2001
    ..These findings imply alterations in arousal and involuntary adaptive processes in cortical networks associated with violent behaviour and alcoholism...
  13. ncbi Ethanol modulates evoked dopamine release in mouse nucleus accumbens: dependence on social stress and dose
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Eur J Pharmacol 401:365-73. 2000
    ..These data suggest that the stress of social defeat may have sensitised the machinery involved in dopamine release to ethanol, a process that may increase the reinforcing properties of this compound...
  14. ncbi Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study
    C C Joyal
    Niuvanniemi Hospital, Kuopio, Finland
    Schizophr Res 91:97-102. 2007
    ..In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz+APD+SUD group than in the Sz-only group...
  15. ncbi Regional cerebral blood flow during exposure to food in obese binge eating women
    L J Karhunen
    Department of Clinical Nutrition, University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    Psychiatry Res 99:29-42. 2000
    ..Left hemisphere and its frontal and pre-frontal regions could thus play a role in binge eating behavior in humans...
  16. ncbi Patterns of dopamine overflow in mouse nucleus accumbens during intracranial self-stimulation
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    Neurosci Lett 293:41-4. 2000
    ..We conclude that the availability of a readily-releasable pool of DA in presynaptic terminals determined the pattern of dopamine overflow in the nucleus accumbens during ICSS in mice...
  17. ncbi Ethanol consumption and DRD2 gene TaqI a polymorphism among socially drinking males
    Tero Hallikainen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Kuopio, Finland
    Am J Med Genet A 119:152-5. 2003
    ..These results in the large sample of non-alcoholic males are also opposite to some previous findings on the higher A1 allele frequency among alcoholic populations...
  18. ncbi Mortality among habitually violent offenders
    J Paanila
    Department of Forensic Psychiatry, University of Kuopio, Finland
    Forensic Sci Int 100:187-91. 1999
    ....
  19. ncbi Effect of alcohol abuse on human brain histamine and tele-methylhistamine
    K Alakärppä
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    Inflamm Res 51:S40-1. 2002