J Tiihonen

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. doi request reprint 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study)
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Kuopio and Niuvanniemi Hospital, Department of Clinical Physiology, Kuopio University Hospital, Kuopio, Finland
    Lancet 374:620-7. 2009
  2. pmc Coexisting social conditions and health problems among clients seeking treatment for illicit drug use in Finland: The HUUTI study
    Ifeoma N Onyeka
    Institute of Public Health and Clinical Nutrition, Faculty of Health Sciences, University of Eastern Finland, P, O, Box 1627, Kuopio, FI, 70211, Finland
    BMC Public Health 13:380. 2013
  3. ncbi request reprint Naltrexone implant for the treatment of polydrug dependence: a randomized controlled trial
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Eastern Finland, and Niuvanniemi Hospital, Kuopio, Finland
    Am J Psychiatry 169:531-6. 2012
  4. doi request reprint Polypharmacy with antipsychotics, antidepressants, or benzodiazepines and mortality in schizophrenia
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, FI 70240 Kuopio, Finland
    Arch Gen Psychiatry 69:476-83. 2012
  5. pmc Elevated midbrain serotonin transporter availability in mixed mania: a case report
    Tommi Tolmunen
    Department of Psychiatry, Kuopio University Hospital, 70210 Kuopio, Finland
    BMC Psychiatry 4:27. 2004
  6. ncbi request reprint Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Mol Psychiatry 4:286-9. 1999
  7. doi request reprint The efficacy of lamotrigine in clozapine-resistant schizophrenia: a systematic review and meta-analysis
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, FI 70240 Kuopio, Finland
    Schizophr Res 109:10-4. 2009
  8. doi request reprint Brain anatomy of persistent violent offenders: more rather than less
    Jari Tiihonen
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Kuopio, Finland
    Psychiatry Res 163:201-12. 2008
  9. ncbi request reprint Antidepressants and the risk of suicide, attempted suicide, and overall mortality in a nationwide cohort
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Kuopio and Niuvanniemi Hospital, Kuopio University Hospital, Kuopio, Finland
    Arch Gen Psychiatry 63:1358-67. 2006
  10. ncbi request reprint Topiramate add-on in treatment-resistant schizophrenia: a randomized, double-blind, placebo-controlled, crossover trial
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Kuopio, Finland
    J Clin Psychiatry 66:1012-5. 2005

Detail Information

Publications99

  1. doi request reprint 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study)
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Kuopio and Niuvanniemi Hospital, Department of Clinical Physiology, Kuopio University Hospital, Kuopio, Finland
    Lancet 374:620-7. 2009
    ..Our aim was to establish the long-term contribution of antipsychotic drugs to mortality in such patients...
  2. pmc Coexisting social conditions and health problems among clients seeking treatment for illicit drug use in Finland: The HUUTI study
    Ifeoma N Onyeka
    Institute of Public Health and Clinical Nutrition, Faculty of Health Sciences, University of Eastern Finland, P, O, Box 1627, Kuopio, FI, 70211, Finland
    BMC Public Health 13:380. 2013
    ..This study described the prevalence and factors associated with social and health problems among clients seeking treatment for illicit drug use...
  3. ncbi request reprint Naltrexone implant for the treatment of polydrug dependence: a randomized controlled trial
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Eastern Finland, and Niuvanniemi Hospital, Kuopio, Finland
    Am J Psychiatry 169:531-6. 2012
    ..The majority of drug addicts are polydrug dependent, and no effective pharmacological treatment is currently available for them. The authors studied the overall real-world effectiveness of naltrexone implant in this patient population...
  4. doi request reprint Polypharmacy with antipsychotics, antidepressants, or benzodiazepines and mortality in schizophrenia
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, FI 70240 Kuopio, Finland
    Arch Gen Psychiatry 69:476-83. 2012
    ..Polypharmacy is widely used in the treatment of schizophrenia, although it is believed to have major adverse effects on the well-being of patients...
  5. pmc Elevated midbrain serotonin transporter availability in mixed mania: a case report
    Tommi Tolmunen
    Department of Psychiatry, Kuopio University Hospital, 70210 Kuopio, Finland
    BMC Psychiatry 4:27. 2004
    ..Results obtained from brain imaging studies indicate that serotonin transporter (SERT) and dopamine transporter (DAT) densities are altered in major depression. However, no such studies have been published on current mania or hypomania...
  6. ncbi request reprint Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Mol Psychiatry 4:286-9. 1999
    ..3% (95% CI 2.3-25.7%). The results indicate that the COMT polymorphism contributes significantly to the development of late-onset alcoholism...
  7. doi request reprint The efficacy of lamotrigine in clozapine-resistant schizophrenia: a systematic review and meta-analysis
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, FI 70240 Kuopio, Finland
    Schizophr Res 109:10-4. 2009
    ..We aimed to study the efficacy of lamotrigine in the treatment of clozapine-resistant schizophrenia...
  8. doi request reprint Brain anatomy of persistent violent offenders: more rather than less
    Jari Tiihonen
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Kuopio, Finland
    Psychiatry Res 163:201-12. 2008
    ..Offenders with psychopathy showed the smallest volumes in these areas. The larger volumes in posterior brain areas may reflect atypical neurodevelopmental processes that underlie early-onset persistent antisocial and aggressive behavior...
  9. ncbi request reprint Antidepressants and the risk of suicide, attempted suicide, and overall mortality in a nationwide cohort
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Kuopio and Niuvanniemi Hospital, Kuopio University Hospital, Kuopio, Finland
    Arch Gen Psychiatry 63:1358-67. 2006
    ..It is unknown if antidepressant treatment is associated with either increased or decreased risk of suicide...
  10. ncbi request reprint Topiramate add-on in treatment-resistant schizophrenia: a randomized, double-blind, placebo-controlled, crossover trial
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Kuopio, Finland
    J Clin Psychiatry 66:1012-5. 2005
    ..We tested the hypothesis that topiramate is more effective than placebo in reducing symptoms in patients with treatment-resistant schizophrenia when combined with ongoing antipsychotic medication...
  11. ncbi request reprint A comparison of aripiprazole, methylphenidate, and placebo for amphetamine dependence
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, and the Department of Psychiatry, Helsinki University Hospital, Finland
    Am J Psychiatry 164:160-2. 2007
    ..To date, evidence on the effectiveness of psychosocial treatments has remained modest, and no pharmacotherapy has proven effective for amphetamine dependence...
  12. pmc Effectiveness of antipsychotic treatments in a nationwide cohort of patients in community care after first hospitalisation due to schizophrenia and schizoaffective disorder: observational follow-up study
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, FIN 70240 Kuopio, Finland
    BMJ 333:224. 2006
    ..To study the association between prescribed antipsychotic drugs and outcome in schizophrenia or schizoaffective disorder in the community...
  13. ncbi request reprint Premorbid intellectual functioning in bipolar disorder and schizophrenia: results from a cohort study of male conscripts
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, FIN 70240 Kuopio, Finland
    Am J Psychiatry 162:1904-10. 2005
    ..In this study, premorbid intellectual ability was investigated in individuals with bipolar disorder, schizophrenia, or other psychoses...
  14. doi request reprint A nationwide cohort study of oral and depot antipsychotics after first hospitalization for schizophrenia
    Jari Tiihonen
    Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland
    Am J Psychiatry 168:603-9. 2011
    ..The authors examined the risk of rehospitalization and drug discontinuation in a nationwide cohort of 2,588 consecutive patients hospitalized for the first time with a diagnosis of schizophrenia between 2000 and 2007 in Finland...
  15. ncbi request reprint Dopamine transporter and D2-receptor density in late-onset alcoholism
    E Repo
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Psychopharmacology (Berl) 147:314-8. 1999
    ..Late onset type 1 alcoholism has been suggested to be associated with an underlying dopaminergic defect. Therefore, it is relevant to study both postsynaptic D2-receptor and presynaptic dopamine transporter (DAT) densities among alcoholics...
  16. ncbi request reprint Abnormal structure of human striatal dopamine re-uptake sites in habitually violent alcoholic offenders: a fractal analysis
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Neurosci Lett 253:195-7. 1998
    ..In addition, in young violent offenders there was no normal left-to-right asymmetry observed in control subjects of the same age. The normalisation of the left-to-right asymmetry may reflect late neurobiological maturation...
  17. ncbi request reprint Dopamine D(2)/D(3)-receptor and transporter densities in nucleus accumbens and amygdala of type 1 and 2 alcoholics
    E Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, FIN 70240 Kuopio, Finland
    Mol Psychiatry 6:261-7. 2001
    ..Our results suggest that such a reduction may result in the chronic overuse of alcohol as an attempt to stimulate DA function...
  18. ncbi request reprint A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism
    M P Laakso
    Department of Neurology, Kuopio University Hospital, Building 5, P O Box 1777, 70211, Kuopio, Finland
    Behav Brain Res 109:177-86. 2000
    ....
  19. ncbi request reprint Iodine-123 labelled PE2I for dopamine transporter imaging: influence of age in healthy subjects
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, FIN 70210 Kuopio, Finland
    Eur J Nucl Med 26:1486-8. 1999
    ..The findings confirm the suitability of [(123)I]PE2I for SPET imaging in clinical routine but emphasize the necessity of using age-matched controls in patient studies...
  20. ncbi request reprint Specific major mental disorders and criminality: a 26-year prospective study of the 1966 northern Finland birth cohort
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Am J Psychiatry 154:840-5. 1997
    ..The purpose of the study was to examine the quantitative risk of criminal behavior associated with specific mental disorders...
  21. ncbi request reprint Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers
    J Kauhanen
    Department of Public Health and General Practice, University of Kuopio, Finland
    Alcohol Clin Exp Res 24:135-9. 2000
    ..Previous studies have shown that type I alcoholism is more common among subjects with low activity COMT genotype (LL), compared with high activity (HH) or heterozygotic (LH) genotypes...
  22. ncbi request reprint Specific binding and laterality of human extrastriatal dopamine D2/D3 receptors in late onset type 1 alcoholic patients
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, FIN 70210, Kuopio, Finland
    Neurosci Lett 292:57-9. 2000
    ..89+/-0.19 vs. 1.10+/-0.19; P<0.05). The results suggest that the specific binding of dopamine D(2)/D(3) receptors in late type 1 alcoholics is decreased and its laterality in the temporal brain is altered from normal...
  23. ncbi request reprint Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: a fractal analysis
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Mol Psychiatry 2:463-71. 1997
    ..The results are consistent with the general hypothesis that high regional heterogeneity of perfusion, metabolism and receptor density is necessary to maintain adaptation ability in the living organism...
  24. ncbi request reprint Reduced serotonin transporter binding in binge eating women
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Psychopharmacology (Berl) 155:310-4. 2001
    ..There is evidence that abnormalities in brain dopamine, norepinephrine and serotonin metabolism may play an important role in binge eating. Serotonin-active antidepressant drugs have also been found to decrease binge eating...
  25. ncbi request reprint Reversal of cerebral asymmetry in schizophrenia measured with magnetoencephalography
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Schizophr Res 30:209-19. 1998
    ..The results suggest that the reversed asymmetry is associated with the higher severity of general psychopathological symptoms...
  26. ncbi request reprint Fentanyl decreases beta-CIT binding to the dopamine transporter
    K A Bergstrom
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Synapse 29:413-5. 1998
    ..According to the present data, fentanyl decreases [123I]beta-CIT binding in the basal ganglia both in human and rats, suggesting that opiates possibly directly affect DA reuptake...
  27. ncbi request reprint Imaging the structure of the striatum: a fractal approach to SPECT image interpretation
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Physiol Meas 19:367-74. 1998
    ..Recognition of the normal variation in heterogeneity is important in evaluation of the striatal dopamine transporter density between controls and patients suffering from various neuropsychiatric disorders...
  28. ncbi request reprint Effects of ageing on serotonin transporters in healthy females
    J T Kuikka
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland
    Eur J Nucl Med 28:911-3. 2001
    ..47; P<0.05) was found in the midbrain. The decline in [123I]nor-beta-CIT binding in the serotonin transporter-rich area is much less than that in dopamine transporters in the striatum (6% per decade)...
  29. ncbi request reprint Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study
    C C Joyal
    Niuvanniemi Hospital, Kuopio, Finland
    Schizophr Res 91:97-102. 2007
    ..In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz+APD+SUD group than in the Sz-only group...
  30. ncbi request reprint Psychopathy and the posterior hippocampus
    M P Laakso
    Department of Neurology, Bldg 5, Kuopio University Hospital, POB 1777, 70211, Kuopio, Finland
    Behav Brain Res 118:187-93. 2001
    ....
  31. ncbi request reprint Seasonal variation in the occurrence of homicide in Finland
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Finland
    Am J Psychiatry 154:1711-4. 1997
    ..A secondary hypothesis was that the seasonal variations in homicides and violent suicides are correlated...
  32. ncbi request reprint Dopamine transporter in vitro binding and in vivo imaging in the brain
    K A Bergstrom
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland
    Pharmacol Toxicol 88:287-93. 2001
    ..Furthermore, the dopamine transporter is a fruitful target for CNS drug discovery. Fundamental nature of drug actions in vivo may be studied using demonstrated in vitro and in vivo imaging methods...
  33. ncbi request reprint Fractal analysis--a new approach in brain receptor imaging
    J Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Ann Med 30:242-8. 1998
    ..This review highlights recent findings in SPET receptor imaging and the use of fractal analysis in the interpretation of images representing various neuropsychiatric disorders...
  34. ncbi request reprint Ethanol modulates evoked dopamine release in mouse nucleus accumbens: dependence on social stress and dose
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Eur J Pharmacol 401:365-73. 2000
    ..These data suggest that the stress of social defeat may have sensitised the machinery involved in dopamine release to ethanol, a process that may increase the reinforcing properties of this compound...
  35. ncbi request reprint A morphometric MRI study of the hippocampus in first-episode, neuroleptic-naïve schizophrenia
    M P Laakso
    Department of Neurology, Bldg 5, Kuopio University Hospital, P O Box 1777, Kuopio, Finland
    Schizophr Res 50:3-7. 2001
    ..These data are at odds with the previous reports on hippocampal volume loss in first-episode schizophrenia, and with the hypothesis of regionally specific hippocampal volume deficit in schizophrenia...
  36. ncbi request reprint Regional cerebral blood flow during exposure to food in obese binge eating women
    L J Karhunen
    Department of Clinical Nutrition, University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    Psychiatry Res 99:29-42. 2000
    ..Left hemisphere and its frontal and pre-frontal regions could thus play a role in binge eating behavior in humans...
  37. ncbi request reprint Extrastriatal dopamine D 2/3 receptor density and distribution in drug-naive schizophrenic patients
    H Tuppurainen
    Department of Psychiatry, University of Kuopio, Kuopio, Finland
    Mol Psychiatry 8:453-5. 2003
    ..86 to -0.90) and negative (r from -0.37 to -0.55) schizophrenic symptoms. These results support the previous hypothesis on dysfunction of mesocortical DA function behind the cognitive and negative symptoms in schizophrenia...
  38. ncbi request reprint Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography
    E Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, Finland
    Neuroimage 14:87-94. 2001
    ..These data indicate that human whole hemisphere autoradiography with the analysis of binding heterogeneity may be a relevant tool to measure pathological processes in the brain...
  39. ncbi request reprint Mortality among habitually violent offenders
    J Paanila
    Department of Forensic Psychiatry, University of Kuopio, Finland
    Forensic Sci Int 100:187-91. 1999
    ....
  40. ncbi request reprint Alcoholics show altered histaminergic neurotransmission in several cortical areas--preliminary report
    K Alakärppä
    Department of Pharmacology and Toxicology, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Inflamm Res 52:S37-8. 2003
  41. ncbi request reprint Altered frontal lobe function suggested by source analysis of event-related potentials in impulsive violent alcoholics
    I M Tarkka
    Department of Neurology and Brain Research and Rehabilitation Center Neuron, Kuopio University Hospital, University of Kuopio, Finland
    Alcohol Alcohol 36:323-8. 2001
    ..These findings imply alterations in arousal and involuntary adaptive processes in cortical networks associated with violent behaviour and alcoholism...
  42. ncbi request reprint Patterns of dopamine overflow in mouse nucleus accumbens during intracranial self-stimulation
    L Yavich
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    Neurosci Lett 293:41-4. 2000
    ..We conclude that the availability of a readily-releasable pool of DA in presynaptic terminals determined the pattern of dopamine overflow in the nucleus accumbens during ICSS in mice...
  43. ncbi request reprint Ethanol consumption and DRD2 gene TaqI a polymorphism among socially drinking males
    Tero Hallikainen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Kuopio, Finland
    Am J Med Genet A 119:152-5. 2003
    ..These results in the large sample of non-alcoholic males are also opposite to some previous findings on the higher A1 allele frequency among alcoholic populations...
  44. ncbi request reprint Effect of alcohol abuse on human brain histamine and tele-methylhistamine
    K Alakärppä
    Department of Pharmacology and Toxicology, University of Kuopio, Finland
    Inflamm Res 51:S40-1. 2002
  45. ncbi request reprint Transmission of violent offending and crime across three generations
    Anu Putkonen
    Dept of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, 70240, Kuopio, Finland
    Soc Psychiatry Psychiatr Epidemiol 42:94-9. 2007
    ..However, there exist neither published data on the quantitative risk for crime or violent offending among parents of violent offenders, nor data on the transmission of the increased prevalence of crime across three generations...
  46. ncbi request reprint Midbrain dopamine D2/3 receptor binding in schizophrenia
    Heli Tuppurainen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, 70240, Kuopio, Finland
    Eur Arch Psychiatry Clin Neurosci 256:382-7. 2006
    ..78 to -0.92). These observations implicate altered dopaminergic activity in the midbrain of schizophrenic patients...
  47. ncbi request reprint Midbrain binding of [123I]nor-beta-CIT in atypical depression
    Soili Lehto
    Department of Psychiatry, Kuopio University Hospital, 70210 Kuopio, Finland
    Prog Neuropsychopharmacol Biol Psychiatry 30:1251-5. 2006
    ..Atypical depression (ATD) has been suggested to be connected to decreased serotonergic transmission, but no studies have been published on the association between brain serotonin transporter density and ATD...
  48. ncbi request reprint Visualization of the cortical dopamine transporter in type 1 and 2 alcoholics with human whole hemisphere autoradiography
    Erkki Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Kuopio, Finland
    Eur Neuropsychopharmacol 16:552-60. 2006
    ....
  49. ncbi request reprint Lower serotonin transporter binding in caudate in alcoholics
    Markus Storvik
    Department of Forensic Psychiatry, University of Kuopio, FI 70240 Kuopio, Finland
    Synapse 59:144-51. 2006
    ....
  50. ncbi request reprint Seasonal variations in [3H]citalopram platelet binding between healthy controls and violent offenders in Finland
    James Callaway
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Hum Psychopharmacol 20:467-72. 2005
    ....
  51. doi request reprint Autoradiographic characterization of alpha(2C)-adrenoceptors in the human striatum
    Veronica Fagerholm
    Turku PET Centre, Turku, Finland
    Synapse 62:508-15. 2008
    ....
  52. ncbi request reprint Reduced midbrain serotonin transporter availability in drug-naïve patients with depression measured by SERT-specific [(123)I] nor-beta-CIT SPECT imaging
    Mikko Joensuu
    Department of Psychiatry, University of Kuopio, Kuopio, Finland
    Psychiatry Res 154:125-31. 2007
    ..No correlation with depression severity was found. These findings indicate that SERT availability in the midbrain area is reduced in depression, and that interindividual variation is considerable in both patients and controls...
  53. doi request reprint Midbrain serotonin and striatum dopamine transporter binding in double depression: a one-year follow-up study
    Soili M Lehto
    Department of Psychiatry, Kuopio University Hospital, 70210 Kuopio, Finland
    Neurosci Lett 441:291-5. 2008
    ..However, low striatum [123I] nor-beta-CIT binding, a marker of DAT binding, may be associated with a longer illness duration in dysthymia...
  54. doi request reprint Striatal dopaminergic terminals in type 1 and type 2 alcoholics measured with [3H]dihydrotetrabenazine and human whole hemisphere autoradiography
    Erkki Tupala
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Kuopio, Finland
    Psychiatry Res 163:70-5. 2008
    ..Although type 1 alcoholics have been reported to have up to 36% lower striatal dopamine transporter levels than controls, the results suggest that the density of their dopaminergic nerve terminals is not altered...
  55. doi request reprint Association between medication and risk of suicide, attempted suicide and death in nationwide cohort of suicidal patients with schizophrenia
    Jari Haukka
    Department of Mental Health and Alcohol Research, National Public Health Institute, FIN 00300 Helsinki, Finland
    Pharmacoepidemiol Drug Saf 17:686-96. 2008
    ..The aim of this study was to investigate, in a nationwide cohort of suicidal schizophrenic individuals, how the risks of suicide, severe suicide attempts and death are associated with usage of antidepressant or antipsychotic treatment...
  56. doi request reprint Temporal cortex dopamine D2/3 receptor binding in major depression
    Soili M Lehto
    Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland
    Psychiatry Clin Neurosci 62:345-8. 2008
    ..Dopaminergic abnormalities may be present in the temporal cortices of major depressives...
  57. ncbi request reprint Correlation between the SERT binding densities in hypothalamus and amygdala in Cloninger type 1 and 2 alcoholics
    Markus Storvik
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Kuopio, FI 70240, Finland
    Alcohol Alcohol 43:25-30. 2008
    ..The physiological effects of emotions are mediated to autonomic nervous system by the hypothalamus, also innervated by the serotonergic Raphe nuclei...
  58. ncbi request reprint Changes in midbrain serotonin transporter availability in atypically depressed subjects after one year of psychotherapy
    Soili M Lehto
    Department of Psychiatry, Kuopio University Hospital, 70210 Kuopio, Finland
    Prog Neuropsychopharmacol Biol Psychiatry 32:229-37. 2008
    ..The effect of psychotherapy on neurotransmitter transporter functions has never been recorded in depressed subjects...
  59. ncbi request reprint Statins are effective in treating dyslipidemia among psychiatric patients using second-generation antipsychotic agents
    Kari Ojala
    Department of Forensic Psychiatry, University of Kuopio, Kuopio, Finland
    J Psychopharmacol 22:33-8. 2008
    ....
  60. ncbi request reprint Body size and violent offending among males in the Northern Finland 1966 birth cohort
    Pauliina Ikäheimo
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Kuopio, 70240, Finland
    Soc Psychiatry Psychiatr Epidemiol 42:845-50. 2007
    ..Previous literature indicates that this behavioral trait may be associated with body size. The present study investigated the association between body sizes at different ages and committing violent crimes in adulthood...
  61. ncbi request reprint Cortical dopamine D(1) receptors in type 1 and type 2 alcoholics measured with human whole hemisphere autoradiography
    Erkki Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Finland
    Psychiatry Res 162:1-9. 2008
    ....
  62. ncbi request reprint Nucleus accumbens serotonin transporters in alcoholics measured by whole-hemisphere autoradiography
    Markus Storvik
    Department of Pharmacology and Toxicology, University of Kuopio, FI 70210, Finland
    Alcohol 40:177-84. 2006
    ..These preliminary results suggest a differential monoaminergic imbalance in type 1 and 2 alcoholism in brain areas important for the regulation of motivation, reward, and reinforcement...
  63. ncbi request reprint Energy substrate metabolism among habitually violent alcoholic offenders having antisocial personality disorder
    Matti Virkkunen
    Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    Psychiatry Res 150:287-95. 2007
    ..Follow-up studies are needed to confirm if abnormal glucose and lipid metabolism can be used to predict violent offending over the course of the APD offender's life span...
  64. ncbi request reprint Amygdala serotonin transporters in alcoholics measured by whole hemisphere autoradiography
    Markus Storvik
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Kuopio, Finland
    Synapse 61:629-36. 2007
    ..These traits may be related to serotonergic regulation in the amygdala and prefrontal cortex...
  65. ncbi request reprint The consequences of Conduct Disorder for males who develop schizophrenia: associations with criminality, aggressive behavior, substance use, and psychiatric services
    Sheilagh Hodgins
    Box PO23, Department of Forensic Mental Health Science, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Schizophr Res 78:323-35. 2005
    ..The results are interpreted to suggest that CD is a distinct co-morbid disorder that runs parallel to the course of schizophrenia...
  66. ncbi request reprint Visualisation of the cortical dopamine D3 receptors in alcoholics and controls with human whole-hemisphere autoradiography
    Erkki Tupala
    Psychopharmacology (Berl) 181:412-3. 2005
  67. ncbi request reprint [Lamotrigine in clozapine treatment-resistant schizophrenia]
    Jari Tiihonen
    Helsingin yliopisto, kliininen laitos ja HYKS n psykiatrian klinikka Lapinlahden sairaala PL 320, 00029 HUS
    Duodecim 120:85-6. 2004
  68. ncbi request reprint [Neural basis of alcohol dependence]
    Kalervo Kiianmaa
    Kansanterveyslaitoksen mielenterveyden ja alkoholitutkimuksen osasto PL 33, 00251 Helsinki
    Duodecim 119:2494-500. 2003
  69. ncbi request reprint The amygdala and schizophrenia: a volumetric magnetic resonance imaging study in first-episode, neuroleptic-naive patients
    Christian C Joyal
    Institut Philippe Pinel de Montréal CCJ, Montreal, Canada
    Biol Psychiatry 54:1302-4. 2003
    ..The attempts to evaluate amygdaloid volumes using magnetic resonance imaging (MRI) in patients with schizophrenia have yielded highly divergent results...
  70. ncbi request reprint Lamotrigine in treatment-resistant schizophrenia: a randomized placebo-controlled crossover trial
    Jari Tiihonen
    Department of Psychiatry, Helsinki University Central Hospital, University of Helsinki, Finland
    Biol Psychiatry 54:1241-8. 2003
    ..The hypothesis tested was that lamotrigine is more effective than placebo in the treatment of positive schizophrenic symptoms when combined with clozapine...
  71. ncbi request reprint Dopamine D2 receptors and transporters in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography
    Erkki Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Kuopio, Finland
    Hum Brain Mapp 20:91-102. 2003
    ..Moreover, WHA provides a useful tool for detailed mapping of neuronal receptors in healthy as well as diseased brain, and can also be used in radioligand development for PET...
  72. ncbi request reprint Dopamine receptors and transporters in the brain reward circuits of type 1 and 2 alcoholics measured with human whole hemisphere autoradiography
    Erkki Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Finland
    Neuroimage 19:145-55. 2003
    ....
  73. ncbi request reprint Treatment improves serotonin transporter binding and reduces binge eating
    Liisa I Tammela
    Department of Clinical Nutrition, University of Kuopio and Kuopio University Hospital, 70211 Kuopio, Finland
    Psychopharmacology (Berl) 170:89-93. 2003
    ..Serotonin (5-HT) is involved in the control of eating behaviour by inhibiting food intake. Obese women with binge-eating disorder (OB-BED) were recently found to have reduced 5-HT transporter binding...
  74. ncbi request reprint Different effect of age on dopamine transporters in the dorsal and ventral striatum of controls and alcoholics
    Erkki Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, FIN 70240 Kuopio, Finland
    Synapse 48:205-11. 2003
    ..Furthermore, dorsal striatal DAT may be more vulnerable to age-related decline than DAT in NAC. This is supported by the notion that DAT in NAC and dorsal striatum have different molecular weights...
  75. ncbi request reprint [Personality disorders and brain imaging]
    Jari Tiihonen
    Duodecim 118:553-5. 2002
  76. ncbi request reprint Seasonal variation in specific methods of suicide: a national register study of 20,234 Finnish people
    Pirkko Räsänen
    Department of Psychiatry, University of Oulu, Peltolantie 5, FIN 90220 Oulu, Finland
    J Affect Disord 71:51-9. 2002
    ..Previous studies have suggested differences in seasonal variation of violent and non-violent suicides, but seasonal distribution of the specific methods of suicide is less clear...
  77. ncbi request reprint Total serum cholesterol level, violent criminal offences, suicidal behavior, mortality and the appearance of conduct disorder in Finnish male criminal offenders with antisocial personality disorder
    Eila Repo-Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Eur Arch Psychiatry Clin Neurosci 252:8-11. 2002
    ..The TC level seems to be a peripheral marker with prognostic value among boys with conduct disorder and antisocial male offenders...
  78. ncbi request reprint Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism
    Mikko P Laakso
    Department of Neurology, Kuopio University Hospital, 70211, Kuopio, Finland
    Psychiatry Res 114:95-102. 2002
    ..Moreover, no significant correlations between any of the volumes and the degree of psychopathy were found...
  79. ncbi request reprint Analysis of monoamine oxidase A (MAOA) promoter polymorphism in Finnish male alcoholics
    Takuya Saito
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Psychiatry Res 109:113-9. 2002
    ..Since MAOA is X-linked, the heterozygotes are probable cases of Klinefelter's syndrome (47,XXY) suggesting that X-chromosome aneuploidy may increase the risk for developing type 2 alcoholism...
  80. ncbi request reprint Brain serotonin 1A receptor binding in bulimia nervosa
    Jari Tiihonen
    Department of Psychiatry, University Hospital, University of Helsinki, Helsinki, Finland
    Biol Psychiatry 55:871-3. 2004
    ..Experimental studies suggest that the therapeutic antidepressant effect of SSRIs is mediated via 5-HT(1A) receptors. The aim of this study was to measure brain 5-HT(1A) receptor binding among nonmedicated patients with bulimia nervosa...
  81. ncbi request reprint Comorbid personality disorders and substance use disorders of mentally ill homicide offenders: a structured clinical study on dual and triple diagnoses
    Anu Putkonen
    Department of Forensic Psychiatry, University of Kuopio and Niuvanniemi Hospital, Finland
    Schizophr Bull 30:59-72. 2004
    ..The fourth possible category, "APD + MMD but no SUD," was not found. The prevention of severe violence by persons with MMD necessitates effective treatments for those with dual diagnosis who also have a history of APD...
  82. ncbi request reprint An outcome of psychodynamic psychotherapy: a case study of the change in serotonin transporter binding and the activation of the dream screen
    Pirjo Irmeli Saarinen
    Adult Psychiatry Division, Department of Psychiatry, Kuopio University Hospital, Finland
    Am J Psychother 59:61-73. 2005
    ..Normalization of SERT binding at the midbrain level was found on 12-month follow-up. Major alleviation of depressive symptoms assessed by rating scales was evident only six months after SERT normalization...
  83. ncbi request reprint Striatal dopamine D1 receptors in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography
    Erkki Tupala
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, FI 70240 Kuopio, Finland
    Brain Res 1031:20-9. 2005
    ....
  84. ncbi request reprint Reduced brain serotonin transporter binding in patients with panic disorder
    Eduard Maron
    Department of Psychiatry, University of Tartu, Raja 31, Tartu 50417, Estonia
    Psychiatry Res 132:173-81. 2004
    ..Altered function of 5-HTT appears to be related to the clinical status of patients. Clinical improvement in the patients in remission is associated with normalization of 5-HTT binding...
  85. ncbi request reprint Dopamine and alcoholism: neurobiological basis of ethanol abuse
    Erkki Tupala
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, FIN 70240 Kuopio, Finland
    Prog Neuropsychopharmacol Biol Psychiatry 28:1221-47. 2004
    ....
  86. ncbi request reprint Serotonin transporter distribution and density in the cerebral cortex of alcoholic and nonalcoholic comparison subjects: a whole-hemisphere autoradiography study
    Tuija Mantere
    Department of Forensic Psychiatry, Niuvanniemi Hospital, Kuopio, Finland
    Am J Psychiatry 159:599-606. 2002
    ....
  87. ncbi request reprint SPECT imaging of serotonin transporter binding in patients with generalized anxiety disorder
    Eduard Maron
    Dept of Psychiatry, University of Tartu, Raja 31, Tartu 50417, Estonia
    Eur Arch Psychiatry Clin Neurosci 254:392-6. 2004
    ..79, p=0.035). This study failed to demonstrate an altered functional activity of 5-HTT in patients with GAD when compared with controls...
  88. ncbi request reprint 123I-beta-CIT binding and recovery from depression. A six-month follow-up study
    Teijamari Laasonen-Balk
    Mental Health Center, Armilankatu 44, 53100 Lappeenranta, Finland
    Eur Arch Psychiatry Clin Neurosci 254:152-5. 2004
    ..12; df = 1, 14; p = 0.013). These results indicate that recovery from depression is associated with an increase in (123)I-beta-CIT binding in the midbrain...
  89. ncbi request reprint Cortical dopamine D2 receptors in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography
    Erkki Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, FIN 70240 Kuopio, Finland
    Synapse 54:129-37. 2004
    ..However, these results especially regarding aging effect must be considered as preliminary due to the different age-range of type 2 alcoholics compared to two other groups...
  90. ncbi request reprint MRI volumetry of the vermis and the cerebellar hemispheres in men with schizophrenia
    Christian C Joyal
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Kuopio, Finland
    Psychiatry Res 131:115-24. 2004
    ..However, the suggestion that schizophrenia is related to abnormal volumes of the lateral cerebellum is not supported...
  91. ncbi request reprint [Treatment for drug addiction]
    Jari Tiihonen
    Duodecim 120:1191-2. 2004
  92. ncbi request reprint [Omega-3 fatty acids, new treatment for depression]
    Antti Tanskanen
    Kuopion yliopiston psykiatrian klinikka
    Duodecim 120:2033-5. 2004
  93. ncbi request reprint Effects of venlafaxine treatment on clozapine plasma levels in schizophrenic patients
    Eila Repo-Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, FI 70240 Kuopio, Finland
    Neuropsychobiology 51:173-6. 2005
    ..Low to moderate doses of venlafaxine did not seem to have any significant effect on clozapine plasma levels...
  94. ncbi request reprint A volumetric MRI study of the entorhinal cortex in first episode neuroleptic-naive schizophrenia
    Christian C Joyal
    Institut Philippe Pinel de Montreal, Montreal, Canada
    Biol Psychiatry 51:1005-7. 2002
    ..Imaging studies have frequently reported volume loss of limbic structures in schizophrenia, yet there appears to be no quantitative data on entorhinal cortex volumes in patients with neuroleptic naive first-episode schizophrenia...
  95. ncbi request reprint Use of statistical techniques in studies of suicide seasonality, 1970 to 1997
    Helinä Hakko
    Department of Psychiatry at the University of Oulu, Finland
    Suicide Life Threat Behav 32:191-208. 2002
    ..The calendar effect was adjusted only in 11 studies. Some recommendations concerning the methodological and reporting issues are summarized for future articles on the seasonal affect on suicides...
  96. ncbi request reprint Is occupation relevant in suicide?
    Outi Koskinen
    Kuopio University Hospital, Department of Psychiatry, P O B 1777, FIN 70211, Kuopio, Finland
    J Affect Disord 70:197-203. 2002
    ..Particularly the amount of occupational outdoor exposure could show differences in the distribution of suicides by season and the selection of suicide method, in addition to age at the time of death...
  97. ncbi request reprint Distribution of 5-HT7 receptors in the human brain: a preliminary autoradiographic study using [3H]SB-269970
    Katarina Varnas
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176 Stockholm, Sweden
    Neurosci Lett 367:313-6. 2004
    ..The distribution pattern obtained in this study supports the involvement of this receptor subtype in affective behavior and cognition...
  98. ncbi request reprint Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis
    Harri J Tuominen
    Department of Psychiatry, University of Helsinki, P O Box 320, FIN 00029 Helsinki University Central Hospital, Finland
    Schizophr Res 72:225-34. 2005
    ..To evaluate the efficacy of glutamatergic drugs, acting agonistically on the N-methyl-D-aspartate (NMDA) or the non-NMDA receptors, in schizophrenia...
  99. doi request reprint Association of serotonin transporter promoter regulatory region polymorphism and cerebral activity to visual presentation of food
    Salla Kaurijoki
    Department of Clinical Nutrition, University of Kuopio, Finland
    Clin Physiol Funct Imaging 28:270-6. 2008
    ..These results demonstrate the possible genetically driven variation in the response of the left PCC to visual presentation of food in humans...