I Thesleff

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth
    Xiu Ping Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Dyn 231:98-108. 2004
  2. ncbi request reprint Tooth morphogenesis and cell differentiation
    I Thesleff
    Institute of Biotechnology, PO Box 56, FIN 00014 University of Helsinki, Finland
    Curr Opin Cell Biol 8:844-50. 1996
  3. ncbi request reprint Developmental biology and building a tooth
    Irma Thesleff
    Developmental Biology Programme, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Quintessence Int 34:613-20. 2003
  4. ncbi request reprint Molecular regulation of tooth development
    I Thesleff
    Developmental Biology Program, Institute of Biotechnology, Vikki Biocenter, University of Helsinki, Finland
    Bone 25:123-5. 1999
  5. ncbi request reprint Stem cells and tissue engineering: prospects for regenerating tissues in dental practice
    Irma Thesleff
    Developmental Biology Research Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki, Finland
    Med Princ Pract 12:43-50. 2003
  6. ncbi request reprint Death receptor signaling giving life to ectodermal organs
    Irma Thesleff
    Developmental Biology Program, Insitute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, 00014 Helsinki, Finland
    Sci STKE 2002:pe22. 2002
  7. ncbi request reprint Epithelial-mesenchymal signalling regulating tooth morphogenesis
    Irma Thesleff
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    J Cell Sci 116:1647-8. 2003
  8. ncbi request reprint Signalling networks regulating dental development
    I Thesleff
    Institute of Biotechnology, University of Helsinki, Finland
    Mech Dev 67:111-23. 1997
  9. ncbi request reprint The genetic basis of tooth development and dental defects
    Irma Thesleff
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Am J Med Genet A 140:2530-5. 2006
  10. ncbi request reprint Regulation of epithelial stem cells in tooth regeneration
    Irma Thesleff
    Developmental Biology Program, Institute of Biotechnology, P O Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    C R Biol 330:561-4. 2007

Detail Information

Publications120 found, 100 shown here

  1. ncbi request reprint Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth
    Xiu Ping Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Dyn 231:98-108. 2004
    ..We propose that finely tuned antagonistic effects between follistatin and TGF beta superfamily signals are critical for enamel knot formation and function, as well as for patterning of tooth cusps...
  2. ncbi request reprint Tooth morphogenesis and cell differentiation
    I Thesleff
    Institute of Biotechnology, PO Box 56, FIN 00014 University of Helsinki, Finland
    Curr Opin Cell Biol 8:844-50. 1996
    ..It has recently become evident that the signaling networks that operate in the development of mammalian teeth are similar to those that are involved in the development of other vertebrate organs...
  3. ncbi request reprint Developmental biology and building a tooth
    Irma Thesleff
    Developmental Biology Programme, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Quintessence Int 34:613-20. 2003
    ..It is also possible that by combining the knowledge of molecular regulation of tooth development with the recent breakthroughs in stem cell research, dreams of building new teeth in dental practice may come true in the future...
  4. ncbi request reprint Molecular regulation of tooth development
    I Thesleff
    Developmental Biology Program, Institute of Biotechnology, Vikki Biocenter, University of Helsinki, Finland
    Bone 25:123-5. 1999
  5. ncbi request reprint Stem cells and tissue engineering: prospects for regenerating tissues in dental practice
    Irma Thesleff
    Developmental Biology Research Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki, Finland
    Med Princ Pract 12:43-50. 2003
    ..This information is already being used for the generation of dentoalveolar tissues in vitro and in vivo. Could we perhaps grow new enamel, dentine, periodontal ligament, bone, or even whole new teeth for our patients in the future?..
  6. ncbi request reprint Death receptor signaling giving life to ectodermal organs
    Irma Thesleff
    Developmental Biology Program, Insitute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, 00014 Helsinki, Finland
    Sci STKE 2002:pe22. 2002
    ..It is also necessary for the development of fish scales, indicating that this pathway and its function have been conserved during the evolution of ectodermal organs...
  7. ncbi request reprint Epithelial-mesenchymal signalling regulating tooth morphogenesis
    Irma Thesleff
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    J Cell Sci 116:1647-8. 2003
  8. ncbi request reprint Signalling networks regulating dental development
    I Thesleff
    Institute of Biotechnology, University of Helsinki, Finland
    Mech Dev 67:111-23. 1997
    ....
  9. ncbi request reprint The genetic basis of tooth development and dental defects
    Irma Thesleff
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Am J Med Genet A 140:2530-5. 2006
    ..Necessary functions of many signals, receptors and transcription factors have been demonstrated in mice, and mutations causing dental defects in humans have been identified in several genes...
  10. ncbi request reprint Regulation of epithelial stem cells in tooth regeneration
    Irma Thesleff
    Developmental Biology Program, Institute of Biotechnology, P O Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    C R Biol 330:561-4. 2007
    ..In addition, subtle variations in this or in related regulatory networks may explain the different regenerative capacities of various organs and animal species...
  11. ncbi request reprint Enamel knots as signaling centers linking tooth morphogenesis and odontoblast differentiation
    I Thesleff
    Developmental Biology Program, Institute of Biotechnology, Vlikki Biocenter, 00014 University of Helsinki, Finland
    Adv Dent Res 15:14-8. 2001
    ..We suggest that the enamel knots are central regulators of tooth development, since they link cell differentiation to morphogenesis...
  12. ncbi request reprint Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF
    J Pispa
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Biol 216:521-34. 1999
    ..Instead FGF-10 partially restored morphogenesis and stimulated the development of additional tooth cusps in cultured Tabby molars...
  13. ncbi request reprint TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis
    J Laurikkala
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 229:443-55. 2001
    ..This is the first demonstration of integration of the Wnt, activin, and TNF signaling pathways...
  14. ncbi request reprint Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis
    Thomas Aberg
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 270:76-93. 2004
    ..We conclude that Runx2 mediates the functions of epithelial FGF signals regulating Fgf3 expression in the dental mesenchyme and that Fgf3 may be a direct target gene of Runx2...
  15. ncbi request reprint The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot
    J Jernvall
    Institute of Biotechnology, University of Helsinki, Finland
    Development 125:161-9. 1998
    ..These results show that the life history of the enamel knot is intimately linked to the initiation of tooth shape development and support the role of the enamel knot as an embryonic signaling center...
  16. ncbi request reprint Gene expression patterns associated with suppression of odontogenesis in mouse and vole diastema regions
    S V Keränen
    Developmental Biology Program, Institute of Biotechnology, Biocenter 1, University of Helsinki, P O Box 56, Helsinki, FIN 00014, Finland
    Dev Genes Evol 209:495-506. 1999
    ..However, based on earlier tissue recombination experiments it is conceivable that the developmental arrest is determined by the early oral epithelium...
  17. ncbi request reprint The enamel knot as a signaling center in the developing mouse tooth
    A Vaahtokari
    Institute of Dentistry, University of Helsinki, Finland
    Mech Dev 54:39-43. 1996
    ..We suggest that the enamel knot acts as a signaling or organizing center, which provides positional information for tooth morphogenesis and regulates the growth of tooth cusps...
  18. ncbi request reprint Apoptosis in murine calvarial bone and suture development
    D P Rice
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    Eur J Oral Sci 107:265-75. 1999
    ....
  19. ncbi request reprint FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development
    H J Kim
    Institute of Biotechnology, University of Helsinki, Finland
    Development 125:1241-51. 1998
    ..Signals from the dura mater may regulate the maintenance of sutural patency prenatally, whereas signals in the osteogenic fronts dominate after birth...
  20. ncbi request reprint Neurturin mRNA expression suggests roles in trigeminal innervation of the first branchial arch and in tooth formation
    K Luukko
    Program of Developmental Biology, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 213:207-19. 1998
    ..In addition, although NTN appears not to be directly involved in the regulation of tooth morphogenesis, it may have non-neuronal, organogenetic functions during tooth formation...
  21. ncbi request reprint Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth
    X P Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, PO Box 56, FIN 00014, University of Helsinki, Finland
    J Dent Res 84:138-43. 2005
    ..Similar buds were also present in Runx2 heterozygotes, and they may represent the extension of dental lamina for successional teeth. The results suggest that Runx2 prevents the formation of Shh-expressing buds for successional teeth...
  22. ncbi request reprint Expression and function of FGFs-4, -8, and -9 suggest functional redundancy and repetitive use as epithelial signals during tooth morphogenesis
    P Kettunen
    Developmental Biology Programme, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 211:256-68. 1998
    ..The coexpression of Fgfs with other signaling molecules including Shh and several Bmps and their partly similar effects suggest that the FGFs participate in the signaling networks during odontogenesis...
  23. ncbi request reprint Tenascin-C in developing mouse teeth: expression of splice variants and stimulation by TGFbeta and FGF
    C Sahlberg
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Eur J Oral Sci 109:114-24. 2001
    ..We conclude that several splice forms are expressed during mouse tooth development, and that TGFbeta- and FGF-family growth factors may act as epithelial signals inducing tenascin expression in the dental mesenchyme...
  24. ncbi request reprint Integration of FGF and TWIST in calvarial bone and suture development
    D P Rice
    Institute of Biotechnology and Institute of Dentistry, PO Box 56, Finland
    Development 127:1845-55. 2000
    ..We propose a model of osteoblast differentiation integrating Twist and FGF in the same pathway, in which FGF acts both at early and late stages. Disruption of this pathway may lead to craniosynostosis...
  25. ncbi request reprint Molecular mechanisms of cell and tissue interactions during early tooth development
    I Thesleff
    Institute of Dentistry, University of Helsinki, Finland
    Anat Rec 245:151-61. 1996
    ..The developing tooth is one of the organs in which the molecular mechanisms of such interactions are starting to be elucidated...
  26. ncbi request reprint Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development
    S Vainio
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Cell 75:45-58. 1993
    ..In addition, BMP-4 induced its own mesenchymal expression. These findings support the hypothesis that BMP-4 mediates epithelial-mesenchymal interactions during early tooth development...
  27. ncbi request reprint Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis
    P Kettunen
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Dyn 219:322-32. 2000
    ..The dynamic expression patterns of different Fgfs in dental epithelium and mesenchyme and their interactions suggest existence of regulatory signaling cascades between epithelial and mesenchymal FGFs during tooth development...
  28. ncbi request reprint Tooth morphogenesis and the differentiation of ameloblasts
    I Thesleff
    Institute of Biotechnology, University of Helsinki, Finland
    Ciba Found Symp 205:3-12; discussion 12-7. 1997
    ..However, the molecular nature of the signals regulating the advancing specialization of the cells in the ameloblast cell lineage remains unknown...
  29. ncbi request reprint Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene
    J Jernvall
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Int J Dev Biol 38:463-9. 1994
    ..Based on these results, we suggest that the enamel knot may control tooth morphogenesis by concurrently stimulating cusp growth (via FGF-4 synthesis) and by directing folding of cusp slopes (by not proliferating itself)...
  30. pmc Midkine (MK), a heparin-binding growth/differentiation factor, is regulated by retinoic acid and epithelial-mesenchymal interactions in the developing mouse tooth, and affects cell proliferation and morphogenesis
    T A Mitsiadis
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    J Cell Biol 129:267-81. 1995
    ..g., salivary gland, kidney) was unaffected. These results suggest important roles for MK in the molecular cascade that regulates tooth development...
  31. ncbi request reprint Association of developmental regulatory genes with the development of different molar tooth shapes in two species of rodents
    S V Keränen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocentre, P O Box 56, University of Helsinki, FIN 00014, Finland
    Dev Genes Evol 208:477-86. 1998
    ....
  32. ncbi request reprint Signaling and subcellular localization of the TNF receptor Edar
    P Koppinen
    Developmental Biology Program, University of Helsinki, Helsinki, 00014, Finland
    Exp Cell Res 269:180-92. 2001
    ..This together with differences in NF-kappaB responses suggests an explanation for the different mode of inheritance of the different downless alleles...
  33. ncbi request reprint Timp-1, -2 and -3 show coexpression with gelatinases A and B during mouse tooth morphogenesis
    C Sahlberg
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Eur J Oral Sci 107:121-30. 1999
    ....
  34. ncbi request reprint Responsiveness of developing dental tissues to fibroblast growth factors: expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9
    P Kettunen
    Developmental Biology Programme, University of Helsinki, Finland
    Dev Genet 22:374-85. 1998
    ..Finally, the intense expression of FGFR1 in odontoblasts and ameloblasts and FGFR2 IIIb in ameloblasts suggests that FGFs participate in regulation of their differentiation and/or secretory functions...
  35. ncbi request reprint Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae
    H S Jung
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocentre, P O Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Mech Dev 81:179-82. 1999
    ..We conclude that these conserved signalling molecules are associated with the initiation and early morphogenesis of the tongue papillae...
  36. ncbi request reprint Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice
    R N D'Souza
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, FIN 00014 University of Helsinki, Finland
    Development 126:2911-20. 1999
    ....
  37. ncbi request reprint Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation
    T Aberg
    Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 210:383-96. 1997
    ..The remarkable overlaps in the expression domains of different Bmp genes may implicate functional redundancy and/or formation of active heterodimers between different BMPs...
  38. ncbi request reprint Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar
    Johanna Laurikkala
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Development 129:2541-53. 2002
    ..In conclusion, we suggest that Eda and Edar are associated with the onset of ectodermal patterning and that ectodysplasin/edar signaling also regulates the morphogenesis of hair follicles...
  39. ncbi request reprint Molecular mechanisms in calvarial bone and suture development, and their relation to craniosynostosis
    David P C Rice
    Developmental Biology Programme, Institute of Biotechnology, and Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    Eur J Orthod 25:139-48. 2003
    ..The microdissection and in vitro culture techniques have begun the task of identifying Fgfrs, Msx2, and Twist interacting in intricate signalling pathways that if disrupted could lead to craniosynostosis...
  40. pmc Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate
    T A Mitsiadis
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    J Cell Biol 130:407-18. 1995
    ..These data suggest that Notch genes may be involved in mediating some of the biological effects of retinoic acid during normal development and after teratogenic exposure...
  41. pmc Evolutionary modification of development in mammalian teeth: quantifying gene expression patterns and topography
    J Jernvall
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Post Office Box 56 Viikinkaariq, FIN 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 97:14444-8. 2000
    ..The diversity of mammalian molar patterns may largely result from the heterotopic and iterative processes...
  42. ncbi request reprint FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis
    U Pirvola
    Institute of Biotechnology and Department of Otorhinolaryngology, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 20:6125-34. 2000
    ..Our findings provide genetic evidence that signaling by FGFR-2(IIIb) is critical for the morphological development of the inner ear...
  43. ncbi request reprint Modulation of epithelial cell fate of the root in vitro
    M Tummers
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, PO Box 56, FIN 00014, Helsinki, Finland
    J Dent Res 86:1063-7. 2007
    ..We conclude that the fate of the epithelium is regulated by external cues influenced by culture conditions, and that the molar has the intrinsic capacity to grow continuously...
  44. ncbi request reprint Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth
    A K Jowett
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Development 117:461-70. 1993
    ..We conclude that expression of msx 1 in jaw mesenchyme requires a non-specific epithelial signal, whereas msx 2 expression in either epithelium or mesenchyme requires reciprocal interactions between specialized dental cell populations...
  45. ncbi request reprint Apoptosis in the developing tooth: association with an embryonic signaling center and suppression by EGF and FGF-4
    A Vaahtokari
    Institute of Biotechnology, University of Helsinki, Finland
    Development 122:121-9. 1996
    ..The apical ectodermal ridge (AER) of the limb bud has similar signaling characteristics as the enamel knot, and it also undergoes apoptosis. Hence, apoptosis may be a general mechanism for the silencing of embryonic signaling centers...
  46. ncbi request reprint Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot
    Johanna Laurikkala
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 264:91-105. 2003
    ....
  47. doi request reprint Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation
    Katja Närhi
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN 00014, Helsinki, Finland
    Development 135:1019-28. 2008
    ..Our data suggest that BMPs are downstream of Wnt/beta-catenin and that their interplay may be a critical component in establishing correct patterning of hair follicles through the reaction-diffusion mechanism...
  48. ncbi request reprint Phenotypic changes in dentition of Runx2 homozygote-null mutant mice
    Thomas Aberg
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    J Histochem Cytochem 52:131-9. 2004
    ..These data support the hypothesis that Runx2 is one of the key mesenchymal factors that influences tooth morphogenesis and the subsequent differentiation of ameloblasts and odontoblasts...
  49. ncbi request reprint Expression of bone morphogenetic proteins and Msx genes during root formation
    T Yamashiro
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, PO Box 56, FIN 00014 University of Helsinki, Finland
    J Dent Res 82:172-6. 2003
    ..Msx2 expression continued in the epithelial cell rests of Malassez, and the nearby cementoblasts intensely expressed Bmp3, which may regulate some functions of the fragmented epithelium...
  50. ncbi request reprint Neurotrophin mRNA expression in the developing tooth suggests multiple roles in innervation and organogenesis
    K Luukko
    Program of Developmental Biology, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 210:117-29. 1997
    ..In addition, the expression patterns of NGF, NT-3, and NT-4/5 as well as of neurotrophin receptors suggest that the neurotrophin system may also serve non-neuronal functions during tooth development...
  51. ncbi request reprint Reiterative signaling and patterning during mammalian tooth morphogenesis
    J Jernvall
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, P O Box 56, 00014, University of Helsinki, Helsinki, Finland
    Mech Dev 92:19-29. 2000
    ..Spatiotemporal induction of the secondary enamel knots determines the cusp patterns of individual teeth and is likely to involve repeated activation and inhibition of signaling as suggested for patterning of other epithelial organs...
  52. ncbi request reprint Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis
    T A Mitsiadis
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Development 121:37-51. 1995
    ....
  53. ncbi request reprint Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion
    M L Mikkola
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Helsinki, Finland
    Mech Dev 88:133-46. 1999
    ..Ectodysplasin is the first TNF-like signaling molecule described known to be required for epithelial morphogenesis...
  54. ncbi request reprint Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth
    Tuija Mustonen
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki FIN 00014, Finland
    Dev Biol 248:281-93. 2002
    ..We conclude that Lunatic fringe may play a role in boundary formation of the enamel knot and that Notch-signaling in the dental epithelium is regulated by mesenchymal FGFs and BMP...
  55. ncbi request reprint Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation
    Xiu Ping Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    Dev Cell 7:719-30. 2004
    ....
  56. ncbi request reprint Changes in the distribution of tenascin during tooth development
    I Thesleff
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Development 101:289-96. 1987
    ..It can be speculated that the remarkable expression of tenascin in the dental mesenchymal cells as compared to other connective tissues is associated with their capacity to differentiate into hard-tissue-forming cells...
  57. doi request reprint Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells
    Marika Suomalainen
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Dyn 239:364-72. 2010
    ..We conclude that epithelial stem cells in the mouse incisors are not regulated directly by Wnt/beta-catenin signaling...
  58. ncbi request reprint Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression
    Marja Pummila
    Institute of Biotechnology, Developmental Biology Program, University of Helsinki, 00014 Helsinki, Finland
    Development 134:117-25. 2007
    ..Moreover, our data indicate that Shh is a likely transcriptional target of Edar, but, unlike noggin, recombinant Shh was unable to rescue primary hair placode formation in Eda-deficient skin explants...
  59. ncbi request reprint Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages
    Tuija Mustonen
    Developmental Biology Program, Institute of Biotechnology, PO Box 56 Viikinkaari 9, University of Helsinki, Finland
    Development 131:4907-19. 2004
    ..Taken together, our results suggest that Eda-A1 signalling promotes placodal cell fate during early development of ectodermal organs...
  60. doi request reprint Novel Golgi protein, GoPro49, is a specific dental follicle marker
    M S Takatalo
    University of Helsinki, Department of Biological and Environmental Sciences, Division of Biochemistry, P O Box 56 Viikinkaari 5D, University of Helsinki FIN 00014, Finland
    J Dent Res 88:534-8. 2009
    ..Abbreviations: Bsp1, bone sialoprotein 1; GoPro49, Golgi protein 49 kDa; E16, embryonic day 16; HERS, Hertwig's epithelial root sheath; PDL, periodontal ligament; dpn, day post-natal...
  61. ncbi request reprint Associations between transforming growth factor beta 1 RNA expression and epithelial-mesenchymal interactions during tooth morphogenesis
    A Vaahtokari
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Development 113:985-94. 1991
    ..Thus, TGF-beta 1 RNA expression seems to be regulated by epithelial-mesenchymal interactions...
  62. ncbi request reprint The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats
    M Bayes
    Department of Medical Genetics, Haartman Institute, PO Box 21, University of Helsinki, 00014 Helsinki, Finland
    Hum Mol Genet 7:1661-9. 1998
    ..Our results will allow mutation diagnostics in the majority of patients...
  63. ncbi request reprint Laminin gamma2 expression is developmentally regulated during murine tooth morphogenesis and is intense in ameloblasts
    C Sahlberg
    Institute of Biotechnology, University of Helsinki, Finland
    J Dent Res 77:1589-96. 1998
    ....
  64. ncbi request reprint Characteristics of incisor-premolar hypodontia in families
    S Arte
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    J Dent Res 80:1445-50. 2001
    ..We conclude that incisor-premolar hypodontia is a genetic condition with autosomal-dominant transmission and that it is associated with several other dental abnormalities...
  65. ncbi request reprint Foxc1 integrates Fgf and Bmp signalling independently of twist or noggin during calvarial bone development
    Ritva Rice
    Developmental Biology Programme, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 233:847-52. 2005
    ..Our findings indicate that Foxc1 integrates the Bmp and Fgf signalling pathways independently of Twist or Noggin. This signalling network is essential for the correct patterning and growth of calvarial bones...
  66. ncbi request reprint MSX1 gene is deleted in Wolf-Hirschhorn syndrome patients with oligodontia
    P Nieminen
    Institute of Dentistry, Biomedicum, PO Box 63, FIN 00014 University of Helsinki, Finland
    J Dent Res 82:1013-7. 2003
    ..One of these presented with the only case of cleft palate among the patients. Our result confirms that haploinsufficiency for MSX1 serves as a mechanism that causes selective tooth agenesis but, alone, is not enough to cause oral clefts...
  67. ncbi request reprint Affecting tooth morphology and renewal by fine-tuning the signals mediating cell and tissue interactions
    Irma Thesleff
    Developmental Biology Research Program, Institute of Biotechnology, POB 56, 00014 University of Helsinki, Finland
    Novartis Found Symp 284:142-53; discussion 153-63. 2007
    ..These findings support the suggestions that tinkering with the signal pathways is the key mechanism underlying the morphological evolution of teeth as well as other organs...
  68. ncbi request reprint p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation
    Johanna Laurikkala
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 133:1553-63. 2006
    ..We also demonstrate that BMP2, BMP7 and FGF10 are potent inducers of p63 in cultured tissue explants. Hence, we suggest that p63 regulates the morphogenesis of surface ectoderm and its derivatives via multiple signalling pathways...
  69. ncbi request reprint Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development
    Takashi Yamashiro
    Institute of Biotechnology, University of Helsinki, 00014, Helsinki, Finland
    Gene Expr Patterns 2:109-12. 2002
    ..Unlike Runx2, Runx3 was expressed in odontoblasts. However, Runx3 mutant mice did not show obvious tooth phenotype or deviations of Runx1 and Runx2 expression patterns in the tooth...
  70. ncbi request reprint The role of growth factors in tooth development
    Irma Thesleff
    Developmental Biology Research Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Int Rev Cytol 217:93-135. 2002
    ..Many targets of the growth factors have been identified, and mutations in several genes within the signaling networks cause defective tooth formation in both humans and mice...
  71. ncbi request reprint A graphical WWW-database on gene expression in tooth
    P Nieminen
    Institute of Biotechnology, University of Helsinki, Finland
    Eur J Oral Sci 106:7-11. 1998
    ..The pages also provide links to other biological databases on the Internet, both as context-dependent and as general links. We welcome submissions from researches elsewhere to include their information of gene expression and function...
  72. ncbi request reprint Association between the expression of murine 72 kDa type IV collagenase by odontoblasts and basement membrane degradation during mouse tooth development
    C Sahlberg
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Arch Oral Biol 37:1021-30. 1992
    ....
  73. ncbi request reprint Identification of a nonsense mutation in the PAX9 gene in molar oligodontia
    P Nieminen
    Institute of Biotechnology, University of Helsinki, Finland
    Eur J Hum Genet 9:743-6. 2001
    ..The phenotype is presumably a consequence of haploinsufficiency of PAX9. In another Finnish family with molar tooth agenesis, we could not find similar sequence changes in PAX9...
  74. ncbi request reprint Developmental regulation and ultrastructure of glycogen deposits during murine tooth morphogenesis
    H Ohshima
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Cell Tissue Res 297:271-81. 1999
    ..These may be associated with the exocytosis of glycosaminoglycan components into extracellular spaces and the formation of the stellate reticulum...
  75. ncbi request reprint Tooth patterning and enamel formation can be manipulated by misexpression of TNF receptor Edar
    Johanna Pispa
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki, Finland
    Dev Dyn 231:432-40. 2004
    ..In addition, tooth enamel formation is defective in a dose-dependent manner. We speculate that the tooth patterning defects are caused by ectopic Edar activity outside the signaling centers...
  76. pmc An integrated gene regulatory network controls stem cell proliferation in teeth
    Xiu Ping Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    PLoS Biol 5:e159. 2007
    ..Subtle variations in this or related regulatory networks may explain the different regenerative capacities of various organs and animal species...
  77. ncbi request reprint Stimulation of ectodermal organ development by Ectodysplasin-A1
    Tuija Mustonen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 259:123-36. 2003
    ..We conclude that ectodysplasin-Edar signaling has several roles in ectodermal organ development controlling their initiation, as well as morphogenesis and differentiation...
  78. doi request reprint Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development
    Johanna Pispa
    Developmental Biology Program, Institute of Biotechnology, 00014 University of Helsinki, PO Box 56, Finland
    Hum Mol Genet 17:3380-91. 2008
    ....
  79. ncbi request reprint Expression of GDNF and its receptors in developing tooth is developmentally regulated and suggests multiple roles in innervation and organogenesis
    K Luukko
    Program of Developmental Biology, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 210:463-71. 1997
    ..Taken together, these results suggest that GDNF acts as a target-derived neurotrophic factor during tooth innervation. In addition, GDNF and its receptors may have nonneuronal organogenetic functions during tooth morphogenesis...
  80. ncbi request reprint Expression of type I collagen pro-alpha 2 chain mRNA in adult human permanent teeth as revealed by in situ hybridization
    P L Lukinmaa
    Department of Dental Radiology Oral Pathology, University of Helsinki, Finland
    J Dent Res 71:36-42. 1992
    ....
  81. ncbi request reprint Chondrogenic potential of mouse calvarial mesenchyme
    Thomas Aberg
    Developmental Biology Programme, Institute of Biotechnology, PO Box 56, FIN 00014, University of Helsinki, Finland
    J Histochem Cytochem 53:653-63. 2005
    ..Only cartilage formed in 4%, and both cartilage and bone formed in 4%. Our study confirms that calvarial mesenchyme, which normally gives rise to intramembranous bone, also has chondrogenic potential...
  82. doi request reprint Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes
    Ingrid Fliniaux
    Institute of Biotechnology, Developmental Biology Program, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 320:60-71. 2008
    ..Several pieces of evidence suggest Lrp4 as a Wnt inhibitor, as well. The finding that Eda-A1 induces placode inhibitors was unexpected, and underlines the importance of delicate fine-tuning of signalling during placode formation...
  83. ncbi request reprint Nonindependence of mammalian dental characters
    Aapo T Kangas
    Developmental Biology Program, Institute of Biotechnology, PO Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Nature 432:211-4. 2004
    ..Our results suggest that most aspects of tooth shape have the developmental potential for correlated changes during evolution which may, if not taken into account, obscure phylogenetic history...
  84. pmc Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling
    Elina Järvinen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, P O Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 103:18627-32. 2006
    ..These results may implicate Wnt signaling in tooth renewal, a capacity that was all but lost when mammals evolved progressively more complicated tooth shapes...
  85. ncbi request reprint Detection of gelatinase B expression reveals osteoclastic bone resorption as a feature of early calvarial bone development
    D P Rice
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    Bone 21:479-86. 1997
    ..We conclude that gelatinase B may have a key role during early bone formation, the regulation of bone modeling, and perhaps in the maintenance of suture width...
  86. ncbi request reprint Fgfr mRNA isoforms in craniofacial bone development
    D P C Rice
    Developmental Biology Programme, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Bone 33:14-27. 2003
    ..Fgfr4 transcripts were found in developing muscles. These data help to explain the disturbances in craniofacial growth exhibited by both patients and the growing number of transgenic mice carrying mutations in genes encoding FGFRs/Fgfrs...
  87. ncbi request reprint Transient and recurrent expression of the Egr-1 gene in epithelial and mesenchymal cells during tooth morphogenesis suggests involvement in tissue interactions and in determination of cell fate
    I Karavanova
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Mech Dev 39:41-50. 1992
    ..No wt-1 expression was detected at any stage of tooth development showing that wt-1 is not obligatory for regulation of Egr-1 expression...
  88. doi request reprint The importance of signal pathway modulation in all aspects of tooth development
    Mark Tummers
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Exp Zool B Mol Dev Evol 312:309-19. 2009
    ..All these findings support the hypothesis that the diversity of tooth types and dental patterns may have resulted from tinkering with the conserved signal pathways, organized into complex networks, during evolution...
  89. doi request reprint Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction
    Pauliina M Munne
    Developmental Biology Program, Institute of Biotechnology, PO Box 56, University of Helsinki, FIN 00014, Helsinki, Finland
    Development 136:393-402. 2009
    ..Considering the role of mesenchyme in tooth induction and the design of tissue engineering protocols, our work may have uncovered how delicate control of tissue quantities alone influences the outcome between induction and inhibition...
  90. doi request reprint The taming of the shrew milk teeth
    Elina Järvinen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    Evol Dev 10:477-86. 2008
    ....
  91. doi request reprint Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs
    Frederic Michon
    Institute of Biotechnology, Developmental Biology Program, PO Box 56, University of Helsinki, FIN 00014, Helsinki, Finland
    Dev Biol 340:355-68. 2010
    ..Based on our findings we suggest that miRNAs modulate tooth morphogenesis largely by fine tuning conserved signaling networks and that miRNAs may have played important roles during tooth evolution...
  92. doi request reprint Observations on continuously growing roots of the sloth and the K14-Eda transgenic mice indicate that epithelial stem cells can give rise to both the ameloblast and root epithelium cell lineage creating distinct tooth patterns
    Mark Tummers
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Evol Dev 10:187-95. 2008
    ..ERM, can be regulated independently from the regulation of stem cell maintenance. This developmental flexibility may underlie the developmental and evolutionary diversity in tooth patterning...
  93. ncbi request reprint Different roles of Runx2 during early neural crest-derived bone and tooth development
    Martyn J James
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    J Bone Miner Res 21:1034-44. 2006
    ..In vitro experiments determined that Runx2 is a part of the FGF and BMP signaling pathways in tooth and bone development, respectively...
  94. doi request reprint Expression of the novel Golgi protein GoPro49 is developmentally regulated during mesenchymal differentiation
    Maarit Takatalo
    Department of Biological and Environmental Sciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland
    Dev Dyn 237:2243-55. 2008
    ..This is the first time a Golgi membrane protein is shown to be expressed in a developmentally regulated manner during mesenchymal and cartilage development in mammals...
  95. ncbi request reprint Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4
    Ritva Rice
    Developmental Biology Programme, Institute of Biotechnology, P O Box 56, 00014 University of Helsinki, Finland
    Dev Biol 262:75-87. 2003
    ..We therefore suggest that Foxc1 regulates BMP-mediated osteoprogenitor proliferation and that this regulation is required for the progression of osteogenesis beyond the initial condensations in calvarial bone development...
  96. ncbi request reprint Developmental toxicity of dioxin to mouse embryonic teeth in vitro: arrest of tooth morphogenesis involves stimulation of apoptotic program in the dental epithelium
    Anna Maija Partanen
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, FIN 00014 Helsinki, Finland
    Toxicol Appl Pharmacol 194:24-33. 2004
    ..TCDD interferes with tooth development by stimulating apoptosis in those cells of the dental epithelium, which are predetermined to undergo apoptosis during normal development...
  97. ncbi request reprint Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis
    Johanna Pispa
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Gene Expr Patterns 3:675-9. 2003
    ..We also studied the expression pattern of a related TNF receptor, TNFRSF19, and show that it is expressed in an overlapping domain with Edar in the tooth, mammary gland, whiskers, and limb bud suggesting a potentially redundant role...
  98. ncbi request reprint Ectodysplasin signaling in development
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, PO Box 56, Helsinki 00014, Finland
    Cytokine Growth Factor Rev 14:211-24. 2003
    ....
  99. ncbi request reprint A missense mutation in PAX9 in a family with distinct phenotype of oligodontia
    Laura Lammi
    Institute of Dentistry, University of Helsinki, Finland
    Eur J Hum Genet 11:866-71. 2003
    ..A mutation of the homologous arginine of PAX6 has been shown to affect the target DNA specificity of PAX6. We suggest that a similar mechanism explains these distinct oligodontia phenotypes...
  100. ncbi request reprint Bono1: a gene associated with regions of deposition of bone and dentine
    Martyn J James
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN 00014 Helsinki, Finland
    Gene Expr Patterns 4:595-9. 2004
    ..In secretory odontoblasts, Bono1 was shown to be co-expressed with Dentin sialophosphoprotein (DSPP). In summary, Bono1 was expressed in functional osteoblasts and odontoblasts and was associated with regions of matrix mineralization...
  101. ncbi request reprint Root or crown: a developmental choice orchestrated by the differential regulation of the epithelial stem cell niche in the tooth of two rodent species
    Mark Tummers
    Institute of Biotechnology, Viikki Biocenter, FIN 00014 University of Helsinki, Finland
    Development 130:1049-57. 2003
    ..The regulation of the epithelial stem cell niche seems to be flexible allowing for the existence of different tooth types, such as continuously growing teeth, and high and low crowned molars...