S Syrjanen

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. pmc Prevalence, genotype distribution and persistence of human papillomavirus in oral mucosa of women: a six-year follow-up study
    Jaana Rautava
    Department of Oral Pathology, Institute of Dentistry, and MediCity Research Laboratory, Faculty of Medicine, University of Turku, Turku, Finland
    PLoS ONE 7:e42171. 2012
  2. doi request reprint Human papillomavirus 16 E2-, E6- and E7-specific T-cell responses in children and their mothers who developed incident cervical intraepithelial neoplasia during a 14-year follow-up of the Finnish Family HPV cohort
    Hanna Mari Koskimaa
    MediCity Research Laboratory and Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland
    J Transl Med 12:44. 2014
  3. pmc Incident cervical infections with high- and low-risk human papillomavirus (HPV) infections among mothers in the prospective Finnish Family HPV Study
    Karolina Louvanto
    MediCity Research Laboratory and Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, 20520 Turku, Finland
    BMC Infect Dis 11:179. 2011
  4. ncbi request reprint Clearance of high-risk human papillomavirus (HPV) DNA and PAP smear abnormalities in a cohort of women subjected to HPV screening in the New Independent States of the former Soviet Union (the NIS cohort study)
    S Syrjanen
    Department of Oral Pathology, Institute of Dentistry, and MediCity Research Laboratory, University of Turku 2, FIN 20520 Turku, Finland
    Eur J Obstet Gynecol Reprod Biol 119:219-27. 2005
  5. ncbi request reprint Human papillomavirus infections and oral tumors
    Stina Syrjanen
    Department of Oral Pathology and Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Finland
    Med Microbiol Immunol 192:123-8. 2003
  6. ncbi request reprint Sexual habits and human papillomavirus infection among females in three New Independent States of the former Soviet Union
    Stina Syrjanen
    Department of Oral Pathology, Institute of Dentistry, and MediCity Research Laboratory, Faculty of Medicine, University of Turku, Turku, Finland
    Sex Transm Dis 30:680-4. 2003
  7. pmc Acquisition of high-risk human papillomavirus infections and pap smear abnormalities among women in the New Independent States of the Former Soviet Union
    Stina Syrjanen
    Department of Oral Pathology, Institute of Dentistry, and MediCity Research Laboratory, University of Turku, Turku, Finland
    J Clin Microbiol 42:505-11. 2004
  8. pmc HPV infections and tonsillar carcinoma
    S Syrjanen
    Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland
    J Clin Pathol 57:449-55. 2004
  9. ncbi request reprint Age-specific incidence and clearance of high-risk human papillomavirus infections in women in the former Soviet Union
    S Syrjanen
    Department of Oral Pathology, Institute of Dentistry, MediCity Research Laboratory, University of Turku, Turku, Finland
    Int J STD AIDS 16:217-23. 2005
  10. ncbi request reprint Human papillomavirus (HPV) in head and neck cancer
    Stina Syrjanen
    Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, FIN 20520 Turku, Finland
    J Clin Virol 32:S59-66. 2005

Collaborators

Detail Information

Publications45

  1. pmc Prevalence, genotype distribution and persistence of human papillomavirus in oral mucosa of women: a six-year follow-up study
    Jaana Rautava
    Department of Oral Pathology, Institute of Dentistry, and MediCity Research Laboratory, Faculty of Medicine, University of Turku, Turku, Finland
    PLoS ONE 7:e42171. 2012
    ..We designed the prospective Finnish HPV Family Study to assess the dynamics of HPV infections in parents and their infants. This study reports HPV genotype distribution and virus persistence in oral mucosa of the mothers...
  2. doi request reprint Human papillomavirus 16 E2-, E6- and E7-specific T-cell responses in children and their mothers who developed incident cervical intraepithelial neoplasia during a 14-year follow-up of the Finnish Family HPV cohort
    Hanna Mari Koskimaa
    MediCity Research Laboratory and Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland
    J Transl Med 12:44. 2014
    ..Our hypothesis according to the common dogma is that there is no HPV16 specific immune response in offspring of the CIN mother as she/he has not started the sexual life yet...
  3. pmc Incident cervical infections with high- and low-risk human papillomavirus (HPV) infections among mothers in the prospective Finnish Family HPV Study
    Karolina Louvanto
    MediCity Research Laboratory and Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, 20520 Turku, Finland
    BMC Infect Dis 11:179. 2011
    ..The knowledge on type specificity and factors that increase or decrease the risk of incident HPV-infections is important to better understand the dynamics of HPV-infections...
  4. ncbi request reprint Clearance of high-risk human papillomavirus (HPV) DNA and PAP smear abnormalities in a cohort of women subjected to HPV screening in the New Independent States of the former Soviet Union (the NIS cohort study)
    S Syrjanen
    Department of Oral Pathology, Institute of Dentistry, and MediCity Research Laboratory, University of Turku 2, FIN 20520 Turku, Finland
    Eur J Obstet Gynecol Reprod Biol 119:219-27. 2005
    ..We analysed the temporal relationships of the clearance of human papillomavirus (HPV) DNA and cytological abnormalities in women participating in a screening study in three NIS countries...
  5. ncbi request reprint Human papillomavirus infections and oral tumors
    Stina Syrjanen
    Department of Oral Pathology and Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Finland
    Med Microbiol Immunol 192:123-8. 2003
    ..Oral benign HPV lesions are mostly asymptomatic, and may persist or regress spontaneously...
  6. ncbi request reprint Sexual habits and human papillomavirus infection among females in three New Independent States of the former Soviet Union
    Stina Syrjanen
    Department of Oral Pathology, Institute of Dentistry, and MediCity Research Laboratory, Faculty of Medicine, University of Turku, Turku, Finland
    Sex Transm Dis 30:680-4. 2003
    ..Recently, the prevalence of all STDs has exploded in these countries...
  7. pmc Acquisition of high-risk human papillomavirus infections and pap smear abnormalities among women in the New Independent States of the Former Soviet Union
    Stina Syrjanen
    Department of Oral Pathology, Institute of Dentistry, and MediCity Research Laboratory, University of Turku, Turku, Finland
    J Clin Microbiol 42:505-11. 2004
    ..At the baseline the high load of a particular HR HPV type is the single most important predictor of an incident Pap smear abnormality, whereas young age and having a sexually transmitted disease predict incident HR HPV infections...
  8. pmc HPV infections and tonsillar carcinoma
    S Syrjanen
    Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland
    J Clin Pathol 57:449-55. 2004
    ..They are also younger and the association with conventional risk factors-smoking and drinking-is less significant than in HPV negative patients. Thus, recent data suggest a distinct pattern for HPV-16 positive TCs...
  9. ncbi request reprint Age-specific incidence and clearance of high-risk human papillomavirus infections in women in the former Soviet Union
    S Syrjanen
    Department of Oral Pathology, Institute of Dentistry, MediCity Research Laboratory, University of Turku, Turku, Finland
    Int J STD AIDS 16:217-23. 2005
    ..These distinct age-specific incidence and clearance rates explain the differences in age-specific prevalence of HR HPV infections in the study population...
  10. ncbi request reprint Human papillomavirus (HPV) in head and neck cancer
    Stina Syrjanen
    Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, FIN 20520 Turku, Finland
    J Clin Virol 32:S59-66. 2005
    ..The molecular mechanisms of HPV-associated carcinogenesis of the head and neck require further study...
  11. ncbi request reprint Human papillomavirus infections in children: the potential role of maternal transmission
    S Syrjanen
    Department of Oral Pathology and Radiology, Institute of Dentistry, Turku, Finland
    Crit Rev Oral Biol Med 11:259-74. 2000
    ....
  12. doi request reprint Dynamics of human papillomavirus serology in women followed up for 36 months after pregnancy
    Stina Syrjanen
    MediCity Research Laboratory and Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, and Department of Obstetrics and Gynaecology, Turku University Hospital, Turku, Finland
    J Gen Virol 90:1515-26. 2009
    ....
  13. pmc In vitro establishment of lytic and nonproductive infection by herpes simplex virus type 1 in three-dimensional keratinocyte culture
    S Syrjanen
    Department of Oral Pathology, Institute of Dentistry, Finland
    J Virol 70:6524-8. 1996
    ..The present results indicate that both nonproductive and lytic HSV infection can be produced in vitro and the outcome of the infection depends on the time of viral inoculation in relation to epithelial maturation...
  14. ncbi request reprint The history of papillomavirus research
    Stina Syrjanen
    Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland
    Cent Eur J Public Health 16:S7-13. 2008
  15. doi request reprint Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review
    S Syrjanen
    Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland
    Oral Dis 17:58-72. 2011
    ..The primary aim was to calculate pooled risk estimates for the association of HPV with OSCC and OPMD when compared with healthy oral mucosa as controls. We also examined the effects of sampling techniques on HPV detection rates...
  16. ncbi request reprint New concepts on the role of human papillomavirus in cell cycle regulation
    S M Syrjanen
    Department of Oral Pathology and Oral Radiology, Institute of Dentistry, University of Turku, Finland
    Ann Med 31:175-87. 1999
    ....
  17. doi request reprint Current concepts on human papillomavirus infections in children
    Stina Syrjanen
    Department of Oral Pathology and Oral Radiology, Institute of Dentistry and MediCity Research Laboratory, University of Turku, Finland
    APMIS 118:494-509. 2010
    ..Early in life, infections by the high-risk HPV genotypes may also remain persistent for a considerable period, and should be of considerable importance for HPV vaccination strategies...
  18. doi request reprint p300 expression is related to high-risk human papillomavirus infections and severity of cervical intraepithelial neoplasia but not to viral or disease outcomes in a longitudinal setting
    Stina Syrjanen
    Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland
    Int J Gynecol Pathol 29:135-45. 2010
    ..036), but p300 was not a significant predictor of disease progression to either CIN1+ or CIN2+.p300 expression was upregulated in CIN lesions and related to detection and viral load of HR-HPV but not to their outcome or to incident CIN...
  19. ncbi request reprint Factors predicting persistence of high-risk human papillomavirus (HPV) infections in women prospectively followed-up in three New Independent States (NIS) of the former Soviet Union
    S Syrjanen
    Department of Oral Pathology, Institute of Dentistry, University of Turku, Finland
    Eur J Gynaecol Oncol 26:491-8. 2005
    ..We completed an analysis of the factors predicting the persistence of high risk (HR) HPV infections in women participating in a multicenter screening trial in three NIS countries...
  20. ncbi request reprint Longitudinal outcomes of high-risk human papillomavirus (HPV) infections as competing-risks events following cervical HPV test at baseline visit in the NIS-LAMS cohort
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Eur J Gynaecol Oncol 33:341-52. 2012
    ..e., no-, transient- or persistent infection) in a longitudinal setting. The covariates associated with these competing events have not been previously assessed using competing-risks regression models...
  21. ncbi request reprint Covariates of high-risk human papillomavirus (HPV) infections are distinct for incident CIN1, CIN2 and CIN3 as disclosed by competing-risks regression models
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Eur J Gynaecol Oncol 33:5-14. 2012
    ....
  22. doi request reprint Persistent high-risk human papillomavirus infections and other end-point markers of progressive cervical disease among women prospectively followed up in the New Independent States of the Former Soviet Union and the Latin American Screening study cohorts
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Int J Gynecol Cancer 19:934-42. 2009
    ..New end points are needed in future human papillomavirus (HPV) vaccine efficacy studies that accurately predict disease progression...
  23. doi request reprint Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Int J STD AIDS 19:251-8. 2008
    ....
  24. ncbi request reprint Epidemiological, clinical and viral determinants of the increased prevalence of high-risk human papillomavirus (HPV) infections in elderly women
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Eur J Gynaecol Oncol 29:114-22. 2008
    ..Population-based studies have reported a second peak of human papillomavirus (HPV) prevalence among women > 55 years, but reasons for this U-shaped HPV prevalence curve are poorly understood...
  25. pmc Human papillomavirus testing with the hybrid capture 2 assay and PCR as screening tools
    S M Kulmala
    Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, Lemminkaisenkatu 2, 205020 Turku, Finland
    J Clin Microbiol 42:2470-5. 2004
    ..Both tests had low PPVs, equal specificities, and equal (almost 100%) NPVs for the detection of HSILs; but the sensitivity of the HC2 assay was slightly better...
  26. doi request reprint Co-factors of high-risk human papillomavirus infections display unique profiles in incident CIN1, CIN2 and CIN3
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, 20521 Turku, Finland
    Int J STD AIDS 22:263-72. 2011
    ....
  27. ncbi request reprint Oral mucosal changes in coeliac patients on a gluten-free diet
    H Lähteenoja
    Department of Medicine, University of Turku, Finland
    Eur J Oral Sci 106:899-906. 1998
    ..Clinically, it is important to study the oral cavity of patients suspected of having CD where the only clue to the disease may reside, since no less than 66% of the patients in this study had oral symptoms...
  28. doi request reprint Risk estimates for persistent high-risk human papillomavirus infections as surrogate endpoints of progressive cervical disease critically depend on reference category: analysis of the combined prospective cohort of the New Independent States of the Former
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Int J STD AIDS 22:315-23. 2011
    ....
  29. pmc Characterization of keratin and cell cycle protein expression in cell lines from squamous intraepithelial lesions progressing towards a malignant phenotype
    S Hietanen
    Department of Obstetrics and Gynecology, Turku University Hospital, Finland
    Br J Cancer 77:766-75. 1998
    ....
  30. ncbi request reprint p53 and bcl-2 proteins as prognostic markers in human papillomavirus-associated cervical lesions
    K Kurvinen
    MediCity Research Laboratory, Faculty of Medicine, University of Turku, Finland
    J Clin Oncol 14:2120-30. 1996
    ..Special attention was focused on the value of individual protein expressions, as well as combined p53/mdm2 and p53/bcl-2 phenotypes, in predicting the clinical course of cervical lesions...
  31. ncbi request reprint Two different human papillomavirus (HPV) types associated with oral mucosal lesions in an HIV-seropositive man
    S Syrjanen
    Department of Oral Pathology, University of Kuopio, Finland
    J Oral Pathol Med 18:366-70. 1989
    ..In situ hybridizations with HPV 11 and HPV 13 probes were negative. Cloning of this 'new' HPV type is currently under way...
  32. pmc Local challenge of oral mucosa with gliadin in patients with coeliac disease
    H Lähteenoja
    Department of Medicine, University of Turku, Finland
    Clin Exp Immunol 120:38-45. 2000
    ..The results suggest that local oral challenge with gliadin may be used as a diagnostic method in coeliac disease; however, further studies in untreated coeliac disease patients are needed to evaluate the usefulness of this method...
  33. ncbi request reprint Detection of human papillomavirus genotypes in bronchial cancer using sensitive multimetrix assay
    K Syrjanen
    FIAC, Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 2, FIN 20521 Turku, Finland
    Anticancer Res 32:625-31. 2012
    ..The causal role of HPV in lung cancer still remains controversial, however, and more data are needed particularly on genotype distribution and cofactors of HPV regarding this disease...
  34. ncbi request reprint Anti-proliferative effect of retinoids and interferon-alpha-2a on vaginal cell lines derived from squamous intra-epithelial lesions
    S Hietanen
    MediCity Research Laboratory, Department of Gynecology and Obstetrics, Turku University, Finland
    Int J Cancer 78:338-45. 1998
    ....
  35. doi request reprint Human papillomavirus infection and its association with HIV
    S Syrjanen
    Department of Oral Pathology and Oral Radiology, Institute of Dentistry and Medicine Research Laboratory, University of Turku, Turku, Finland
    Adv Dent Res 23:84-9. 2011
    ..Regarding HIV genes, there is evidence of an interaction between HPV and tat, rev, and vpr. HIV might play a role in HPV-associated pathogenesis by exhorting oncogenic stimuli via tat and rev or visa versa...
  36. doi request reprint The role of human papillomavirus infection in head and neck cancers
    S Syrjanen
    Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Finland
    Ann Oncol 21:vii243-5. 2010
    ..Interestingly, the risk factors of HNSCC are the same as for HPV, including the number of sexual partners, younger age at first sexual intercourse, practice of oral sex, history of genital warts and younger age...
  37. ncbi request reprint Comparing PAP smear cytology, aided visual inspection, screening colposcopy, cervicography and HPV testing as optional screening tools in Latin America. Study design and baseline data of the LAMS study
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Central Hospital, Turku, Finland
    Anticancer Res 25:3469-80. 2005
    ....
  38. ncbi request reprint Distribution of insulin-like growth factor-I mRNA in the mandibular condyle and rib cartilage of the rat during growth
    V Visnapuu
    Institute of Dentistry, University of Turku, Lemminkaisenkatu 2, FIN 20520, Turku, Finland
    Arch Oral Biol 47:791-8. 2002
    ..The findings shed light on the problem of overgrowth often associated with the use of costochondral grafts to replace defective mandibular condyles...
  39. ncbi request reprint Stable marital relationship protects men from oral and genital HPV infections
    K M Kero
    Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku, P O Box 52, 20521, Turku, Finland
    Eur J Clin Microbiol Infect Dis 33:1211-21. 2014
    ..The risk of incident genital HPV infections increased among men reporting a change of sexual partner during FU, implicating that a stable marital relationship protects against oral and genital HPV infection. ..
  40. ncbi request reprint Effects of 17beta-estradiol and progesterone on transcription of human papillomavirus 16 E6/E7 oncogenes in CaSki and SiHa cell lines
    M Ruutu
    Department of Oral Pathology and Oral Radiology, Institute of Dentistry and MediCity Research Laboratory, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, FIN 20520 Turku, Finland
    Int J Gynecol Cancer 16:1261-8. 2006
    ..In addition, estrogen acts as an antiapoptotic agent allowing growth advance of the cells infected with oncogenic HPV...
  41. ncbi request reprint Expression of estrogen receptor (ER) in oral mucosa and salivary glands
    R Leimola-Virtanen
    Department of Oral Pathology, Institute of Dentistry and MediCity Research Laboratory, University of Turku, Lemminkaisenkatu 2, FIN 20520, Turku, Finland
    Maturitas 36:131-7. 2000
    ..Salivary gland biopsies were taken from the minor labial salivary glands (n=6), submandibular glands (n=5) and parotid gland (n=1) from women at different ages...
  42. ncbi request reprint Human papillomavirus, Epstein-Barr virus, human herpesvirus 8 and human cytomegalovirus involvement in salivary gland tumours
    T Atula
    MediCity Research Laboratory, Faculty of Medicine, University of Turku, Finland
    Oral Oncol 34:391-5. 1998
    ..HPV, HHV-8 and CMV DNA were not detected in any of the tumour samples. The results indicate that HPV, HHV-8 and CMV do not seem to have any role in the etiology of salivary gland neoplasms...
  43. doi request reprint Smoking increases oral HPV persistence among men: 7-year follow-up study
    K Kero
    Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku, P O Box 52, 20521, Turku, Finland
    Eur J Clin Microbiol Infect Dis 33:123-33. 2014
    ..046). To conclude, most of the persisting oral infections in males were caused by HPV16. Smoking increased while previous genital warts decreased oral HR-HPV persistence. No predictors of HR-HPV clearance were disclosed...
  44. ncbi request reprint Mutations of TP53 do not correlate with the sensitivity to paclitaxel--a study using 27 gynaecological cancer cell lines
    V Rantanen
    Department of Gynecology, Turku City Hospital, Turku, Finland
    Eur J Cancer 38:1783-91. 2002
    ..e. normal, cancerous or transformed cells. Our results support the view that paclitaxel sensitivity of tumour-derived cancer cell lines is not related to the TP53 status...
  45. ncbi request reprint Increase in T-cell subsets of oral mucosa: a late immune response in patients with treated coeliac disease?
    H Lähteenoja
    Department of Medicine, University of Turku, Turku, Finland
    Scand J Immunol 52:602-8. 2000
    ..Thus, the number of inflammatory cells in the oral mucosa would decrease in patients with coeliac disease on a gluten-free diet...