Research Topics
| S SyrjanenSummaryAffiliation: University of Turku Country: Finland Publications
| Collaborators
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Detail Information
Publications
Incident cervical infections with high- and low-risk human papillomavirus (HPV) infections among mothers in the prospective Finnish Family HPV StudyKarolina Louvanto
MediCity Research Laboratory and Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, 20520 Turku, Finland
BMC Infect Dis 11:179. 2011..The knowledge on type specificity and factors that increase or decrease the risk of incident HPV-infections is important to better understand the dynamics of HPV-infections...- Age-specific incidence and clearance of high-risk human papillomavirus infections in women in the former Soviet UnionS Syrjanen
Department of Oral Pathology, Institute of Dentistry, MediCity Research Laboratory, University of Turku, Turku, Finland
Int J STD AIDS 16:217-23. 2005..These distinct age-specific incidence and clearance rates explain the differences in age-specific prevalence of HR HPV infections in the study population... - HPV infections and tonsillar carcinomaS Syrjanen
Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland
J Clin Pathol 57:449-55. 2004..They are also younger and the association with conventional risk factors-smoking and drinking-is less significant than in HPV negative patients. Thus, recent data suggest a distinct pattern for HPV-16 positive TCs... - Acquisition of high-risk human papillomavirus infections and pap smear abnormalities among women in the New Independent States of the Former Soviet UnionStina Syrjanen
Department of Oral Pathology, Institute of Dentistry, and MediCity Research Laboratory, University of Turku, Turku, Finland
J Clin Microbiol 42:505-11. 2004..At the baseline the high load of a particular HR HPV type is the single most important predictor of an incident Pap smear abnormality, whereas young age and having a sexually transmitted disease predict incident HR HPV infections... - Sexual habits and human papillomavirus infection among females in three New Independent States of the former Soviet UnionStina Syrjanen
Department of Oral Pathology, Institute of Dentistry, and MediCity Research Laboratory, Faculty of Medicine, University of Turku, Turku, Finland
Sex Transm Dis 30:680-4. 2003..Recently, the prevalence of all STDs has exploded in these countries... - Human papillomavirus infections and oral tumorsStina Syrjanen
Department of Oral Pathology and Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Finland
Med Microbiol Immunol 192:123-8. 2003..Oral benign HPV lesions are mostly asymptomatic, and may persist or regress spontaneously... - Clearance of high-risk human papillomavirus (HPV) DNA and PAP smear abnormalities in a cohort of women subjected to HPV screening in the New Independent States of the former Soviet Union (the NIS cohort study)S Syrjanen
Department of Oral Pathology, Institute of Dentistry, and MediCity Research Laboratory, University of Turku 2, FIN 20520 Turku, Finland
Eur J Obstet Gynecol Reprod Biol 119:219-27. 2005..We analysed the temporal relationships of the clearance of human papillomavirus (HPV) DNA and cytological abnormalities in women participating in a screening study in three NIS countries... - Human papillomavirus infections in children: the potential role of maternal transmissionS Syrjanen
Department of Oral Pathology and Radiology, Institute of Dentistry, Turku, Finland
Crit Rev Oral Biol Med 11:259-74. 2000.... - Human papillomavirus (HPV) in head and neck cancerStina Syrjanen
Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, FIN 20520 Turku, Finland
J Clin Virol 32:S59-66. 2005..The molecular mechanisms of HPV-associated carcinogenesis of the head and neck require further study... - The history of papillomavirus researchStina Syrjanen
Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland
Cent Eur J Public Health 16:S7-13. 2008 - Dynamics of human papillomavirus serology in women followed up for 36 months after pregnancyStina Syrjanen
MediCity Research Laboratory and Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, and Department of Obstetrics and Gynaecology, Turku University Hospital, Turku, Finland
J Gen Virol 90:1515-26. 2009.... - New concepts on the role of human papillomavirus in cell cycle regulationS M Syrjanen
Department of Oral Pathology and Oral Radiology, Institute of Dentistry, University of Turku, Finland
Ann Med 31:175-87. 1999.... - p300 expression is related to high-risk human papillomavirus infections and severity of cervical intraepithelial neoplasia but not to viral or disease outcomes in a longitudinal settingStina Syrjanen
Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland
Int J Gynecol Pathol 29:135-45. 2010..036), but p300 was not a significant predictor of disease progression to either CIN1+ or CIN2+.p300 expression was upregulated in CIN lesions and related to detection and viral load of HR-HPV but not to their outcome or to incident CIN... - Current concepts on human papillomavirus infections in childrenStina Syrjanen
Department of Oral Pathology and Oral Radiology, Institute of Dentistry and MediCity Research Laboratory, University of Turku, Finland
APMIS 118:494-509. 2010..Early in life, infections by the high-risk HPV genotypes may also remain persistent for a considerable period, and should be of considerable importance for HPV vaccination strategies... - Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic reviewS Syrjanen
Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland
Oral Dis 17:58-72. 2011..The primary aim was to calculate pooled risk estimates for the association of HPV with OSCC and OPMD when compared with healthy oral mucosa as controls. We also examined the effects of sampling techniques on HPV detection rates... - In vitro establishment of lytic and nonproductive infection by herpes simplex virus type 1 in three-dimensional keratinocyte cultureS Syrjanen
Department of Oral Pathology, Institute of Dentistry, Finland
J Virol 70:6524-8. 1996..The present results indicate that both nonproductive and lytic HSV infection can be produced in vitro and the outcome of the infection depends on the time of viral inoculation in relation to epithelial maturation... - Factors predicting persistence of high-risk human papillomavirus (HPV) infections in women prospectively followed-up in three New Independent States (NIS) of the former Soviet UnionS Syrjanen
Department of Oral Pathology, Institute of Dentistry, University of Turku, Finland
Eur J Gynaecol Oncol 26:491-8. 2005..We completed an analysis of the factors predicting the persistence of high risk (HR) HPV infections in women participating in a multicenter screening trial in three NIS countries... - Longitudinal outcomes of high-risk human papillomavirus (HPV) infections as competing-risks events following cervical HPV test at baseline visit in the NIS-LAMS cohortK Syrjanen
Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
Eur J Gynaecol Oncol 33:341-52. 2012..e., no-, transient- or persistent infection) in a longitudinal setting. The covariates associated with these competing events have not been previously assessed using competing-risks regression models... - Covariates of high-risk human papillomavirus (HPV) infections are distinct for incident CIN1, CIN2 and CIN3 as disclosed by competing-risks regression modelsK Syrjanen
Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
Eur J Gynaecol Oncol 33:5-14. 2012.... - Persistent high-risk human papillomavirus infections and other end-point markers of progressive cervical disease among women prospectively followed up in the New Independent States of the Former Soviet Union and the Latin American Screening study cohortsKari Syrjanen
Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
Int J Gynecol Cancer 19:934-42. 2009..New end points are needed in future human papillomavirus (HPV) vaccine efficacy studies that accurately predict disease progression... - Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohortK Syrjanen
Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
Int J STD AIDS 19:251-8. 2008.... - Epidemiological, clinical and viral determinants of the increased prevalence of high-risk human papillomavirus (HPV) infections in elderly womenK Syrjanen
Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
Eur J Gynaecol Oncol 29:114-22. 2008..Population-based studies have reported a second peak of human papillomavirus (HPV) prevalence among women > 55 years, but reasons for this U-shaped HPV prevalence curve are poorly understood... - Oral mucosal changes in coeliac patients on a gluten-free dietH Lähteenoja
Department of Medicine, University of Turku, Finland
Eur J Oral Sci 106:899-906. 1998..Clinically, it is important to study the oral cavity of patients suspected of having CD where the only clue to the disease may reside, since no less than 66% of the patients in this study had oral symptoms... - Co-factors of high-risk human papillomavirus infections display unique profiles in incident CIN1, CIN2 and CIN3K Syrjanen
Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, 20521 Turku, Finland
Int J STD AIDS 22:263-72. 2011.... - Risk estimates for persistent high-risk human papillomavirus infections as surrogate endpoints of progressive cervical disease critically depend on reference category: analysis of the combined prospective cohort of the New Independent States of the FormerK Syrjanen
Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
Int J STD AIDS 22:315-23. 2011.... - Characterization of keratin and cell cycle protein expression in cell lines from squamous intraepithelial lesions progressing towards a malignant phenotypeS Hietanen
Department of Obstetrics and Gynecology, Turku University Hospital, Finland
Br J Cancer 77:766-75. 1998.... - p53 and bcl-2 proteins as prognostic markers in human papillomavirus-associated cervical lesionsK Kurvinen
MediCity Research Laboratory, Faculty of Medicine, University of Turku, Finland
J Clin Oncol 14:2120-30. 1996..Special attention was focused on the value of individual protein expressions, as well as combined p53/mdm2 and p53/bcl-2 phenotypes, in predicting the clinical course of cervical lesions... - Two different human papillomavirus (HPV) types associated with oral mucosal lesions in an HIV-seropositive manS Syrjanen
Department of Oral Pathology, University of Kuopio, Finland
J Oral Pathol Med 18:366-70. 1989..In situ hybridizations with HPV 11 and HPV 13 probes were negative. Cloning of this 'new' HPV type is currently under way... - Local challenge of oral mucosa with gliadin in patients with coeliac diseaseH Lähteenoja
Department of Medicine, University of Turku, Finland
Clin Exp Immunol 120:38-45. 2000..The results suggest that local oral challenge with gliadin may be used as a diagnostic method in coeliac disease; however, further studies in untreated coeliac disease patients are needed to evaluate the usefulness of this method... - Detection of human papillomavirus genotypes in bronchial cancer using sensitive multimetrix assayK Syrjanen
FIAC, Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 2, FIN 20521 Turku, Finland
Anticancer Res 32:625-31. 2012..The causal role of HPV in lung cancer still remains controversial, however, and more data are needed particularly on genotype distribution and cofactors of HPV regarding this disease... - Anti-proliferative effect of retinoids and interferon-alpha-2a on vaginal cell lines derived from squamous intra-epithelial lesionsS Hietanen
MediCity Research Laboratory, Department of Gynecology and Obstetrics, Turku University, Finland
Int J Cancer 78:338-45. 1998.... - The role of human papillomavirus infection in head and neck cancersS Syrjanen
Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Finland
Ann Oncol 21:vii243-5. 2010..Interestingly, the risk factors of HNSCC are the same as for HPV, including the number of sexual partners, younger age at first sexual intercourse, practice of oral sex, history of genital warts and younger age... - Comparing PAP smear cytology, aided visual inspection, screening colposcopy, cervicography and HPV testing as optional screening tools in Latin America. Study design and baseline data of the LAMS studyK Syrjanen
Department of Oncology and Radiotherapy, Turku University Central Hospital, Turku, Finland
Anticancer Res 25:3469-80. 2005.... - Human papillomavirus infection and its association with HIVS Syrjanen
Department of Oral Pathology and Oral Radiology, Institute of Dentistry and Medicine Research Laboratory, University of Turku, Turku, Finland
Adv Dent Res 23:84-9. 2011..Regarding HIV genes, there is evidence of an interaction between HPV and tat, rev, and vpr. HIV might play a role in HPV-associated pathogenesis by exhorting oncogenic stimuli via tat and rev or visa versa... - Distribution of insulin-like growth factor-I mRNA in the mandibular condyle and rib cartilage of the rat during growthV Visnapuu
Institute of Dentistry, University of Turku, Lemminkaisenkatu 2, FIN 20520, Turku, Finland
Arch Oral Biol 47:791-8. 2002..The findings shed light on the problem of overgrowth often associated with the use of costochondral grafts to replace defective mandibular condyles... - Effects of 17beta-estradiol and progesterone on transcription of human papillomavirus 16 E6/E7 oncogenes in CaSki and SiHa cell linesM Ruutu
Department of Oral Pathology and Oral Radiology, Institute of Dentistry and MediCity Research Laboratory, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, FIN 20520 Turku, Finland
Int J Gynecol Cancer 16:1261-8. 2006..In addition, estrogen acts as an antiapoptotic agent allowing growth advance of the cells infected with oncogenic HPV... - Expression of estrogen receptor (ER) in oral mucosa and salivary glandsR Leimola-Virtanen
Department of Oral Pathology, Institute of Dentistry and MediCity Research Laboratory, University of Turku, Lemminkaisenkatu 2, FIN 20520, Turku, Finland
Maturitas 36:131-7. 2000..Salivary gland biopsies were taken from the minor labial salivary glands (n=6), submandibular glands (n=5) and parotid gland (n=1) from women at different ages... - Mutations of TP53 do not correlate with the sensitivity to paclitaxel--a study using 27 gynaecological cancer cell linesV Rantanen
Department of Gynecology, Turku City Hospital, Turku, Finland
Eur J Cancer 38:1783-91. 2002..e. normal, cancerous or transformed cells. Our results support the view that paclitaxel sensitivity of tumour-derived cancer cell lines is not related to the TP53 status... - Human papillomavirus testing with the hybrid capture 2 assay and PCR as screening toolsS-M Kulmala
Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, , 205020 Turku, Finland
J Clin Microbiol 42:2470-5. 2004..Both tests had low PPVs, equal specificities, and equal (almost 100%) NPVs for the detection of HSILs; but the sensitivity of the HC2 assay was slightly better... - Increase in T-cell subsets of oral mucosa: a late immune response in patients with treated coeliac disease?H Lähteenoja
Department of Medicine, University of Turku, Turku, Finland
Scand J Immunol 52:602-8. 2000..Thus, the number of inflammatory cells in the oral mucosa would decrease in patients with coeliac disease on a gluten-free diet...