K Syrjanen

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint Persistent high-risk human papillomavirus (HPV) infections as surrogate endpoints of progressive cervical disease. Potential new endpoint for efficacy studies with new-generation (non-HPV 16/18) prophylactic HPV vaccines
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Eur J Gynaecol Oncol 32:17-33. 2011
  2. ncbi request reprint Epidemiological, clinical and viral determinants of the increased prevalence of high-risk human papillomavirus (HPV) infections in elderly women
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Eur J Gynaecol Oncol 29:114-22. 2008
  3. doi request reprint Detection of human papillomavirus in esophageal papillomas: systematic review and meta-analysis
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    APMIS 121:363-74. 2013
  4. doi request reprint Detection of human papillomavirus in sinonasal carcinoma: systematic review and meta-analysis
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, FIN 20521 Turku, Finland
    Hum Pathol 44:983-91. 2013
  5. doi request reprint Geographic origin is a significant determinant of human papillomavirus prevalence in oesophageal squamous cell carcinoma: systematic review and meta-analysis
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Scand J Infect Dis 45:1-18. 2013
  6. doi request reprint Detection of human papillomavirus in sinonasal papillomas: systematic review and meta-analysis
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Laryngoscope 123:181-92. 2013
  7. ncbi request reprint Longitudinal outcomes of high-risk human papillomavirus (HPV) infections as competing-risks events following cervical HPV test at baseline visit in the NIS-LAMS cohort
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Eur J Gynaecol Oncol 33:341-52. 2012
  8. ncbi request reprint Detection of human papillomavirus in lung cancer: systematic review and meta-analysis
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, FIN 20521 Turku, Finland
    Anticancer Res 32:3235-50. 2012
  9. ncbi request reprint Covariates of high-risk human papillomavirus (HPV) infections are distinct for incident CIN1, CIN2 and CIN3 as disclosed by competing-risks regression models
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Eur J Gynaecol Oncol 33:5-14. 2012
  10. pmc Incident cervical infections with high- and low-risk human papillomavirus (HPV) infections among mothers in the prospective Finnish Family HPV Study
    Karolina Louvanto
    MediCity Research Laboratory and Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, 20520 Turku, Finland
    BMC Infect Dis 11:179. 2011

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Persistent high-risk human papillomavirus (HPV) infections as surrogate endpoints of progressive cervical disease. Potential new endpoint for efficacy studies with new-generation (non-HPV 16/18) prophylactic HPV vaccines
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Eur J Gynaecol Oncol 32:17-33. 2011
    ....
  2. ncbi request reprint Epidemiological, clinical and viral determinants of the increased prevalence of high-risk human papillomavirus (HPV) infections in elderly women
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Eur J Gynaecol Oncol 29:114-22. 2008
    ..Population-based studies have reported a second peak of human papillomavirus (HPV) prevalence among women > 55 years, but reasons for this U-shaped HPV prevalence curve are poorly understood...
  3. doi request reprint Detection of human papillomavirus in esophageal papillomas: systematic review and meta-analysis
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    APMIS 121:363-74. 2013
    ..In stratified meta-analysis and formal meta-regression, the variability in HPV detection rates in ESCPs is not explained by the HPV detection method or geographic origin of the study...
  4. doi request reprint Detection of human papillomavirus in sinonasal carcinoma: systematic review and meta-analysis
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, FIN 20521 Turku, Finland
    Hum Pathol 44:983-91. 2013
    ..In formal meta-regression, the variability in HPV detection rates reported in sinonasal SCCs was not explained by the HPV detection method or geographic origin of the study...
  5. doi request reprint Geographic origin is a significant determinant of human papillomavirus prevalence in oesophageal squamous cell carcinoma: systematic review and meta-analysis
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Scand J Infect Dis 45:1-18. 2013
    ..However no formal meta-analysis of this literature has been published yet. The objective of this study was to perform a systematic review and formal meta-analysis of the literature reporting HPV detection in ESCC...
  6. doi request reprint Detection of human papillomavirus in sinonasal papillomas: systematic review and meta-analysis
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Laryngoscope 123:181-92. 2013
    ..Since first reported in 1983, the etiological role for human papillomavirus (HPV) in sinonasal papillomas has been subject to increasing interest...
  7. ncbi request reprint Longitudinal outcomes of high-risk human papillomavirus (HPV) infections as competing-risks events following cervical HPV test at baseline visit in the NIS-LAMS cohort
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Eur J Gynaecol Oncol 33:341-52. 2012
    ..e., no-, transient- or persistent infection) in a longitudinal setting. The covariates associated with these competing events have not been previously assessed using competing-risks regression models...
  8. ncbi request reprint Detection of human papillomavirus in lung cancer: systematic review and meta-analysis
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, FIN 20521 Turku, Finland
    Anticancer Res 32:3235-50. 2012
    ..We performed a systematic review and formal meta-analysis of the literature reporting on HPV detection in lung cancer...
  9. ncbi request reprint Covariates of high-risk human papillomavirus (HPV) infections are distinct for incident CIN1, CIN2 and CIN3 as disclosed by competing-risks regression models
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Eur J Gynaecol Oncol 33:5-14. 2012
    ....
  10. pmc Incident cervical infections with high- and low-risk human papillomavirus (HPV) infections among mothers in the prospective Finnish Family HPV Study
    Karolina Louvanto
    MediCity Research Laboratory and Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, 20520 Turku, Finland
    BMC Infect Dis 11:179. 2011
    ..The knowledge on type specificity and factors that increase or decrease the risk of incident HPV-infections is important to better understand the dynamics of HPV-infections...
  11. doi request reprint Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Int J STD AIDS 19:251-8. 2008
    ....
  12. ncbi request reprint New concepts on risk factors of HPV and novel screening strategies for cervical cancer precursors
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Eur J Gynaecol Oncol 29:205-21. 2008
    ..Needless to reiterate that screening for cervical cancer precursors will be mandatory until the foreseeable future, even in this emerging era of prophylactic HPV vaccination...
  13. ncbi request reprint Value of conventional pap smear, liquid-based cytology, visual inspection and human papillomavirus testing as optional screening tools among latin american women <35 and > or =35 years of age: experience from the Latin American Screening Study
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Finland
    Acta Cytol 52:641-53. 2008
    ..To compare performance of conventional Pap test, liquid based cytology (LBC) and visual inspection with acetic acid (VIA), as well as human papillomavirus (HPV) testing in 2 subcohorts of women, <35 and > or =35 years of age...
  14. doi request reprint Annual disease burden due to human papillomavirus (HPV) 6 and 11 infections in Finland
    Kari J Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, FIN 20521 Turku, Finland
    Scand J Infect Dis Suppl 107:3-32. 2009
    ..The implications of these data in the era of effective prophylactic HPV vaccination against HPV6 and HPV11 should be clear...
  15. doi request reprint Cervical cancer screening in Mediterranean countries: implications for the future
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Cytopathology 21:359-67. 2010
    ....
  16. doi request reprint Prophylactic HPV vaccines: the Finnish perspective
    Kari J Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, FIN 20521, Turku, Finland
    Expert Rev Vaccines 9:45-57. 2010
    ..It is the personal conviction of this author that there are no sustainable arguments remaining that advocate continuing this Finnish perspective on HPV vaccines any further...
  17. doi request reprint Age at menarche is not an independent risk factor for high-risk human papillomavirus infections and cervical intraepithelial neoplasia
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, Turku FIN 20521, Finland
    Int J STD AIDS 19:16-25. 2008
    ..In conclusion, age at menarche and the intervals between menarche and (i) onset of sexual activity, (ii) first pregnancy and iii) first delivery, are not independent predictors of HR-HPV infections and CIN2 in multivariate analysis...
  18. doi request reprint Co-factors of high-risk human papillomavirus infections display unique profiles in incident CIN1, CIN2 and CIN3
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, 20521 Turku, Finland
    Int J STD AIDS 22:263-72. 2011
    ....
  19. doi request reprint Persistent high-risk human papillomavirus infections and other end-point markers of progressive cervical disease among women prospectively followed up in the New Independent States of the Former Soviet Union and the Latin American Screening study cohorts
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Int J Gynecol Cancer 19:934-42. 2009
    ..New end points are needed in future human papillomavirus (HPV) vaccine efficacy studies that accurately predict disease progression...
  20. ncbi request reprint Smoking is an independent risk factor for oncogenic human papillomavirus (HPV) infections but not for high-grade CIN
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, Turku, 20521, Finland
    Eur J Epidemiol 22:723-35. 2007
    ..Recent evidence implicates smoking as a risk factor for cervical cancer (CC), but the confounding from high-risk human papillomavirus (HPV) infections is not clear...
  21. ncbi request reprint Detection of human papillomavirus genotypes in bronchial cancer using sensitive multimetrix assay
    K Syrjanen
    FIAC, Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 2, FIN 20521 Turku, Finland
    Anticancer Res 32:625-31. 2012
    ..The causal role of HPV in lung cancer still remains controversial, however, and more data are needed particularly on genotype distribution and cofactors of HPV regarding this disease...
  22. ncbi request reprint Oral contraceptives are not an independent risk factor for cervical intraepithelial neoplasia or high-risk human papillomavirus infections
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Anticancer Res 26:4729-40. 2006
    ..The aim of the present was study to analyse the risk estimates for OC users in order to develop several intermediate end-point markers in cervical carcinogenesis...
  23. ncbi request reprint Reproducibility of classification and correction for verification bias as determinants of performance of Papanicolaou smear cytology in the screening setting: experience from the New Independent States of the former Soviet Union cohort study
    Kari Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Department of Oral Pathology, University of Turku, Turku, Finland
    Acta Cytol 53:548-57. 2009
    ....
  24. doi request reprint Annual disease burden due to human papillomavirus 16 and 18 infections in Finland
    Kari J Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, FIN 20521 Turku, Finland
    Scand J Infect Dis Suppl 108:2-32. 2009
    ....
  25. ncbi request reprint Factors predicting persistence of high-risk human papillomavirus (HPV) infections in women prospectively followed-up in three New Independent States (NIS) of the former Soviet Union
    S Syrjanen
    Department of Oral Pathology, Institute of Dentistry, University of Turku, Finland
    Eur J Gynaecol Oncol 26:491-8. 2005
    ..We completed an analysis of the factors predicting the persistence of high risk (HR) HPV infections in women participating in a multicenter screening trial in three NIS countries...
  26. ncbi request reprint Comparing PAP smear cytology, aided visual inspection, screening colposcopy, cervicography and HPV testing as optional screening tools in Latin America. Study design and baseline data of the LAMS study
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Central Hospital, Turku, Finland
    Anticancer Res 25:3469-80. 2005
    ....
  27. ncbi request reprint Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases
    R Bendardaf
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Savitehtaankatu 1, Finland
    Acta Oncol 47:1046-53. 2008
    ..Thymidylate synthase (TS) is inhibited by 5-FU, being another potential mediator of therapeutic resistance to 5-FU. The clinical relevance of these observations remains unclear...
  28. doi request reprint PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage II colorectal carcinoma
    A Buhmeida
    Department of Oncology and Radiotherapy, Turku University Hospital, University of Turku, Turku, Finland
    Ann Oncol 20:1230-5. 2009
    ..The present work was designed to assess the value of group IIA phospholipase A2 (PLA2) as a predictor of disease outcome in stage II CRC patients with long-term follow-up...
  29. pmc Human papillomavirus testing with the hybrid capture 2 assay and PCR as screening tools
    S M Kulmala
    Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, Lemminkaisenkatu 2, 205020 Turku, Finland
    J Clin Microbiol 42:2470-5. 2004
    ..Both tests had low PPVs, equal specificities, and equal (almost 100%) NPVs for the detection of HSILs; but the sensitivity of the HC2 assay was slightly better...
  30. ncbi request reprint Age-specific incidence and clearance of high-risk human papillomavirus infections in women in the former Soviet Union
    S Syrjanen
    Department of Oral Pathology, Institute of Dentistry, MediCity Research Laboratory, University of Turku, Turku, Finland
    Int J STD AIDS 16:217-23. 2005
    ..These distinct age-specific incidence and clearance rates explain the differences in age-specific prevalence of HR HPV infections in the study population...
  31. ncbi request reprint DNA image cytometry predicts disease outcome in stage II colorectal carcinoma
    A Buhmeida
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Anticancer Res 29:99-106. 2009
    ..The present work was designed to study the prognostic value of nuclear DNA content in stage II CRC of patients with long-term followup...
  32. doi request reprint Risk estimates for persistent high-risk human papillomavirus infections as surrogate endpoints of progressive cervical disease critically depend on reference category: analysis of the combined prospective cohort of the New Independent States of the Former
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Int J STD AIDS 22:315-23. 2011
    ....
  33. ncbi request reprint DNA image cytometry is a useful adjunct tool in the prediction of disease outcome in patients with stage II and stage III colorectal cancer
    A Buhmeida
    Department of Oncology and Radiotherapy, Turku University Hospital, University of Turku, Turku, Finland
    Oncology 70:427-37. 2006
    ..We assessed the prognostic value of the nuclear DNA content measured in the primary tumours of 123 patients with stage II or stage III colorectal cancer (CRC)...
  34. ncbi request reprint Mismatch repair status is a predictive factor of tumour response to 5-fluorouracil and irinotecan chemotherapy in patients with advanced colorectal cancer
    R Bendardaf
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Tumour Biol 28:212-20. 2007
    ..To determine the association between DNA mismatch repair (MMR) protein expression and response to chemotherapy in patients with advanced colorectal cancer (CRC)...
  35. doi request reprint Expression of the cell-cell adhesion molecule beta-catenin in colorectal carcinomas and their metastases
    A Buhmeida
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    APMIS 116:1-9. 2008
    ....
  36. ncbi request reprint Pronounced tumour regression after radiotherapy is associated with negative/weak glucose transporter-1 expression in rectal cancer
    E Korkeila
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Anticancer Res 31:311-5. 2011
    ..The aim of this study was to assess glucose transporter-1 (GLUT-1) expression as a predictor of disease outcome in rectal cancer treated by preoperative radio- or chemoradiotherapy...
  37. doi request reprint Preoperative radiotherapy downregulates the nuclear expression of hypoxia-inducible factor-1alpha in rectal cancer
    E Korkeila
    Department of Oncology and Radiotherapy, University of Turku and Turku University Hospital, Turku, Finland
    Scand J Gastroenterol 45:340-8. 2010
    ..To assess the value of hypoxia-inducible factor-1alpha (HIF-1alpha) expression as a predictor of disease outcome in rectal cancer treated by preoperative radio- or chemoradiotherapy...
  38. ncbi request reprint Two different human papillomavirus (HPV) types associated with oral mucosal lesions in an HIV-seropositive man
    S Syrjanen
    Department of Oral Pathology, University of Kuopio, Finland
    J Oral Pathol Med 18:366-70. 1989
    ..In situ hybridizations with HPV 11 and HPV 13 probes were negative. Cloning of this 'new' HPV type is currently under way...
  39. ncbi request reprint p53 and bcl-2 proteins as prognostic markers in human papillomavirus-associated cervical lesions
    K Kurvinen
    MediCity Research Laboratory, Faculty of Medicine, University of Turku, Finland
    J Clin Oncol 14:2120-30. 1996
    ..Special attention was focused on the value of individual protein expressions, as well as combined p53/mdm2 and p53/bcl-2 phenotypes, in predicting the clinical course of cervical lesions...
  40. ncbi request reprint Mechanisms and predictors of high-risk human papillomavirus (HPV) clearance in the uterine cervix
    K Syrjanen
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Eur J Gynaecol Oncol 28:337-51. 2007
    ..Early detection of cervical cancer precursors among these elderly HR-HPV positive women past the usual age of organised screening remains a major challenge also in the future...
  41. ncbi request reprint Needs of developing the skills of palliative care at the oncology ward: an audit of symptoms among 203 consecutive cancer patients in Finland
    E Salminen
    Department of Oncology and Radiotherapy, Turku University Hospital, P O Box 52, Savitehtaankatu 1, Turku, Finland
    Support Care Cancer 16:3-8. 2008
    ..To clarify the prevalence and severity of the symptoms, 203 consecutive patients with breast, prostate and other cancers treated mainly for palliation were surveyed...
  42. ncbi request reprint Anaemia and other predictors of fatigue among patients on palliative therapy for advanced cancer
    A Latvala
    Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, FIN 20521 Turku, Finland
    Anticancer Res 29:2569-75. 2009
    ..Fatigue was common among cancer patients on palliative care. The single most powerful independent explanatory factor of fatigue was anaemia, implicating a need for interventional studies...
  43. pmc Characterization of keratin and cell cycle protein expression in cell lines from squamous intraepithelial lesions progressing towards a malignant phenotype
    S Hietanen
    Department of Obstetrics and Gynecology, Turku University Hospital, Finland
    Br J Cancer 77:766-75. 1998
    ....
  44. pmc Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer
    E Korkeila
    Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, PB 52, Turku FIN 20521, Finland
    Br J Cancer 100:874-80. 2009
    ..2 for dying of disease with moderate-intense CA IX expression as compared with CA IX-negative/weak cases. Negative/weak CA IX staining intensity is an independent predictor of longer DFS and DSS in rectal cancer...
  45. doi request reprint Smoking increases oral HPV persistence among men: 7-year follow-up study
    K Kero
    Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku, P O Box 52, 20521, Turku, Finland
    Eur J Clin Microbiol Infect Dis 33:123-33. 2014
    ..046). To conclude, most of the persisting oral infections in males were caused by HPV16. Smoking increased while previous genital warts decreased oral HR-HPV persistence. No predictors of HR-HPV clearance were disclosed. ..
  46. ncbi request reprint Comparison of CD44 expression in primary tumours and metastases of colorectal cancer
    R Bendardaf
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Oncol Rep 16:741-6. 2006
    ..CD44 expression may also provide valuable biological information as suggested by the observation that up-regulated CD44s expression in metastases is associated with a shorter DFS...
  47. ncbi request reprint Effects of 17beta-estradiol and progesterone on transcription of human papillomavirus 16 E6/E7 oncogenes in CaSki and SiHa cell lines
    M Ruutu
    Department of Oral Pathology and Oral Radiology, Institute of Dentistry and MediCity Research Laboratory, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, FIN 20520 Turku, Finland
    Int J Gynecol Cancer 16:1261-8. 2006
    ..In addition, estrogen acts as an antiapoptotic agent allowing growth advance of the cells infected with oncogenic HPV...