Vappu Sirén

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Transforming growth factor beta induces urokinase receptor expression in cultured retinal pigment epithelial cells
    V Siren
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    Ophthalmic Res 31:184-91. 1999
  2. ncbi request reprint Urokinase, tissue-type plasminogen activator and plasminogen activator inhibitor-1 expression in severely stenosed and occluded vein grafts with thrombosis
    Vappu Sirén
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Blood Coagul Fibrinolysis 14:369-77. 2003
  3. ncbi request reprint uPA, tPA and PAI-1 mRNA expression in periretinal membranes
    Vappu Sirén
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Curr Eye Res 27:261-7. 2003
  4. ncbi request reprint Plasminogen activation in neurofibromatosis 2-associated and sporadic schwannomas
    V Siren
    Department of Virology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Acta Neurochir (Wien) 146:111-8. 2004
  5. ncbi request reprint Plasminogen activators and their inhibitor gene expression in cutaneous NF1-related neurofibromas
    Vappu Sirén
    Haartman Institute, University of Helsinki, P O Box 21, 00014, Helsinki, Finland
    Arch Dermatol Res 297:421-4. 2006
  6. ncbi request reprint Cell-cell contact activation of fibroblasts increases the expression of matrix metalloproteinases
    Vappu Sirén
    Haartman Institute, University of Helsinki, Finland
    Ann Med 38:212-20. 2006
  7. ncbi request reprint Co-localization of human herpes virus 6 and tissue plasminogen activator in multiple sclerosis brain tissue
    Jussi Oskari Virtanen
    Haartman Institute, Department of Virology, University of Helsinki, Finland
    Med Sci Monit 11:BR84-7. 2005
  8. ncbi request reprint High concentrations of plasminogen activator inhibitor-1 in lungs of preterm infants with respiratory distress syndrome
    Katariina Cederqvist
    Department of Pediatrics, University of Helsinki, Helsinki, Finland
    Pediatrics 117:1226-34. 2006
  9. ncbi request reprint Plasminogen activators and their inhibitors in human saliva and salivary gland tissue
    Oskari J Virtanen
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    Eur J Oral Sci 114:22-6. 2006
  10. ncbi request reprint Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system
    Tambet Teesalu
    Haartman Institute, University of Helsinki and HUCH Laboratory Diagnostics, Finland
    Thromb Haemost 92:358-68. 2004

Detail Information

Publications11

  1. ncbi request reprint Transforming growth factor beta induces urokinase receptor expression in cultured retinal pigment epithelial cells
    V Siren
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    Ophthalmic Res 31:184-91. 1999
    ..The increase in uPAR gene expression by IFN-gamma did not seem to translate into the protein level. We conclude that TGF-beta regulates the pericellular proteolysis in RPE cells by increasing uPAR expression...
  2. ncbi request reprint Urokinase, tissue-type plasminogen activator and plasminogen activator inhibitor-1 expression in severely stenosed and occluded vein grafts with thrombosis
    Vappu Sirén
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Blood Coagul Fibrinolysis 14:369-77. 2003
    ..We conclude that fibrinolytic system is upregulated at sites of graft stenosis, and local proteolytic degradation of the graft wall associates with thrombus formation...
  3. ncbi request reprint uPA, tPA and PAI-1 mRNA expression in periretinal membranes
    Vappu Sirén
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Curr Eye Res 27:261-7. 2003
    ....
  4. ncbi request reprint Plasminogen activation in neurofibromatosis 2-associated and sporadic schwannomas
    V Siren
    Department of Virology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Acta Neurochir (Wien) 146:111-8. 2004
    ..Invasiveness and higher proliferative potential compared to sporadic tumours are features of NF2-associated schwannomas...
  5. ncbi request reprint Plasminogen activators and their inhibitor gene expression in cutaneous NF1-related neurofibromas
    Vappu Sirén
    Haartman Institute, University of Helsinki, P O Box 21, 00014, Helsinki, Finland
    Arch Dermatol Res 297:421-4. 2006
    ..Large extent of tumor cells of Schwann cell origin and prominent expression levels of uPA, tPA and PAI-1 indicated that these cells are responsible for the main source of PA components in cutaneous NF1-related neurofibromas...
  6. ncbi request reprint Cell-cell contact activation of fibroblasts increases the expression of matrix metalloproteinases
    Vappu Sirén
    Haartman Institute, University of Helsinki, Finland
    Ann Med 38:212-20. 2006
    ..On the surface of the decomposing spheroids, activation of the major extracellular proteolytic cascade, plasminogen activation, associated with surface exposure of alpha-enolase, took place...
  7. ncbi request reprint Co-localization of human herpes virus 6 and tissue plasminogen activator in multiple sclerosis brain tissue
    Jussi Oskari Virtanen
    Haartman Institute, Department of Virology, University of Helsinki, Finland
    Med Sci Monit 11:BR84-7. 2005
    ..The aim of this study was to investigate the interrelationship of human herpesvirus 6 (HHV-6) and plasminogen activation at the cellular level in MS plaques...
  8. ncbi request reprint High concentrations of plasminogen activator inhibitor-1 in lungs of preterm infants with respiratory distress syndrome
    Katariina Cederqvist
    Department of Pediatrics, University of Helsinki, Helsinki, Finland
    Pediatrics 117:1226-34. 2006
    ..We studied levels of major plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA) in lungs of preterm infants with RDS...
  9. ncbi request reprint Plasminogen activators and their inhibitors in human saliva and salivary gland tissue
    Oskari J Virtanen
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    Eur J Oral Sci 114:22-6. 2006
    ..The tPA activity in saliva suggests an active proteolysis. Plasminogen activator inhibitor 2 was found to be the main inhibitor of PAs in saliva...
  10. ncbi request reprint Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system
    Tambet Teesalu
    Haartman Institute, University of Helsinki and HUCH Laboratory Diagnostics, Finland
    Thromb Haemost 92:358-68. 2004
    ..Our analysis documents a detailed map of expression of tPA and its inhibitor in the human CNS and is compatible with the view that tPA is a key player in CNS physiology and pathology...
  11. doi request reprint Formation and activation of fibroblast spheroids depend on fibronectin-integrin interaction
    Pertteli Salmenperä
    Haartman Institute, POB 21, FIN 00014 University of Helsinki, Finland
    Exp Cell Res 314:3444-52. 2008
    ..Our results present a new mechanism of fibroblast activation, which is initiated by interaction of FN with its integrin receptors...