H Sariola

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Crosstalk between Jagged1 and GDNF/Ret/GFRalpha1 signalling regulates ureteric budding and branching
    Satu Kuure
    Developmental Biology, Institute of Biomedicine, P O Box 63, Haartmaninkatu 8, University of Helsinki, Helsinki FIN 00014, Finland
    Mech Dev 122:765-80. 2005
  2. pmc GDNF promotes tubulogenesis of GFRalpha1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase
    Anna Popsueva
    Developmental Biology, Institute of Biomedicine, University of Helsinki, FIN 00014 Helsinki, Finland
    J Cell Biol 161:119-29. 2003
  3. ncbi request reprint GDNF and its receptors in the regulation of the ureteric branching
    H Sariola
    Institute of Biotechnology, Viikki Biocentre, University of Helsinki, Finland
    Int J Dev Biol 43:413-8. 1999
  4. ncbi request reprint The neurotrophic factors in non-neuronal tissues
    H Sariola
    Developmental Biology Research Program, Institute of Biotechnology, University of Helsinki, Finland
    Cell Mol Life Sci 58:1061-6. 2001
  5. ncbi request reprint Nephron induction revisited: from caps to condensates
    Hannu Sariola
    Institute of Biomedicine, Developmental Biology, University of Helsinki, Finland
    Curr Opin Nephrol Hypertens 11:17-21. 2002
  6. ncbi request reprint The tip-top branching ureter
    H Sariola
    Developmental Biology Research Programme, Institute of Biotechnology, Biocenter 1A, University of Helsinki, Finland
    Curr Opin Cell Biol 9:877-84. 1997
  7. ncbi request reprint [The chance and necessity of life]
    Hannu Sariola
    bioläaketieteen laitos, kehitysbiologia PL 63, 00014 Helsingin yliopisto
    Duodecim 118:2425-31. 2002
  8. ncbi request reprint GDNF-induced seminomatous tumours in mouse--an experimental model for human seminomas?
    Hannu Sariola
    Institute of Biomedicine and Institute of Biotechnology, P O Box 63 Haartmaninkatu 8, FIN 00014 University of Helsinki, Finland
    APMIS 111:192-6; discussion 196. 2003
  9. ncbi request reprint Novel functions and signalling pathways for GDNF
    Hannu Sariola
    Institute of Biomedicine, University of Helsinki, PO Box 63 Haartmaninkatu 8, FIN 00014, Finland
    J Cell Sci 116:3855-62. 2003
  10. ncbi request reprint [Genes behind humanity, rage, peace and the brain of apes]
    Hannu Sariola
    bioläaketieteen laitos, Biomedicum Helsinki, Helsingin yliopisto
    Duodecim 120:1836-7. 2004

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Crosstalk between Jagged1 and GDNF/Ret/GFRalpha1 signalling regulates ureteric budding and branching
    Satu Kuure
    Developmental Biology, Institute of Biomedicine, P O Box 63, Haartmaninkatu 8, University of Helsinki, Helsinki FIN 00014, Finland
    Mech Dev 122:765-80. 2005
    ..Thus, the data provide evidence for a novel crosstalk between Notch and Ret/GFRalpha1 signalling during early nephrogenesis...
  2. pmc GDNF promotes tubulogenesis of GFRalpha1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase
    Anna Popsueva
    Developmental Biology, Institute of Biomedicine, University of Helsinki, FIN 00014 Helsinki, Finland
    J Cell Biol 161:119-29. 2003
    ..The GDNF-induced branching of MDCK cells requires Src activation, whereas the HGF-induced branching does not. Our data show a mechanism for the GDNF-induced branching morphogenesis in non-Ret signaling...
  3. ncbi request reprint GDNF and its receptors in the regulation of the ureteric branching
    H Sariola
    Institute of Biotechnology, Viikki Biocentre, University of Helsinki, Finland
    Int J Dev Biol 43:413-8. 1999
    ....
  4. ncbi request reprint The neurotrophic factors in non-neuronal tissues
    H Sariola
    Developmental Biology Research Program, Institute of Biotechnology, University of Helsinki, Finland
    Cell Mol Life Sci 58:1061-6. 2001
    ..However, several examples can be presented of essential non-neuronal functions played by neurotrophins in e.g., cardiac, hair follicle, and vascular differentiation, and the maintenance of immune cells...
  5. ncbi request reprint Nephron induction revisited: from caps to condensates
    Hannu Sariola
    Institute of Biomedicine, Developmental Biology, University of Helsinki, Finland
    Curr Opin Nephrol Hypertens 11:17-21. 2002
    ..Apart from being the source for the pretubular aggregates, the role of the cap condensate is unknown. It is now proposed that the cap regulates ureteric branching morphogenesis...
  6. ncbi request reprint The tip-top branching ureter
    H Sariola
    Developmental Biology Research Programme, Institute of Biotechnology, Biocenter 1A, University of Helsinki, Finland
    Curr Opin Cell Biol 9:877-84. 1997
    ..The active receptor complex for GDNF includes the receptor tyrosine kinase Ret and a novel class of glycosylphosphatidylinositol-linked receptors, called GDNF family receptor alpha s...
  7. ncbi request reprint [The chance and necessity of life]
    Hannu Sariola
    bioläaketieteen laitos, kehitysbiologia PL 63, 00014 Helsingin yliopisto
    Duodecim 118:2425-31. 2002
  8. ncbi request reprint GDNF-induced seminomatous tumours in mouse--an experimental model for human seminomas?
    Hannu Sariola
    Institute of Biomedicine and Institute of Biotechnology, P O Box 63 Haartmaninkatu 8, FIN 00014 University of Helsinki, Finland
    APMIS 111:192-6; discussion 196. 2003
    ..Thus, by several histological, molecular, and histochemical characteristics, the GDNF-induced tumours mimic classical seminomas in men, but the precursor lesions are apparently different in mouse and man...
  9. ncbi request reprint Novel functions and signalling pathways for GDNF
    Hannu Sariola
    Institute of Biomedicine, University of Helsinki, PO Box 63 Haartmaninkatu 8, FIN 00014, Finland
    J Cell Sci 116:3855-62. 2003
    ..GDNF family ligands also signal through the neural cell adhesion molecule NCAM. In cells lacking RET, GDNF binds with high affinity to the NCAM and GFRalpha1 complex, which activates Fyn and FAK...
  10. ncbi request reprint [Genes behind humanity, rage, peace and the brain of apes]
    Hannu Sariola
    bioläaketieteen laitos, Biomedicum Helsinki, Helsingin yliopisto
    Duodecim 120:1836-7. 2004
  11. ncbi request reprint Cell lineages in the embryonic kidney: their inductive interactions and signalling molecules
    H Sariola
    Developmental Biology Research Programme, University of Helsinki, Finland
    Biochem Cell Biol 76:1009-16. 1998
    ....
  12. ncbi request reprint Promotion of seminomatous tumors by targeted overexpression of glial cell line-derived neurotrophic factor in mouse testis
    X Meng
    Developmental Biology and Molecular Neurobiology Research Programs, Institute of Biotechnology, Viikki Biocenter, FIN 00014 University of Helsinki, Finland
    Cancer Res 61:3267-71. 2001
    ..The data also show that a deregulated stimulation of a normal proto-oncogene by its ligand can be an initiative event in carcinogenesis...
  13. ncbi request reprint Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium
    K Sainio
    Programme of Developmental Biology, Institute of Biotechnology, University of Helsinki, Finland
    Development 124:4077-87. 1997
    ..Thus, GDNF is the first defined inducer in the embryonic metanephric kidney...
  14. ncbi request reprint Regulation of cell fate decision of undifferentiated spermatogonia by GDNF
    X Meng
    Research Programs of Developmental Biology, Molecular Neurobiology, Electron Microscopy Unit, Institute of Biotechnology, Viikki Biocenter, Finland
    Science 287:1489-93. 2000
    ..Nonmetastatic testicular tumors are regularly formed in older GDNF-overexpressing mice. Thus, GDNF contributes to paracrine regulation of spermatogonial self-renewal and differentiation...
  15. ncbi request reprint Transient disruption of spermatogenesis by deregulated expression of neurturin in testis
    X Meng
    Institute of Biomedicine, Developmental Biology, Biomedicum Helsinki and HUCH-Diagnostics, PO Box 63 (Haartmaninkatu 8, FIN-00014 University of Helsinki, Helsinki, Finland
    Mol Cell Endocrinol 184:33-9. 2001
    ....
  16. ncbi request reprint Other neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF)
    M Saarma
    Program for Molecular Neurobiology, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Microsc Res Tech 45:292-302. 1999
    ..NTN, ART, and PSP are also expressed in the developing kidney, and NTN and PSP induce ureteric branching in vitro, but their true in vivo role in kidney morphogenesis is still unclear...
  17. ncbi request reprint Neurotrophin mRNA expression in the developing tooth suggests multiple roles in innervation and organogenesis
    K Luukko
    Program of Developmental Biology, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 210:117-29. 1997
    ..In addition, the expression patterns of NGF, NT-3, and NT-4/5 as well as of neurotrophin receptors suggest that the neurotrophin system may also serve non-neuronal functions during tooth development...
  18. ncbi request reprint Hirschsprung's disease genes and the development of the enteric nervous system
    K Wartiovaara
    Institute of Biotechnology, Developmental Biology Research Programme, University of Helsinki, Hospital for Children and Adolescents, Finland
    Ann Med 30:66-74. 1998
    ..We combine here the present clinical data on the gene mutations in Hirschsprung's disease with the experimental molecular biology data, and formulate a hypothesis on the pathogenesis of this multigenic-multifactorial disease...
  19. ncbi request reprint Exclusion of the p75 neurotrophin receptor gene as a candidate gene for Meckel syndrome
    K Wartiovaara
    Institute of Biotechnology, University of Helsinki, Finland
    Clin Dysmorphol 6:213-7. 1997
    ..The sequence analysis of the coding region of the gene revealed one polymorphism but no potential disease mutation. Physical mapping of the critical chromosomal region finally showed that the NGFR gene lies outside the MKS locus...
  20. ncbi request reprint Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha
    P Suvanto
    Institute of Biotechnology, University of Helsinki, Finland
    Hum Mol Genet 6:1267-73. 1997
    ..The distinct tissue distribution of GDNFR-beta mRNA and its ability to mediate GDNF signal in transfected cells suggest a role in signal transduction of GDNF and, possibly, related neurotrophic factors in vivo...
  21. ncbi request reprint BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney
    A Raatikainen-Ahokas
    Developmental Biology Research Program, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 217:146-58. 2000
    ..Thus, BMP-4 may be a physiological regulator of the development of the periureteric smooth muscle layer and ureteric elongation...
  22. ncbi request reprint E6/E7 oncogenes increase and tumor suppressors decrease the proportion of self-renewing neural progenitor cells
    K Piltti
    Developmental Biology, Institute of Biomedicine, University of Helsinki, and HUCH Laboratory Diagnostics, Helsinki University Central Hospital, Finland
    Oncogene 25:4880-9. 2006
    ..These findings provide one explanation how oncogenes and tumour suppressors control tissue homeostasis and highlight their importance in stem cell self- renewal, linked both to cancer and life-long tissue turnover...
  23. ncbi request reprint Distribution of glial cell line-derived neurotrophic factor mRNA in human colon suggests roles for muscularis mucosae in innervation
    K Wartiovaara
    Institute of Biotechnology, University of Helsinki, The Hospital for Children and Adolescents, and HUCH Diagnostics, Finland
    J Pediatr Surg 33:1501-6. 1998
    ..The aim of this study was to analyze the mRNA distribution of these genes in the developing human intestine to understand their roles in enteric innervation...
  24. doi request reprint A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus
    Tiina Immonen
    Department of Medical Biochemistry and Developmental Biology, Institute of Biomedicine, Biomedicum Helsinki, P O Box 63, FI 00014 University of Helsinki, Finland
    Exp Neurol 210:793-6. 2008
    ..The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor...
  25. ncbi request reprint [From infected bandages to genome of the individual]
    Tiina Immonen
    Biomedicum Helsinki, bioläaketieteen laitos, kehitysbiologia PL 63 Haartmanin katu 8, 00014 Helsingin yliopisto
    Duodecim 119:2453-9. 2003
  26. doi request reprint Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney
    Nina Perälä
    Institute of Biomedicine Medical Biochemistry and Developmental Biology, Biomedicum Helsinki, PO Box 63, FI 00014 University of Helsinki, Finland
    Differentiation 81:81-91. 2011
    ....
  27. ncbi request reprint SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney
    Minna Kujala
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Nephron Exp Nephrol 101:e50-8. 2005
    ..They are expressed in kidney, but their exact localization in human kidney has not been studied. We therefore examined SLC26A6 and A7 expression in human kidneys...
  28. ncbi request reprint [Nematode--the mother or father of programmed cell death]
    Kirsi Sainio
    Helsingin yliopiston biolääketieteen laitos PL 63, 00014 Helsingin yliopisto
    Duodecim 118:2267-9. 2002
  29. ncbi request reprint Glycogen synthase kinase-3 inactivation and stabilization of beta-catenin induce nephron differentiation in isolated mouse and rat kidney mesenchymes
    Satu Kuure
    Biochemistry and Developmental Biology, Institute of Biomedicine, PO Box 63, Haartmaninkatu 8, University of Helsinki, FIN 00014, Finland
    J Am Soc Nephrol 18:1130-9. 2007
    ..These data show that activation of canonical Wnt pathway is sufficient to induce nephrogenesis and suggest that this pathway mediates the nephron induction in murine kidney mesenchymes...
  30. doi request reprint High frequency of SNAIL-expressing cells confirms and predicts metastatic potential of phaeochromocytoma
    V Häyry
    Institute of Biomedicine, Developmental Biology, University of Helsinki, Biomedicum, Helsinki, Finland
    Endocr Relat Cancer 16:1211-8. 2009
    ..We conclude that the expression of SNAIL may be of use in predicting the metastatic potential of phaeochromocytoma...
  31. doi request reprint Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours
    V Häyry
    Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Neuropathol Appl Neurobiol 34:555-63. 2008
    ..However, the significance of BMI-1 in human glioma has not been investigated. Here we describe expression of the polycomb protein BMI-1 and its downstream targets p16(Ink4a) and MDM2 in both high- and low-grade human glioma...
  32. ncbi request reprint Differential regulation of two sets of mesonephric tubules by WT-1
    K Sainio
    Department of Pathology, Haartman Institute, University of Helsinki, Finland
    Development 124:1293-9. 1997
    ..WT-1 therefore seems to be necessary for the mesenchyme to epithelium transitions at different stages of nephrogenesis...
  33. ncbi request reprint Nephron induction
    Hannu Sariola
    Institute of Biomedicine, Developmental Biology, University of Helsinki, FIN 00014, Finland
    Nephrol Dial Transplant 17:88-90. 2002
    ..In the rat, fibroblast growth factor-2 maintains the nephrogenic mesenchyme; leukaemia inhibitory factor together with transforming growth factor beta-2 induce its condensation; and autocrine secretion of Wnt-4 converts it to epithelium...
  34. ncbi request reprint The expression of plexins during mouse embryogenesis
    Nina M Perälä
    Developmental Biology, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P O Box 63, FIN 00014, Finland
    Gene Expr Patterns 5:355-62. 2005
    ..In the testis, Plxna1, Plxnb1 and Plxnc1 are expressed in the developing sex chords. This study shows that during development, plexins are expressed in specific and distinct patterns also in non-neuronal tissues...
  35. ncbi request reprint Congenital hypoplastic anemia, diabetes, and severe renal tubular dysfunction associated with a mitochondrial DNA deletion
    A Majander
    Department of Medical Chemistry, University of Helsinki, Finland
    Pediatr Res 30:327-30. 1991
    ..Decreased respiratory chain enzyme activities were demonstrated in muscle, and an mtDNA deletion was demonstrated in muscle, kidney, leukocytes, and fibroblasts...
  36. doi request reprint Myc increases self-renewal in neural progenitor cells through Miz-1
    Laura Kerosuo
    Developmental Biology, Institute of Biomedicine, Haartmaninkatu 8, PO Box 63, 00014 University of Helsinki, Finland
    J Cell Sci 121:3941-50. 2008
    ..Our results suggest that Myc, through Miz-1, enhances self-renewal of NPCs and influences the way progenitor cells react to the environmental cues that normally dictate the cellular identity of tissues containing self-renewing cells...
  37. doi request reprint CIP2A increases self-renewal and is linked to Myc in neural progenitor cells
    Laura Kerosuo
    Medical Biochemistry and Developmental Biology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Differentiation 80:68-77. 2010
    ....
  38. doi request reprint GDNF maintains mouse spermatogonial stem cells in vivo and in vitro
    Hannu Sariola
    Institute of Biomedicine, Biochemistry and Developmental Biology, University of Helsinki, Finland
    Methods Mol Biol 450:127-35. 2008
    ..We describe in detail the culture system of SSCs developed by Dr. Takashi Shinohara in 2003...
  39. ncbi request reprint RET tyrosine kinase signaling in development and cancer
    Elena Arighi
    Developmental Biology, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Finland
    Cytokine Growth Factor Rev 16:441-67. 2005
    ..We now review the role and mechanisms of RET signaling in development and carcinogenesis...
  40. ncbi request reprint Transgene insertion induced dominant male sterility and rescue of male fertility using round spermatid injection
    Xiaojuan Meng
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, FIN 00014 Helsinki, Finland
    Biol Reprod 66:726-34. 2002
    ..Furthermore, mice carrying this genetic trait might be useful for studies of assisted reproductive technologies and male contraceptives...
  41. ncbi request reprint Biological effects of the dual phenotypic Janus mutation of ret cosegregating with both multiple endocrine neoplasia type 2 and Hirschsprung's disease
    Elena Arighi
    Developmental Biology, Institute of Biomedicine, Biomedicum Helsinki, P O Box 63, University of Helsinki, Helsinki, Finland FIN 00014
    Mol Endocrinol 18:1004-17. 2004
    ....
  42. pmc The GDNF target Vsnl1 marks the ureteric tip
    Roxana Ola
    Biochemistry and Developmental Biology, Institute of Biomedicine, P O Box 63, Haartmaninkatu 8, University of Helsinki, FIN 00014, Finland
    J Am Soc Nephrol 22:274-84. 2011
    ..In summary, Vsnl1 marks ureteric bud tips in embryonic kidneys, and its mosaic pattern demonstrates a heterogeneity of cell types that may be critical for normal ureteric branching...
  43. ncbi request reprint An adenosine triphosphatase of the sucrose nonfermenting 2 family, androgen receptor-interacting protein 4, is essential for mouse embryonic development and cell proliferation
    Fu Ping Zhang
    Biomedicum Helsinki, Institute of Biomedicine, University of Helsinki, Haartmaninkatu 8, FI 00014, Helsinki, Finland
    Mol Endocrinol 21:1430-42. 2007
    ..Collectively, ARIP4 plays an essential role in mouse embryonic development and cell proliferation, and it appears to coordinate multiple essential biological processes, possibly through a complex chromatin remodeling system...
  44. doi request reprint Copy number alterations of the polycomb gene BMI1 in gliomas
    Valtteri Häyry
    Developmental Biology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Acta Neuropathol 116:97-102. 2008
    ..This data suggests that BMI1 gene is aberrant at the chromosomal level in a subset of gliomas, and possibly contributes to brain tumour pathogenesis...
  45. ncbi request reprint Differential requirement of Tyr1062 multidocking site by RET isoforms to promote neural cell scattering and epithelial cell branching
    Debora Degl'Innocenti
    Department of Experimental Oncology, Research Unit 3, Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milan, Italy
    Oncogene 23:7297-309. 2004
    ..GRB2 is the only known adaptor protein binding to Tyr1096. Dominant-negative GRB2 expressed in MDCK cells together with RET9 or RET51 significantly reduces branching. Therefore, GRB2 is necessary for RET-mediated branching of MDCK cells...
  46. pmc Gdnf haploinsufficiency causes Hirschsprung-like intestinal obstruction and early-onset lethality in mice
    Liya Shen
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814 2790, USA
    Am J Hum Genet 70:435-47. 2002
    ..These findings may have general implications for the genetic analysis of cause and effect in complex human diseases...
  47. ncbi request reprint Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications
    Craig M Stolen
    MediCity Research Laboratory, University of Turku and National Public Health Institute, Turku, Finland
    FASEB J 18:702-4. 2004
    ..These findings suggest that, although manipulation of VAP-1/SSAO has potential to serve as a therapeutic treatment in insulin-resistant conditions, care must be taken to fully understand its impact on obesity and vascular damage...
  48. ncbi request reprint Neural precursor cells from a fatal human motoneuron disease differentiate despite aberrant gene expression
    Niklas Pakkasjärvi
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    Dev Neurobiol 67:270-84. 2007
    ....
  49. ncbi request reprint [Time is our most important capital]
    Hannu Sariola
    Duodecim 118:2357-9. 2002
  50. ncbi request reprint [Micro-RNAs--a new way to regulate protein synthesis]
    Tiina Immonen
    Duodecim 118:661-2. 2002