Alberto Sanz

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. ncbi The mitochondrial free radical theory of aging: a critical view
    Alberto Sanz
    Mitochondrial Gene Expression and Disease Group, Institute of Medical Technology, University of Tampere, Biokatu 6, FI 33520 Tampere, Finland
    Curr Aging Sci 1:10-21. 2008
  2. doi Production of reactive oxygen species by the mitochondrial electron transport chain in Drosophila melanogaster
    Alberto Sanz
    Institute of Medical Technology and Tampere University Hospital, University of Tampere, Tampere, FI 33014, Finland
    J Bioenerg Biomembr 42:135-42. 2010
  3. pmc Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction
    Alberto Sanz
    Institute of Medical Technology and Tampere University Hospital, FI 33014 University of Tampere, Finland
    Proc Natl Acad Sci U S A 107:9105-10. 2010
  4. pmc Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila
    Alberto Sanz
    Institute of Medical Technology and Tampere University Hospital, FI 33014 University of Tampere, Finland
    Aging (Albany NY) 2:200-23. 2010
  5. pmc dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster
    Rhoda Stefanatos
    Institute of Biomedical Technology and Tampere University Hospital, University of Tampere, Tampere, Finland
    Cell Cycle 11:3876-86. 2012
  6. pmc A cytoplasmic suppressor of a nuclear mutation affecting mitochondrial functions in Drosophila
    Shanjun Chen
    Institute of Biomedical Technology and Tampere University Hospital, FI 33014 University of Tampere, Finland
    Genetics 192:483-93. 2012
  7. doi Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation
    Daniel J M Fernández-Ayala
    Institute of Medical Technology, Tampere University Hospital, University of Tampere, 33014 Tampere, Finland
    Cell Metab 9:449-60. 2009
  8. pmc Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency
    Kia K Kemppainen
    Institute of Biomedical Technology and Tampere University Hospital, University of Tampere, FI 33014 Tampere, Finland
    Hum Mol Genet 23:2078-93. 2014
  9. doi Regulation of lifespan by the mitochondrial electron transport chain: reactive oxygen species-dependent and reactive oxygen species-independent mechanisms
    Filippo Scialò
    1 Institute of Biomedical Technology and Tampere University Hospital, University of Tampere, Tampere, Finland
    Antioxid Redox Signal 19:1953-69. 2013

Collaborators

  • Howard T Jacobs
  • Pierre Rustin
  • Reinald Pamplona
  • Jongkyeong Chung
  • Takao Yagi
  • Massimo Zeviani
  • Kia K Kemppainen
  • Rhoda Stefanatos
  • Filippo Scialò
  • Ashwin Sriram
  • Shanjun Chen
  • Tea Tuomela
  • Daniel J M Fernández-Ayala
  • Juho Rinne
  • Matti Lakanmaa
  • Akbar Zeb
  • Anna Popplestone
  • Satpal Singh
  • Venkatesh Mallikarjun
  • Essi Kiviranta
  • Esko Kemppainen
  • Barbara Schlicht
  • Atsushi Fukuoh
  • Victoria Ayala
  • Marcos T Oliveira
  • Laurie S Kaguni
  • Aravind Mohan
  • Suvi Vartiainen
  • Kevin M C O'Dell
  • Marek Babusiak
  • Eero Mustalahti
  • Rodolfo Costa

Detail Information

Publications10

  1. ncbi The mitochondrial free radical theory of aging: a critical view
    Alberto Sanz
    Mitochondrial Gene Expression and Disease Group, Institute of Medical Technology, University of Tampere, Biokatu 6, FI 33520 Tampere, Finland
    Curr Aging Sci 1:10-21. 2008
    ..g. insulin signalling). If MFRTA is true animals producing fewer mtROS must have the ability to live much longer than their experimental controls...
  2. doi Production of reactive oxygen species by the mitochondrial electron transport chain in Drosophila melanogaster
    Alberto Sanz
    Institute of Medical Technology and Tampere University Hospital, University of Tampere, Tampere, FI 33014, Finland
    J Bioenerg Biomembr 42:135-42. 2010
    ..These results clearly show that Drosophila mitochondria function in a very similar way to mammalian mitochondria, and therefore are a very relevant experimental model for biochemical studies related to ageing...
  3. pmc Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction
    Alberto Sanz
    Institute of Medical Technology and Tampere University Hospital, FI 33014 University of Tampere, Finland
    Proc Natl Acad Sci U S A 107:9105-10. 2010
    ..Our results support a central role of mitochondrial oxidative phosphorylation complex I in influencing longevity via oxidative stress, independently of pathways connected to nutrition and growth signaling...
  4. pmc Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila
    Alberto Sanz
    Institute of Medical Technology and Tampere University Hospital, FI 33014 University of Tampere, Finland
    Aging (Albany NY) 2:200-23. 2010
    ..In summary, these results do not systematically support the predictions of the MFRTA. Accordingly, MFRTA should be revised to accommodate these findings...
  5. pmc dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster
    Rhoda Stefanatos
    Institute of Biomedical Technology and Tampere University Hospital, University of Tampere, Tampere, Finland
    Cell Cycle 11:3876-86. 2012
    ..Our results reveal an important role of dj-1β in oxidative stress handling, insulin-like signaling and development in Drosophila melanogaster...
  6. pmc A cytoplasmic suppressor of a nuclear mutation affecting mitochondrial functions in Drosophila
    Shanjun Chen
    Institute of Biomedical Technology and Tampere University Hospital, FI 33014 University of Tampere, Finland
    Genetics 192:483-93. 2012
    ..Our findings provide a paradigm for understanding the role of mtDNA genotype in human disease...
  7. doi Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation
    Daniel J M Fernández-Ayala
    Institute of Medical Technology, Tampere University Hospital, University of Tampere, 33014 Tampere, Finland
    Cell Metab 9:449-60. 2009
    ..AOX appears to offer promise as a wide-spectrum therapeutic tool in OXPHOS disorders...
  8. pmc Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency
    Kia K Kemppainen
    Institute of Biomedical Technology and Tampere University Hospital, University of Tampere, FI 33014 Tampere, Finland
    Hum Mol Genet 23:2078-93. 2014
    ..These findings confirm the potential utility of alternative respiratory chain enzymes as tools to combat mitochondrial disease, while indicating important limitations thereof. ..
  9. doi Regulation of lifespan by the mitochondrial electron transport chain: reactive oxygen species-dependent and reactive oxygen species-independent mechanisms
    Filippo Scialò
    1 Institute of Biomedical Technology and Tampere University Hospital, University of Tampere, Tampere, Finland
    Antioxid Redox Signal 19:1953-69. 2013
    ....