J T Salonen

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi Markers of oxidative damage and antioxidant protection: assessment of LDL oxidation
    J T Salonen
    Research Institute of Public Health, University of Kuopio, Finland
    Free Radic Res 33:S41-6. 2000
  2. ncbi Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study
    Riitta M Salonen
    Research Institute of Public Health, University of Kuopio, Finland
    Circulation 107:947-53. 2003
  3. ncbi Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis
    J T Salonen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland and Department of Clinical Pharmacology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Intern Med 248:377-86. 2000
  4. ncbi Clinical trials testing cardiovascular benefits of antioxidant supplementation
    Jukka T Salonen
    Department of Public Health and General Practice, The Research Institute of Public Health, University of Kuopio, 70211 Kuopio, Finland
    Free Radic Res 36:1299-306. 2002
  5. ncbi Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome
    David E Laaksonen
    Department of Physiology, University of Kuopio, Kuopio, Finland Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Diabetes Care 25:1612-8. 2002
  6. ncbi Mercury accumulation and accelerated progression of carotid atherosclerosis: a population-based prospective 4-year follow-up study in men in eastern Finland
    J T Salonen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211, Kuopio, Finland
    Atherosclerosis 148:265-73. 2000
  7. ncbi Liver damage and protective effect of high density lipoprotein cholesterol
    Jukka T Salonen
    Research Institute of Public Health, Department of Public Health and General Practice, University of Kuopio, Box 1627, FIN-70211 Kuopio, Finland
    BMJ 327:1082-3. 2003
  8. ncbi Cardiac power during exercise and the risk of stroke in men
    S Kurl
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Stroke 36:820-4. 2005
  9. ncbi Supplementation with vitamin E but not with vitamin C lowers lipid peroxidation in vivo in mildly hypercholesterolemic men
    J Kaikkonen
    Oy Jurilab Ltd, Kuopio, Finland
    Free Radic Res 35:967-78. 2001
  10. ncbi Association of exercise-induced, silent ST-segment depression with the risk of stroke and cardiovascular diseases in men
    S Kurl
    Research Institute of Public Health, Kuopio, Finland
    Stroke 34:1760-5. 2003

Detail Information

Publications104 found, 100 shown here

  1. ncbi Markers of oxidative damage and antioxidant protection: assessment of LDL oxidation
    J T Salonen
    Research Institute of Public Health, University of Kuopio, Finland
    Free Radic Res 33:S41-6. 2000
    ..g. F2-isoprostanes. A second approach is to measure the immunologic response to antigenic lipid peroxidation products. In vitro measurements such as the susceptibility of isolated lipoprotein to oxidants are less preferable...
  2. ncbi Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study
    Riitta M Salonen
    Research Institute of Public Health, University of Kuopio, Finland
    Circulation 107:947-53. 2003
    ..This article examines the 6-year effect of supplementation on common carotid artery (CCA) intima-media thickness (IMT)...
  3. ncbi Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis
    J T Salonen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland and Department of Clinical Pharmacology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Intern Med 248:377-86. 2000
    ..To study the efficacy of vitamin E and C supplementation on the progression of carotid atherosclerosis, hypothesizing an enhanced preventive effect in men and in smokers and synergism between vitamins...
  4. ncbi Clinical trials testing cardiovascular benefits of antioxidant supplementation
    Jukka T Salonen
    Department of Public Health and General Practice, The Research Institute of Public Health, University of Kuopio, 70211 Kuopio, Finland
    Free Radic Res 36:1299-306. 2002
    ..The results of these studies will become available during 2003-2006. They may provide the necessary additional information concerning the effect of antioxidants on cardiovascular events...
  5. ncbi Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome
    David E Laaksonen
    Department of Physiology, University of Kuopio, Kuopio, Finland Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Diabetes Care 25:1612-8. 2002
    ..We studied the associations of LTPA and cardiorespiratory fitness with development of the metabolic syndrome (World Health Organization [WHO] and the National Cholesterol Education Program [NCEP] definitions)...
  6. ncbi Mercury accumulation and accelerated progression of carotid atherosclerosis: a population-based prospective 4-year follow-up study in men in eastern Finland
    J T Salonen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211, Kuopio, Finland
    Atherosclerosis 148:265-73. 2000
    ..9%) greater in the highest fifth than in the other fifths (P<0.05 for the difference). These findings suggest that mercury accumulation in the human body is associated with accelerated progression of carotid atherosclerosis...
  7. ncbi Liver damage and protective effect of high density lipoprotein cholesterol
    Jukka T Salonen
    Research Institute of Public Health, Department of Public Health and General Practice, University of Kuopio, Box 1627, FIN-70211 Kuopio, Finland
    BMJ 327:1082-3. 2003
  8. ncbi Cardiac power during exercise and the risk of stroke in men
    S Kurl
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Stroke 36:820-4. 2005
    ..The aim of this study was to examine the relationship of exercise cardiac power (ECP), defined as a ratio of VO2max with peak systolic blood pressure (SBP) during exercise, with the risk for stroke...
  9. ncbi Supplementation with vitamin E but not with vitamin C lowers lipid peroxidation in vivo in mildly hypercholesterolemic men
    J Kaikkonen
    Oy Jurilab Ltd, Kuopio, Finland
    Free Radic Res 35:967-78. 2001
    ..This observation may provide a mechanism for the observed ability of vitamin E supplements to prevent atherosclerosis...
  10. ncbi Association of exercise-induced, silent ST-segment depression with the risk of stroke and cardiovascular diseases in men
    S Kurl
    Research Institute of Public Health, Kuopio, Finland
    Stroke 34:1760-5. 2003
    ..4 to 6.1). CONCLUSIONS: Exercise-induced silent myocardial ischemia is an important indicator of increased risk of stroke and CVD in men with other risk factors, such as smoking, hypercholesterolemia, hypertension, and being overweight...
  11. ncbi Systolic blood pressure response to exercise stress test and risk of stroke
    S Kurl
    Research Institute of Public Health, Department of Public Health and General Practice, University of Kuopio, Finland
    Stroke 32:2036-41. 2001
    ..Exercise SBP testing may be recommended as an additional tool in the prediction of future stroke...
  12. ncbi Exercise-induced silent myocardial ischemia and coronary morbidity and mortality in middle-aged men
    J A Laukkanen
    Research Institute of Public Health, University of Kuopio, Finland
    J Am Coll Cardiol 38:72-9. 2001
    ....
  13. ncbi Cardiorespiratory fitness and the progression of carotid atherosclerosis in middle-aged men
    T A Lakka
    University of Kuopio, Kuopio Research Institute of Exercise Medicine, Kuopio University Hospital, Finland
    Ann Intern Med 134:12-20. 2001
    ..Good cardiorespiratory fitness has been associated with reduced risk for clinical events of atherosclerotic vascular diseases, but whether it is related to slower progression of early atherosclerosis is unclear...
  14. ncbi Cardiovascular fitness as a predictor of mortality in men
    J A Laukkanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, Harjulantie 1 B, 70211 Kuopio, Finland
    Arch Intern Med 161:825-31. 2001
    ..To examine the relations of cardiorespiratory fitness, as measured by maximal oxygen uptake and exercise test duration at the initiation of the study, with overall, cardiovascular disease (CVD)-related, and non-CVD-related mortality...
  15. ncbi Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study
    T H Rissanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland
    Br J Nutr 85:749-54. 2001
    ..Our study suggests that a low serum level of lycopene is associated with an increased risk of atherosclerotic vascular events in middle-aged men previously free of CHD and stroke...
  16. ncbi Depression and early retirement: prospective population based study in middle aged men
    M Karpansalo
    Department of Public Health and General Practice, University of Kuopio, PO Box 1927, 70120 Kuopio, Finland
    J Epidemiol Community Health 59:70-4. 2005
    ..Mental depression is an important health problem in many countries. It reduces productivity at work and is the fastest increasing reason for early retirement...
  17. ncbi Hyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middle-aged men
    J T Salonen
    Research Institute of Public Health and Department of Public Health and General Practice, University of Kuopio, Finland
    Diabetes 47:270-5. 1998
    ....
  18. ncbi Lowering of body iron stores by blood letting and oxidation resistance of serum lipoproteins: a randomized cross-over trial in male smokers
    J T Salonen
    Research Institute of Public Health, University of Kuopio, Finland
    J Intern Med 237:161-8. 1995
    ..The purpose of this study was to test the hypothesis that the reduction of body iron stores by venesection (blood letting) would reduce the susceptibility to oxidation of atherogenic serum lipoproteins...
  19. ncbi Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Mol Psychiatry 4:286-9. 1999
    ..3% (95% CI 2.3-25.7%). The results indicate that the COMT polymorphism contributes significantly to the development of late-onset alcoholism...
  20. ncbi The predictive value of cardiorespiratory fitness combined with coronary risk evaluation and the risk of cardiovascular and all-cause death
    J A Laukkanen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    J Intern Med 262:263-72. 2007
    ..We investigated the prognostic significance of risk scores and cardiorespiratory fitness with respect to cardiovascular disease and all-cause mortality...
  21. ncbi Homocysteine as a risk factor for CVD mortality in men with other CVD risk factors: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study
    J K Virtanen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    J Intern Med 257:255-62. 2005
    ..The purpose of the study was to explore the joint effect of increased serum tHcy concentration and other risk factors on the risk of CVD mortality in middle-aged men without a history of heart disease or stroke...
  22. ncbi Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers
    J Kauhanen
    Department of Public Health and General Practice, University of Kuopio, Finland
    Alcohol Clin Exp Res 24:135-9. 2000
    ..Previous studies have shown that type I alcoholism is more common among subjects with low activity COMT genotype (LL), compared with high activity (HH) or heterozygotic (LH) genotypes...
  23. ncbi Exhaustive exercise increases plasma/serum total oxidation resistance in moderately trained men and women, whereas their VLDL + LDL lipoprotein fraction is more susceptible to oxidation
    J Kaikkonen
    Oy Jurilab Ltd, Kuopio, Finland
    Scand J Clin Lab Invest 62:599-607. 2002
    ..On the basis of these results, several in vitro measurements of lipid peroxidation assessing both water and lipid soluble plasma fractions are needed if a true perspective of the plasma redox status is to be obtained...
  24. ncbi Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study
    S Voutilainen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Circulation 103:2674-80. 2001
    ..Our findings provide further support in favor of a role of folate in the promotion of good cardiovascular health...
  25. ncbi Oxidative DNA damage in vivo: relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion
    H E Poulsen
    Department of Clinical Pharmacology, Rigshospitalet, University Hospital Copenhagen, Denmark
    Free Radic Res 29:565-71. 1998
    ..50, p < 0.05). We conclude that 8-oxodG excretion is determined by factors like oxygen consumption and CYP1A2 activity rather than by factors like plasma antioxidant concentrations...
  26. ncbi Pattern of alcohol drinking and progression of atherosclerosis
    J Kauhanen
    Research Institute of Public Health and the Department of Public Health and General Practice, University of Kuopio, Finland
    Arterioscler Thromb Vasc Biol 19:3001-6. 1999
    ..We conclude that the pattern of drinking associates with the progression of carotid atherosclerosis independently of the total level of alcohol consumption and risk factors...
  27. ncbi Peak oxygen pulse during exercise as a predictor for coronary heart disease and all cause death
    J A Laukkanen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Heart 92:1219-24. 2006
    ....
  28. ncbi Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men
    D E Laaksonen
    Department of Physiology, and Research Institute of Public Health, University of Kuopio, and Department of Medicine, Kuopio University Hospital, Kuopio, and Inner Savo Health Centre, Suonerjoki, Finland
    Diabet Med 19:456-64. 2002
    ..These findings support recommendations to substitute vegetable fat for animal and dairy fat in the prevention of disturbances of glucose and lipid metabolism...
  29. ncbi C18 hydroxy fatty acids as markers of lipid peroxidation ex vivo and in vivo
    J Kaikkonen
    Oy Jurilab Ltd, Kuopio, Finland
    Scand J Clin Lab Invest 64:457-68. 2004
    ..Under high oxidation conditions, 9-and 13-OHFAs seem to be the most useful indices because of their high formation capacity...
  30. ncbi C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men
    D E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetologia 47:1403-10. 2004
    ..CONCLUSIONS/INTERPRETATION: Low-grade inflammation may increase the risk of the metabolic syndrome and diabetes in middle-aged men, but some of the risk is mediated through obesity and factors related to insulin resistance...
  31. ncbi Hyperinsulinemia and the risk of cardiovascular death and acute coronary and cerebrovascular events in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
    H M Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    Arch Intern Med 160:1160-8. 2000
    ..The role of hyperinsulinemia as a cardiovascular risk factor is controversial. We studied whether hyperinsulinemia is independently associated with increased cardiovascular morbidity and mortality...
  32. ncbi Plasma vitamin C modifies the association between hypertension and risk of stroke
    S Kurl
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Stroke 33:1568-73. 2002
    ..48 to 4.90; P=0.001) for any stroke after adjustment for age, examination months, and other risk factors. CONCLUSIONS: Low plasma vitamin C was associated with increased risk of stroke, especially among hypertensive and overweight men...
  33. ncbi Workload at the heart rate of 100 beats/min and mortality in middle-aged men with known or suspected coronary heart disease
    K P Savonen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Heart 94:e14. 2008
    ..To investigate whether a workload which an individual is able to perform at the heart rate (HR) of 100 beats/min (WL(100)) independently predicts mortality in middle-aged men with known or suspected coronary heart disease (CHD)...
  34. ncbi Blood pressure and the progression of carotid atherosclerosis in middle-aged men
    T A Lakka
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Hypertension 34:51-6. 1999
    ..Therefore, more attention should be paid to the level of SBP in the evaluation of CVD risk and in the treatment of hypertension...
  35. ncbi Low maximal oxygen uptake is associated with elevated depressive symptoms in middle-aged men
    T Tolmunen
    Department of Psychiatry, Kuopio University Hospital, P O Box 1777, FIN 70211, Kuopio, Finland
    Eur J Epidemiol 21:701-6. 2006
    ..38; 95% CI: 1.60-7.14; p < 0.001). In conclusion, low VO(2max) is associated with having elevated depressive symptoms in middle-aged men...
  36. ncbi Plasma N-terminal fragments of natriuretic peptides predict the risk of stroke and atrial fibrillation in men
    S Kurl
    Research Institute of Public Health, University of Kuopio, PO Box 1627, Kuopio 70211, Finland
    Heart 95:1067-71. 2009
    ..Prognostic value of natriuretic peptides has been established in patients with heart failure. However, the prognostic significance of natriuretic peptides with respect to stroke is not well known in general populations...
  37. ncbi Cardiorespiratory fitness and risk of disability pension: a prospective population based study in Finnish men
    M Karpansalo
    Research Institute of Public Health, University of Kuopio, Finland
    Occup Environ Med 60:765-9. 2003
    ..Early retiring is a major social problem in many western countries...
  38. ncbi Obesity and weight gain are associated with increased incidence of hyperinsulinemia in non-diabetic men
    H M Lakka
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Horm Metab Res 34:492-8. 2002
    ..Hyperinsulinemia at baseline was not associated with weight gain during the follow-up. This prospective population-based study emphasizes the importance of avoiding obesity and weight gain during adulthood in preventing hyperinsulinemia...
  39. ncbi Neuropeptide Y polymorphism and alcohol consumption in middle-aged men
    J Kauhanen
    Department of Public Health and General Practice, University of Kuopio, Finland
    Am J Med Genet 93:117-21. 2000
    ..1% vs. 8.2%, P = 0.10). Our study provides the first evidence that alcohol preference in humans is likely to be regulated by the NPY system...
  40. ncbi Gene transfer of extracellular superoxide dismutase to atherosclerotic mice
    M O Laukkanen
    A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Antioxid Redox Signal 3:397-402. 2001
    ..It is concluded that short-term overexpression of EC-SOD in vivo does not affect atherogenesis in LDL receptor -/- mice...
  41. ncbi Abdominal obesity is associated with increased risk of acute coronary events in men
    H-M Lakka
    Department of Public Health and General Practice, Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Eur Heart J 23:706-13. 2002
    ..Since the effect of abdominal obesity was strongest in smoking and unfit men, the strategy for lifestyle modification to prevent coronary heart disease should address these issues jointly...
  42. ncbi Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine
    V P Valkonen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Lancet 358:2127-8. 2001
    ..62 micromol/L) had a 3.9-fold (95% CI 1.25-12.3, p=0.02) increase in risk of acute coronary events compared with the other quartiles. Our findings suggest that ADMA is a predictor of acute coronary events...
  43. ncbi Phloem fortification in rye bread elevates serum enterolactone level
    M Vanharanta
    The Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Eur J Clin Nutr 56:952-7. 2002
    ..SPONSORSHIP: Phloem powder and the study breads were provided by Finnpettu Oy and Linkosuo Oy, respectively. The clinical study work was sponsored in part by Oy Jurilab Ltd...
  44. ncbi Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutation : a prospective cohort study in men in eastern Finland
    T P Tuomainen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Circulation 100:1274-9. 1999
    ..1 to 4.8; P=0.03) risk of acute myocardial infarction compared with noncarriers. Conclusions-Male carriers of the common hemochromatosis gene mutation are at 2-fold risk for first acute myocardial infarction compared with noncarriers...
  45. ncbi Associations between apolipoprotein E phenotype, glucose metabolism and cognitive function in men. An explorative study in a population sample
    E L Helkala
    Department of Public Health and General Practice of University of Kuopio, Kuopio, Finland
    Diabet Med 18:991-7. 2001
    ..To investigate the associations of the apolipoprotein E phenotype (apoE) and disturbed glucose metabolism with cognitive function in a random population sample...
  46. ncbi Ethanol consumption and DRD2 gene TaqI a polymorphism among socially drinking males
    Tero Hallikainen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Kuopio, Finland
    Am J Med Genet A 119:152-5. 2003
    ..These results in the large sample of non-alcoholic males are also opposite to some previous findings on the higher A1 allele frequency among alcoholic populations...
  47. ncbi Polyphenol-rich phloem enhances the resistance of total serum lipids to oxidation in men
    Jaakko Mursu
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    J Agric Food Chem 53:3017-22. 2005
    ..in a dose-dependent manner. Our results suggest that polyphenols may inhibit lipid peroxidation in the hydrophilic fraction of serum...
  48. ncbi Metabolic syndrome and the risk of stroke in middle-aged men
    Sudhir Kurl
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Stroke 37:806-11. 2006
    ..The aim of this study was to examine the relationship of metabolic syndrome, as defined by National Cholesterol Education Program (NCEP) and World Health Organization (WHO) criteria, with the risk for stroke...
  49. ncbi The effects of coffee consumption on lipid peroxidation and plasma total homocysteine concentrations: a clinical trial
    Jaakko Mursu
    Research Institute of Public Health, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Free Radic Biol Med 38:527-34. 2005
    ..In conclusion, the consumption of filtered coffee does not have any detectable effects on lipid peroxidation in healthy nonsmoking men. The effect of coffee consumption on tHcy concentrations needs further investigation...
  50. ncbi Heart rate response during exercise test and cardiovascular mortality in middle-aged men
    Kai P Savonen
    Kuopio Research Institute of Exercise Medicine, Haapaniementie 16, 70100 Kuopio, Finland
    Eur Heart J 27:582-8. 2006
    ..CONCLUSION: By considering an HR response throughout an exercise test, we found that a blunted HR increase at 40-100% of maximal workload was associated with increased CVD mortality...
  51. ncbi Left atrium size and the risk of cardiovascular death in middle-aged men
    Jari A Laukkanen
    Research Institute of Public Health, University of Kuopio, 70211 Kuopio, Finland
    Arch Intern Med 165:1788-93. 2005
    ..Although echocardiography is widely used in the evaluation of cardiac structures and function, the prognostic value of echocardiographic assessment of left atrium (LA) size for risk stratification of cardiovascular death is unknown...
  52. ncbi Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids
    David E Laaksonen
    Department of Physiology, University of Kuopio, Kuopio, Finland
    Arch Intern Med 165:193-9. 2005
    ..Dietary fat quality seems more important than fat quantity in the reduction of cardiovascular mortality in men...
  53. ncbi Serum homocysteine, folate and risk of stroke: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study
    Jyrki K Virtanen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Eur J Cardiovasc Prev Rehabil 12:369-75. 2005
    ..Homocysteine and folate have been suggested to have opposite effects on the risk of stroke, although the results are controversial...
  54. ncbi Mediation and modification of the association between hopelessness, hostility, and progression of carotid atherosclerosis
    Ricardo A Pollitt
    Department of Epidemiology, School of Public Health, The University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    J Behav Med 28:53-64. 2005
    ..SBP significantly modified the relation between hostility and PCA in participants of moderate hostility. The above biological pathways are implicated in the mechanisms connecting hopelessness, hostility, and PCA...
  55. ncbi Association between low serum enterolactone and increased plasma F2-isoprostanes, a measure of lipid peroxidation
    Meri Vanharanta
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Atherosclerosis 160:465-9. 2002
    ..Our present data suggest that low serum enterolactone concentration is associated with enhanced in vivo lipid peroxidation in men...
  56. ncbi C-reactive protein in the prediction of cardiovascular and overall mortality in middle-aged men: a population-based cohort study
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, PO Box 1777, FIN 70211 Kuopio, Finland
    Eur Heart J 26:1783-9. 2005
    ..We therefore assessed the association of C-reactive protein levels with cardiovascular mortality in a population-based cohort of 2321 middle-aged men stratified by the presence of cardiovascular disease (CVD) at baseline...
  57. ncbi Urinary excretion of epsilondA is not predictive of cancer development: a prospective nested case-control study
    Peter R Hillestrøm
    Department of Clinical Pharmacology Q7642, Rigshospitalet, University Hospital Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Free Radic Res 39:51-3. 2005
    ..73 (95% CI 0.29-1.80, p = 0.49). In this study, the urinary excretion of epsilondA provides no additional prediction of cancer development in males after controlling for smoking...
  58. ncbi Plasma N-terminal fragments of natriuretic propeptides predict the risk of cardiovascular events and mortality in middle-aged men
    Jari A Laukkanen
    Research Institute of Public Health, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Eur Heart J 27:1230-7. 2006
    ..We, therefore, studied if both NT-proANP and NT-proBNP are predictive for overall death, cardiovascular events, and atrial fibrillation (AF) among middle-aged men without heart failure or AF at baseline...
  59. ncbi Systolic blood pressure response to exercise testing is related to the risk of acute myocardial infarction in middle-aged men
    Jari A Laukkanen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Eur J Cardiovasc Prev Rehabil 13:421-8. 2006
    ..We assessed the association of systolic blood pressure response to exercise with the risk of an acute myocardial infarction...
  60. ncbi Changes in LDL fatty acid composition as a response to olive oil treatment are inversely related to lipid oxidative damage: The EUROLIVE study
    Arrigo F G Cicero
    GC Descovich Atherosclerosis and Metabolic Disease Research Unit, Internal Medicine, Aging and Kidney Diseases Dept, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy
    J Am Coll Nutr 27:314-20. 2008
    ..The aim of our study was to assess the changes in the fatty acid composition of low density lipoproteins (LDL) after sustained consumption of olive oil at real-life doses (25 mL/day) and their relationship with lipid oxidative damage...
  61. ncbi Intake of flavonoids and risk of cancer in Finnish men: The Kuopio Ischaemic Heart Disease Risk Factor Study
    Jaakko Mursu
    Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Int J Cancer 123:660-3. 2008
    ..No association between flavonoid intake and risk of prostate or colorectal cancer were found. We conclude that high intake of flavonoids is associated with decreased risk of lung cancer in middle-aged Finnish smoking men...
  62. ncbi Occupational physical activity, energy expenditure and 11-year progression of carotid atherosclerosis
    Niklas Krause
    Department of Medicine, University of California at San Francisco, UC Berkeley Richmond Field Station, Richmond CA 94804, USA
    Scand J Work Environ Health 33:405-24. 2007
    ..This study prospectively assessed the effects of occupational physical activity on atherosclerosis progression...
  63. ncbi Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men
    Anita M Tuomainen
    Institute of Dentistry, University of Helsinki, Haartmaninkatu 8, P O Box 63, FI 00014 Helsinki, Finland
    Arterioscler Thromb Vasc Biol 27:2722-8. 2007
    ..Results on the association of serum MMP-8 concentrations and cardiovascular diseases (CVD) are, however, scarce and contradictory...
  64. ncbi Effectiveness of workload at the heart rate of 100 beats/min in predicting cardiovascular mortality in men aged 42, 48, 54, or 60 years at baseline
    Kai P Savonen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Am J Cardiol 100:563-8. 2007
    ..In conclusion, WL(100) predicts CVD and CHD mortality in men without previous CHD. The association of WL(100) with CVD and CHD mortality is not explained by maximal cardiorespiratory performance...
  65. ncbi Effects of astaxanthin supplementation on lipid peroxidation
    Jouni Karppi
    Research Institute of Public Health, University of Kuopio, P O Box 1627, FI 70211 Kuopio, Finland
    Int J Vitam Nutr Res 77:3-11. 2007
    ..The present study suggests that intestinal absorption of astaxanthin delivered as capsules is adequate, and well tolerated. Supplementation with astaxanthin may decrease in vivo oxidation of fatty acids in healthy men...
  66. ncbi High dietary methionine intake increases the risk of acute coronary events in middle-aged men
    Jyrki K Virtanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Nutr Metab Cardiovasc Dis 16:113-20. 2006
    ..To date, the effects of dietary intake of methionine, the key amino acid in homocysteine metabolism, on CVD have not been studied. Our aim was to examine the effects of dietary methionine intake on the risk of acute coronary events...
  67. ncbi The intake of flavonoids and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Jaakko Mursu
    The Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Br J Nutr 98:814-8. 2007
    ..There was a trend for an inverse association between intake of flavonols and mean CCA-IMT (P = 0.055). We conclude that high intake of flavonoids is associated with decreased carotid atherosclerosis in middle-aged Finnish men...
  68. ncbi Socioeconomic and psychosocial exposures across the life course and binge drinking in adulthood: population-based study
    Seungmi Yang
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada
    Am J Epidemiol 165:184-93. 2007
    ....
  69. ncbi The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial
    Maria Isabel Covas
    Municipal Institute for Medical Research, Barcelona, Spain
    Ann Intern Med 145:333-41. 2006
    ..Little information is available on the effect of the phenolic compounds of olive oil on plasma lipid levels. No international study with a large sample size has been done...
  70. ncbi Dietary folate and depressive symptoms are associated in middle-aged Finnish men
    Tommi Tolmunen
    Department of Psychiatry, University of Kuopio, Finland
    J Nutr 133:3233-6. 2003
    ..46, 95% CI = 1.01-2.12, P = 0.044). There were no associations between the intake of cobalamin, pyridoxine or riboflavin, and depression. These results indicate that nutrition may have a role in the prevention of depression...
  71. ncbi Consumption of juice fortified with oregano extract markedly increases excretion of phenolic acids but lacks short- and long-term effects on lipid peroxidation in healthy nonsmoking men
    Anna Nurmi
    Division of Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, Finland
    J Agric Food Chem 54:5790-6. 2006
    ....
  72. ncbi Carotid artery intima-media thickness in Finnish families with familial combined hyperlipidemia
    Kati Ylitalo
    Department of Medicine, Helsinki University Central Hospital, University of Helsinki, PO Box 340, Floor 11, Haartmaninkatu 4, 0029 HUS, Finland
    Atherosclerosis 162:171-8. 2002
    ..CONCLUSIONS: The IMT findings in FCHL family members indicate that the current lipid criteria alone are of limited value in predicting long-term risk of cardiovascular disease in asymptomatic members of FCHL families...
  73. ncbi Association between depressive symptoms and serum concentrations of homocysteine in men: a population study
    Tommi Tolmunen
    Department of Psychiatry, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 80:1574-8. 2004
    ..23; 95% CI: 1.30, 3.83; P=0.004). CONCLUSION: High serum concentrations of tHcy may be associated with depression in middle-aged men...
  74. ncbi Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland
    Jyrki K Virtanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Arterioscler Thromb Vasc Biol 25:228-33. 2005
    ..We investigated the effects of high mercury content in hair on the risk of acute coronary events and cardiovascular and all-cause mortality in men from eastern Finland...
  75. ncbi Coenzyme Q10: absorption, antioxidative properties, determinants, and plasma levels
    Jari Kaikkonen
    Oy Jurilab Ltd, Kuopio, Finland
    Free Radic Res 36:389-97. 2002
    ..High dose vitamin E supplementation decreased this proportion, which suggests in vivo regeneration of tocopheryl radicals by ubiquinol...
  76. ncbi Arginine intake, blood pressure, and the incidence of acute coronary events in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Birgitta Venho
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 76:359-64. 2002
    ..Arginine intake was also not consistently associated with blood pressure. CONCLUSION: Dietary arginine intake is not associated with the risk of acute coronary events in middle-aged men in eastern Finland...
  77. ncbi Insulin resistance syndrome revisited: application of self-organizing maps
    Veli-Pekka Valkonen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Int J Epidemiol 31:864-71. 2002
    ..CONCLUSIONS: This study shows that the multidimensional structures of insulin resistance syndrome can be visualized and identified at qualitative and quantitative level using the SOM algorithm...
  78. ncbi Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome
    Timo A Lakka
    Research Institute of Public Health, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 35:1279-86. 2003
    ....
  79. ncbi Cardiorespiratory fitness and the risk for stroke in men
    Sudhir Kurl
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Arch Intern Med 163:1682-8. 2003
    ..The VO(2)max was one of the strongest predictors of stroke, comparable with other modifiable risk factors...
  80. ncbi Cardiorespiratory fitness and vigorous leisure-time physical activity modify the association of small size at birth with the metabolic syndrome
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Care 26:2156-64. 2003
    ..We studied the association of size at birth with the metabolic syndrome...
  81. ncbi The European perspective on vitamin E: current knowledge and future research
    Regina Brigelius-Flohe
    German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Am J Clin Nutr 76:703-16. 2002
    ..Future research on this essential vitamin should focus on what makes it essential for humans, why the body apparently utilizes alpha-tocopherol preferentially, and what functions other forms of vitamin E have...
  82. ncbi New paraoxonase 1 polymorphism I102V and the risk of prostate cancer in Finnish men
    Marja Marchesani
    Oy Jurilab Ltd, Kuopio, Finland
    J Natl Cancer Inst 95:812-8. 2003
    ..We sought new functional mutations in PON1 and determined whether known or new PON1 mutations were associated with the risk for prostate cancer in a prospective, random, population-based sample of Finnish men and in a case-control study...
  83. ncbi Physical workload and risk of early retirement: prospective population-based study among middle-aged men
    Minna Karpansalo
    Research Institute of Public Health, University of Kuopio, PO Box 1927, 70120 Kuopio, Finland
    J Occup Environ Med 44:930-9. 2002
    ..In heavy physical work, the risk is increased especially among men with musculoskeletal or cardiovascular disease and poor cardiorespiratory fitness...
  84. ncbi Risk of cardiovascular disease-related and all-cause death according to serum concentrations of enterolactone: Kuopio Ischaemic Heart Disease Risk Factor Study
    Meri Vanharanta
    Research Institute of Public Health, University of Kuopio, Harjulantie 1B, 70210 Kuopio, Finland
    Arch Intern Med 163:1099-104. 2003
    ..These results add to the evidence supporting the importance of whole grain foods, fruits, and vegetables in the prevention of premature death from CVD...
  85. ncbi Cardiorespiratory fitness and physical activity as risk predictors of future atherosclerotic cardiovascular diseases
    Jari A Laukkanen
    Research Institute of Public Health, University of Kuopio, PO 1627, 70211 Kuopio, Finland
    Curr Atheroscler Rep 4:468-76. 2002
    ..In the future, well-defined, disease-specific training programs for exercise prescriptions in different risk groups are needed as a clinical tool...
  86. ncbi Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Tiina H Rissanen
    Research Institute of Public Health, Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 77:133-8. 2003
    ..Increased thickness of the intima-media has been shown to predict coronary events; thus, lycopene intakes and serum concentrations may have clinical and public health relevance...
  87. ncbi The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    Hanna Maaria Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    JAMA 288:2709-16. 2002
    ..Despite its high prevalence, little is known of the prospective association of the metabolic syndrome with cardiovascular and overall mortality...
  88. ncbi Sex hormones, inflammation and the metabolic syndrome: a population-based study
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Eur J Endocrinol 149:601-8. 2003
    ..Even in the absence of late-stage consequences such as diabetes and cardiovascular disease, subtle derangements in sex hormones are present in the metabolic syndrome, and may contribute to its pathogenesis...
  89. ncbi Self-esteem and mortality: prospective evidence from a population-based study
    Katherine A Stamatakis
    Center for Social Epidemiology and Population Health, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 48104, USA
    Ann Epidemiol 14:58-65. 2004
    ..The objective of this study was to assess whether low self-esteem was prospectively associated with increased risk of death in a population-based sample of Finnish men...
  90. ncbi Asymmetrical dimethylarginine (ADMA) and risk of acute coronary events. Does statin treatment influence plasma ADMA levels?
    Veli Pekka Valkonen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Atheroscler Suppl 4:19-22. 2003
    ..However, aggressive treatment with either simvastatin or atorvastatin did not reduce plasma ADMA levels...
  91. ncbi The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men: a prospective cohort study
    David E Laaksonen
    Department of Medicine, Kuopio University, P.O. Box 1627, FIN-70211 Kuopio, Finland
    J Clin Endocrinol Metab 90:712-9. 2005
    ..Prevention of abdominal obesity and the accompanying metabolic syndrome in middle age may decrease the risk of hypogonadism in men, especially in those who quit smoking...
  92. ncbi Systolic blood pressure during recovery from exercise and the risk of acute myocardial infarction in middle-aged men
    Jari A Laukkanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Hypertension 44:820-5. 2004
    ..This emphasizes the importance of SBP measurements after the exercise test because it provides additional valuable prognostic measure with regard to acute myocardial infarction...
  93. ncbi Inflammation, abdominal obesity, and smoking as predictors of hypertension
    Leo Niskanen
    Department of Medicine, Kuopio University Hospital, Finland
    Hypertension 44:859-65. 2004
    ....
  94. ncbi Metabolic syndrome and the risk of prostate cancer in Finnish men: a population-based study
    Jari A Laukkanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211, Finland
    Cancer Epidemiol Biomarkers Prev 13:1646-50. 2004
    ..Individual components of metabolic syndrome have been linked to an increased risk for prostate cancers. We hypothesized that metabolic syndrome itself could confer an increased risk for incident prostate cancer...
  95. ncbi Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans
    Jaakko Mursu
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Free Radic Biol Med 37:1351-9. 2004
    ..Cocoa polyphenols may increase the concentration of HDL cholesterol, whereas chocolate fatty acids may modify the fatty acid composition of LDL and make it more resistant to oxidative damage...
  96. ncbi Coffee drinking is dose-dependently related to the risk of acute coronary events in middle-aged men
    Pertti Happonen
    Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland
    J Nutr 134:2381-6. 2004
    ..In conclusion, heavy coffee consumption increases the short-term risk of acute myocardial infarction or coronary death, independent of the brewing method or currently recognized risk factors for CHD...
  97. ncbi The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study
    Jari A Laukkanen
    Research Institute of Public Health, University of Kuopio, Finland
    Eur Heart J 25:1428-37. 2004
    ..Our objective was to determine whether VO2peak could predict fatal and non-fatal cardiac events in 2361 men aged 42-60 years with and without conventional risk predictors of CVD or with documented CVD during a 13-year follow-up...
  98. ncbi Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study
    Leo K Niskanen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Arch Intern Med 164:1546-51. 2004
    ..Despite abundant epidemiologic evidence, the role of elevated serum uric acid level as a cardiovascular risk factor is controversial. We assessed the predictive value of serum uric acid levels for cardiovascular and overall mortality...
  99. ncbi Serum folate and homocysteine and the incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Sari Voutilainen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Am J Clin Nutr 80:317-23. 2004
    ....
  100. ncbi Association between carotid intima-media thickness and low-density lipoprotein size and susceptibility of low-density lipoprotein to oxidation in asymptomatic members of familial combined hyperlipidemia families
    Ming-Lin Liu
    Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Stroke 33:1255-60. 2002
    ..These results imply that small, dense LDL as an inherent feature of FCHL is an important diagnostic indicator for coronary artery disease risk in FCHL...
  101. ncbi Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study
    David E Laaksonen
    Department of Physiology, University of Kuopio, Kuopio, Finland
    Int J Cancer 111:444-50. 2004
    ....