S Salminen

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi Probiotic bacteria in the management of atopic disease: underscoring the importance of viability
    Pirkka V Kirjavainen
    Department of Biochemistry and Food Chemistry, University of Turku, FIN 20014 Turku, Finland
    J Pediatr Gastroenterol Nutr 36:223-7. 2003
  2. ncbi Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota
    Minna M Rinne
    The University of Turku, 20014 Turku, Finland Department of Pediatrics, Turku University Central Hospital, 20520 Turku, Finland
    FEMS Immunol Med Microbiol 43:59-65. 2005
  3. ncbi Competitive exclusion of enteropathogens from human intestinal mucus by Bifidobacterium strains with acquired resistance to bile--a preliminary study
    Miguel Gueimonde
    Functional Foods Forum, University of Turku, Turku, Finland
    Int J Food Microbiol 113:228-32. 2007
  4. ncbi Comparison of four methods to enumerate probiotic bifidobacteria in a fermented food product
    Sampo J Lahtinen
    Functional Foods Forum, Department of Food Chemistry and Biochemistry, University of Turku, 20520 Turku, Finland
    Food Microbiol 23:571-7. 2006
  5. ncbi Specific Bifidobacterium strains isolated from elderly subjects inhibit growth of Staphylococcus aureus
    Sampo J Lahtinen
    Functional Foods Forum, Department of Food Chemistry and Biochemistry, University of Turku, 20520 Turku, Finland
    Int J Food Microbiol 117:125-8. 2007
  6. ncbi The genomics of probiotic intestinal microorganisms
    Seppo Salminen
    Functional Foods Forum, University of Turku, FIN 20014 Turku, Finland
    Genome Biol 6:225. 2005
  7. ncbi Microbial-host interactions: selecting the right probiotics and prebiotics for infants
    Seppo Salminen
    Functional Foods Forum, University of Turku, Turku, Finland
    Nestle Nutr Workshop Ser Pediatr Program 64:201-13; discussion 213-7, 251-7. 2009
  8. ncbi Influence of mode of delivery on gut microbiota composition in seven year old children
    S Salminen
    Functional Foods Forum, University of Turku, 20014 Turku, Finland
    Gut 53:1388-9. 2004
  9. ncbi Intestinal colonisation, microbiota and future probiotics?
    Seppo Salminen
    Functional Foods Forum, University of Turku, Turku, Finland
    Asia Pac J Clin Nutr 15:558-62. 2006
  10. ncbi Probiotics that modify disease risk
    Seppo J Salminen
    Functional Foods Forum and Department of Biochemistry and Food Chemistry, University of Turku, Finland
    J Nutr 135:1294-8. 2005

Collaborators

Detail Information

Publications100

  1. ncbi Probiotic bacteria in the management of atopic disease: underscoring the importance of viability
    Pirkka V Kirjavainen
    Department of Biochemistry and Food Chemistry, University of Turku, FIN 20014 Turku, Finland
    J Pediatr Gastroenterol Nutr 36:223-7. 2003
    ..The aim of this study was to assess the efficacy of oral supplementation of viable and heat-inactivated probiotic bacteria in the management of atopic disease and to observe their effects on the composition of the gut microbiota...
  2. ncbi Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota
    Minna M Rinne
    The University of Turku, 20014 Turku, Finland Department of Pediatrics, Turku University Central Hospital, 20520 Turku, Finland
    FEMS Immunol Med Microbiol 43:59-65. 2005
    ..This would suggest that early gut Bifidobacterium microbiota can be modified by special diets up to the age of 6 months...
  3. ncbi Competitive exclusion of enteropathogens from human intestinal mucus by Bifidobacterium strains with acquired resistance to bile--a preliminary study
    Miguel Gueimonde
    Functional Foods Forum, University of Turku, Turku, Finland
    Int J Food Microbiol 113:228-32. 2007
    ..Different molecules appear to be involved in the adhesion of the strains B. bifidum M6 and B. bifidum M6dCo. These differences in the cellular surface may explain the differences in competitive exclusion observed between both strains...
  4. ncbi Comparison of four methods to enumerate probiotic bifidobacteria in a fermented food product
    Sampo J Lahtinen
    Functional Foods Forum, Department of Food Chemistry and Biochemistry, University of Turku, 20520 Turku, Finland
    Food Microbiol 23:571-7. 2006
    ..The strain-specific properties and the objects of the analysis should be taken into account when enumeration methods for different probiotic strains are chosen...
  5. ncbi Specific Bifidobacterium strains isolated from elderly subjects inhibit growth of Staphylococcus aureus
    Sampo J Lahtinen
    Functional Foods Forum, Department of Food Chemistry and Biochemistry, University of Turku, 20520 Turku, Finland
    Int J Food Microbiol 117:125-8. 2007
    ..However, specific strains were identified which showed considerable inhibitory activity against S. aureus...
  6. ncbi The genomics of probiotic intestinal microorganisms
    Seppo Salminen
    Functional Foods Forum, University of Turku, FIN 20014 Turku, Finland
    Genome Biol 6:225. 2005
    ..The genomic characterization of probiotic bacteria and other commensal intestinal bacteria that is now under way will help to deepen our understanding of their beneficial effects...
  7. ncbi Microbial-host interactions: selecting the right probiotics and prebiotics for infants
    Seppo Salminen
    Functional Foods Forum, University of Turku, Turku, Finland
    Nestle Nutr Workshop Ser Pediatr Program 64:201-13; discussion 213-7, 251-7. 2009
    ..Continuous control of probiotic strains or strain combinations is a must as small changes in production process or growth media may significantly affect the properties of a strain or strain combination...
  8. ncbi Influence of mode of delivery on gut microbiota composition in seven year old children
    S Salminen
    Functional Foods Forum, University of Turku, 20014 Turku, Finland
    Gut 53:1388-9. 2004
  9. ncbi Intestinal colonisation, microbiota and future probiotics?
    Seppo Salminen
    Functional Foods Forum, University of Turku, Turku, Finland
    Asia Pac J Clin Nutr 15:558-62. 2006
    ..Potential combinations of specific probiotics may prove to be the next step to reduce the risk on intestinal diseases and reconstruct specific microbial deviations...
  10. ncbi Probiotics that modify disease risk
    Seppo J Salminen
    Functional Foods Forum and Department of Biochemistry and Food Chemistry, University of Turku, Finland
    J Nutr 135:1294-8. 2005
    ..Most recently, a reduction in risk of atopic diseases followed early administration of specific probiotics...
  11. ncbi Early differences in fecal microbiota composition in children may predict overweight
    Marko Kalliomaki
    Functional Foods Forum and Program on Health Biosciences and the Department of Pediatrics, University of Turku, Turku, Finland
    Am J Clin Nutr 87:534-8. 2008
    ..Experimental studies suggest that gut microbiota deviations predispose toward energy storage and obesity...
  12. ncbi Adhesion of inactivated probiotic strains to intestinal mucus
    A C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, and Turku, Finland
    Lett Appl Microbiol 31:82-6. 2000
    ..Inactivation by u.v. was not observed to modulate the adhesion of the tested strains and it was concluded to be the most appropriate method for studying non-viable probiotics and preparing control products...
  13. ncbi Polyunsaturated fatty acids in maternal diet, breast milk, and serum lipid fatty acids of infants in relation to atopy
    P Kankaanpaa
    Departments of Biochemistry and Food Chemistry, and Pediatrics, University of Turku, Turku, Finland
    Allergy 56:633-8. 2001
    ..We aimed to investigate whether maternal diet and atopic status influence the PUFA composition of breast milk and the serum lipid fatty acids of infants...
  14. ncbi Assessment of adhesion properties of novel probiotic strains to human intestinal mucus
    A C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Int J Food Microbiol 64:119-26. 2001
    ..The growth media and the food matrix significantly affect the adhesive ability of the tested strains. This has previously not been taken into account when selecting novel probiotic strains...
  15. ncbi Adhesion of Bifidobacterium spp. to human intestinal mucus
    F He
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Microbiol Immunol 45:259-62. 2001
    ..animalis and B. lactis was not preferential. These results suggest that the mucosal adhesive properties of bifidobacteria may be a strain dependent feature, and the mucosal binding of the human bifidobacteria may be more host specific...
  16. ncbi Dietary fatty acids and allergy
    P Kankaanpaa
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Ann Med 31:282-7. 1999
    ..Therefore, it is concluded that careful manipulation of dietary PUFAs may play a key role in the successful management of inflammation associated with atopic diseases...
  17. ncbi Maternal breast-milk and intestinal bifidobacteria guide the compositional development of the Bifidobacterium microbiota in infants at risk of allergic disease
    M M Grönlund
    Department of Pediatrics, Turku University Central Hospital, Turku, Finland
    Clin Exp Allergy 37:1764-72. 2007
    ..The sources and the impact of maternal bacteria on the initial inoculum of the intestinal microflora of newborn infants remain elusive...
  18. ncbi Bifidobacterium and Lactobacillus DNA in the human placenta
    R Satokari
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, Turun yliopisto, Finland
    Lett Appl Microbiol 48:8-12. 2009
    ..Although the newborn infant is considered immunologically immature, exposure by bacterial DNA may programme the infant's immune development during foetal life earlier than previously considered...
  19. ncbi Modulation of the maturing gut barrier and microbiota: a novel target in allergic disease
    E Isolauri
    Department of Paediatrics, University of Turku, 20520 Turku, Finland
    Curr Pharm Des 14:1368-75. 2008
    ....
  20. ncbi Combining strains of lactic acid bacteria may reduce their toxin and heavy metal removal efficiency from aqueous solution
    T Halttunen
    University of Turku, Functional Foods Forum, Turku, Finland
    Lett Appl Microbiol 46:160-5. 2008
    ..rhamnosus LC705, Propionibacterium freudenreichii shermanii JS and Bifidobacterium breve Bbi99/E8, separately and in combination...
  21. ncbi Probiotics: effects on immunity
    E Isolauri
    Department of Pediatrics, The University of Turku, Turku, Finland
    Am J Clin Nutr 73:444S-450S. 2001
    ..These results suggest that specific immunomodulatory properties of probiotic bacteria should be characterized when developing clinical applications for extended target populations...
  22. ncbi Mode of delivery directs the phagocyte functions of infants for the first 6 months of life
    M M Grönlund
    Department of Paediatrics, Turku University Central Hospital, Turku, Finland
    Clin Exp Immunol 116:521-6. 1999
    ....
  23. ncbi Exopolysaccharides produced by probiotic strains modify the adhesion of probiotics and enteropathogens to human intestinal mucus
    Patricia Ruas-Madiedo
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, FIN 20014, Turku, Finland
    J Food Prot 69:2011-5. 2006
    ..To the best of our knowledge, this is the first work reporting the effect of EPSs from probiotics on bacterial adhesion properties...
  24. ncbi Adhesion properties and competitive pathogen exclusion ability of bifidobacteria with acquired acid resistance
    M Carmen Collado
    Functional Foods Forum, University of Turku, , FIN 20520, Turku, Finland
    J Food Prot 69:1675-9. 2006
    ....
  25. ncbi Adhesion of selected Bifidobacterium strains to human intestinal mucus and the role of adhesion in enteropathogen exclusion
    M Carmen Collado
    Functional Food Forum, University of Turku, , FIN 20014, Turku, Finland
    J Food Prot 68:2672-8. 2005
    ..The results indicate that different molecules are implicated in the adhesion of bifidobacteria to the human intestinal mucus, constituting a multifactorial process...
  26. ncbi Interaction of orally administered Lactobacillus rhamnosus GG with skin and gut microbiota and humoral immunity in infants with atopic dermatitis
    M Nermes
    Department of Pediatrics, Turku University Central Hospital, Turku, Finland
    Clin Exp Allergy 41:370-7. 2011
    ..The maturational events in the gut parallel its step-wise colonization. Atopic dermatitis (AD) is associated with aberrant barrier functions of the skin epithelium and, in a subgroup of patients, of the gut mucosa...
  27. ncbi New functional foods in the treatment of food allergy
    E Isolauri
    Department of Paediatrics, University of Turku, Finland
    Ann Med 31:299-302. 1999
    ..However, it represents an initial link in the development of more permanent sensitization to aeroallergens...
  28. ncbi Wheat or rye supplemented diets do not affect faecal mucus concentration or the adhesion of probiotic micro-organisms to faecal mucus
    A C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    Lett Appl Microbiol 31:30-3. 2000
    ....
  29. ncbi Differences in composition and mucosal adhesion of bifidobacteria isolated from healthy adults and healthy seniors
    F He
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Curr Microbiol 43:351-4. 2001
    ..This shift to a Bifidobacterium flora with reduced adhesive abilities may explain the decrease in bifidobacteria levels in the intestinal microflora of aging people...
  30. ncbi Development of new probiotics by strain combinations: is it possible to improve the adhesion to intestinal mucus?
    M C Collado
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, 20520 Turku, Finland
    J Dairy Sci 90:2710-6. 2007
    ..Combinations of probiotic strains may therefore have synergistic adhesion effects, and such combinations also should be assessed in clinical studies...
  31. ncbi Performance of bifidobacteria in oat-based media
    Riikka Laine
    Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland
    Int J Food Microbiol 83:105-9. 2003
    ..However, their adhesion to colonic tissue was significantly lower. Prior exposure to the oat-based medium increased the adhesion of two of the strains...
  32. ncbi Bifidobacterium microbiota and parameters of immune function in elderly subjects
    Arthur C Ouwehand
    Functional Foods Forum, University of Turku, Turku, Finland
    FEMS Immunol Med Microbiol 53:18-25. 2008
    ..This indicates that modulation of the faecal Bifidobacterium microbiota may provide a means of influencing inflammatory responses...
  33. ncbi Probiotics: a role in the treatment of intestinal infection and inflammation?
    E Isolauri
    Department of Paediatrics, University of Turku, Finland
    Gut 50:III54-9. 2002
    ..Realisation of this has led to the introduction of novel modes of therapeutic and prophylactic intervention based on the consumption of mono and mixed cultures of beneficial live microorganisms as probiotics...
  34. ncbi Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus
    M C Collado
    Functional Foods Forum, University of Turku, Turku, Finland
    Lett Appl Microbiol 45:454-60. 2007
    ....
  35. ncbi Characterization of the properties of human- and dairy-derived probiotics for prevention of infectious diseases in fish
    S Nikoskelainen
    Department of Biochemistry and Food Chemistry, University of Turku, 20014 Turku, Finland
    Appl Environ Microbiol 67:2430-5. 2001
    ..rhamnosus ATCC 53103 and L. bulgaricus can be considered for future in vivo challenge studies in fish as a novel and safe treatment in aquaculture...
  36. ncbi A probiotic, Lactobacillus fermentum ME-3, has antioxidative capacity in soft cheese spreads with different fats
    S Jarvenpaa
    Department of Biochemistry and Food Chemistry, University of Turku, FIN 20014 Turku, Finland
    J Dairy Sci 90:3171-7. 2007
    ..A functional spread cheese containing n-3 fatty acids can be prepared with the probiotic Lactobacillus fermentum ME-3 strain leading to a reduced need for chemical anti-oxidants...
  37. ncbi Short communication: effect of exopolysaccharide isolated from "viili" on the adhesion of probiotics and pathogens to intestinal mucus
    P Ruas-Madiedo
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, FIN 20014, Turku, Finland
    J Dairy Sci 89:2355-8. 2006
    ..However, no modifications were detected on the adhesion levels of the pathogenic strains tested at a concentration of 1 mg/mL of EPS. Results obtained in the present work should be considered in the design of new probiotic products...
  38. ncbi Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing
    M Kalliomaki
    Department of Pediatrics, University of Turku, Turku
    J Allergy Clin Immunol 107:129-34. 2001
    ..On the basis of both intensity and timing of stimulus, it has been hypothesized that exposure to commensal microflora may represent another key protective modulator of immunity against atopy and subsequent atopic diseases...
  39. ncbi Effects of polyunsaturated fatty acids in growth medium on lipid composition and on physicochemical surface properties of lactobacilli
    P Kankaanpaa
    Department of Biochemistry and Food Chemistry, Turku University Central Hospital, University of Turku, Turku, Finland
    Appl Environ Microbiol 70:129-36. 2004
    ..The potential role of lactobacilli as regulators of PUFA absorption may represent another means by which probiotics could redirect the delicate balance of inflammatory mediators derived from PUFA within the inflamed intestine...
  40. ncbi Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
    M Kalliomaki
    Department of Paediatrics, University of Turku and Turku University Hospital, Finland
    Lancet 357:1076-9. 2001
    ..We assessed the effect on atopic disease of Lactobacillus GG (which is safe at an early age and effective in treatment of allergic inflammation and food allergy)...
  41. ncbi Safety assessment of Lactobacillus strains: presence of putative risk factors in faecal, blood and probiotic isolates
    Satu Vesterlund
    Department of Biochemistry and Food Chemistry and Functional Foods Forum, University of Turku, 20014 Turku, Finland
    Int J Food Microbiol 116:325-31. 2007
    ..However, the significance of adhesion to mucus, low induction of respiratory burst in PMN and resistance to human serum-mediated killing may need further evaluation in experimental animal models and in epidemiological data...
  42. ncbi Protection mechanism of probiotic combination against human pathogens: in vitro adhesion to human intestinal mucus
    M Carmen Collado
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, Turku, Finland
    Asia Pac J Clin Nutr 15:570-5. 2006
    ..Such combinations should be assessed in clinical studies in subjects where the intestinal microbiota aberrancies have been identified...
  43. ncbi Potential probiotic characteristics of Lactobacillus and Enterococcus strains isolated from traditional dadih fermented milk against pathogen intestinal colonization
    M Carmen Collado
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, 20014 Turku, Finland
    J Food Prot 70:700-5. 2007
    ..All tested LAB strains displaced and inhibited pathogen adhesion, but the results were strain-specific and dependent on time and pathogen strains. In general, L. plantarum IS-10506 showed the best ability against pathogen adhesion...
  44. ncbi Probiotic bacteria as potential detoxification tools: assessing their heavy metal binding isotherms
    Fandi Ibrahim
    Department of Biochemistry and Food Chemistry and Functional Foods Forums, University of Turku, Finland
    Can J Microbiol 52:877-85. 2006
    ..The binding seemed to occur instantaneously and in a pH-dependent manner, which can be perfectly described by a segmented linear-plateau model...
  45. ncbi Breast milk: a source of bifidobacteria for infant gut development and maturation?
    Miguel Gueimonde
    Functional Foods Forum and Departments, University of Turku, Turku, Finland
    Neonatology 92:64-6. 2007
    ..Aberrant gut microbiota at an early age may predispose to disease later in life. Breast-fed infants harbor a characteristic intestinal microbiota dominated by bifidobacteria...
  46. ncbi Probiotic strains and their combination inhibit in vitro adhesion of pathogens to pig intestinal mucosa
    M C Collado
    Functional Foods Forum, University of Turku, Turku, Finland
    Curr Microbiol 55:260-5. 2007
    ..Specific protective probiotics could be selected for particular pig pathogens. Probiotic strains from human origin and intended for human use also adhere to pig intestinal mucus and are able to displace and inhibit pathogens...
  47. ncbi Specific probiotics in reducing the risk of acute infections in infancy--a randomised, double-blind, placebo-controlled study
    Samuli Rautava
    Department of Paediatrics, University of Turku, Turku, Finland
    Br J Nutr 101:1722-6. 2009
    ..Further clinical trials are warranted...
  48. ncbi Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women
    Maria Carmen Collado
    Functional Foods Forum and Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    Am J Clin Nutr 88:894-9. 2008
    ..The mother influences the original inoculum and the development of infant microbiota, which in turn is associated with later weight gain...
  49. ncbi Positive interactions with the microbiota: probiotics
    Marko Kalliomaki
    Department of Paediatrics, University of Turku, Turku, Finland
    Adv Exp Med Biol 635:57-66. 2008
    ..Introduction of genetic engineering has provided advanced tools to amend probiotics' properties in the fight against different inflammatory conditions...
  50. ncbi Probiotics: use in allergic disorders: a Nutrition, Allergy, Mucosal Immunology, and Intestinal Microbiota (NAMI) Research Group Report
    Erika Isolauri
    Department of Paediatrics, University of Turku, Finland
    J Clin Gastroenterol 42:S91-6. 2008
    ....
  51. ncbi Probiotics and immunosenescence: cheese as a carrier
    Fandi Ibrahim
    Functional Foods Forum, University of Turku, Turku, Finland
    FEMS Immunol Med Microbiol 59:53-9. 2010
    ..It remains to be determined whether this enhancement correlates with a beneficial effect on the health of the elderly population...
  52. ncbi Specific probiotic strains and their combinations counteract adhesion of Enterobacter sakazakii to intestinal mucus
    Maria Carmen Collado
    Functional Foods Forum, University of Turku, Turku, Finland
    FEMS Microbiol Lett 285:58-64. 2008
    ..This approach may also allow the development of new probiotic combinations to counteract the risks associated with other pathogens by improving the intestinal barrier against pathogens...
  53. ncbi Interaction of probiotics and pathogens--benefits to human health?
    Seppo Salminen
    Functional Foods Forum, University of Turku, 20014 Turku, Finland
    Curr Opin Biotechnol 21:157-67. 2010
    ..The same aim is targeted in characterizing the role of probiotics in inactivating pathogens and viruses of health importance to facilitate the establishment of novel means of disease risk reduction related health benefits...
  54. ncbi Effect of mother's weight on infant's microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy
    Maria Carmen Collado
    Functional Foods Forum, University of Turku, Turku, Finland
    Am J Clin Nutr 92:1023-30. 2010
    ..Alterations in microbiota compositions of mothers may be transferred to infants and lead to an increased risk of overweight...
  55. ncbi Mode of delivery - effects on gut microbiota and humoral immunity
    Anu Huurre
    Department of Pediatrics, Turku University Central Hospital and University of Turku, Turku, Finland
    Neonatology 93:236-40. 2008
    ..The rate of caesarean deliveries has increased 10-fold worldwide during the past decades...
  56. ncbi Indigenous dadih lactic acid bacteria: cell-surface properties and interactions with pathogens
    M Carmen Collado
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, FI 20014 Turku, Finland
    J Food Sci 72:M89-93. 2007
    ....
  57. ncbi Measurement of aggregation properties between probiotics and pathogens: in vitro evaluation of different methods
    M Carmen Collado
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, FI 20014 Turku, Finland
    J Microbiol Methods 71:71-4. 2007
    ..Co-aggregation may be useful for preliminary screening in order to identify potentially probiotic strains suitable for food, human or animal use...
  58. ncbi Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly
    M Carmen Collado
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, 5th Floor, FI 20520 Turku, Finland
    Appl Environ Microbiol 73:7767-70. 2007
    ..05) in the elderly...
  59. ncbi Obesity - extending the hygiene hypothesis
    Erika Isolauri
    Department of Pediatrics, Functional Foods Forum, and Department of Biochemistry and Food Chemistry, University of Turku, Turku University Central Hospital, Turku, Finland
    Nestle Nutr Workshop Ser Pediatr Program 64:75-85; discussion 85-9, 251-7. 2009
    ....
  60. ncbi New methods for selecting and evaluating probiotics
    Miguel Gueimonde
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu, Turku, Finland
    Dig Liver Dis 38:S242-7. 2006
    ..We should expect to see new, third generation probiotics emerging in the near future and also new selection criteria further defining the targets of future probiotics...
  61. ncbi Probiotic intervention in the first months of life: short-term effects on gastrointestinal symptoms and long-term effects on gut microbiota
    Minna Rinne
    Department of Pediatrics, Turku University Central Hospital, Finland
    J Pediatr Gastroenterol Nutr 43:200-5. 2006
    ..To determine whether probiotics administered for 6 months postnatally affect gastrointestinal symptoms, crying and the compositional development of the gut microbiota through infancy...
  62. ncbi Female patients tend to alter their diet following the diagnosis of rheumatoid arthritis and breast cancer
    Eeva Salminen
    Department of Radiotherapy and Oncology, University of Turku, 20520, Finland
    Prev Med 34:529-35. 2002
    ..This study investigated the beliefs and attitudes of female patients regarding diet and their need for dietary counseling in relation to years since diagnosis, age, and education...
  63. ncbi Phenotypic differences between commercial Lactobacillus rhamnosus GG and L. rhamnosus strains recovered from blood
    Arthur C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    Clin Infect Dis 39:1858-60. 2004
    ..We compared the virulence potential of these clinical isolates with that of the probiotic strain. It was observed that all isolates differed significantly in 1 or more phenotypic properties...
  64. ncbi Microbiota composition of the intestinal mucosa: association with fecal microbiota?
    Arthur C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, 20014 Turku, Finland
    Microbiol Immunol 48:497-500. 2004
    ..This indicates that the unidentified part of the microbiota, especially on the mucosa, deserves more attention...
  65. ncbi New real-time quantitative PCR procedure for quantification of bifidobacteria in human fecal samples
    Miguel Gueimonde
    Department of Biochemistry and Food Chemistry, University of Turku, Vatselankatu 2, FIN 20014 Turku, Finland
    Appl Environ Microbiol 70:4165-9. 2004
    ..We conclude that the real-time PCR procedure described here is a specific, accurate, rapid, and easy method for the quantification of bifidobacteria in feces...
  66. ncbi Microbial-gut interactions in health and disease. Probiotics
    Erika Isolauri
    Department of Paediatrics, Turku University Central Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Best Pract Res Clin Gastroenterol 18:299-313. 2004
    ..However, further rigorous scientific efforts are required to characterize the immunomodulatory potential of specific probiotic strains for these targets...
  67. ncbi The hygiene hypothesis of atopic disease--an extended version
    Samuli Rautava
    Department of Pediatrics, Turku University Central Hospital, Finland
    J Pediatr Gastroenterol Nutr 38:378-88. 2004
    ..Third, in addition to protection against atopy, protection against infectious, inflammatory, and autoimmune diseases may also depend upon healthy host-microbe interactions implicated in the hygiene hypothesis...
  68. ncbi In vivo safety assessment of two Bifidobacterium longum strains
    Henna Mäkeläinen
    Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    Microbiol Immunol 47:911-4. 2003
    ..Based on this study it appears that the two strains are well tolerated by human subjects and there are no reservations about their food use...
  69. ncbi Disease-dependent adhesion of lactic acid bacteria to the human intestinal mucosa
    Arthur C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Clin Diagn Lab Immunol 10:643-6. 2003
    ..rhamnosus strain GG, displayed disease-specific adhesion to intestinal mucus. These results suggest that strains with optimal binding characteristics for a particular intestinal disease can be selected...
  70. ncbi Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial
    Marko Kalliomaki
    Department of Paediatrics, University of Turku, Finland
    Lancet 361:1869-71. 2003
    ..Our results suggest that the preventive effect of lactobacillus GG on atopic eczema extends beyond infancy...
  71. ncbi Resected human colonic tissue: new model for characterizing adhesion of lactic acid bacteria
    Arthur C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, FIN 20014 Turku, Finland
    Clin Diagn Lab Immunol 9:184-6. 2002
    ..The adhesion of commonly used probiotic strains to human intestinal tissue pieces and mucus was assessed. The strains tested adhered to the intestinal tissue at low levels and adhered to the intestinal mucus at higher levels...
  72. ncbi The role of the intestinal microflora for the development of the immune system in early childhood
    Arthur Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Eur J Nutr 41:I32-7. 2002
    ..The precise mechanisms behind these immune modulatory activities are not well understood and require further investigation...
  73. ncbi Effect of probiotics on constipation, fecal azoreductase activity and fecal mucin content in the elderly
    Arthur C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Ann Nutr Metab 46:159-62. 2002
    ..Constipation is a common problem in elderly subjects, probiotics have been suggested to improve intestinal motility and reduce fecal enzyme activity...
  74. ncbi Role of probiotics in food hypersensitivity
    Erika Isolauri
    Department of Pediatrics, University of Turku, Finland
    Curr Opin Allergy Clin Immunol 2:263-71. 2002
    ....
  75. ncbi Immune enhancement in rainbow trout (Oncorhynchus mykiss) by potential probiotic bacteria (Lactobacillus rhamnosus)
    Sami Nikoskelainen
    Department of Biochemistry and Food Chemistry, University of Turku, 20014 Turku, Finland
    Fish Shellfish Immunol 15:443-52. 2003
    ..Serum immunoglobulin levels were significantly raised only in LAB8 group on week 1 and in LAB4 and LAB8 at the end of the trial. The results show that rainbow trout immune parameters were enhanced by using probiotic bacteria...
  76. ncbi Ability of Bifidobacterium strains with acquired resistance to bile to adhere to human intestinal mucus
    Miguel Gueimonde
    Department of Biochemistry and Food Chemistry, University of Turku, Vatselankatu 2, FIN 20014 Turku, Finland
    Int J Food Microbiol 101:341-6. 2005
    ..It was concluded that the acquisition of bile resistance by our Bifidobacterium strains promoted changes in hydrophobicity and in the adhesion of these microorganisms to human intestinal mucus...
  77. ncbi Probiotics: an overview of beneficial effects
    Arthur C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, FIN 20014 Turku, Finland
    Antonie Van Leeuwenhoek 82:279-89. 2002
    ..Results from well conducted clinical studies will expand and increase the acceptance of probiotics for the treatment and prevention of selected diseases...
  78. ncbi Probiotics, gut inflammation and barrier function
    Erika Isolauri
    Department of Pediatrics, University of Turku, 20520 Turku, Finland
    Gastroenterol Clin North Am 34:437-50, viii. 2005
  79. ncbi Effect of maternal consumption of lactobacillus GG on transfer and establishment of fecal bifidobacterial microbiota in neonates
    Miguel Gueimonde
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A 5th Floor, FIN 20014 Turku, Finland
    J Pediatr Gastroenterol Nutr 42:166-70. 2006
    ..Deviations in this process precede the development of specific diseases providing the rationale for the use of probiotics to counteract them...
  80. ncbi Probiotic intervention in neonates--will permanent colonization ensue?
    Miguel Gueimonde
    Functional Foods Forum and Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    J Pediatr Gastroenterol Nutr 42:604-6. 2006
    ..The presence of the strain at the end of the administration period was correlated with a reduced prevalence of atopic eczema later in life...
  81. ncbi Effect of probiotics and breastfeeding on the bifidobacterium and lactobacillus/enterococcus microbiota and humoral immune responses
    Minna Rinne
    University of Turku, Department of Pediatrics, Turku University Central Hospital, Turku, Finland
    J Pediatr 147:186-91. 2005
    ..To assess impact of probiotics and breastfeeding on gut microecology...
  82. ncbi Staphylococcus aureus adheres to human intestinal mucus but can be displaced by certain lactic acid bacteria
    Satu Vesterlund
    Functional Foods Forum, Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    Microbiology 152:1819-26. 2006
    ..This study shows for the first time that Staph. aureus can adhere to human intestinal mucus and adherent bacteria can be displaced and killed by certain LAB strains via in situ production of antimicrobial substances...
  83. ncbi Probiotics: on-going research on atopic individuals
    K Laiho
    Department of Paediatrics, University of Turku, 20520, Finland
    Br J Nutr 88:S19-27. 2002
    ..Future research will clarify the mechanisms to control specific physiological processes in the evolution of atopic disease in at-risk populations or in the management of allergic diseases...
  84. ncbi Quantitative assessment of faecal bifidobacterial populations by real-time PCR using lanthanide probes
    M Gueimonde
    Functional Foods Forum, Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    J Appl Microbiol 102:1116-22. 2007
    ..To develop real-time quantitative PCR methods, based on the use of probes labelled with a stable fluorescent lanthanide chelate, for the quantification of different human faecal bifidobacterial populations...
  85. ncbi The allergy epidemic extends beyond the past few decades
    E Isolauri
    Department of Paediatrics, University of Turku and Turku University Central Hospital, Turku, Finland
    Clin Exp Allergy 34:1007-10. 2004
    ..Increased prevalence of allergic diseases in western societies has been described as an epidemic. The precise turning point for the epidemic and the antigens responsible for it remain obscure...
  86. ncbi Probiotics for the skin: a new area of potential application?
    A C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    Lett Appl Microbiol 36:327-31. 2003
    ..The current study aimed at assessing, in vitro, the potential use of probiotics for the skin...
  87. ncbi Gut microbiota in infants between 6 and 24 months of age
    Seppo Salminen
    Functional Foods Forum, Program on Helath Biosciences, University of Turku, Turku, Finland
    Nestle Nutr Workshop Ser Pediatr Program 56:43-51; discussion 51-6. 2005
  88. ncbi Rapid removal of lead and cadmium from water by specific lactic acid bacteria
    T Halttunen
    University of Turku, Department of Biochemistry and Food Chemistry, 20014 Turku, Finland
    Int J Food Microbiol 114:30-5. 2007
    ..The highest maximum cadmium and lead removal capacities of 54.7 mg metal/g and 175.7 mg/g dry biomass, respectively, were obtained with B. longum 46...
  89. ncbi Opportunities for improving the health and nutrition of the human infant by probiotics
    Seppo Salminen
    Functional Foods Forum, University of Turku, Turku, Finland
    Nestle Nutr Workshop Ser Pediatr Program 62:223-33; discussion 233-7. 2008
    ..With new methodologies we have been able to identify more specific aberrancies in microbiota prior to or during different disease states...
  90. ncbi Arsenic removal by native and chemically modified lactic acid bacteria
    Teemu Halttunen
    University of Turku, Functional Foods Forum, 20014 Turku, Finland
    Int J Food Microbiol 120:173-8. 2007
    ..Desorption with 1.5 mM HNO3 and NaOH released all bound As(V) indicating that removal occurred at the bacterial surface...
  91. ncbi Inventing probiotic functional foods for patients with allergic disease
    Kirsi Laiho
    Department of Paediatrics, University of Turku, Turku, Finland
    Ann Allergy Asthma Immunol 89:75-82. 2002
    ....
  92. ncbi Presence of specific antibiotic (tet) resistance genes in infant faecal microbiota
    Miguel Gueimonde
    Functional Foods Forum, University of Turku, Turku, Finland
    FEMS Immunol Med Microbiol 48:21-5. 2006
    ..Our results suggest that genes carrying antibiotic resistance are common in the environment, as even healthy breast-fed infants with no direct or indirect previous exposure to antibiotics harbour these genes...
  93. ncbi Modulation of human humoral immune response through orally administered bovine colostrum
    F He
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    FEMS Immunol Med Microbiol 31:93-6. 2001
    ..These results suggest that bovine colostrum may possess some potential to enhance human special immune responses...
  94. ncbi Dietary attitudes and changes as well as use of supplements and complementary therapies by Australian and Finnish women following the diagnosis of breast cancer
    E Salminen
    Department of Radiotherapy and Oncology, University of Turku, Finland
    Eur J Clin Nutr 58:137-44. 2004
    ..This study investigated self-reported dietary attitudes and changes, and use of complementary approaches among breast cancer patients in relation to age, education and time since diagnosis...
  95. ncbi Intrinsic properties of so-called dormant probiotic bacteria, determined by flow cytometric viability assays
    Sampo J Lahtinen
    Department of Biochemistry and Food Chemistry, University of Turku, 20014 Turku, Finland
    Appl Environ Microbiol 72:5132-4. 2006
    ..The strains showed reduction in plate counts but were able to maintain esterase activity, intact cytoplasmic membrane, and pH gradient. The apparently uncultivable probiotic cells were active and stress resistant...
  96. ncbi Probiotic bacteria may become dormant during storage
    Sampo J Lahtinen
    Functional Foods Forum University of Turku, Itainen Pitkakatu 4, 20014 Turku, Finland
    Appl Environ Microbiol 71:1662-3. 2005
    ..A subpopulation of nonculturable cells retained a functional cell membrane typical of viable cells, indicating that probiotic bacteria become dormant during storage...
  97. ncbi Effect of glucose in removal of microcystin-LR by viable commercial probiotic strains and strains isolated from dadih fermented milk
    Sonja M K Nybom
    Department of Biochemistry and Pharmacy, Abo Akademi University, Tykistokatu 6A, 20520 Turku, Finland
    J Agric Food Chem 56:3714-20. 2008
    ..A maximum removal of 95% was observed for L. plantarum strain IS-20506 (37 degrees C, 10 (11) colony-forming units mL(-1)) with 1-2% glucose supplementation and 75% in PBS alone...
  98. ncbi Removal of microcystin-LR by strains of metabolically active probiotic bacteria
    Sonja M K Nybom
    Department of Biochemistry and Pharmacy, Abo Akademi University, Turku, Finland
    FEMS Microbiol Lett 270:27-33. 2007
    ..Removal of microcystin-LR was shown to be dependent on both temperature and bacterial concentration. It is concluded that some of the tested strains have good potential in removing microcystins from aqueous solutions...
  99. ncbi Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from Southern China
    Hani S El-Nezami
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 83:1199-203. 2006
    ..In vitro and in vivo studies suggest that selected strains of probiotic bacteria can form tight complexes with aflatoxin B(1) and other carcinogens...
  100. ncbi Specific strains of probiotic bacteria are efficient in removal of several different cyanobacterial toxins from solution
    Sonja M K Nybom
    Department of Biochemistry and Pharmacy, Abo Akademi University, Tykistokatu 6A, 20520 Turku, Finland
    Toxicon 52:214-20. 2008
    ..We conclude that specific strains of probiotic bacteria are effective in elimination of different cyanotoxins from solution...