A Salminen

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. pmc A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices
    Jari Huuskonen
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    J Neuroinflammation 2:25. 2005
  2. ncbi Down-regulation of Ku autoantigen, DNA-dependent protein kinase, and poly(ADP-ribose) polymerase during cellular senescence
    A Salminen
    Department of Neuroscience and Neurology, University of Kuopio, Finland
    Biochem Biophys Res Commun 238:712-6. 1997
  3. doi SIRT1 regulates the ribosomal DNA locus: epigenetic candles twinkle longevity in the Christmas tree
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biochem Biophys Res Commun 378:6-9. 2009
  4. doi SIRT1: regulation of longevity via autophagy
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
    Cell Signal 21:1356-60. 2009
  5. doi Regulation of the aging process by autophagy
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, Kuopio FIN 70211, Finland
    Trends Mol Med 15:217-24. 2009
  6. ncbi Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 87:181-94. 2009
  7. doi NF-kappaB signaling in the aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
    J Clin Immunol 29:397-405. 2009
  8. doi Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, Kuopio FIN 70211, Finland
    Cell Signal 22:573-7. 2010
  9. doi Siglec receptors and hiding plaques in Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    J Mol Med (Berl) 87:697-701. 2009
  10. doi Genetics vs. entropy: longevity factors suppress the NF-kappaB-driven entropic aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Ageing Res Rev 9:298-314. 2010

Collaborators

Detail Information

Publications73

  1. pmc A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices
    Jari Huuskonen
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    J Neuroinflammation 2:25. 2005
    ..Our aim was to gain a more detailed insight and understanding of the behaviour of hippocampus tissue slices in serum-free, interface culture per se and after exposure to different pro- and anti-inflammatory compounds...
  2. ncbi Down-regulation of Ku autoantigen, DNA-dependent protein kinase, and poly(ADP-ribose) polymerase during cellular senescence
    A Salminen
    Department of Neuroscience and Neurology, University of Kuopio, Finland
    Biochem Biophys Res Commun 238:712-6. 1997
    ....
  3. doi SIRT1 regulates the ribosomal DNA locus: epigenetic candles twinkle longevity in the Christmas tree
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biochem Biophys Res Commun 378:6-9. 2009
    ..The eNoSC complex links SIRT1-induced longevity regulation to the metabolic rate theory of aging...
  4. doi SIRT1: regulation of longevity via autophagy
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
    Cell Signal 21:1356-60. 2009
    ..The interactions of SIRT1 with the FoxO and p53 signaling can also regulate both the autophagic degradation and lifespan extension emphasizing the key role of autophagy in the regulation of lifespan...
  5. doi Regulation of the aging process by autophagy
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, Kuopio FIN 70211, Finland
    Trends Mol Med 15:217-24. 2009
    ..We discuss the possibility that these well-known stress resistance and longevity factors regulate the aging process via autophagy...
  6. ncbi Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 87:181-94. 2009
    ..In addition, we will discuss whether AD pathology could be the outcome of chronic activation of the innate immunity defence in the brain of AD patients...
  7. doi NF-kappaB signaling in the aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
    J Clin Immunol 29:397-405. 2009
    ..Explaining the aging process has given rise to a cornucopia for different theories in which the basic difference has been the question whether aging is genetically regulated or an entropic degeneration process...
  8. doi Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, Kuopio FIN 70211, Finland
    Cell Signal 22:573-7. 2010
    ..We will discuss the evidence that insulin/IGF-1 signaling can enhance the NF-kappaB signaling and subsequently potentiate the aging process and aggravate age-related degenerative diseases...
  9. doi Siglec receptors and hiding plaques in Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    J Mol Med (Berl) 87:697-701. 2009
    ..This kind of immune evasion can prevent the microglial cleansing process of aggregating amyloid plaques in AD...
  10. doi Genetics vs. entropy: longevity factors suppress the NF-kappaB-driven entropic aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Ageing Res Rev 9:298-314. 2010
    ....
  11. ncbi Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging
    Antero Salminen
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    Ageing Res Rev 7:83-105. 2008
    ..Our conclusion is that NF-kB signaling seems to be the culprit of inflamm-aging, since this signaling system integrates the intracellular regulation of immune responses in both aging and age-related diseases...
  12. doi SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Finland
    Bioessays 30:939-42. 2008
    ..Longevity factors, such as SIRT1 and its activators, might regulate the efficiency of the NF-kappaB signaling, the major outcome of which is inflamm-aging via proinflammatory responses...
  13. doi Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, and Kuopio University Hospital, Kuopio, Finland
    J Cell Mol Med 12:2255-62. 2008
    ....
  14. ncbi Neuronal apoptosis induced by histone deacetylase inhibitors
    A Salminen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Brain Res Mol Brain Res 61:203-6. 1998
    ..These observations show that an excessive level of histone acetylation induces a stress response and an apoptotic cell death in neuronal cells...
  15. doi Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential
    A Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, Kuopio, 70211, Finland
    Cell Mol Life Sci 65:2979-99. 2008
    ..It seems that during evolution, plants have established a terpene-based host defense which also represents a cornucopia of effective therapeutic compounds for common human diseases...
  16. pmc ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    J Neuroinflammation 6:41. 2009
    ..We will describe the mechanisms which could link the ER stress of neurons to the activation of the inflammatory response and the evolution of pathological changes in AD...
  17. doi ROCK, PAK, and Toll of synapses in Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, Kuopio FIN 70211, Finland
    Biochem Biophys Res Commun 371:587-90. 2008
    ..We will review here the dysfunction of ROCK, PAK, and Toll signaling associated with AD pathology. The protection of synapses in AD may provide new therapeutic approaches to combatting the cognitive impairment in AD...
  18. doi Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
    J Cell Physiol 224:1-6. 2010
    ..We will discuss the role of p53 in the regulation of glycolysis-dependent activation of NF-kappaB signaling in both cancer and aging process...
  19. doi Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90
    Antero Salminen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Immunol Lett 117:9-15. 2008
    ....
  20. doi Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1
    A Salminen
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    Cell Mol Life Sci 65:1049-58. 2008
    ..We provide evidence that signaling via the longevity factors of FoxOs and SIRT1 can inhibit NF-kappaB signaling and simultaneously protect against inflamm-aging process...
  21. ncbi The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis
    P Kerokoski
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    Biochem Biophys Res Commun 280:998-1002. 2001
    ..We conclude that neuronal apoptosis is accompanied with a decrease in the levels of p35, p25, and cdk5, and tau phosphorylation. These changes may reinforce the neuronal damage...
  22. ncbi Insulin-like growth factor binding protein 5 and type-1 insulin-like growth factor receptor are differentially regulated during apoptosis in cerebellar granule cells
    M Roschier
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    J Neurochem 76:11-20. 2001
    ..It seems that the expression of IGFBP-5 and IGF1R is regulated to maximize the availability of IGF and the activity of IGF-triggered survival signalling...
  23. ncbi Anti-inflammatory effect of selective estrogen receptor modulators (SERMs) in microglial cells
    T Suuronen
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Inflamm Res 54:194-203. 2005
    ..Our aim was to study how different SERMs modulate the inflammatory responses induced by lipopolysaccharide (LPS) or unmethylated CpG-oligonucleotides in mouse and rat microglial cells...
  24. ncbi Neuronal cells show regulatory differences in the hsp70 gene response
    K Kaarniranta
    Department of Anatomy, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Brain Res Mol Brain Res 101:136-40. 2002
    ..These observations suggest that neuronal cells display different hsp70 gene expression patterns which range from undetected response to transcriptional and posttranscriptional regulation during heat stress...
  25. ncbi Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells
    E Kuusisto
    Department of Neuroscience and Neurology, University of Kuopio, FIN 70211 Kuopio, Finland
    Biochem Biophys Res Commun 280:223-8. 2001
    ..Results also suggest that the induction of p62 expression by proteasomal inhibitors may be a response to elevated levels of ubiquitinated proteins, possibly constituting a protective mechanism...
  26. ncbi Induction of clusterin/apoJ expression by histone deacetylase inhibitors in neural cells
    Tapio Nuutinen
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Neurochem Int 47:528-38. 2005
    ..These observations suggest that clusterin induction is NF-kappaB-independent and unrelated to the inflammatory response in N9 microglia...
  27. ncbi Characterization of the pro-inflammatory signaling induced by protein acetylation in microglia
    Tiina Suuronen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurochem Int 49:610-8. 2006
    ..These results indicate that PI 3-kinase regulates the transactivation efficiency of NF-kappaB-dependent transcription rather than transduction of NF-kappaB signaling...
  28. doi Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease
    S Helisalmi
    Institute of Clinical Medicine, Unit of Neurology and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio University, PL 1627, 70211 Kuopio, Finland
    J Neurol 255:668-73. 2008
    ..We conclude that there is no real association with SNPs available in the present study between SIRT1, PPARD or PGC-1alpha genes and AD risk in the Finnish population...
  29. ncbi Regulation of microglial inflammatory response by histone deacetylase inhibitors
    Tiina Suuronen
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    J Neurochem 87:407-16. 2003
    ..Our results suggest that environmental stresses, ageing, diet and diseases that regulate protein acetylation status may also affect the inflammatory response...
  30. doi Characterization of a novel transgenic rat carrying human tau with mutation P301L
    P Korhonen
    Institute of Clinical Medicine, Neurology, University of Kuopio, 70211 Kuopio, Finland
    Neurobiol Aging 32:2314-5. 2011
    ..In conclusion, this transgenic tau rat may be a useful model for 'pretangle' pathology, although in this study conditions were not sufficient to induce significant neuronal loss or behavioral deficits...
  31. ncbi Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation
    E Kuusisto
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    Neuropathol Appl Neurobiol 28:228-37. 2002
    ..The results suggest that early involvement of p62 might be critical in the aggregation of hyperphosphorylated tau into perikaryal aggregates, i.e. NFTs...
  32. ncbi Differential regulation of the Sir2 histone deacetylase gene family by inhibitors of class I and II histone deacetylases
    S Kyrylenko
    Department of Neuroscience and Neurology, University of Kuopio, 70211 Kuopio, Finland
    Cell Mol Life Sci 60:1990-7. 2003
    ..Differential responses in SIRT mRNA expression profiles indicate that the expression of the Sir2 family of genes is selectively regulated and dependent on histone/protein acetylation status...
  33. ncbi Glutamate-induced changes in the DNA-binding complexes of transcription factor YY1 in cultured hippocampal and cerebellar granule cells
    P Korhonen
    Department of Neuroscience and Neurology, University of Kuopio, Finland
    Brain Res Mol Brain Res 52:330-3. 1997
    ..Our results show that excitotoxic treatment affects the regulation of YY1 transcription factor and suggest that YY1 is a significant nuclear target for stress-related signaling pathways in neuronal degeneration...
  34. ncbi Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease
    S Iivonen
    Department of Neuroscience and Neurology, University Hospital and University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Neuroscience 113:301-10. 2002
    ..The results presented here indicate that seladin-1 transcription is selectively down-regulated in brain regions vulnerable to Alzheimer's disease and this down-regulation is associated with the hyperphosphorylation of tau protein...
  35. ncbi Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells
    Kai Kaarniranta
    Department of Ophthalmology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Brain Res Mol Brain Res 137:126-31. 2005
    ..Interestingly, GA treatment accumulated Hsp70 protein and attenuated OA-induced cytotoxicity. This study suggests that Hsp70 and Hsp90 are closely related to cytoprotection of RPE cells in response to protein phosphatase inhibition...
  36. ncbi Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies
    E Kuusisto
    1Department of Neuroscience and Neurology, Section of Neuropathology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Neuroreport 12:2085-90. 2001
    ....
  37. pmc Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation
    Milla Koistinaho
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Proc Natl Acad Sci U S A 99:1610-5. 2002
    ..These findings elucidate molecular mechanisms of neuronal injury in AD and suggest that antiinflammatory compounds preventing activation of p38 MAPK in microglia may reduce neuronal vulnerability in AD...
  38. ncbi Regulation of PTEN expression in neuronal apoptosis
    S Kyrylenko
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Brain Res Mol Brain Res 73:198-202. 1999
    ....
  39. doi Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90
    Tiina Suuronen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    Neurochem Res 33:1768-75. 2008
    ..Our results reveal that ER alpha signaling is dependent on protein acetylation and epigenetic regulation...
  40. doi Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone
    Päivi H Kiviranta
    Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Bioorg Med Chem 16:8054-62. 2008
    ..The N-(3-phenylpropenoyl)-glycine tryptamide backbone is also a good backbone for SIRT2 inhibitors, and the series of compounds includes several potent SIRT2 inhibitors...
  41. doi Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells
    Johanna O Ojala
    University of Kuopio, Institute of Clinical Medicine Neurology, Canthia, P O B 1627, FIN 70211 Kuopio, Finland
    J Neuroimmunol 205:86-93. 2008
    ..Tau phosphorylation and expression of cyclin G1, involved in neuronal regeneration, increased at 72 h. In vivo, over-expression of IL-18 may induce hyperphosphorylation of tau and induce cell cycle activators...
  42. doi Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors
    Tero Huhtiniemi
    Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    J Med Chem 51:4377-80. 2008
    ..The most potent compound in the series was nearly as potent as the reference compound (6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide)...
  43. ncbi Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation
    Petri Kerokoski
    Department of Neuroscience and Neurology, University of Kuopio, Finland
    Biochem Biophys Res Commun 298:693-8. 2002
    ..We conclude that, in neuronal cells, the cleavage of p35 to p25 is associated with increased activity of cdk5 but not with tau hyperphosphorylation...
  44. ncbi The role of topoisomerase II in the excision of DNA loop domains during apoptosis
    Victor T Solovyan
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    J Biol Chem 277:21458-67. 2002
    ....
  45. ncbi Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons
    Petri Kerokoski
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Neurosci Lett 368:181-5. 2004
    ..Different factors, such as maturation state of neurons or desensitization properties of non-NMDA receptors, may determine which receptor predominantly mediates the effect of glutamate on p35 cleavage...
  46. ncbi Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35
    Petri Kerokoski
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, Finland
    Brain Res Mol Brain Res 106:50-6. 2002
    ..We conclude that p35 phosphorylation influences the proteasome-mediated degradation of p35 and calpain-mediated cleavage of p35 to p25...
  47. ncbi N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors
    Päivi H Kiviranta
    Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Bioorg Med Chem Lett 17:2448-51. 2007
    ....
  48. ncbi Upregulation of class II histone deacetylases mRNA during neural differentiation of cultured rat hippocampal progenitor cells
    Farzam Ajamian
    Department of Neurobiology, A I Virtanen Institute for Molecular Science, University of Kuopio, FIN 70211, Kuopio, Finland
    Neurosci Lett 346:57-60. 2003
    ..mRNAs for HDAC 4, 8 and 10 were not detectable by Northern analysis. We suggest that the changes in HDAC mRNA expression levels might be connected with chromatin rearrangement during neural differentiation...
  49. ncbi N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors
    Päivi H Kiviranta
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    J Med Chem 49:7907-11. 2006
    ..The most potent compound was N,N'-bis(2-hydroxybenzylidene)benzene-1,4-diamine, which was equipotent with the most potent hit compound and well-known SIRT2 inhibitor sirtinol...
  50. ncbi Selective regulation of class I and class II histone deacetylases expression by inhibitors of histone deacetylases in cultured mouse neural cells
    Farzam Ajamian
    Department of Neurobiology, A I Virtanen Institute for Molecular Science, University of Kuopio, P O Box 1627 Neulaniementie 2, FIN 70211 Kuopio, Finland
    Neurosci Lett 365:64-8. 2004
    ..There exists an auto-regulatory feedback loop to the expression levels of several HDACs after inhibition of their biochemical activity, adding several HDAC genes to the list of genes regulated by HDAC inhibitors...
  51. ncbi Comparative and pharmacophore model for deacetylase SIRT1
    Tero Huhtiniemi
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, Kuopio, FIN 70211, Finland
    J Comput Aided Mol Des 20:589-99. 2006
    ..To distinguish between active and inactive compounds, a post-docking filter based on H-bond network was constructed. Docking results were used to investigate the pharmacophore and to identify a filter for database mining...
  52. doi Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors
    K Kaarniranta
    Department of Ophthalmology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    J Mol Med (Berl) 87:117-23. 2009
    ..In addition, we will discuss whether AMD pathology could represent the outcome of chronic activation of the innate immunity defence in human macula...
  53. ncbi The expression of heat shock protein 27 in retinal ganglion and glial cells in a rat glaucoma model
    G Kalesnykas
    Department of Ophthalmology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, Kuopio FIN 70211, Finland
    Neuroscience 150:692-704. 2007
    ..This study suggests that constitutive HSP27 expression is a cell-type specific phenomenon in the rat retina. However, at the same time, HSP27 might be considered as a marker for neuronal injury in the rat glaucoma model...
  54. pmc Regulation of microglial inflammatory response by sodium butyrate and short-chain fatty acids
    Jari Huuskonen
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Br J Pharmacol 141:874-80. 2004
    ....
  55. ncbi Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells
    Kai Kaarniranta
    Department of Ophthalmology, University of Kuopio, 70211 Kuopio, Finland
    Neurosci Lett 382:185-90. 2005
    ..This study reveals that the Hsps have an important role in the cytoprotection of RPE cells subjected to HNE-derived oxidative stress...
  56. ncbi Discovering inhibitors of human sirtuin type 2: novel structural scaffolds
    Anu J Tervo
    Department of Pharmaceutical Chemistry, University of Kuopio, and Department of Neurology, Kuopio University Hospital, Post Office Box 1777, 70211 Kuopio, Finland
    J Med Chem 49:7239-41. 2006
    ..Two of these compounds inhibited SIRT2 with IC50 (microM) values of 51 and 91; moreover, one of the new inhibitors was comprised of an entirely new SIRT2-inhibiting structural scaffold...
  57. pmc p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells
    Johanna Viiri
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Mol Vis 16:1399-414. 2010
    ..In the present study, the functional roles of p62 and HSP70 were evaluated in conjunction with proteasome inhibitor-induced autophagy in human RPE cells (ARPE-19)...
  58. ncbi Piroxicam and NS-398 rescue neurones from hypoxia/reoxygenation damage by a mechanism independent of cyclo-oxygenase inhibition
    N Vartiainen
    A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    J Neurochem 76:480-9. 2001
    ..Instead, piroxicam and NS-398-induced phosphorylation through ERK pathway may contribute to the increased neuronal survival...
  59. doi Clusterin: a forgotten player in Alzheimer's disease
    Tapio Nuutinen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Brain Res Rev 61:89-104. 2009
    ..Though clusterin can be viewed as a multipotent guardian of brain, it is unable to prevent the progressive neuropathology in chronic AD...
  60. ncbi An in silico approach to discovering novel inhibitors of human sirtuin type 2
    Anu J Tervo
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    J Med Chem 47:6292-8. 2004
    ..This phenol group, together with a hydrophobic moiety and hydrogen-bonding features, is suggested to form an active SIRT2 pharmacophore...
  61. ncbi The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells
    Tuomas Paimela
    Department of Ophthalmology, University of Kuopio, Kuopio, Finland
    Immunol Lett 110:139-44. 2007
    ..The level of TLR4 gene expression was not affected by LPS exposure. Our results indicate that IL-6 expression is regulated through NF-kappaB transcription factor and stereoid-receptor signalling pathways in ARPE-19 cells...
  62. doi N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors
    Päivi H Kiviranta
    Department of Pharmaceutical Chemistry, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
    J Med Chem 52:2153-6. 2009
    ..The most potent SIRT1 inhibitors were equipotent with the reference compound (6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide) with the IC(50) values of 180-330 nM...
  63. ncbi Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells
    Tiina Suuronen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biochem Biophys Res Commun 357:397-401. 2007
    ..Our results indicate that epigenetic factors regulate the clusterin expression of RPE cells and thus might affect the pathogenesis of AMD via the inhibition of angiogenesis and inflammation...
  64. doi NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?
    Antero Salminen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biochem Biophys Res Commun 367:715-8. 2008
    ..The NEMO shuttle may link genotoxic stress to the activation of the innate immunity system and cause premature aging via inflamm-aging process...
  65. doi Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19)
    Tuomas Paimela
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, and Kuopio University Hospital, P O Box 1627, FIN 70211 Kuopio, Finland
    Eur J Pharmacol 640:219-25. 2010
    ..These results indicate that estrogen and HM-D can suppress the lipopolysaccharide-induced inflammatory response but signalling is not mediated through estrogen response element transcription in human retinal pigment epithelial cells...
  66. doi N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2
    Tero Huhtiniemi
    School of Pharmacy, University of Eastern Finland, Kuopio Campus, PO Box 1627, 70211 Kuopio, Finland
    Bioorg Med Chem 18:5616-25. 2010
    ..These results are applicable for further screening of N(epsilon)-acetyl analogues...
  67. doi Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease
    Tapio Nuutinen
    Department of Neurology, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurosci Lett 475:64-8. 2010
    ..One could postulate that valproic acid may be able to prevent amyloid-beta aggregation in AD, as observed in transgenic AD mice, by increasing clusterin expression...
  68. ncbi Changes in DNA binding pattern of transcription factor YY1 in neuronal degeneration
    Pauliina Korhonen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurosci Lett 377:121-4. 2005
    ..We suggest that despite the different cell death mechanisms, glutamate and okadaic acid activate signalling cascades that affect the formation of YY1 complexes and probably YY1-mediated gene regulation...
  69. ncbi Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden
    Tarja M Malm
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, FIN 70211 Kuopio, Finland
    J Neurosci 27:3712-21. 2007
    ..Because PDTC is capable of transferring external Cu2+ into a cell, and, in turn, Cu2+ is able to activate Akt, we hypothesize that PDTC provides the beneficial effect in transgenic AD mice through Cu2+-activated Akt pathway...
  70. ncbi Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis
    Toni Ahtoniemi
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO B 1627, FIN 70211 Kuopio, Finland
    Mol Pharmacol 71:30-7. 2007
    ..These results suggest that PDTC acts as an immunoproteasome inhibitor in mutant SOD1 rats and that immunoproteasome may help the nervous system to cope with deleterious effects of SOD1-G93A mutation...
  71. ncbi Amyloid-beta 1-42 induced endocytosis and clusterin/apoJ protein accumulation in cultured human astrocytes
    Tapio Nuutinen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurochem Int 50:540-7. 2007
    ..Endocytic response associated with the accumulation of clusterin/apoJ protein suggests that clusterin/apoJ has a role in the clearance of amyloid-beta peptides...
  72. ncbi Heat shock proteins as gatekeepers of proteolytic pathways-Implications for age-related macular degeneration (AMD)
    Kai Kaarniranta
    Department of Ophthalmology, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    Ageing Res Rev 8:128-39. 2009
    ..In addition to classical lysosomal proteolysis, we focus on the increasing evidence that, HSPs, proteasomes and autophagy regulate protein turnover in the RPE cells and thus have important roles in AMD disease...
  73. doi Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells
    Tuomas Ryhanen
    Department of Ophthalmology, University of Kuopio, Kuopio, Finland
    Eur J Pharmacol 584:229-36. 2008
    ..05) radicicol, but not in geldanamycin-treated RPE cells. These novel findings help in understanding the influence of HSP90 inhibition and regulatory mechanisms of drug delivery to retinal cells...