Marko Salmi

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi VAP-1: an adhesin and an enzyme
    M Salmi
    MediCity Research Laboratory, Tykistokatu 6A, University of Turku, FIN 20520 Turku, Finland
    Trends Immunol 22:211-6. 2001
  2. ncbi Human vascular adhesion protein-1 (VAP-1) plays a critical role in lymphocyte-endothelial cell adhesion cascade under shear
    M Salmi
    MediCity Research Laboratory, University of Turku, and National Public Health Institute, Department in Turku, Turku, Finland
    Circ Res 86:1245-51. 2000
  3. ncbi Human leukocyte subpopulations from inflamed gut bind to joint vasculature using distinct sets of adhesion molecules
    M Salmi
    MediCity Research Laboratory, Turku University, Turku, Finland
    J Immunol 166:4650-7. 2001
  4. ncbi A cell surface amine oxidase directly controls lymphocyte migration
    M Salmi
    MediCity Research Laboratory, Turku University and National Public Health Institute Department in Turku, Turku FIN 20520, Finland
    Immunity 14:265-76. 2001
  5. ncbi Immune cell trafficking in uterus and early life is dominated by the mucosal addressin MAdCAM-1 in humans
    M Salmi
    Department of Medical Microbiology, MediCity Research Laboratory, Turku University and National Public Health Institute, Department in Turku, Finland
    Gastroenterology 121:853-64. 2001
  6. ncbi Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetes
    Marko Salmi
    MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    Am J Pathol 161:2255-62. 2002
  7. ncbi Developmental regulation of the adhesive and enzymatic activity of vascular adhesion protein-1 (VAP-1) in humans
    Marko Salmi
    National Public Health Institute, Turku, Finland
    Blood 108:1555-61. 2006
  8. ncbi Cell-surface enzymes in control of leukocyte trafficking
    Marko Salmi
    MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    Nat Rev Immunol 5:760-71. 2005
  9. ncbi CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium
    Marko Salmi
    MediCity Research Laboratory, Turku University, Tykistokatu 6A, 20520 Turku, Finland
    Blood 104:3849-57. 2004
  10. ncbi The role of two distinct endothelial molecules, vascular adhesion protein-1 and peripheral lymph node addressin, in the binding of lymphocyte subsets to human lymph nodes
    M Salmi
    MediCity Research Laboratory, University of Turku, Finland
    J Immunol 160:5629-36. 1998

Detail Information

Publications74

  1. ncbi VAP-1: an adhesin and an enzyme
    M Salmi
    MediCity Research Laboratory, Tykistokatu 6A, University of Turku, FIN 20520 Turku, Finland
    Trends Immunol 22:211-6. 2001
    ..Thus, VAP-1 is an ectoenzyme that has inter-related adhesive and enzymatic functions in regulating physiological trafficking and inflammation...
  2. ncbi Human vascular adhesion protein-1 (VAP-1) plays a critical role in lymphocyte-endothelial cell adhesion cascade under shear
    M Salmi
    MediCity Research Laboratory, University of Turku, and National Public Health Institute, Department in Turku, Turku, Finland
    Circ Res 86:1245-51. 2000
    ..Together, these data show that VAP-1 can reconstitute the lymphocyte-endothelial adhesion cascade under shear and propose a critical role for VAP-1 in lymphocyte emigration from the blood...
  3. ncbi Human leukocyte subpopulations from inflamed gut bind to joint vasculature using distinct sets of adhesion molecules
    M Salmi
    MediCity Research Laboratory, Turku University, Turku, Finland
    J Immunol 166:4650-7. 2001
    ....
  4. ncbi A cell surface amine oxidase directly controls lymphocyte migration
    M Salmi
    MediCity Research Laboratory, Turku University and National Public Health Institute Department in Turku, Turku FIN 20520, Finland
    Immunity 14:265-76. 2001
    ..Enzymatic regulation of lymphocyte adhesion to endothelium provides a previously unrecognized rapid way of controlling the extravasation process...
  5. ncbi Immune cell trafficking in uterus and early life is dominated by the mucosal addressin MAdCAM-1 in humans
    M Salmi
    Department of Medical Microbiology, MediCity Research Laboratory, Turku University and National Public Health Institute, Department in Turku, Finland
    Gastroenterology 121:853-64. 2001
    ..Because nothing is known about these addressins during human development, we studied the expression and function of MAdCAM-1 (and PNAd for comparison) in fetuses and children...
  6. ncbi Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetes
    Marko Salmi
    MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    Am J Pathol 161:2255-62. 2002
    ..In conclusion insulin appears to regulate shedding or clearance of VAP-1, and an increase in sVAP-1 because of absolute or relative insulin deficiency may be directly involved in the pathogenesis of diabetic angiopathy...
  7. ncbi Developmental regulation of the adhesive and enzymatic activity of vascular adhesion protein-1 (VAP-1) in humans
    Marko Salmi
    National Public Health Institute, Turku, Finland
    Blood 108:1555-61. 2006
    ..Thus, VAP-1 may contribute critically to the oxidase activities in utero, and prove important for lymphocyte trafficking during human ontogeny...
  8. ncbi Cell-surface enzymes in control of leukocyte trafficking
    Marko Salmi
    MediCity Research Laboratory, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    Nat Rev Immunol 5:760-71. 2005
    ..Here, we provide new insights into how ectoenzymes--including nucleotidases, cyclases, ADP-ribosyltransferases, peptidases, proteases and oxidases--guide leukocyte traffic...
  9. ncbi CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium
    Marko Salmi
    MediCity Research Laboratory, Turku University, Tykistokatu 6A, 20520 Turku, Finland
    Blood 104:3849-57. 2004
    ..Notably, CLEVER-1 is the first adhesion molecule shown to be involved in the PBMC transmigration through the lymphatic arm of the immune system...
  10. ncbi The role of two distinct endothelial molecules, vascular adhesion protein-1 and peripheral lymph node addressin, in the binding of lymphocyte subsets to human lymph nodes
    M Salmi
    MediCity Research Laboratory, University of Turku, Finland
    J Immunol 160:5629-36. 1998
    ..Together, these data show that initial adhesion of CD8-positive lymphocytes to PLN HEV requires a PNAd- and a VAP-1-dependent step that are both essential and may occur simultaneously or sequentially...
  11. ncbi Homing of mucosal leukocytes to joints. Distinct endothelial ligands in synovium mediate leukocyte-subtype specific adhesion
    M Salmi
    National Public Health Institute, and MediCity Research Laboratory, Turku University, Finland
    J Clin Invest 99:2165-72. 1997
    ..Antiadhesive therapy against these inducible molecules should ablate the pathogenetic cascade leading to inappropriate homing of leukocytes to joints in arthritis...
  12. ncbi Vascular adhesion protein 1 (VAP-1) mediates lymphocyte subtype-specific, selectin-independent recognition of vascular endothelium in human lymph nodes
    M Salmi
    National Public Health Institute, and MediCity Research Laboratory, Turku University, 20520 Turku, Finland
    J Exp Med 186:589-600. 1997
    ..In conclusion, VAP-1 is a novel contact-initiating ligand that discriminates between different subpopulations of mononuclear cells and is an appealing target for selective modulation of adhesion of CD8- and CD16-positive effector cells...
  13. ncbi Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate
    Elina Kivi
    MediCity Research Laboratory, University of Turku, Turku, Finland
    Blood 114:5385-92. 2009
    ..Thus, the Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products...
  14. ncbi Clever-1/Stabilin-1 regulates lymphocyte migration within lymphatics and leukocyte entrance to sites of inflammation
    Marika Karikoski
    MediCity and Department of Medical Microbiology and Immunology, University of Turku and National Institute of Health and Welfare, Turku, Finland
    Eur J Immunol 39:3477-87. 2009
    ..These results indicate that anti-Clever-1/Stabilin-1 treatment can target two different arms of the vasculature--traffic via lymphatics and inflamed blood vessels...
  15. ncbi Identification of two imidazole binding sites and key residues for substrate specificity in human primary amine oxidase AOC3
    Heli Elovaara
    MediCity Research Laboratory, University of Turku, FI 20520 Turku, Finland
    Biochemistry 50:5507-20. 2011
    ..As a result, Met211 and Leu469 were shown to be key residues for substrate specificity. The native structures of sAOC3 and the mutational data presented in this study will aid the design of hAOC3 specific inhibitors...
  16. ncbi Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer
    Kristiina Aalto
    MediCity Research Laboratory and Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland
    Blood 118:3725-33. 2011
    ..Thus, the peptide binding to the enzymatic groove of VAP-1 can be used for imaging conditions, such as inflammation and cancer...
  17. ncbi The oxidase activity of vascular adhesion protein-1 (VAP-1) induces endothelial E- and P-selectins and leukocyte binding
    Sirpa Jalkanen
    MediCity Research Laboratory, University of Turku, Turku, Finland
    Blood 110:1864-70. 2007
    ..Our findings indicate cross-talk between adhesion molecules involved in the tethering and rolling of leukocytes and show that VAP-1-dependent signaling can prime the vessels for an enhanced inflammatory response...
  18. ncbi Vascular adhesion protein-1 is involved in both acute and chronic inflammation in the mouse
    Marika Merinen
    MediCity Research Laboratory, University of Turku and National Public Health Institute, 20520 Turku, Finland
    Am J Pathol 166:793-800. 2005
    ..The results show for the first time that in mouse models of inflammation, VAP-1 mediates leukocyte trafficking to sites of inflammation and thus is a potential target for anti-inflammatory therapies...
  19. ncbi Stabilin-1/CLEVER-1, a type 2 macrophage marker, is an adhesion and scavenging molecule on human placental macrophages
    Senthil Palani
    MediCity Research Laboratory, Department of Medical Biochemistry and Genetics, University of Turku, and National Institute of Health and Welfare, Turku, Finland
    Eur J Immunol 41:2052-63. 2011
    ..Together, these data suggest that macrophage stabilin-1/CLEVER-1 can potentially regulate leukocyte migration and scavenging during the development of the placenta and fetus...
  20. ncbi The prototype endothelial marker PAL-E is a leukocyte trafficking molecule
    Johannes Keuschnigg
    MediCity Research Laboratory and Department of Medical Microbiology, University of Turku and National Public Health Institute, Turku, Finland
    Blood 114:478-84. 2009
    ..Here we thus define leukocyte transendothelial migration as the first known function for PV-1...
  21. ncbi Vascular adhesion protein-1, intercellular adhesion molecule-1 and P-selectin mediate leukocyte binding to ischemic heart in humans
    K Jaakkola
    National Public Health Institute and MediCity Research Laboratory, University of Turku, Finland
    J Am Coll Cardiol 36:122-9. 2000
    ..The expression of endothelial adhesion molecules and their functional significance in leukocyte adhesion to human myocardial blood vessels in acute myocardial infarction (AMI) were studied...
  22. ncbi Vascular amine oxidases are needed for leukocyte extravasation into inflamed joints in vivo
    Fumiko Marttila-Ichihara
    University of Turku, and National Public Health Institute, Turku, Finland
    Arthritis Rheum 54:2852-62. 2006
    ..We undertook this study to determine the contribution of AOC3 and its oxidase activity to leukocyte trafficking into inflamed joints in vivo...
  23. ncbi Altered purinergic signaling in CD73-deficient mice inhibits tumor progression
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku, and National Institute of Health and Welfare, Turku, Finland
    Eur J Immunol 41:1231-41. 2011
    ....
  24. ncbi The same endothelial receptor controls lymphocyte traffic both in vascular and lymphatic vessels
    Heikki Irjala
    MediCity Research Laboratory, Department of Medical Microbiology, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    Eur J Immunol 33:815-24. 2003
    ..These findings suggest that CLEVER-1 is involved in regulation of lymphocyte recirculation and migration of leukocytes to sites of inflammation and is a potential new target to control inflammation...
  25. ncbi Recirculation and homing of lymphocyte subsets: dual homing specificity of beta 7-integrin(high)-lymphocytes in nonobese diabetic mice
    A Hänninen
    National Public Health Institute, Turku, Finland
    Blood 88:934-44. 1996
    ....
  26. ncbi Macrophage mannose receptor on lymphatics controls cell trafficking
    Fumiko Marttila-Ichihara
    MediCity Research Laboratory and Department of Medical Microbiology, Turku University and National Public Health Institute, Turku, Finland
    Blood 112:64-72. 2008
    ..Blocking of MR may provide a new approach to controlling inflammation and cancer metastasis by targeting the lymphatic vasculature...
  27. ncbi Small-molecule inhibitors of vascular adhesion protein-1 reduce the accumulation of myeloid cells into tumors and attenuate tumor growth in mice
    Fumiko Marttila-Ichihara
    MediCity Research Laboratory, University of Turku, Turku, Finland
    J Immunol 184:3164-73. 2010
    ..We conclude that tumors use the catalytic activity of VAP-1 to recruit myeloid cells into tumors and to support tumor progression. Small-molecule VAP-1 inhibitors therefore might be a potential new tool for immunotherapy of tumors...
  28. ncbi VAP-1-deficient mice display defects in mucosal immunity and antimicrobial responses: implications for antiadhesive applications
    Kaisa Koskinen
    MediCity Research Laboratory, Turku, Finland
    J Immunol 179:6160-8. 2007
    ..In conclusion, VAP-1-deficient mice have mild deviations in the mucosal immune system and therapeutic targeting of VAP-1 does not appear to cause a generalized increase in the risk of infection...
  29. ncbi Ischemia-reperfusion injury is attenuated in VAP-1-deficient mice and by VAP-1 inhibitors
    Jan Kiss
    MediCity Research Laboratory, University of Turku, Turku, Finland
    Eur J Immunol 38:3041-9. 2008
    ..These data thus indicate that VAP-1 regulates the inflammatory response in ischemia-reperfusion injury and suggest that blockade of VAP-1 may have therapeutic value...
  30. ncbi Vascular adhesion protein-1 enhances tumor growth by supporting recruitment of Gr-1+CD11b+ myeloid cells into tumors
    Fumiko Marttila-Ichihara
    MediCity Research Laboratory, University of Turku, Turku, Finland
    Cancer Res 69:7875-83. 2009
    ..They also suggest that VAP-1 is a potential new tool for immunotherapy of tumors that could be exploited to reduce tumor burden by controlling the traffic of Gr-1+CD11b+ myeloid cells...
  31. ncbi Molecular identification of PAL-E, a widely used endothelial-cell marker
    Harri Niemelä
    MediCity Research Laboratory, Turku University, Finland
    Blood 106:3405-9. 2005
    ..Molecular identification of PLVAP should help in the production of new tools for the identification of vascular as opposed to lymphatic endothelium and to elucidate the function of this protein...
  32. ncbi The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase
    Sam Kaitaniemi
    MediCity Research Laboratory, University of Turku, and National Institute for Health and Welfare, Tykistokatu 6, 20520 Turku, Finland
    Cell Mol Life Sci 66:2743-57. 2009
    ..Characterization of AOC2 will help in evaluating the contribution of this enzyme to the pathological processes attributed to the SSAO activity and in designing specific inhibitors for the individual members of the SSAO family...
  33. ncbi A peptide inhibitor of vascular adhesion protein-1 (VAP-1) blocks leukocyte-endothelium interactions under shear stress
    Gennady G Yegutkin
    MediCity Research Laboratory, , 20520 Turku, Finland
    Eur J Immunol 34:2276-85. 2004
    ..Moreover, the inhibitory peptide diminishes leukocyte interactions with endothelial cells under conditions of shear, and thus it may be useful to treat inflammatory conditions...
  34. ncbi Different role of CD73 in leukocyte trafficking via blood and lymph vessels
    Annika Algars
    MediCity Research Laboratory, University of Turku, Turku, Finland
    Blood 117:4387-93. 2011
    ..Instead, lymphocyte CD73 is intimately involved in lymphocyte migration via afferent lymphatic vessels...
  35. ncbi PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1
    Johannes Keuschnigg
    MediCity Research Laboratory, University of Turku, Turku, Finland
    Blood 120:232-5. 2012
    ..This connects, for the first time, 2 molecules involved in leukocyte trafficking and angiogenesis, thereby opening interesting possibilities for future research in this field...
  36. ncbi VAP-1 and CD73, endothelial cell surface enzymes in leukocyte extravasation
    Sirpa Jalkanen
    MediCity Research Laboratory, Tykistokatu 6A, 20520 Turku, Finland
    Arterioscler Thromb Vasc Biol 28:18-26. 2008
    ....
  37. ncbi IFN-beta protects from vascular leakage via up-regulation of CD73
    Jan Kiss
    MediCity Research Laboratory, University of Turku, Department of Medical Microbiology, and Turku University Hospital, Department of Surgery, Finland
    Eur J Immunol 37:3334-8. 2007
    ..Moreover, IFN-beta treatment may be useful in alleviating vascular leakage induced by ischemia-reperfusion injury...
  38. ncbi Absence of the endothelial oxidase AOC3 leads to abnormal leukocyte traffic in vivo
    Craig M Stolen
    Department of Medical Microbiology, MediCity Research Laboratory, National Public Health Institute, Turku University, 20520 Turku, Finland
    Immunity 22:105-15. 2005
    ....
  39. ncbi Regulation of lymphocyte traffic to mucosa-associated lymphatic tissues
    M Salmi
    Department of Medical Microbiology, Turku University, Finland
    Gastroenterol Clin North Am 20:495-510. 1991
    ..These same molecules may be equally responsible for the pathologic characteristics of the immune response seen, for example, in inflammatory bowel diseases...
  40. ncbi Type and location of tumor-infiltrating macrophages and lymphatic vessels predict survival of colorectal cancer patients
    Annika Algars
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Int J Cancer 131:864-73. 2012
    ..03). The results of this work suggest that the type of macrophages, number of lymphatic vessels and their location contribute to the clinical behavior of colorectal cancer in a disease stage-specific manner...
  41. ncbi Soluble vascular adhesion protein-1 correlates with cardiovascular risk factors and early atherosclerotic manifestations
    Kristiina Aalto
    MediCity Research Laboratory, Tykistokatu 6A, 20520 Turku, Finland
    Arterioscler Thromb Vasc Biol 32:523-32. 2012
    ..The relations of soluble vascular adhesion protein-1 (sVAP-1) with cardiovascular risk factors and markers of subclinical atherosclerosis at a population level have not been studied...
  42. ncbi Ectoenzymes controlling leukocyte traffic
    Marko Salmi
    MediCity Research Laboratory, University of Turku, Turku, Finland
    Eur J Immunol 42:284-92. 2012
    ....
  43. ncbi Enzymatic control of leukocyte trafficking: role of VAP-1
    Marko Salmi
    MediCity Research Laboratory, University of Turku and National Public Health Institute, Department in Turku, Finland
    Adv Exp Med Biol 512:57-63. 2002
  44. ncbi Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule
    D J Smith
    MediCity Research Laboratories, University of Turku, FIN 20520 Turku, Finland
    J Exp Med 188:17-27. 1998
    ..Its primary function in other locations where it is expressed, such as smooth muscle, may depend on its inherent monoamine oxidase activity...
  45. ncbi Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications
    Tomi T Airenne
    Department of Biochemistry and Pharmacy, Abo Akademi University, FIN 20520 Turku, Finland
    Protein Sci 14:1964-74. 2005
    ..Thirdly, the existence of a solvent-exposed RGD motif at the entrance to each active site in hVAP-1 suggests that it may have a functional role...
  46. ncbi Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells
    L Airas
    National Public Health Institute, MediCity Research Laboratory, Turku University, Finland
    J Cell Biol 136:421-31. 1997
    ..We suggest that the ligand-induced shedding of lymphocyte CD73 represents an important and novel means of controlling lymphocyte-EC interactions...
  47. ncbi Mannose receptor is a novel ligand for L-selectin and mediates lymphocyte binding to lymphatic endothelium
    H Irjala
    MediCity Research Laboratory, University of Turku, Finland
    J Exp Med 194:1033-42. 2001
    ..Taken together, interaction between L-selectin and MR is the first molecularly defined mechanism mediating lymphocyte binding to lymphatic endothelium...
  48. ncbi Lymphocyte homing to the gut: attraction, adhesion, and commitment
    Marko Salmi
    National Public Health Institute Turku, MediCity Research Laboratory, Department of Medical Microbiology, Turku University, Turku, Finland
    Immunol Rev 206:100-13. 2005
    ..A detailed understanding of the mucosal homing has recently led to the development of the first successful anti-adhesive therapeutics in human...
  49. ncbi Homing-associated molecules CD73 and VAP-1 as targets to prevent harmful inflammations and cancer spread
    Marko Salmi
    MediCity Research Laboratory, University of Turku and National Institute of Health and Welfare, Turku, Finland
    FEBS Lett 585:1543-50. 2011
    ..In this review, we will discuss about the most recent advances in studies elucidating the role of two homing-associated ecto-enzymes in physiological and pathological cell trafficking and their use as drug targets...
  50. ncbi [Welcome to visit the new targets in the field of immunology]
    Marko Salmi
    Duodecim 119:745-6. 2003
  51. ncbi CD73 mediates lymphocyte binding to vascular endothelium in inflamed human skin
    A M Arvilommi
    National Public Health Institute and MediCity Research Laboratories, University of Turku, Finland
    Eur J Immunol 27:248-54. 1997
    ..In the future, these findings may offer new means to treat inflammatory disorders of the skin...
  52. ncbi HLA-B27 modulates intracellular survival of Salmonella enteritidis in human monocytic cells
    P Laitio
    National Public Health Institute, Turku, Finland
    Eur J Immunol 27:1331-8. 1997
    ..This modulation of the host/microbe interaction by HLA-B27 may have an important role in the pathogenesis of ReA...
  53. ncbi Organ-selective regulation of vascular adhesion protein-1 expression in man
    A M Arvilommi
    MediCity Research Laboratories, University of Turku, Finland
    Eur J Immunol 27:1794-800. 1997
    ..These results indicate that the expression of VAP-1 is regulated in a tissue- and cell type-selective manner, and a correct micromilieu is required for the up-regulation to occur...
  54. ncbi Lymphocyte binding to vascular endothelium in inflamed skin revisited: a central role for vascular adhesion protein-1 (VAP-1)
    A M Arvilommi
    National Public Health Institute, Finland
    Eur J Immunol 26:825-33. 1996
    ..These findings suggest important roles also for VAP-1 and PNAd in lymphocyte homing into inflamed skin...
  55. ncbi Circulating form of human vascular adhesion protein-1 (VAP-1): increased serum levels in inflammatory liver diseases
    R Kurkijärvi
    National Public Health Institute, Turku University, Finland
    J Immunol 161:1549-57. 1998
    ..These findings indicate that there is a functionally active, soluble form of VAP-1 in circulation and suggest that the serum level of sVAP-1 might be a useful marker of disease activity in inflammatory liver diseases...
  56. ncbi Isolation, structural characterization, and chromosomal mapping of the mouse vascular adhesion protein-1 gene and promoter
    P Bono
    MediCity Research Laboratories, University of Turku, National Public Health Institute, Finland
    J Immunol 161:2953-60. 1998
    ....
  57. ncbi Human monocytic U937 cells kill Salmonella in vitro by NO-independent mechanisms
    P Ekman
    National Public Health Institute, Department in Turku, Turku, Finland
    Infect Immun 67:3670-3. 1999
    ..Both human monocytic transfectants produced NO equally well and killed Salmonella via NO-independent mechanisms...
  58. ncbi Cloning and characterization of mouse vascular adhesion protein-1 reveals a novel molecule with enzymatic activity
    P Bono
    MediCity Research Laboratory, University of Turku, Finland
    J Immunol 160:5563-71. 1998
    ..Cloning of mVAP-1 provides a valuable tool for in vivo studies of the significance of VAP-1 for lymphocyte-endothelial cell interactions and of the possible relationship between leukocyte adhesion and amine oxidase activity...
  59. ncbi Vascular adhesion protein 1 mediates binding of immunotherapeutic effector cells to tumor endothelium
    H Irjala
    National Public Health Institute and MediCity Research Laboratory, University of Turku, Tykistokatu 6A, FIN 20520 Turku, Finland
    J Immunol 166:6937-43. 2001
    ..These data suggest that VAP-1 is an important interplayer in the antitumor response. Thus, by up-regulating the expression of VAP-1 in tumor vasculature, it can be possible to improve the effectiveness of TIL therapy...
  60. ncbi Cell surface monoamine oxidases: enzymes in search of a function
    S Jalkanen
    MediCity Research Laboratory, Turku University, Tykistokatu 6A, 20520 Turku, Finland
    EMBO J 20:3893-901. 2001
    ..The emerging functions of ectoenzymes in signalling and cell-cell adhesion suggest a novel mode of molecular control of these complex processes...
  61. ncbi Vascular adhesion protein-1 (VAP-1) mediates lymphocyte-endothelial interactions in chronic kidney rejection
    R Kurkijärvi
    MediCity Research Laboratory, University of Turku and National Public Health Institute, Department in Turku, Turku, Finland
    Eur J Immunol 31:2876-84. 2001
    ..These results are the first evidence that VAP-1 is able to mediate leukocyte binding into a rejected organ. Thus, anti-adhesive therapies targeting VAP-1 may be useful in controlling chronic kidney graft rejection...
  62. ncbi Distinct ligand binding properties of Mac-2-binding protein and mouse cyclophilin [correction of mousephilin] C-associated protein
    K Jalkanen
    Centre for Biotechnology, University of Turku, Turku, Finland
    Eur J Immunol 31:3075-84. 2001
    ..We conclude that these proteins may be part of a larger family of proteins of immunological importance in which closer functional homologues might exists...
  63. ncbi The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling
    Elina Mattila
    VTT Technical Research Centre of Finland, Medical Biotechnology, Turku FIN 20520, Finland
    J Cell Sci 121:3570-80. 2008
    ..We conclude that matrix-controlled TCPTP phosphatase activity can inhibit VEGFR2 signalling, and the growth, migration and differentiation of human endothelial cells...
  64. ncbi Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes
    Riikka Lautamaki
    Turku PET Centre, University of Turku, Turku, Finland
    Am J Physiol Endocrinol Metab 291:E282-90. 2006
    ..Further studies will reveal the effect of hepatic fat reduction on myocardial metabolism and coronary function...
  65. ncbi Tumor infiltrating immune cells and outcome of Merkel cell carcinoma: a population-based study
    Harri Sihto
    Laboratory of Molecular Oncology and Molecular Cancer Biology Program, University of Helsinki, Helsinki, Finland
    Clin Cancer Res 18:2872-81. 2012
    ..Merkel cell carcinoma (MCC) is a rare skin cancer that often harbors Merkel cell polyomavirus (MCPyV) DNA. The clinical importance of intratumoral immune cells and their associations with MCPyV infection are poorly understood...
  66. ncbi Blockade of vascular adhesion protein-1 inhibits lymphocyte infiltration in rat liver allograft rejection
    Timi Martelius
    Department of Surgery, University of Helsinki and Helsinki University Hospital, P O Box 340, 00029 HUS Helsinki, Finland
    Am J Pathol 165:1993-2001. 2004
    ..This is the first demonstration in any prolonged in vivo model that VAP-1 plays an important role in lymphocyte infiltration to sites of inflammation, and, in particular, liver allograft rejection...
  67. ncbi Granulocyte transmigration through the endothelium is regulated by the oxidase activity of vascular adhesion protein-1 (VAP-1)
    Kaisa Koskinen
    MediCity Research Laboratory and Department of Medical Microbiology, Turku University Finland
    Blood 103:3388-95. 2004
    ..These data show that the oxidase activity of VAP-1 controls PMN exit from the blood during the relatively poorly understood transmigration step...
  68. ncbi Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: a role for alpha-4 integrin and vascular adhesion protein-1
    Claudine S Bonder
    Immunology Research Group, Department Physiology and Biophysics, University of Calgary, Alberta, Canada
    Immunity 23:153-63. 2005
    ..While this may still be true for neutrophils, Th1 and Th2 cells use alpha(4)-integrin and VAP-1, respectively, to adhere within the liver sinusoids...
  69. ncbi [Leucocyte migration to the site of inflammation]
    Marko Salmi
    Duodecim 119:781-91. 2003
  70. ncbi Function-blocking antibodies to human vascular adhesion protein-1: a potential anti-inflammatory therapy
    Christopher M Kirton
    Immunology Division, Department of Pathology, Cambridge University, Cambridge, UK
    Eur J Immunol 35:3119-30. 2005
    ..Furthermore, the chimeric antibodies prevented leukocyte adhesion and transmigration in vitro and in vivo. Hence, these chimeric antibodies have the potential to be used as a new anti-inflammatory therapy...
  71. ncbi Vascular adhesion protein-1 mediates adhesion and transmigration of lymphocytes on human hepatic endothelial cells
    Patricia F Lalor
    Liver Research Laboratories, University of Birmingham Institute of Clinical Science, Medical Research Council Center for Immune Regulation, Edgbaston, Birmingham, United Kingdom
    J Immunol 169:983-92. 2002
    ..Moreover, since VAP-1 is induced on nonhepatic endothelium in response to inflammation, its ability to support lymphocyte transendothelial migration may be an important systemic function of VAP-1...
  72. ncbi Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease
    Allister J Grant
    Liver Research Laboratories, University of Birmingham Institute of Clinical Science, MRC Centre for Immune Regulation, Queen Elizabeth Hospital, Edgbaston, B15 2TT, Birmingham, UK
    Lancet 359:150-7. 2002
    ..Recent reports that some lymphocyte homing-receptors are shared by the liver and gut provide a molecular basis for this hypothesis and explain the distribution of extraintestinal disease in inflammatory bowel disease...
  73. ncbi [Cell surface adhesion molecules and cancer]
    Petri Bono
    , 00029 HUS
    Duodecim 120:1211-8. 2004
  74. ncbi Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects
    Eija Ruotsalainen
    University of Kuopio, Department of Medicine, 70210 Kuopio, Finland
    Atherosclerosis 197:271-7. 2008
    ..Inflammatory markers and adhesion molecules were correlated suggesting that low-grade inflammation may precede the elevation of levels of adhesion molecules...