K Salmenkivi

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis
    K Salmenkivi
    Department of Pathology, Haartman Institute, University of Helsinki, Finland
    J Clin Endocrinol Metab 86:2231-5. 2001
  2. ncbi request reprint Increased expression of tenascin in pheochromocytomas correlates with malignancy
    K Salmenkivi
    Department of Pathology, Haartman Institute, University of Helsinki and HUCH Laboratory Diagnostics, Helsinki University Central Hospital, Helsinki, Finland
    Am J Surg Pathol 25:1419-23. 2001
  3. ncbi request reprint Lack of histologically suspicious features, proliferative activity, and p53 expression suggests benign diagnosis in phaeochromocytomas
    K Salmenkivi
    Department of Pathology, Haartman Institute, PO Box 21, FIN 00014 University of Helsinki, Finland
    Histopathology 43:62-71. 2003
  4. ncbi request reprint Malignancy in pheochromocytomas
    Kaisa Salmenkivi
    Department of Pathology, Haartman Institute, University of Helsinki and HUCH Laboratory Diagnostics, Helsinki University Central Hospital, Helsinki, Finland
    APMIS 112:551-9. 2004
  5. ncbi request reprint Expression of inhibin alpha in adrenocortical tumours reflects the hormonal status of the neoplasm
    J Arola
    Department of Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Finland
    J Endocrinol 165:223-9. 2000
  6. doi request reprint The prevalence of and risk factors for four or more metastatic axillary lymph nodes in breast cancer patients undergoing sentinel node biopsy
    M Leidenius
    Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland
    J Surg Oncol 98:21-6. 2008
  7. doi request reprint High frequency of SNAIL-expressing cells confirms and predicts metastatic potential of phaeochromocytoma
    V Häyry
    Institute of Biomedicine, Developmental Biology, University of Helsinki, Biomedicum, Helsinki, Finland
    Endocr Relat Cancer 16:1211-8. 2009
  8. ncbi request reprint Increased expression of cyclooxygenase-2 in malignant pheochromocytomas
    K Salmenkivi
    Department of Pathology, Haartman Institute, University of Helsinki and HUCH Laboratory Diagnostics, Helsinki University Central Hospital, FIN 00014 Helsinki, Finland
    J Clin Endocrinol Metab 86:5615-9. 2001
  9. doi request reprint Outcome of patients with ductal carcinoma in situ and sentinel node biopsy
    T J Meretoja
    Breast Surgery Unit, Department of Gastrointestinal and General Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Ann Surg Oncol 19:2345-51. 2012
  10. pmc DNA copy number loss and allelic imbalance at 2p16 in lung cancer associated with asbestos exposure
    E Kettunen
    Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland
    Br J Cancer 100:1336-42. 2009

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis
    K Salmenkivi
    Department of Pathology, Haartman Institute, University of Helsinki, Finland
    J Clin Endocrinol Metab 86:2231-5. 2001
    ..This suggests that loss of inhibin/activin betaB-subunit expression in pheochromocytomas may be used as an indicator of malignant potential...
  2. ncbi request reprint Increased expression of tenascin in pheochromocytomas correlates with malignancy
    K Salmenkivi
    Department of Pathology, Haartman Institute, University of Helsinki and HUCH Laboratory Diagnostics, Helsinki University Central Hospital, Helsinki, Finland
    Am J Surg Pathol 25:1419-23. 2001
    ..We therefore suggest that tenascin may be associated with the malignant transformation and metastasis of pheochromocytomas. It is also a potential marker predicting more aggressive behavior in pheochromocytomas...
  3. ncbi request reprint Lack of histologically suspicious features, proliferative activity, and p53 expression suggests benign diagnosis in phaeochromocytomas
    K Salmenkivi
    Department of Pathology, Haartman Institute, PO Box 21, FIN 00014 University of Helsinki, Finland
    Histopathology 43:62-71. 2003
    ..The aim of this study was to assess the histopathological and clinical features, as well as the proliferative activity, and to analyse p53 and p21 expression in 105 phaeochromocytomas...
  4. ncbi request reprint Malignancy in pheochromocytomas
    Kaisa Salmenkivi
    Department of Pathology, Haartman Institute, University of Helsinki and HUCH Laboratory Diagnostics, Helsinki University Central Hospital, Helsinki, Finland
    APMIS 112:551-9. 2004
    ..In this overview of malignancy in pheochromocytomas, different steps of the tumorigenesis and several markers associated with them are discussed...
  5. ncbi request reprint Expression of inhibin alpha in adrenocortical tumours reflects the hormonal status of the neoplasm
    J Arola
    Department of Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Finland
    J Endocrinol 165:223-9. 2000
    ..We did not find any significant difference in inhibin alpha expression between benign and malignant adrenocortical tumours. Thus inhibin alpha gene does not seem to have a tumour suppressor role in human adrenal cortex...
  6. doi request reprint The prevalence of and risk factors for four or more metastatic axillary lymph nodes in breast cancer patients undergoing sentinel node biopsy
    M Leidenius
    Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland
    J Surg Oncol 98:21-6. 2008
    ..Our aim was to investigate the prevalence of and risk factors for having four or more positive axillary lymph nodes among breast cancer patients undergoing sentinel node (SN) biopsy...
  7. doi request reprint High frequency of SNAIL-expressing cells confirms and predicts metastatic potential of phaeochromocytoma
    V Häyry
    Institute of Biomedicine, Developmental Biology, University of Helsinki, Biomedicum, Helsinki, Finland
    Endocr Relat Cancer 16:1211-8. 2009
    ..We conclude that the expression of SNAIL may be of use in predicting the metastatic potential of phaeochromocytoma...
  8. ncbi request reprint Increased expression of cyclooxygenase-2 in malignant pheochromocytomas
    K Salmenkivi
    Department of Pathology, Haartman Institute, University of Helsinki and HUCH Laboratory Diagnostics, Helsinki University Central Hospital, FIN 00014 Helsinki, Finland
    J Clin Endocrinol Metab 86:5615-9. 2001
    ..These findings suggest that negative or weak Cox-2 expression in pheochromocytomas favors benign diagnosis...
  9. doi request reprint Outcome of patients with ductal carcinoma in situ and sentinel node biopsy
    T J Meretoja
    Breast Surgery Unit, Department of Gastrointestinal and General Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Ann Surg Oncol 19:2345-51. 2012
    ..The prognostic significance of such findings is largely unknown. The aim of this study is to examine the outcome of DCIS and DCISM patients with SNB...
  10. pmc DNA copy number loss and allelic imbalance at 2p16 in lung cancer associated with asbestos exposure
    E Kettunen
    Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland
    Br J Cancer 100:1336-42. 2009
    ..1-p16.1 using 14 microsatellite markers and also AI at 2p16 was related to asbestos exposure (P=0.003). Our results suggest that alterations at 2p16 combined with other markers could be useful in diagnosing asbestos-related lung cancer...
  11. ncbi request reprint Expression of vascular endothelial growth factor in human adrenals
    P Heikkila
    Department of Pathology, Helsinki University Central Hospital, University of Helsinki, Finland
    Endocr Res 26:867-71. 2000
    ..The mRNA levels were increased after 24h stimulation with either ACTH or cAMP. The effect of cAMP was dose-dependent. This suggests that ACTH-induced VEGF mRNA expression is mediated via protein kinase A dependent pathway...
  12. doi request reprint Diagnosing isolated cardiac sarcoidosis
    R Kandolin
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    J Intern Med 270:461-8. 2011
    ..We set out to analyse our experience of repeated and imaging-guided biopsies in clinically isolated CS...
  13. ncbi request reprint No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia
    A Raitila
    Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, PO Box 63, Haartmaninkatu 8, FIN 00014 University of Helsinki, Finland
    Endocr Relat Cancer 14:901-6. 2007
    ..The data also support the previous finding that somatic AIP mutations are not common in pituitary adenomas and suggest that such mutations are rare in other endocrine tumors as well...
  14. ncbi request reprint Gene copy number analysis in malignant pleural mesothelioma using oligonucleotide array CGH
    P M Lindholm
    Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Finland
    Cytogenet Genome Res 119:46-52. 2007
    ..3, 7p22.3-->p22.2, 12q13.3, and 17q21.32-->qter. The results suggest that gene copy number losses are a major mechanism of MM carcinogenesis and reveal a recurrent pattern of copy number changes in MM...
  15. ncbi request reprint Gremlin localization and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype
    M Myllärniemi
    Department of Medicine and Division of Pulmonary Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    J Pathol 214:456-63. 2008
    ..Gremlin expression levels correlating negatively and BMP-4 levels positively with disease severity support recent observations of a fibroprotective role for the BMPs...
  16. ncbi request reprint Increased expression of high mobility group A proteins in lung cancer
    V K Sarhadi
    Department of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    J Pathol 209:206-12. 2006
    ..As HMGA proteins were expressed in about 90% of lung carcinomas and their expression was inversely associated with survival, they may provide useful markers for lung cancer diagnosis and prognosis...
  17. ncbi request reprint Tumour-positive sentinel node findings in patients with ductal carcinoma in situ
    M Leidenius
    Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland
    J Surg Oncol 94:380-4. 2006
    ..Our aim was to evaluate the prevalence of and risk factors for tumour-positive sentinel node (SN) findings in patients with ductal carcinoma in situ (DCIS)...
  18. ncbi request reprint VEGF in 105 pheochromocytomas: enhanced expression correlates with malignant outcome
    Kaisa Salmenkivi
    Department of Pathology, Haartman Institute, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
    APMIS 111:458-64. 2003
    ..Normal medullary cells are immunohistochemically negative. Thus, low VEGF expression in pheochromocytomas favors a benign diagnosis...
  19. pmc Peroxiredoxin II expression and its association with oxidative stress and cell proliferation in human idiopathic pulmonary fibrosis
    Kirsi Vuorinen
    Pulmonary Division, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    J Histochem Cytochem 56:951-9. 2008
    ..The results suggest that Prx II oxidation does not relate to the pathogenesis of IPF/UIP and that Prx II, PDGFRs, and proliferating cells colocalize in the IPF/UIP lung. Unexpectedly, FF represented areas of low cell proliferation...
  20. ncbi request reprint CDK4 is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancer
    Harriet Wikman
    Department of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    Genes Chromosomes Cancer 42:193-9. 2005
    ..Although CDK4 amplification seems to be a relatively rare event (4.3%) in lung tumors, it indicates the significance of the RB1-CCND1 pathway in lung tumorigenesis...
  21. ncbi request reprint Cutaneous T-cell lymphoma-associated lung cancers show chromosomal aberrations differing from primary lung cancer
    Sonja Hahtola
    Department of Dermatology and Allergology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Genes Chromosomes Cancer 47:107-17. 2008
    ..These preliminary observations warrant further prospective studies to identify the common underlying factors between CTCL and CTCL-associated lung cancer...
  22. pmc Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis
    Marjukka Myllärniemi
    University of Helsinki, Biomedicum A506, P O Box 63, Haartmaninkatu 8, 00014 Helsinki, Finland
    Am J Respir Crit Care Med 177:321-9. 2008
    ..We have observed that the BMP antagonist, gremlin, is highly up-regulated in idiopathic pulmonary fibrosis (IPF)...
  23. ncbi request reprint Up-regulation of trypsin and mesenchymal MMP-8 during development of hyperoxic lung injury in the rat
    Katariina Cederqvist
    Department of Pediatrics, Helsinki University Central Hospital and University of Helsinki, FIN 00290 Helsinki, Finland
    Pediatr Res 60:395-400. 2006
    ..Marked up-regulation of trypsin and MMP-8 early during hyperoxic lung injury suggests that these enzymes play a role in the pathogenesis of acute lung injury and may therefore be potential targets for therapy of lung injury...
  24. ncbi request reprint Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarrays
    Harriet Wikman
    Departments of Medical Genetics and Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Laboratory Diagnostics, Helsinki, Finland
    J Pathol 203:584-93. 2004
    ..Some of these genes may provide novel diagnostic markers for lung cancer...
  25. pmc Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis
    Katri Koli
    Department of Virology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Am J Pathol 169:61-71. 2006
    ..The overexpression of this developmental gene in IPF may be a key event in the persistence of myofibroblasts in the lung interstitium and provides a potential target for therapeutic intervention...
  26. ncbi request reprint Copy number gains on 5p15, 6p11-q11, 7p12, and 8q24 are rare in sputum cells of individuals at high risk of lung cancer
    Eeva Kettunen
    Finnish Institute of Occupational Health, Centre of Expertise for Health and Work Ability, Topeliuksenkatu 41 a A, FI 00250 Helsinki, Finland
    Lung Cancer 54:169-76. 2006
    ..One of such probe sets, LAVysion, detects copy number changes in the centromeric region of chromosome 6 (CEP6), and regions 5p15, 8q24, and 7p12, often gained in lung cancer...
  27. ncbi request reprint Elevated matrilysin levels in bronchoalveolar lavage fluid do not distinguish idiopathic pulmonary fibrosis from other interstitial lung diseases
    Kirsi Vuorinen
    Department of Medicine and Division of Pulmonary Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    APMIS 115:969-75. 2007
    ..These results demonstrate that elevated BALF MMP-7 is not restricted to IPF alone but is also observed in other interstitial lung diseases and cannot be used as a differential diagnostic marker for IPF...
  28. pmc ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis
    Ulla Hodgson
    Department of Pulmonary Medicine, Helsinki University Central Hospital, Finland
    Am J Hum Genet 79:149-54. 2006
    ..05). Our results suggest ELMOD2 as a novel candidate gene for susceptibility in familial IPF...
  29. ncbi request reprint Frequent loss of heterozygosity at 6q in pheochromocytoma
    Sebsebe Lemeta
    Department of Pathology, University of Helsinki and HUSLAB, Helsinki, Finland
    Hum Pathol 37:749-54. 2006
    ..Similar to our findings for capillary hemangioblastomas, our data for the first time suggest that one or several tumor suppressor genes located at 6q, particularly at 6q23-24, may play a role in the tumorigenesis of PCCs...