Isaac Salazar-Ciudad

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. pmc A gene network model accounting for development and evolution of mammalian teeth
    Isaac Salazar-Ciudad
    Complex Systems Research Group, Department of Physics and Nuclear Engineering, Polytechnic University of Catalonia, North Campus, Modul B5, 08034 Barcelona, Spain
    Proc Natl Acad Sci U S A 99:8116-20. 2002
  2. ncbi request reprint Mechanisms of pattern formation in development and evolution
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, PO Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Development 130:2027-37. 2003
  3. ncbi request reprint How different types of pattern formation mechanisms affect the evolution of form and development
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, P O Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Evol Dev 6:6-16. 2004
  4. ncbi request reprint Graduality and innovation in the evolution of complex phenotypes: insights from development
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, FIN 00014, University of Helsinki, Helsinki, Finland
    J Exp Zool B Mol Dev Evol 304:619-31. 2005
  5. ncbi request reprint The economy of tinkering mammalian teeth
    Jukka Jernvall
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, P O Box 56, University of Helsinki, FIN 00014, Helsinki, Finland
    Novartis Found Symp 284:207-16; discussion 216-24. 2007
  6. ncbi request reprint Tooth morphogenesis in vivo, in vitro, and in silico
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, P O Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Curr Top Dev Biol 81:341-71. 2008
  7. doi request reprint Adaptive dynamics under development-based genotype-phenotype maps
    Isaac Salazar-Ciudad
    Evolutionary phenomics group Developmental Biology Program, Institute of Biotechnology, University of Helsinki, PO Box 56, FIN 00014 Helsinki, Finland
    Nature 497:361-4. 2013
  8. ncbi request reprint Developmental constraints vs. variational properties: How pattern formation can help to understand evolution and development
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, FIN 00014, University of Helsinki, Helsinki, Finland
    J Exp Zool B Mol Dev Evol 306:107-25. 2006
  9. doi request reprint Tooth patterning and evolution
    Isaac Salazar-Ciudad
    Evolutionary Phenomics Group, Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Curr Opin Genet Dev 22:585-92. 2012
  10. ncbi request reprint On the origins of morphological disparity and its diverse developmental bases
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, PO Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Bioessays 28:1112-22. 2006

Collaborators

Detail Information

Publications16

  1. pmc A gene network model accounting for development and evolution of mammalian teeth
    Isaac Salazar-Ciudad
    Complex Systems Research Group, Department of Physics and Nuclear Engineering, Polytechnic University of Catalonia, North Campus, Modul B5, 08034 Barcelona, Spain
    Proc Natl Acad Sci U S A 99:8116-20. 2002
    ..This finding may be consistent with why predicting the morphological outcomes of molecular experiments is challenging. Nevertheless, models incorporating morphology and gene activity show promise for linking genotypes to phenotypes...
  2. ncbi request reprint Mechanisms of pattern formation in development and evolution
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, PO Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Development 130:2027-37. 2003
    ....
  3. ncbi request reprint How different types of pattern formation mechanisms affect the evolution of form and development
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, P O Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Evol Dev 6:6-16. 2004
    ..In addition, type of mechanism affects the tempo and mode of morphological evolution. These results suggest that the basic principles by which development is organized can influence the likelihood of morphological evolution...
  4. ncbi request reprint Graduality and innovation in the evolution of complex phenotypes: insights from development
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, FIN 00014, University of Helsinki, Helsinki, Finland
    J Exp Zool B Mol Dev Evol 304:619-31. 2005
    ..This work also explores further consequences of these results in our understanding of phenotypic evolution...
  5. ncbi request reprint The economy of tinkering mammalian teeth
    Jukka Jernvall
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, P O Box 56, University of Helsinki, FIN 00014, Helsinki, Finland
    Novartis Found Symp 284:207-16; discussion 216-24. 2007
    ..These kinds of developmentally influenced tendencies may be hypothesized to be typical to many organs and systems showing repeated evolutionary patterns...
  6. ncbi request reprint Tooth morphogenesis in vivo, in vitro, and in silico
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, P O Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Curr Top Dev Biol 81:341-71. 2008
    ..Overall, this review should be interesting to either readers interested in the mechanistic bases of tooth morphogenesis, without necessarily being interested in modeling per se, and readers interested in development modeling in general...
  7. doi request reprint Adaptive dynamics under development-based genotype-phenotype maps
    Isaac Salazar-Ciudad
    Evolutionary phenomics group Developmental Biology Program, Institute of Biotechnology, University of Helsinki, PO Box 56, FIN 00014 Helsinki, Finland
    Nature 497:361-4. 2013
    ..The results contribute developmental understanding to the long-standing question of which aspects of phenotype can be effectively optimized by natural selection...
  8. ncbi request reprint Developmental constraints vs. variational properties: How pattern formation can help to understand evolution and development
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, FIN 00014, University of Helsinki, Helsinki, Finland
    J Exp Zool B Mol Dev Evol 306:107-25. 2006
    ..That is what kind of pattern formation mechanisms, in which relative temporal order, and which kind of phenotypic changes, are expected to be found in development...
  9. doi request reprint Tooth patterning and evolution
    Isaac Salazar-Ciudad
    Evolutionary Phenomics Group, Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Curr Opin Genet Dev 22:585-92. 2012
    ..Those are discussed here since they provide clues about how reaction-diffusion systems may work in actual developmental systems. Mathematical models implementing what we know about tooth development are discussed...
  10. ncbi request reprint On the origins of morphological disparity and its diverse developmental bases
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, PO Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Bioessays 28:1112-22. 2006
    ..Some specific examples of these kinds of morphologic changes are explained...
  11. ncbi request reprint Looking at the origin of phenotypic variation from pattern formation gene networks
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, FIN 00014, University of Helsinki, Helsinki, Finland
    J Biosci 34:573-87. 2009
    ..Re-use leads to extensive modularity in gene networks while developmental drift blurs this modularity. Evolutionary opportunism makes developmental gene networks very dependent on epigenetic factors...
  12. pmc Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling
    Elina Järvinen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, P O Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 103:18627-32. 2006
    ..These results may implicate Wnt signaling in tooth renewal, a capacity that was all but lost when mammals evolved progressively more complicated tooth shapes...
  13. ncbi request reprint Replaying evolutionary transitions from the dental fossil record
    Enni Harjunmaa
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P O Box 56, FIN 00014 Helsinki, Finland
    Nature 512:44-8. 2014
    ..Taken together, evolutionarily informative transitions can be experimentally reproduced, thereby providing development-based expectations for character-state transitions used in evolutionary studies. ..
  14. ncbi request reprint The origin and loss of periodic patterning in the turtle shell
    Jacqueline E Moustakas-Verho
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P O Box 56, Helsinki FIN 00014, Finland
    Development 141:3033-9. 2014
    ....
  15. doi request reprint Evolution in biological and nonbiological systems under different mechanisms of generation and inheritance
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014, Helsinki, Finland
    Theory Biosci 127:343-58. 2008
    ....
  16. ncbi request reprint Commonalities in fly embryogenesis and mammalian pituitary patterning
    Reiner A Veitia
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Trends Endocrinol Metab 18:261-5. 2007
    ..Variability in gene expression at territory boundaries might give rise to a poorly differentiated pool of cells, which could harbor stem-like properties. The ideas outlined here deserve further theoretical and experimental exploration...