Ulpu Saarialho-Kere

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Accumulation of matrilysin (MMP-7) and macrophage metalloelastase (MMP-12) in actinic damage
    U Saarialho-Kere
    Department of Dermatology, Helsinki University Central Hospital, Finland
    J Invest Dermatol 113:664-72. 1999
  2. ncbi request reprint Patterns of matrix metalloproteinase and TIMP expression in chronic ulcers
    U K Saarialho-Kere
    Department of Dermatology, Helsinki University Central Hospital, Finland
    Arch Dermatol Res 290:S47-54. 1998
  3. ncbi request reprint Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair
    Ulpu Saarialho-Kere
    Department of Dermatology, Biomedicum Helsinki, University Central Hospital, University of Helsinki, Meilahdentie 2, 00250 Helsinki, Finland
    J Invest Dermatol 119:14-21. 2002
  4. ncbi request reprint The gut-skin axis
    Ulpu Saarialho-Kere
    Department of Dermatology, Helsinki University Central Hospital, Meilahdentie 2, 00250 Helsinki, Finland
    J Pediatr Gastroenterol Nutr 39:S734-5. 2004
  5. doi request reprint MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer
    Sonja Boyd
    Department of Pathology, Helsinki University Central Hospital and Haartman Institute, University of Helsinki, Helsinki, Finland
    Exp Dermatol 18:1044-52. 2009
  6. ncbi request reprint HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes
    Sari Suomela
    Department of Dermatology, Helsinki University Central Hospital, Helsinki, Finland
    J Invest Dermatol 121:1360-4. 2003
  7. ncbi request reprint Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus
    Kati Asumalahti
    Department of Medical Genetics and Finnish Genome Center, University of Helsinki, 00014 Helsinki, Finland
    Hum Mol Genet 11:589-97. 2002
  8. ncbi request reprint Matrix metalloproteinase-19 is expressed by proliferating epithelium but disappears with neoplastic dedifferentiation
    Ulla Impola
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, Helsinki, Finland
    Int J Cancer 103:709-16. 2003
  9. ncbi request reprint Matrix metalloproteinase-21 is expressed epithelially during development and in cancer and is up-regulated by transforming growth factor-beta1 in keratinocytes
    Katja Ahokas
    Department of Dermatology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland
    Lab Invest 83:1887-99. 2003
  10. ncbi request reprint Matrilysin-2 (matrix metalloproteinase-26) is upregulated in keratinocytes during wound repair and early skin carcinogenesis
    Katja Ahokas
    Department of Dermatology, Helsinki University Central Hospital, Biomedicum Helsinki, Helsinki, Finland
    J Invest Dermatol 124:849-56. 2005

Detail Information

Publications56

  1. ncbi request reprint Accumulation of matrilysin (MMP-7) and macrophage metalloelastase (MMP-12) in actinic damage
    U Saarialho-Kere
    Department of Dermatology, Helsinki University Central Hospital, Finland
    J Invest Dermatol 113:664-72. 1999
    ..Our results suggest that both matrix metalloproteinase-7 and -12 may contribute to remodeling of elastotic areas in sun-damaged skin...
  2. ncbi request reprint Patterns of matrix metalloproteinase and TIMP expression in chronic ulcers
    U K Saarialho-Kere
    Department of Dermatology, Helsinki University Central Hospital, Finland
    Arch Dermatol Res 290:S47-54. 1998
    ..Analogous to chronic cutaneous wounds, MMP-1 and -3 are abundantly expressed in chronic small and large bowel ulcers, while the migrating surface epithelium is negative for TIMP-1 expression...
  3. ncbi request reprint Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair
    Ulpu Saarialho-Kere
    Department of Dermatology, Biomedicum Helsinki, University Central Hospital, University of Helsinki, Meilahdentie 2, 00250 Helsinki, Finland
    J Invest Dermatol 119:14-21. 2002
    ....
  4. ncbi request reprint The gut-skin axis
    Ulpu Saarialho-Kere
    Department of Dermatology, Helsinki University Central Hospital, Meilahdentie 2, 00250 Helsinki, Finland
    J Pediatr Gastroenterol Nutr 39:S734-5. 2004
  5. doi request reprint MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer
    Sonja Boyd
    Department of Pathology, Helsinki University Central Hospital and Haartman Institute, University of Helsinki, Helsinki, Finland
    Exp Dermatol 18:1044-52. 2009
    ..MMP-21 does not associate with invasion of SCC but may be involved in keratinocyte differentiation...
  6. ncbi request reprint HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes
    Sari Suomela
    Department of Dermatology, Helsinki University Central Hospital, Helsinki, Finland
    J Invest Dermatol 121:1360-4. 2003
    ..Based on the observations that HCR is detected in cancers of epithelial origin in Ki67-negative areas and that interferon-gamma downregulates its expression, we suggest it to have an antiproliferative function...
  7. ncbi request reprint Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus
    Kati Asumalahti
    Department of Medical Genetics and Finnish Genome Center, University of Helsinki, 00014 Helsinki, Finland
    Hum Mol Genet 11:589-97. 2002
    ..These results provide strong evidence for the HCR*WWCC allele as a major genetic determinant for psoriasis, probably by a mechanism impacting on keratinocyte proliferation...
  8. ncbi request reprint Matrix metalloproteinase-19 is expressed by proliferating epithelium but disappears with neoplastic dedifferentiation
    Ulla Impola
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, Helsinki, Finland
    Int J Cancer 103:709-16. 2003
    ..Our data suggest that, unlike most MMPs, MMP-19 expression in the epidermis is downregulated during transformation and histologic dedifferentiation...
  9. ncbi request reprint Matrix metalloproteinase-21 is expressed epithelially during development and in cancer and is up-regulated by transforming growth factor-beta1 in keratinocytes
    Katja Ahokas
    Department of Dermatology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland
    Lab Invest 83:1887-99. 2003
    ..Unlike many classical MMPs, it is present in various normal adult tissues. Among epithelial MMPs, MMP-21 has a unique expression pattern in cancer...
  10. ncbi request reprint Matrilysin-2 (matrix metalloproteinase-26) is upregulated in keratinocytes during wound repair and early skin carcinogenesis
    Katja Ahokas
    Department of Dermatology, Helsinki University Central Hospital, Biomedicum Helsinki, Helsinki, Finland
    J Invest Dermatol 124:849-56. 2005
    ..Thus, lack of MMP-26 in SCC could be a marker of aggressive growth...
  11. pmc CCHCR1 is up-regulated in skin cancer and associated with EGFR expression
    Sari Suomela
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    PLoS ONE 4:e6030. 2009
    ..We conclude that both in psoriasis and the early stages of KC transformation, CCHCR1 may function as a negative regulator of proliferation, but beyond a certain point in oncogenesis cannot control this phenomenon any longer...
  12. ncbi request reprint Matrix metalloproteinase-21, the human orthologue for XMMP, is expressed during fetal development and in cancer
    Katja Ahokas
    Department of Dermatology, University of Helsinki, and Helsinki University Central Hospital, Meilahdentie 2, FIN 00250, Helsinki, Finland
    Gene 301:31-41. 2002
    ..MMP-21 protein can also be detected in malignancies such as ovarian and colon carcinomas by immunohistochemical staining. Our findings suggest that MMP-21 functions in embryogenesis and tumor progression...
  13. ncbi request reprint Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9
    Hannes Lohi
    Department of Medical Genetics, Biomedicum Helsinki and Helsinki University Central Hospital, P O Box 63 Haartmaninkatu 8, 00014 University of Helsinki, Helsinki, Finland
    J Biol Chem 277:14246-54. 2002
    ..The functional characterization of the novel tissue-specific members may provide new insights to anion transport physiology in different parts of body...
  14. doi request reprint The PSORS1 locus gene CCHCR1 affects keratinocyte proliferation in transgenic mice
    Inkeri Tiala
    Department of Medical Genetics, University of Helsinkiand Helsinki University Central Hospital, Helsinki, Finland
    Hum Mol Genet 17:1043-51. 2008
    ..Our data show that CCHCR1 may function as a negative regulator of keratinocyte proliferation. Thus, aberrant function of CCHCR1 may lead to abnormal keratinocyte proliferation which is a key feature of psoriatic epidermis...
  15. ncbi request reprint Matrilysin-1 (MMP-7) and MMP-19 are expressed by Paget's cells in extramammary Paget's disease
    Tiina Kuivanen
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, Helsinki, Finland
    J Cutan Pathol 31:483-91. 2004
    ..Tumor growth depends on the ability of tumor cells to migrate by proteolysis and on angiogenesis. The matrix metalloproteinase (MMP) enzymes have been implicated in both of these processes in other types of skin cancer...
  16. pmc IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease
    Elisabet Einarsdottir
    Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    BMC Med Genet 10:8. 2009
    ..IL23R also associates with psoriasis, suggesting that the gene may be an important candidate for many chronic inflammatory diseases...
  17. ncbi request reprint Differential expression of stromal MMP-1, MMP-9 and TIMP-1 in basal cell carcinomas of immunosuppressed patients and controls
    Sonja Boyd
    Department of Pathology, Helsinki University Central Hospital and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Virchows Arch 452:83-90. 2008
    ..Our results suggest that abundant peritumoral expression of TIMP-1 in non-immunocompromised patients limits ECM degradation permissive for cancer cell migration...
  18. ncbi request reprint The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes
    Inkeri Tiala
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    J Mol Med (Berl) 85:589-601. 2007
    ....
  19. ncbi request reprint Clinical associations of the risk alleles of HLA-Cw6 and CCHCR1*WWCC in psoriasis
    Sari Suomela
    Department of Dermatology, Helsinki University Central Hospital, Helshinki, Finland
    Acta Derm Venereol 87:127-34. 2007
    ..Clinical profiling may be a useful approach to distinguishing genetic effects of candidate genes even within a locus in sufficiently large cohorts...
  20. ncbi request reprint Increased expression of matrix metalloproteinases-21 and -26 and TIMP-4 in pancreatic adenocarcinoma
    Ville Bister
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Mod Pathol 20:1128-40. 2007
    ..The putative role of MMP-26 as a marker of metastases warrants further studies. Unlike other TIMPs, TIMP-4 was not upregulated in relation to aggressiveness of pancreatic cancer...
  21. doi request reprint Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinoma
    Sari Suomela
    Department of Dermatology, University of Helsinki, Meilahdentie 2, 00250, Helsinki, Finland
    Virchows Arch 455:495-503. 2009
    ..Expression of MMP-21 and MMP-28 seems to associate with the tumors of lesser malignant potential. We also confirm the previous finding on the role of MMP-10 in MCC pathogenesis...
  22. doi request reprint Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus
    Tiina M Järvinen
    Department of Dermatology, Institute of Clinical Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Exp Dermatol 19:123-31. 2010
    ..0065, OR = 2.51, 95% CI = 1.25-5.04). Our results show that the TYK2, IRF5 and CTLA4 genes previously associated with SLE also confer risk for DLE and SCLE, suggesting that different LE subphenotypes may share pathogenetic pathways...
  23. ncbi request reprint Psoriasis susceptibility locus on 18p revealed by genome scan in Finnish families not associated with PSORS1
    Kati Asumalahti
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    J Invest Dermatol 121:735-40. 2003
    ..Further, the 18p locus has shown nominal evidence of linkage with psoriasis in the British population. Taken together, these findings confirm the presence of a minor susceptibility locus for psoriasis on 18p11...
  24. pmc Polymorphisms of the ITGAM gene confer higher risk of discoid cutaneous than of systemic lupus erythematosus
    Tiina M Järvinen
    Department of Dermatology, Institute of Clinical Medicine and Biomedicum Helsinki, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    PLoS ONE 5:e14212. 2010
    ..Genetic association studies have recently identified several strong susceptibility genes for SLE, including integrin alpha M (ITGAM), also known as CD11b, whereas the genetic background of DLE is less clear...
  25. doi request reprint Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes
    Leena Latonen
    Haartman Institute, University of Helsinki, Helsinki, Finland
    Photodermatol Photoimmunol Photomed 26:70-7. 2010
    ..Our aim was to investigate the effects of UV radiation on CRP1 in keratinocytes, the main cell type subjected to UV radiation in the human body...
  26. doi request reprint Expression profiles of matrix metalloproteinases and their inhibitors in colonic inflammation related to pediatric inflammatory bowel disease
    Laura Mäkitalo
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Scand J Gastroenterol 45:862-71. 2010
    ....
  27. pmc Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis
    Laura Mäkitalo
    Hospital for Children and Adolescents, Helsinki University Central Hospital, University of Helsinki, FIN 00029 Helsinki, Finland
    World J Gastroenterol 18:4028-36. 2012
    ..To investigate matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in pouch mucosa of pediatric onset ulcerative colitis (UC)...
  28. ncbi request reprint Matrix metalloproteinases 21 and 26 are differentially expressed in esophageal squamous cell cancer
    Katja Ahokas
    Department of Dermatology, Helsinki University Central Hospital, and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Tumour Biol 27:133-41. 2006
    ..MMP-21 may provide a marker for differentiating tumor areas. The putative role of MMP-26 as a marker of dysplasia and incipient invasion warrants further studies...
  29. ncbi request reprint Matrilysins-1 and -2 (MMP-7 and -26) and metalloelastase (MMP-12), unlike MMP-19, are up-regulated in necrotizing enterocolitis
    Ville Bister
    Department of Dermatology, Helsinki University Central Hospital, Helsinki, Finland
    J Pediatr Gastroenterol Nutr 40:60-6. 2005
    ..Matrix metalloproteinases (MMP) are involved in tissue remodeling and cell migration, both being important aspects of inflammatory disease. The aim of this study was to investigate whether MMPs play a role in the pathogenesis of NEC...
  30. ncbi request reprint MMP-21 is upregulated at early stages of melanoma progression but disappears with more aggressive phenotype
    Tiina Kuivanen
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, Helsinki, Finland
    Virchows Arch 447:954-60. 2005
    ..Our results suggest that expression of MMP-21 may serve as a marker of malignant transformation of melanocytes and does not associate with the presence of micrometastases...
  31. ncbi request reprint Expression of MMP-9, MMP-10 and TNF-alpha and lack of epithelial MMP-1 and MMP-26 characterize pyoderma gangrenosum
    Ville Bister
    Department of Dermatology, Helsinki University Central Hospital, and University of Helsinki, Helsinki, Finland
    J Cutan Pathol 34:889-98. 2007
    ..Matrix metalloproteinases (MMPs) have been implicated as mediators of tissue destruction in chronic cutaneous and intestinal wounds...
  32. ncbi request reprint Matrix metalloproteinase-19 is expressed by keratinocytes in psoriasis
    Sari Suomela
    Department of Dermatology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Derm Venereol 83:108-14. 2003
    ..Upregulation of MMP-19 in keratinocytes may be influenced by changes in the architecture of the basement membrane zone...
  33. doi request reprint IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors
    Terhi Savinko
    Unit of Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    J Invest Dermatol 132:1392-400. 2012
    ..These results suggest an important role for IL-33-ST2 interaction in AD and highlight the fact that bacterial and viral infections may increase the production of IL-33...
  34. ncbi request reprint Transgenic mouse models support HCR as an effector gene in the PSORS1 locus
    Outi Elomaa
    Department of Medical Genetics, University of Helsinki, Helsinki University Central Hospital, Finland
    Hum Mol Genet 13:1551-61. 2004
    ..These observations are also compatible with a model that a susceptibility gene for psoriasis induces changes that are contributory but not sufficient by itself to produce the clinical phenotype...
  35. ncbi request reprint Metalloelastase (MMP-12) expression by tumour cells in squamous cell carcinoma of the vulva correlates with invasiveness, while that by macrophages predicts better outcome
    Erja Kerkela
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, University of Helsinki, Meilahdentie 2, 00250 Helsinki, Finland
    J Pathol 198:258-69. 2002
    ..MMP-9 was usually expressed by neutrophils and macrophages; epithelial protein was predominantly found in grade II/III tumours. These results suggest a dual role for MMP-12 in tumour progression...
  36. doi request reprint Matrix metalloproteinase-26 is present more frequently in squamous cell carcinomas of immunosuppressed compared with immunocompetent patients
    Tiina Kuivanen
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum, University of Helsinki, Helsinki, Finland
    J Cutan Pathol 36:929-36. 2009
    ....
  37. ncbi request reprint Interferon alpha-inducible protein 27 (IFI27) is upregulated in psoriatic skin and certain epithelial cancers
    Sari Suomela
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, Helsinki, Finland
    J Invest Dermatol 122:717-21. 2004
    ..Our results suggest that IFI27 is a novel marker of epithelial proliferation and cancer...
  38. doi request reprint Changes in matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinases (TIMP) expression profile in Crohn's disease after immunosuppressive treatment correlate with histological score and calprotectin values
    Laura Mäkitalo
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, University of Helsinki, Meilahdentie 2, 00250, Helsinki, Finland
    Int J Colorectal Dis 24:1157-67. 2009
    ....
  39. doi request reprint Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families
    Kati Kainu
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Exp Dermatol 18:109-15. 2009
    ..The families supported association to the two gene regions, but there was also evidence of allelic heterogeneity...
  40. ncbi request reprint Downstream target genes of the neuropeptide S-NPSR1 pathway
    Johanna Vendelin
    Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Finland, and Department of Biosciences and Nutrition, Clinical Research Centre, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    Hum Mol Genet 15:2923-35. 2006
    ..Because remodeling of airway epithelium is a feature of chronic asthma, the up-regulation of MMP10 and TIMP3 by NPS-NPSR1 signaling may be of relevance in the pathogenesis of asthma...
  41. ncbi request reprint Genetic analysis of PSORS1 distinguishes guttate psoriasis and palmoplantar pustulosis
    Kati Asumalahti
    Department of Medical Genetics, University of Helsinki, Finland
    J Invest Dermatol 120:627-32. 2003
    ..Our results show conclusively that psoriasis vulgaris and guttate psoriasis have a similar genetic basis for their association to PSORS1, whereas palmoplantar pustulosis appears to be a distinct disorder...
  42. doi request reprint Matrix metalloproteinase-β19 expressed in cerebral amyloid angiopathy
    Maarit Tanskanen
    Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Amyloid 18:3-9. 2011
    ..Previous studies have revealed matrix metalloproteinase (MMP) expression in a mouse model of CAA and in human intracerebral haemorrhage. Here we studied the involvement of MMPs in human CAA and CAAH...
  43. ncbi request reprint Th1 response and cytotoxicity genes are down-regulated in cutaneous T-cell lymphoma
    Sonja Hahtola
    Department of Dermatology, Helsinki University Central Hospital, Helsinki, Finland
    Clin Cancer Res 12:4812-21. 2006
    ..To identify the molecular background and to study whether shared by the most common CTCL subtype, mycosis fungoides, we analyzed the gene expression profiles in both subtypes...
  44. ncbi request reprint Metalloelastase (MMP-12) is upregulated in the gut of pediatric patients with potential celiac disease and in type 1 diabetes
    Ville Bister
    Department of Dermatology, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Gastroenterol 40:1413-22. 2005
    ....
  45. ncbi request reprint Ectopic localization of matrix metalloproteinase-9 in chronic cutaneous wounds
    Ursula Mirastschijski
    Department of Surgery, Malmo University Hospital, University of Lund, Malmo, Sweden
    Hum Pathol 33:355-64. 2002
    ..Chronic nonhealing wounds may not be caused by excessive gelatinase activity, but are distinguished from healing wounds by an unfavorable distribution and persistance of MMP-9...
  46. ncbi request reprint Matrix metalloproteinase inhibitor BB-3103 unlike the serine proteinase inhibitor aprotinin abrogates epidermal healing of human skin wounds ex vivo
    Ursula Mirastschijski
    Department of Surgery, Malmo University Hospital, University of Lund, Malmo, Sweden
    J Invest Dermatol 118:55-64. 2002
    ..Our findings demonstrate that keratinocyte migration is associated with active matrix metalloproteinase-2 but occurs independently of serine proteinases and active matrix metalloproteinase-9 in fibrin-deficient skin wound healing...
  47. ncbi request reprint Temporal and spatial expression of matrix metalloproteinases during wound healing of human corneal tissue
    Julie T Daniels
    Epithelial Repair and Regeneration Group, Wound Healing Research Unit, Division of Pathology, Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK
    Exp Eye Res 77:653-64. 2003
    ..This study demonstrates matrix metalloproteinase expression in epithelial and fibroblast-like cells following wounding of human corneal tissue in culture where the cells remain in contact with their natural matrices...
  48. pmc Increased expression of beta6-integrin in skin leads to spontaneous development of chronic wounds
    Lari Hakkinen
    Department of Oral Biological and Medical Sciences, Laboratory of Periodontal Biology, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
    Am J Pathol 164:229-42. 2004
    ..The findings suggest that increased alphavbeta6-integrin in keratinocytes plays an active part in abnormal wound healing possibly through a mechanism involving increased activation of TGF-beta...
  49. ncbi request reprint Matrix metalloproteinase-19 expression in dermal wounds and by fibroblasts in culture
    Niina Hieta
    Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    J Invest Dermatol 121:997-1004. 2003
    ....
  50. ncbi request reprint Comparison of growth-inhibitory agents by fluorescence imaging of human skin re-epithelialization in vitro
    Sofi Forsberg
    Department of Medical Sciences, Dermatology and Venereology, Uppsala University Hospital, Sweden
    Acta Derm Venereol 86:292-9. 2006
    ..This study exemplifies the versatility of combined dynamic and morphological analysis and emphasizes the potential of epidermal growth factor receptor-directed inhibition in hyperproliferative disorders of the epidermis...
  51. ncbi request reprint MMP-21 is expressed by macrophages and fibroblasts in vivo and in culture
    Tiina Skoog
    Clinical Research Center, Novum, Karolinska University Hospital, and Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
    Exp Dermatol 15:775-83. 2006
    ..Our results suggest these two novel MMPs are not only associated with cancer but may be important in connective tissue remodelling and pathobiology of various benign skin disorders...
  52. ncbi request reprint Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar
    Johanna Laurikkala
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Development 129:2541-53. 2002
    ..In conclusion, we suggest that Eda and Edar are associated with the onset of ectodermal patterning and that ectodysplasin/edar signaling also regulates the morphogenesis of hair follicles...
  53. ncbi request reprint Collagenase-2 (MMP-8) and matrilysin-2 (MMP-26) expression in human wounds of different etiologies
    Emma Pirilä
    Institute of Dentistry, University of Oulu, Oulu, Finland
    Wound Repair Regen 15:47-57. 2007
    ..Inhibiting MMP-26 resulted in aberrant keratinocyte migration and proliferation. We conclude that MMP-8 and MMP-26 are differentially expressed in acute and chronic wounds...
  54. ncbi request reprint Expression of allograft inflammatory factor-1 in inflammatory skin disorders
    Christina Orsmark
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    Acta Derm Venereol 87:223-7. 2007
    ..We conclude that AIF-1 may mediate survival and pro-inflammatory properties of macrophages in skin diseases...
  55. ncbi request reprint Human corneal epithelial cells require MMP-1 for HGF-mediated migration on collagen I
    Julie T Daniels
    Epithelial Repair and Regeneration Group, Wound Healing Research Unit, Division of Pathology, Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 44:1048-55. 2003
    ..To investigate the potential regulation of matrix metalloproteinases (MMPs) by hepatocyte growth factor (HGF), and to identify individual MMPs essential for migration of human corneal epithelial cells...
  56. ncbi request reprint Antitumor activity and bystander effect of adenovirally delivered tissue inhibitor of metalloproteinases-3
    Matti Ahonen
    Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    Mol Ther 5:705-15. 2002
    ....