Affiliation: University of Tampere
- Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancerAnnika Rökman
Laboratory of Cancer Genetics, Institute of Medical Technology, Temepere University, and Tempere University Hospital, Tempere, Finland
Am J Hum Genet 70:1299-304. 2002..This suggests a possible modifying role in cancer predisposition. The impact that the RNASEL sequence variants have on PRCA burden at the population level seems small but deserves further study...
- Hereditary prostate cancer in Finland: fine-mapping validates 3p26 as a major predisposition locusAnnika Rökman
Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere 33014, Finland
Hum Genet 116:43-50. 2005..However, the mildly positive 3p LOD scores in a recent GWL analysis of patients from the United States suggest that the locus may also be important in other populations...
- Germ-line alterations in MSR1 gene and prostate cancer riskEija H Seppala
Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere, Finland
Clin Cancer Res 9:5252-6. 2003..Mutations in MSR1 have been reported to associate with prostate cancer (PRCA) risk. Here we report a follow-up study from Finland to evaluate the association between PRCA and MSR1 gene...
- Androgen receptor CAG polymorphism and prostate cancer riskNina Mononen
Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Lenkkeilijankatu 6, 33520 Tampere, Finland
Hum Genet 111:166-71. 2002..Our results suggest that the CAG polymorphism of the AR gene is unlikely to have a major role in the development or progression of PC in the Finnish population. The association of CAG repeats with the risk of BPH warrants further study...