Claudio Rivera

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2
    Claudio Rivera
    Department of Biosciences, University of Helsinki, Helsinki, FIN 00014 Finland
    J Neurosci 24:4683-91. 2004
  2. pmc BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion
    Claudio Rivera
    Department of Biosciences, Division of Animal Physiology, Institute of Biotechnology, University of Helsinki, Finland
    J Cell Biol 159:747-52. 2002
  3. doi request reprint Agonist occupancy is essential for forward trafficking of AMPA receptors
    Sarah K Coleman
    Department of Biological and Environmental Sciences, Division of Biochemistry, Viikki Biocenter, University of Helsinki, Helsinki, Finland
    J Neurosci 29:303-12. 2009
  4. ncbi request reprint KCC2 interacts with the dendritic cytoskeleton to promote spine development
    Hong Li
    Institute of Biotechnology, University of Helsinki, Viikinkaari 4, FIN 00014, Helsinki, Finland
    Neuron 56:1019-33. 2007
  5. doi request reprint Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription
    Anastasia Ludwig
    Institute of Biotechnology, University of Helsinki, Viikki Biocenter, Viikinkaari 9, FIN 00014, Helsinki, Finland
    J Neurosci 31:644-9. 2011
  6. doi request reprint Cation-chloride cotransporters and neuronal function
    Peter Blaesse
    Department of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1, FIN 00014, Helsinki, Finland
    Neuron 61:820-38. 2009
  7. ncbi request reprint Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices
    Stanislav Khirug
    Department of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland
    Eur J Neurosci 21:899-904. 2005
  8. ncbi request reprint A novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation
    Judith Thomas-Crusells
    Program for Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, Viikki Biocenter, FIN 00014, Helsinki, Finland
    J Neurosci Methods 125:159-66. 2003
  9. ncbi request reprint Slow endogenous activity transients and developmental expression of K+-Cl- cotransporter 2 in the immature human cortex
    Sampsa Vanhatalo
    Department of Biological and Environmental Sciences, P O Box 65, 00014 University of Helsinki, Finland
    Eur J Neurosci 22:2799-804. 2005
  10. pmc Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis
    Pirta Hotulainen
    Institute of Biotechnology, University of Helsinki, Helsinki FI 00014, Finland
    J Cell Biol 185:323-39. 2009

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2
    Claudio Rivera
    Department of Biosciences, University of Helsinki, Helsinki, FIN 00014 Finland
    J Neurosci 24:4683-91. 2004
    ..A downregulation of KCC2 may be a general early response involved in various kinds of neuronal trauma...
  2. pmc BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion
    Claudio Rivera
    Department of Biosciences, Division of Animal Physiology, Institute of Biotechnology, University of Helsinki, Finland
    J Cell Biol 159:747-52. 2002
    ....
  3. doi request reprint Agonist occupancy is essential for forward trafficking of AMPA receptors
    Sarah K Coleman
    Department of Biological and Environmental Sciences, Division of Biochemistry, Viikki Biocenter, University of Helsinki, Helsinki, Finland
    J Neurosci 29:303-12. 2009
    ..Our results are consistent with the hypothesis that AMPA receptors are synthesized as intrinsically unstable molecules, which require glutamate binding for structural stability and for transport-competence...
  4. ncbi request reprint KCC2 interacts with the dendritic cytoskeleton to promote spine development
    Hong Li
    Institute of Biotechnology, University of Helsinki, Viikinkaari 4, FIN 00014, Helsinki, Finland
    Neuron 56:1019-33. 2007
    ..1N may play an important role. A more general conclusion based on our data is that KCC2 acts as a synchronizing factor in the functional development of glutamatergic and GABAergic synapses in cortical neurons and networks...
  5. doi request reprint Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription
    Anastasia Ludwig
    Institute of Biotechnology, University of Helsinki, Viikki Biocenter, Viikinkaari 9, FIN 00014, Helsinki, Finland
    J Neurosci 31:644-9. 2011
    ..These results indicate that Egr4 is an important component in the mechanism of BDNF-dependent KCC2 gene regulation via the ERK1/2 pathway in immature neurons...
  6. doi request reprint Cation-chloride cotransporters and neuronal function
    Peter Blaesse
    Department of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1, FIN 00014, Helsinki, Finland
    Neuron 61:820-38. 2009
    ..The rapidly expanding work on CCCs promotes our understanding of fundamental mechanisms that control brain development and functions under normal and pathophysiological conditions...
  7. ncbi request reprint Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices
    Stanislav Khirug
    Department of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland
    Eur J Neurosci 21:899-904. 2005
    ....
  8. ncbi request reprint A novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation
    Judith Thomas-Crusells
    Program for Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, Viikki Biocenter, FIN 00014, Helsinki, Finland
    J Neurosci Methods 125:159-66. 2003
    ....
  9. ncbi request reprint Slow endogenous activity transients and developmental expression of K+-Cl- cotransporter 2 in the immature human cortex
    Sampsa Vanhatalo
    Department of Biological and Environmental Sciences, P O Box 65, 00014 University of Helsinki, Finland
    Eur J Neurosci 22:2799-804. 2005
    ..Our work indicates that slow endogenous activity transients in the immature human neocortex are mostly confined to the prenatal stage and appear to be terminated in parallel with the maturation of functional GABAergic inhibition...
  10. pmc Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis
    Pirta Hotulainen
    Institute of Biotechnology, University of Helsinki, Helsinki FI 00014, Finland
    J Cell Biol 185:323-39. 2009
    ..Finally, we show that perturbation of these key steps in actin dynamics results in altered synaptic transmission...
  11. pmc Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain
    Pavel Uvarov
    Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, Finland
    J Biol Chem 284:13696-704. 2009
    ..Consistent with this, native gel analysis shows that a substantial part of endogenous KCC2 isoforms in the neonatal brain constitute dimers...
  12. ncbi request reprint A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2
    Pavel Uvarov
    Neuroscience Center, Viikinkaari 4, University of Helsinki, Finland
    J Biol Chem 282:30570-6. 2007
    ....
  13. pmc Microtechnologies to fuel neurobiological research with nanometer precision
    Cecilia A Brunello
    Neuroscience Center, University of Helsinki, P O Box 56, Viikinkaari 4, FI 00014, Helsinki, Finland
    J Nanobiotechnology 11:11. 2013
    ..Here we review some of the compartmentalization techniques developed so far to highlight how high-precision control of neuronal connectivity allows new approaches for studying axonal and synaptic biology...
  14. ncbi request reprint Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4
    Pavel Uvarov
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 26:13463-73. 2006
    ..Together, the results indicate an important role for Egr4 in the developmental upregulation of KCC2 gene expression...
  15. ncbi request reprint Patterns of cation-chloride cotransporter expression during embryonic rodent CNS development
    Hong Li
    Institute of Biotechnology, PO Box 56, Viikinkaari 9C, FIN 00014 University of Helsinki, Finland
    Eur J Neurosci 16:2358-70. 2002
    ..These unique spatiotemporal expression patterns of distinct CCCs during embryonic development suggests that Cl- regulatory mechanisms are critically involved in the control of neuronal development...
  16. ncbi request reprint Cation-chloride co-transporters in neuronal communication, development and trauma
    John A Payne
    Department of Human Physiology, School of Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Trends Neurosci 26:199-206. 2003
    ....
  17. ncbi request reprint Developmental up-regulation of KCC2 in the absence of GABAergic and glutamatergic transmission
    Anastasia Ludwig
    Institute of Biotechnology, FIN 00014, University of Helsinki, Finland
    Eur J Neurosci 18:3199-206. 2003
    ..These data show that neither neuronal spiking nor ionotropic glutamatergic and GABAergic transmission are required for the developmental expression of KCC2 in mouse hippocampal neurons in vitro...
  18. ncbi request reprint Carbonic anhydrase isoform VII acts as a molecular switch in the development of synchronous gamma-frequency firing of hippocampal CA1 pyramidal cells
    Eva Ruusuvuori
    Department of Biosciences and Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN 00014 Helsinki, Finland
    J Neurosci 24:2699-707. 2004
    ..These results point to a crucial role for the developmental expression of intrapyramidal carbonic anhydrase VII activity in shaping integrative functions, long-term plasticity and susceptibility to epileptogenesis...
  19. pmc Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII
    Claudio Rivera
    Institute of Biotechnology, University of Helsinki, FIN 00014 Helsinki, Finland
    J Physiol 562:27-36. 2005
    ....
  20. doi request reprint Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons
    Anastasia Shulga
    Institute of Biotechnology, Department of Biological and Environmental Sciences, and Neuroscience Center, University of Helsinki, FIN 00014 Helsinki, Finland
    J Neurosci 28:6996-7005. 2008
    ..This is likely mediated through BDNF itself, because injured neurons reverse their response to this neurotrophin by switching the BDNF-induced downregulation of KCC2 to upregulation...
  21. ncbi request reprint Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy
    Gilles Huberfeld
    INSERM U739, Faculté de Médecine Pitié Salpêtrière, Universite Pierre et Marie Curie Paris 6, IFR70, CHU Pitie Salpetriere, 75013 Paris, France
    J Neurosci 27:9866-73. 2007
    ..Changes in Cl- transporter expression thus contribute to human epileptiform activity, and molecules acting on these transporters may be useful antiepileptic drugs...
  22. ncbi request reprint Interaction between SAP97 and PSD-95, two Maguk proteins involved in synaptic trafficking of AMPA receptors
    Chunlin Cai
    Department of Biological and Environmental Sciences, University of Helsinki, Finland
    J Biol Chem 281:4267-73. 2006
    ..Our results demonstrated a direct interaction between SAP97 and PSD-95 and suggested that this association may play a functional role in the trafficking and clustering of AMPA receptors...
  23. pmc Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis
    Sebastian Schuchmann
    Department of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1 POB 65, 00014 Helsinki, Finland
    Nat Med 12:817-23. 2006
    ..Our work indicates a mechanism for triggering hyperthermic seizures and suggests new strategies in the research and therapy of fever-related epileptic syndromes...