Juha O Rinne

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint Loss of cholinergic neurons in the pedunculopontine nucleus in Parkinson's disease is related to disability of the patients
    Juha O Rinne
    Department of Neurology, University of Turku and Turku University Hospital, FIN 20520 Turku, Finland Turku, Finland
    Parkinsonism Relat Disord 14:553-7. 2008
  2. doi request reprint 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study
    Juha O Rinne
    Turku PET Centre and Clinical Research Services Turku, University of Turku and Turku University Hospital, Turku, Finland
    Lancet Neurol 9:363-72. 2010
  3. ncbi request reprint Positron emission tomography in at risk patients and in the progression of mild cognitive impairment to Alzheimer's disease
    Juha O Rinne
    Turku PET Centre, Turku, Finland
    J Alzheimers Dis 19:291-300. 2010
  4. doi request reprint Cognitive decline and amyloid accumulation in patients with mild cognitive impairment
    Jaana Koivunen
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Dement Geriatr Cogn Disord 34:31-7. 2012
  5. doi request reprint The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects
    Sargo Aalto
    Turku PET Centre, University of Turku, 20014 Turku, Finland
    Eur J Nucl Med Mol Imaging 36:475-83. 2009
  6. ncbi request reprint Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease
    Nina M Kemppainen
    Turku Positron Emission Tomography Centre, University of Turku, Turku, Finland
    Ann Neurol 63:112-8. 2008
  7. doi request reprint [(11)C]PIB-, [(18)F]FDG-PET and MRI imaging in patients with Parkinson's disease with and without dementia
    Pekka Jokinen
    Turku PET Centre, Turku University Hospital, 20520 Turku, Finland
    Parkinsonism Relat Disord 16:666-70. 2010
  8. ncbi request reprint Regional cerebral glucose metabolism in monozygotic twins discordant for Alzheimer's disease
    Tarja Järvenpää
    Turku PET Centre, University of Turku, Turku, Finland
    Dement Geriatr Cogn Disord 16:245-52. 2003
  9. doi request reprint Midlife cardiovascular risk factors and late cognitive impairment
    Jyri J Virta
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Eur J Epidemiol 28:405-16. 2013
  10. ncbi request reprint Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: a positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457
    Sargo Aalto
    Turku PET Centre, University of Turku, FIN 20014 Turku, Finland
    J Neurosci 25:2471-7. 2005

Detail Information

Publications75

  1. ncbi request reprint Loss of cholinergic neurons in the pedunculopontine nucleus in Parkinson's disease is related to disability of the patients
    Juha O Rinne
    Department of Neurology, University of Turku and Turku University Hospital, FIN 20520 Turku, Finland Turku, Finland
    Parkinsonism Relat Disord 14:553-7. 2008
    ..66, p=0.03). The neuron number decreased much more than could be expected on the basis of decrease in cell size alone...
  2. doi request reprint 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study
    Juha O Rinne
    Turku PET Centre and Clinical Research Services Turku, University of Turku and Turku University Hospital, Turku, Finland
    Lancet Neurol 9:363-72. 2010
    ..We used (11)C-PiB PET to investigate whether bapineuzumab, a humanised anti-amyloid-beta monoclonal antibody, would reduce cortical fibrillar amyloid-beta load in patients with Alzheimer's disease...
  3. ncbi request reprint Positron emission tomography in at risk patients and in the progression of mild cognitive impairment to Alzheimer's disease
    Juha O Rinne
    Turku PET Centre, Turku, Finland
    J Alzheimers Dis 19:291-300. 2010
    ..In the future, multi-tracer imaging or development of agents enabling imaging of other protein aggregations in neurodegenerative diseases could further help in the early and differential diagnostics and evaluation of novel treatments...
  4. doi request reprint Cognitive decline and amyloid accumulation in patients with mild cognitive impairment
    Jaana Koivunen
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Dement Geriatr Cogn Disord 34:31-7. 2012
    ....
  5. doi request reprint The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects
    Sargo Aalto
    Turku PET Centre, University of Turku, 20014 Turku, Finland
    Eur J Nucl Med Mol Imaging 36:475-83. 2009
    ..The dopamine D(2)/D(3) receptor ligand [(11)C]FLB 457 and PET enable quantification of low-density extrastriatal D(2)/D(3) receptors, but it is uncertain whether [(11)C]FLB 457 can be used for measuring extrastriatal dopamine release...
  6. ncbi request reprint Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease
    Nina M Kemppainen
    Turku Positron Emission Tomography Centre, University of Turku, Turku, Finland
    Ann Neurol 63:112-8. 2008
    ..Our aim was to find possible differences in brain amyloid ligand 11C-labeled Pittsburgh Compound B ([11C]PIB) uptake and glucose metabolism in high- and low-educated patients with mild AD...
  7. doi request reprint [(11)C]PIB-, [(18)F]FDG-PET and MRI imaging in patients with Parkinson's disease with and without dementia
    Pekka Jokinen
    Turku PET Centre, Turku University Hospital, 20520 Turku, Finland
    Parkinsonism Relat Disord 16:666-70. 2010
    ....
  8. ncbi request reprint Regional cerebral glucose metabolism in monozygotic twins discordant for Alzheimer's disease
    Tarja Järvenpää
    Turku PET Centre, University of Turku, Turku, Finland
    Dement Geriatr Cogn Disord 16:245-52. 2003
    ..Their non-demented co-twins showed milder reductions, which may be an indication of genetic susceptibility for dementia, and an early sign of a dementing illness in them...
  9. doi request reprint Midlife cardiovascular risk factors and late cognitive impairment
    Jyri J Virta
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Eur J Epidemiol 28:405-16. 2013
    ..Also, a risk score including easily measurable midlife factors predicts an individual's cognitive impairment risk well...
  10. ncbi request reprint Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: a positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457
    Sargo Aalto
    Turku PET Centre, University of Turku, FIN 20014 Turku, Finland
    J Neurosci 25:2471-7. 2005
    ..Our results indicate that regionally specific components of the frontotemporal dopaminergic network are functionally involved in WM performance in humans...
  11. doi request reprint Cognitive slowing in Parkinson's disease is related to frontostriatal dopaminergic dysfunction
    Pekka Jokinen
    Turku PET Centre, Turku University Hospital, Turku, Finland
    J Neurol Sci 329:23-8. 2013
    ..Frontostriatal and cognitive dysfunctions in Parkinson's disease (PD) are hypothesized to be linked predominately to dopaminergic dysfunction within neural networks linking dorsal striatum to dorsolateral prefrontal cortex...
  12. ncbi request reprint Striatal subregional 6-[18F]fluoro-L-dopa uptake in early Parkinson's disease: a two-year follow-up study
    Anna Brück
    Turku PET Center, University of Turku, Turku, Finland
    Mov Disord 21:958-63. 2006
    ..In contrast to the striatal decline, the increased cortical F-dopa uptake prevails at least during the first years of PD...
  13. doi request reprint Effects of intravenous placebo with glucose expectation on human basal ganglia dopaminergic function
    Lauri T Haltia
    Department of Neurology, University of Turku, Turku, Finland
    Synapse 62:682-8. 2008
    ..g., amphetamine and glucose). Also, they suggest that the DA release in the ventral striatum mediates placebo responses in the context of glucose expectation...
  14. ncbi request reprint Posterior cortical atrophy: a rare form of dementia with in vivo evidence of amyloid-beta accumulation
    Olli Tenovuo
    Department of Neurology, University of Turku, Turku, Finland
    J Alzheimers Dis 15:351-5. 2008
    ..Here we describe a patient who had a typical clinical course for this syndrome and who showed a positive accumulation of amyloid-beta in posterior areas studied with positron emission tomography...
  15. pmc Midlife sleep characteristics associated with late life cognitive function
    Jyri J Virta
    Hjelt Institute, Department of Public Health, University of Helsinki, Finland Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Sleep 36:1533-41, 1541A. 2013
    ..We investigated the association between midlife sleep characteristics and late life cognitive function...
  16. ncbi request reprint Effects of intravenous glucose on dopaminergic function in the human brain in vivo
    Lauri T Haltia
    Department of Neurology, University of Turku, Turku, Finland
    Synapse 61:748-56. 2007
    ....
  17. ncbi request reprint Mobile phone affects cerebral blood flow in humans
    Sargo Aalto
    Turku PET Centre, University of Turku, Turku, Finland
    J Cereb Blood Flow Metab 26:885-90. 2006
    ..Our results provide the first evidence, suggesting that the EMF emitted by a commercial mobile phone affects rCBF in humans. These results are consistent with the postulation that EMF induces changes in neuronal activity...
  18. doi request reprint Seasonality of striatal dopamine synthesis capacity in Parkinson's disease
    Valtteri Kaasinen
    Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland
    Neurosci Lett 530:80-4. 2012
    ..Findings concerning season of birth further suggest that there may be gestational or perinatal seasonal factors, which influence dopaminergic function in adulthood...
  19. ncbi request reprint Cerebral glucose metabolism in dizygotic twin pairs discordant for Alzheimer's disease
    Jyri J Virta
    Turku PET Centre, University of Turku, Turku, Finland
    Dement Geriatr Cogn Disord 25:9-16. 2008
    ..The non-demented twins showed no such reductions on any cortical region compared to unrelated control subjects. This implies that both genes and environment, and not genes alone, are causative in the pathogenesis of AD...
  20. doi request reprint Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation
    Jussi Hirvonen
    Turku PET Centre, University of Turku and Turku University Hospital, P O Box 52, 20521, Turku, Finland
    Eur J Nucl Med Mol Imaging 37:606-12. 2010
    ..Despite its widespread use, the radiation burden associated with (11)C-(R)-PK11195 in humans is not known. To examine this, we performed dynamic whole-body imaging with PET and (11)C-(R)-PK11195 in healthy humans...
  21. doi request reprint Reproducibility of automated simplified voxel-based analysis of PET amyloid ligand [11C]PIB uptake using 30-min scanning data
    Sargo Aalto
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Eur J Nucl Med Mol Imaging 36:1651-60. 2009
    ..The purpose of this study was to evaluate both region- and voxel-level reproducibility of automated and simplified [11C]PIB quantitation when using only 30 min of imaging data...
  22. ncbi request reprint Dopaminergic effects of caffeine in the human striatum and thalamus
    Valtteri Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521, Turku, Finland
    Neuroreport 15:281-5. 2004
    ..81, p = 0.03). The findings indicate that caffeine has effects on dopaminergic neurotransmission in the human brain, which may be differential in the striatum and the thalamus...
  23. doi request reprint Pharmacokinetics of [¹⁸F]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer's disease
    Anniina Snellman
    MediCity PET Preclinical Laboratory, Turku PET Centre, University of Turku, Tykistokatu 6A, FI 20520 Turku, Finland
    Eur J Nucl Med Mol Imaging 39:1784-95. 2012
    ..In addition, binding of [(18)F]flutemetamol to Aβ deposits was studied in the Tg2576 transgenic mouse model of Alzheimer's disease...
  24. doi request reprint No effects of short-term GSM mobile phone radiation on cerebral blood flow measured using positron emission tomography
    Myoung Soo Kwon
    Department of Psychology, Centre for Cognitive Neuroscience, University of Turku, Finland
    Bioelectromagnetics 33:247-56. 2012
    ..The exposure induced a slight temperature rise in the ear canals but did not affect brain hemodynamics and task performance. The results provided no evidence for acute effects of short-term mobile phone radiation on cerebral blood flow...
  25. doi request reprint COMT Val158Met genotype does not alter cortical or striatal dopamine D2 receptor availability in vivo
    Mika M Hirvonen
    Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland
    Mol Imaging Biol 12:192-7. 2010
    ..We studied whether the functional COMT gene polymorphism (Val158Met) associates with altered dopamine D2 receptor binding characteristics in vivo hypothesizing an effect in the cortex but not in the striatum...
  26. pmc Reproducibility of striatal and thalamic dopamine D2 receptor binding using [11C]raclopride with high-resolution positron emission tomography
    Kati Alakurtti
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    J Cereb Blood Flow Metab 31:155-65. 2011
    ..However, the ICC values were only moderate, in the range of 0.34 to 0.66, for all regions except the putamen (0.87). Experimental signal processing methods improved neither ICC nor VAR values significantly...
  27. ncbi request reprint Rostrocaudal gradients of dopamine D2/3 receptor binding in striatal subregions measured with [(11)C]raclopride and high-resolution positron emission tomography
    Kati Alakurtti
    Turku PET Centre, University of Turku and Turku University Hospital, PO Box 52, FIN 20521 Turku, Finland
    Neuroimage 82:252-9. 2013
    ..Furthermore, the average distribution of D2/3 receptor binding revealed in this study could serve as a basis for a database that includes distributions of various DA markers as a function of healthy aging...
  28. pmc Adenosine A2A receptors in secondary progressive multiple sclerosis: a [(11)C]TMSX brain PET study
    Eero Rissanen
    Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland
    J Cereb Blood Flow Metab 33:1394-401. 2013
    ..This study shows, that A2ARs are increased in the brain of SPMS patients, and that [(11)C]TMSX-PET provides a novel approach to learn about central nervous system pathology in SPMS in vivo...
  29. doi request reprint Mesolimbic dopamine release is linked to symptom severity in pathological gambling
    Juho Joutsa
    Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland
    Neuroimage 60:1992-9. 2012
    ..Human reward-seeking gambling behavior, and especially pathological gambling, has been presumed to be modulated by brain dopamine...
  30. doi request reprint A follow-up study on 6-[18F]fluoro-L-dopa uptake in early Parkinson's disease shows nonlinear progression in the putamen
    Anna Brück
    Turku PET Centre, University of Turku, Turku, Finland
    Mov Disord 24:1009-15. 2009
    ..3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofuncion in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease...
  31. pmc GSM mobile phone radiation suppresses brain glucose metabolism
    Myoung Soo Kwon
    Department of Psychology, Centre for Cognitive Neuroscience, University of Turku, Turku, Finland
    J Cereb Blood Flow Metab 31:2293-301. 2011
    ..The exposure did not affect task performance (reaction time, error rate). Our results show that short-term mobile phone exposure can locally suppress brain energy metabolism in humans...
  32. ncbi request reprint Insular dopamine D2 receptors and novelty seeking personality in Parkinson's disease
    Valtteri Kaasinen
    Department of Neurology, University of Turku, Finland
    Mov Disord 19:1348-51. 2004
    ..The results provide further support for a relationship between novelty seeking and insular D2 receptors. They indicate that the association is cross-cultural, independent of age, and unaffected by dopaminergic degeneration...
  33. doi request reprint Longitudinal amyloid imaging in mouse brain with 11C-PIB: comparison of APP23, Tg2576, and APPswe-PS1dE9 mouse models of Alzheimer disease
    Anniina Snellman
    MediCity PET Preclinical Laboratory, University of Turku, Turku PET Centre, Turku, Finland
    J Nucl Med 54:1434-41. 2013
    ....
  34. ncbi request reprint Carbon monoxide poisoning-induced nigrostriatal dopaminergic dysfunction detected using positron emission tomography (PET)
    Eero Rissanen
    Department of Neurology, Turku University Hospital, Turku, Finland
    Neurotoxicology 31:403-7. 2010
    ..Our results emphasize that CO intoxication can lead to striatal dopaminergic hypofunction, and that PET is a sensitive tool in evaluating extrapyramidal system after sudden neurotoxic insult...
  35. ncbi request reprint Acute hormonal changes following intravenous glucose challenge in lean and obese human subjects
    Lauri T Haltia
    Department of Neurology, University of Turku, Finland
    Scand J Clin Lab Invest 70:275-80. 2010
    ..v. glucose bolus on insulin, leptin, ghrelin, peptide YY (PYY), free fatty acids (FFA), glucagon and glucagon-like peptide-1 (GLP-1) concentrations together with self-reported satiety ratings in lean and obese human subjects...
  36. ncbi request reprint 19F/18F exchange synthesis for a novel [18F]S1P3-radiopharmaceutical
    Johanna Rokka
    Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Porthaninkatu 3, FI 20500, Turku, Finland
    J Labelled Comp Radiopharm 56:385-91. 2013
    ..This afforded a radiochemical yield of ~10% with an SA of 0.3 GBq/µmol. Results from this study are of interest for new tracer development where high initial (18)F-activity and (19)F/(18)F isotope exchange is used...
  37. doi request reprint Cerebral acetylcholinesterase activity is not decreased in MS patients with cognitive impairment
    Jere R Virta
    Turku PET Centre, University of Turku, Finland
    Mult Scler 17:931-8. 2011
    ..The findings on the efficacy of AChEI medication in MS associated cognitive symptoms are preliminary and no studies concerning cerebral acetylcholinesterase (AChE) activity in these patients have been published...
  38. doi request reprint Cerebral oxygen and glucose metabolism in patients with mitochondrial m.3243A>G mutation
    Markus M Lindroos
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Brain 132:3274-84. 2009
    ..Our results show that the m.3243A>G mutation leads to a global decrease in oxygen consumption in the grey matter including areas where no other signs of disease were present...
  39. doi request reprint Whole-body distribution and metabolism of [N-methyl-11C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide in humans; an imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography
    Anne Roivainen
    Turku PET Centre, Turku University Hospital, Turku, Finland
    Eur J Nucl Med Mol Imaging 36:671-82. 2009
    ..We sought to clarify the metabolic fate of (11)C-PK11195 in a test-retest setting using radio-HPLC in comparison with radio-TLC, and the whole-body distribution in humans...
  40. doi request reprint Simple ratio analysis of 18F-fluorodopa uptake in striatal subregions separates patients with early Parkinson disease from healthy controls
    Pekka Jokinen
    Turku PET Centre, Turku University Hospital, University of Turku, Turku, Finland
    J Nucl Med 50:893-9. 2009
    ....
  41. ncbi request reprint Expectation of caffeine induces dopaminergic responses in humans
    Valtteri Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521, Turku, Finland
    Eur J Neurosci 19:2352-6. 2004
    ..The results therefore suggest that caffeine and placebo caffeine may share some dopaminergic mechanisms of action...
  42. ncbi request reprint Brain ¹⁸F-FDG and ¹¹C-PiB PET findings in two siblings with FTD/ALS associated with the C9ORF72 repeat expansion
    Mika H Martikainen
    a Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland
    Neurocase 20:150-7. 2014
    ..His sister was diagnosed with FTD, and the C9ORF72 expansion was detected in both siblings. We conclude that ¹¹C-PiB PET imaging may help the early differential diagnosis between AD and FTD, including C9FTD/ALS...
  43. ncbi request reprint Synthesis and evaluation of a (18)F-curcumin derivate for β-amyloid plaque imaging
    Johanna Rokka
    Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Porthaninkatu 3, FI 20500 Turku, Finland
    Bioorg Med Chem 22:2753-62. 2014
    ..We aimed to synthesize an (18)F-labeled curcumin derivate ([(18)F]4) and to characterize its positron emission tomography (PET) tracer-binding properties to β-amyloid plaques in a transgenic APP23 mouse model of AD...
  44. ncbi request reprint Cortical ¹¹C-PIB uptake is associated with age, APOE genotype, and gender in "healthy aging"
    Noora M Scheinin
    Turku PET Centre, University of Turku and Turku University Hospital, Finland
    J Alzheimers Dis 41:193-202. 2014
    ..Our aim was to elucidate factors that contribute to amyloid-β (Aβ) accumulation in the brains of the seemingly healthy elderly population, and whether there is interplay between those factors...
  45. ncbi request reprint A 90-year-old monozygotic female twin pair discordant for Alzheimer's disease
    Tarja Järvenpää
    Turku PET Centre, University of Turku, P O Box 52, FIN 20521, Turku, Finland
    Neurobiol Aging 24:941-5. 2003
    ..Our results further address the influence of environmental factors on the onset of AD, especially the possible protective effect of anti-inflammatory medication...
  46. doi request reprint Midlife alcohol consumption and later risk of cognitive impairment: a twin follow-up study
    Jyri J Virtaa
    Turku PET Centre, University of Turku, Turku, Finland
    J Alzheimers Dis 22:939-48. 2010
    ..In addition, binge drinking was found to be an independent risk factor for cognitive impairment...
  47. ncbi request reprint Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders
    Juho Joutsa
    Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland
    Mov Disord 27:778-82. 2012
    ..Impulse control disorders (ICDs) occur frequently in PD patients...
  48. doi request reprint Central executive function in mild cognitive impairment: a PET activation study
    Matti Laine
    Department of Psychology, Abo Akademi University, Turku, Finland
    Scand J Psychol 50:33-40. 2009
    ..During dual task performance, the patients showed attenuated activity in the left inferior frontal region when compared to the controls. This suggests abnormalities in the neural processes underlying attentional control in aMCI...
  49. ncbi request reprint Reduced striatal dopamine synthesis capacity is associated with symptoms of depression in patients with de novo unmedicated Parkinson's disease
    Juho Joutsa
    Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland
    J Parkinsons Dis 3:325-9. 2013
    ....
  50. ncbi request reprint Progression of dopaminergic hypofunction in striatal subregions in Parkinson's disease using [18F]CFT PET
    Elina Nurmi
    Department of Neurology, University of Turku, FIN 20521, Turku, Finland
    Synapse 48:109-15. 2003
    ..Synapse 48:109-115, 2003...
  51. doi request reprint 1-11C-methyl-4-piperidinyl-N-butyrate radiation dosimetry in humans by dynamic organ-specific evaluation
    Jere R Virta
    Turku University Hospital, Turku PET Centre, Turku, Finland
    J Nucl Med 49:347-53. 2008
    ..Two different data acquisition protocols-dynamic organ-specific evaluation (DOSE) and whole-body scanning-were compared. Both methods are widely used for evaluation of radiation burden of (11)C-labeled PET tracers...
  52. pmc Striatal volume is related to phonemic verbal fluency but not to semantic or alternating verbal fluency in early Parkinson's disease
    Ulla Ellfolk
    Department of Psychology and Logopedics, Abo Akademi University, 20500, Turku, Finland
    J Neural Transm 121:33-40. 2014
    ....
  53. ncbi request reprint Visual assessment of [(11)C]PIB PET in patients with cognitive impairment
    Timo Suotunen
    Turku PET Centre, P O Box 52, 20521, Turku, Finland
    Eur J Nucl Med Mol Imaging 37:1141-7. 2010
    ....
  54. ncbi request reprint Positron emission tomography examination of cerebral blood flow and glucose metabolism in young CADASIL patients
    Susanna Tuominen
    Department of Neurology, Turku University Hospital and University of Turku, Turku, Finland
    Stroke 35:1063-7. 2004
    ..The purpose of this study was to assess whether cerebral blood flow (CBF) and regional cerebral metabolic rates of glucose (rCMR(gluc)) in CADASIL patients are affected in early adulthood...
  55. doi request reprint C957T polymorphism of dopamine D2 receptor gene affects striatal DRD2 in vivo availability by changing the receptor affinity
    Mika M Hirvonen
    Department of Pharmacology, Drug Development and Therapeutics, University of Turku, 20014 Turku, Finland
    Synapse 63:907-12. 2009
    ..The hypothesis that the two SNPs may have independent effects on dopamine neurotransmission needs to be further tested...
  56. ncbi request reprint Cortical 6-[18F]fluoro-L-dopa uptake and frontal cognitive functions in early Parkinson's disease
    Anna Brück
    Turku PET Center, University of Turku, POB 52, FIN 20521 Turku, Finland
    Neurobiol Aging 26:891-8. 2005
    ..The results show that cortical Fdopa uptake is increased in early non-medicated PD and suggest that the changes in frontal Fdopa uptake are related to cognitive impairments found in early PD...
  57. doi request reprint Brain volumetric correlates of memory in early Parkinson's disease
    Ulla Ellfolk
    Department of Psychology and Logopedics, Abo Akademi University, Turku, Finland Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland
    J Parkinsons Dis 3:593-601. 2013
    ..Their association with brain structural changes has not been established. Objective: We studied local gray matter volumes in relation to different memory tasks in early stage PD...
  58. ncbi request reprint Effects of a 902 MHz mobile phone on cerebral blood flow in humans: a PET study
    Christian Haarala
    Centre for Cognitive Neuroscience, University of Turku, Turku, Finland
    Neuroreport 14:2019-23. 2003
    ..Therefore, it is not reasoned to attribute this finding to the EMF emitted by the phone. Further study on human rCBF during exposure to EMF of a mobile phone is needed...
  59. ncbi request reprint Binge drinking in midlife and dementia risk
    Tarja Järvenpää
    Turku PET Centre and Department of Neurology, University of Turku, Turku, Finland
    Epidemiology 16:766-71. 2005
    ..Our goal was to determine whether a long follow-up period combined with information about drinking patterns, in addition to total alcohol consumption, would provide new insights about the relationship of alcohol use with dementia risk...
  60. doi request reprint [(18)F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid β detection in living subjects with normal pressure hydrocephalus: pooled analysis of four studies
    Juha O Rinne
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Acta Neuropathol 124:833-45. 2012
    ....
  61. doi request reprint Impaired cognitive performance in Parkinson's disease is related to caudate dopaminergic hypofunction and hippocampal atrophy
    Pekka Jokinen
    Turku University Hospital, University of Turku, FIN 20521 Turku, Finland
    Parkinsonism Relat Disord 15:88-93. 2009
    ....
  62. ncbi request reprint Personality traits and striatal 6-[18F]fluoro-L-dopa uptake in healthy elderly subjects
    Valtteri Kaasinen
    Department of Neurology, University of Turku, P O Box 52, FIN 20521 Turku, Finland
    Neurosci Lett 332:61-4. 2002
    ..The results indicate that the previous positive findings concerning harm avoidance and (18)F-dopa uptake in Parkinson's disease are disease-related, and that they can not be generalized to healthy individuals...
  63. ncbi request reprint Age-related loss of extrastriatal dopamine D(2) -like receptors in women
    Valtteri Kaasinen
    Department of Neurology, University of Turku, Turku, Finland
    J Neurochem 81:1005-10. 2002
    ..The results may prove to be important in studies where the biochemical basis of clinical sex differences is examined in patients with dopamine-related neuropsychiatric disorders...
  64. ncbi request reprint Functional imaging studies of dopamine system and cognition in normal aging and Parkinson's disease
    Valtteri Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521, Turku, Finland
    Neurosci Biobehav Rev 26:785-93. 2002
    ..In particular, the focus is on describing and discussing the relationships between aging, cognition and the dopaminergic system in healthy subjects and in patients with Parkinson's disease...
  65. ncbi request reprint Striatal dopamine D1 and D2 receptors in burning mouth syndrome
    Nora Hagelberg
    Department of Anesthesiology and Intensive Care, Turku University Central Hospital, PO Box 52, FIN 20521, Turku, Finland
    Pain 101:149-54. 2003
    ..65+/-0.05 vs. 0.70+/-0.05, P=0.05) when compared to controls. Increased 11C-raclopride uptake and the subsequent decrease in the D1/D2 ratio may indicate a decline in endogenous dopamine levels in the putamen in burning mouth patients...
  66. ncbi request reprint Catechol-O-methyl transferase (COMT) inhibitors in patients with Parkinson's disease: is COMT genotype a useful indicator of clinical efficacy?
    Juha O Rinne
    Turku PET Center, University of Turku, Turku, Finland
    Am J Pharmacogenomics 3:11-5. 2003
    ..These data suggest that the COMT genotype is not a major factor in deciding the clinical efficacy of COMT inhibitors...
  67. ncbi request reprint Endogenous dopamine release in Parkinson's disease
    Juha O Rinne
    Turku PET Centre, University of Turku, FIN 20520, Turku, Finland
    Lancet Neurol 2:460-1. 2003
  68. ncbi request reprint Biodistribution and radiation dosimetry of the amyloid imaging agent 11C-PIB in humans
    Noora M Scheinin
    Turku PET Centre, University of Turku, Turku, Finland
    J Nucl Med 48:128-33. 2007
    ..Previous radiation exposure estimates have been based on animal experiments. A dosimetry study in humans is essential for a balanced risk-benefit assessment of (11)C-PIB PET studies...
  69. ncbi request reprint Naming multiple objects: neural correlates as measured by positron emission tomography
    Kati Renvall
    Department of Psychology, University of Turku, Finland
    Appl Neuropsychol 10:224-33. 2003
    ..These findings thus provide independent evidence for the claim that CP is a valid paradigm for the study of word production proper...
  70. ncbi request reprint Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease
    Valtteri Kaasinen
    Department of Neurology, University of Turku, Turku, Finland
    J Clin Psychopharmacol 22:615-20. 2002
    ..We hypothesize that the clinical improvement in behavioral and attentional symptoms of AD due to AChE inhibitors is associated with the frontal AChE inhibition...
  71. ncbi request reprint Brain white matter expansion in human obesity and the recovering effect of dieting
    Lauri T Haltia
    Department of Neurology, University of Turku, P O Box 52, FIN 20521 Turku, Finland
    J Clin Endocrinol Metab 92:3278-84. 2007
    ..We hypothesized that possible differences seen in the brains of obese subjects would disappear or diminish after an intensive dieting period...
  72. ncbi request reprint Visual object recognition deficits in early Parkinson's disease
    Sari Laatu
    Centre for Cognitive Neuroscience, University of Turku, Assistenkatu 7, 20014, University of Turku, Finland
    Parkinsonism Relat Disord 10:227-33. 2004
    ..The results indicate some selective problems in both basic perceptual and semantic visual processing at an early stage of cognitive deterioration in PD...
  73. ncbi request reprint Characteristics of two telephone screens for cognitive impairment
    Tarja Järvenpää
    Department of Neurology and Turku PET Centre, University of Turku, Finland
    Dement Geriatr Cogn Disord 13:149-55. 2002
    ..0001). These results indicate that both screens are sensitive and specific instruments for differentiating AD patients from healthy controls and have a strong correlation with face-to-face measures of cognitive function...
  74. ncbi request reprint A rare mitochondrial DNA haplotype observed in Koreans
    Niina Snäll
    Department of Biology, University of Turku, Finland
    Hum Biol 74:253-62. 2002
    ..The observed rare haplotype was also found among Japanese, which suggests that it is one of the ancestral lineages originally peopling Japan...
  75. doi request reprint Amyloid PET imaging in patients with mild cognitive impairment: a 2-year follow-up study
    J Koivunen
    Turku PET Centre, University of Turku, Turku, Finland
    Neurology 76:1085-90. 2011
    ..Increased brain amyloid burden in AD and MCI has been demonstrated with PET using [(11)C] Pittsburgh compound B (PiB) as a tracer...