J O Rinne

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. pmc Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease
    Yi Li
    New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 35:2169-81. 2008
  2. ncbi request reprint Increased brain histamine levels in Parkinson's disease but not in multiple system atrophy
    J O Rinne
    Department of Neurology and Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    J Neurochem 81:954-60. 2002
  3. ncbi request reprint Positron emission tomography shows reduced striatal dopamine D1 but not D2 receptors in juvenile neuronal ceroid lipofuscinosis
    J O Rinne
    Turku PET Centre, University of Turku, Finland
    Neuropediatrics 33:138-41. 2002
  4. ncbi request reprint Striatal dopaminergic system in dopa-responsive dystonia: a multi-tracer PET study shows increased D2 receptors
    J O Rinne
    Turku PET Centre, University of Turku, Finland
    J Neural Transm 111:59-67. 2004
  5. ncbi request reprint [(18)F]FDOPA and [(18)F]CFT are both sensitive PET markers to detect presynaptic dopaminergic hypofunction in early Parkinson's disease
    O J Rinne
    Department of Neurology, University of Turku, Turku, Finland
    Synapse 40:193-200. 2001
  6. ncbi request reprint Semantic decision making in early probable AD: a PET activation study
    J O Rinne
    Turku PET Centre, University of Turku, PO Box 52, FIN 20521 Turku, Finland
    Brain Res Cogn Brain Res 18:89-96. 2003
  7. ncbi request reprint Unchanged striatal dopamine transporter availability in narcolepsy: a PET study with [11C]-CFT
    J O Rinne
    Turku PET Centre, University of Turku, Turku, Finland
    Acta Neurol Scand 109:52-5. 2004
  8. ncbi request reprint The translating brain: cerebral activation patterns during simultaneous interpreting
    J O Rinne
    Turku PET Center, University of Turku, P O Box 52, FIN 20521, Turku, Finland
    Neurosci Lett 294:85-8. 2000
  9. ncbi request reprint Cognitive impairment and the brain dopaminergic system in Parkinson disease: [18F]fluorodopa positron emission tomographic study
    J O Rinne
    Department of Neurology, University of Turku, Finland
    Arch Neurol 57:470-5. 2000
  10. ncbi request reprint Striatal dopamine transporter and extrapyramidal symptoms in frontotemporal dementia
    J O Rinne
    Turku PET Centre, University of Turku, Finland
    Neurology 58:1489-93. 2002

Detail Information

Publications92

  1. pmc Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease
    Yi Li
    New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 35:2169-81. 2008
    ....
  2. ncbi request reprint Increased brain histamine levels in Parkinson's disease but not in multiple system atrophy
    J O Rinne
    Department of Neurology and Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    J Neurochem 81:954-60. 2002
    ..These results indicate that histamine concentration, but not its metabolism is increased in PD, but not in MSA. This finding may have implications in developing new drug therapies for PD and in differential diagnosis between PD and MSA...
  3. ncbi request reprint Positron emission tomography shows reduced striatal dopamine D1 but not D2 receptors in juvenile neuronal ceroid lipofuscinosis
    J O Rinne
    Turku PET Centre, University of Turku, Finland
    Neuropediatrics 33:138-41. 2002
    ..The contribution of these changes to the extrapyramidal symptoms of the patients and their treatment deserves further studies...
  4. ncbi request reprint Striatal dopaminergic system in dopa-responsive dystonia: a multi-tracer PET study shows increased D2 receptors
    J O Rinne
    Turku PET Centre, University of Turku, Finland
    J Neural Transm 111:59-67. 2004
    ..The increased D2 receptor availability may be due to reduced competition by endogenous dopamine or a compensatory response to dopamine deficiency, or both...
  5. ncbi request reprint [(18)F]FDOPA and [(18)F]CFT are both sensitive PET markers to detect presynaptic dopaminergic hypofunction in early Parkinson's disease
    O J Rinne
    Department of Neurology, University of Turku, Turku, Finland
    Synapse 40:193-200. 2001
    ..They demonstrate a considerable reduction of tracer uptake that is greatest in the posterior putamen, followed by the anterior putamen and the caudate nucleus...
  6. ncbi request reprint Semantic decision making in early probable AD: a PET activation study
    J O Rinne
    Turku PET Centre, University of Turku, PO Box 52, FIN 20521 Turku, Finland
    Brain Res Cogn Brain Res 18:89-96. 2003
    ....
  7. ncbi request reprint Unchanged striatal dopamine transporter availability in narcolepsy: a PET study with [11C]-CFT
    J O Rinne
    Turku PET Centre, University of Turku, Turku, Finland
    Acta Neurol Scand 109:52-5. 2004
    ..To investigate dopamine reuptake sites (dopamine transporter) in the caudate nucleus and putamen in narcolepsy...
  8. ncbi request reprint The translating brain: cerebral activation patterns during simultaneous interpreting
    J O Rinne
    Turku PET Center, University of Turku, P O Box 52, FIN 20521, Turku, Finland
    Neurosci Lett 294:85-8. 2000
    ..Brain activation patterns were clearly modulated by direction of translation, with more extensive activation during translation into the non-native language which is often considered to a be more demanding task...
  9. ncbi request reprint Cognitive impairment and the brain dopaminergic system in Parkinson disease: [18F]fluorodopa positron emission tomographic study
    J O Rinne
    Department of Neurology, University of Turku, Finland
    Arch Neurol 57:470-5. 2000
    ..To investigate the role of the brain dopaminergic system in cognitive impairment in patients with Parkinson disease (PD)...
  10. ncbi request reprint Striatal dopamine transporter and extrapyramidal symptoms in frontotemporal dementia
    J O Rinne
    Turku PET Centre, University of Turku, Finland
    Neurology 58:1489-93. 2002
    ..To evaluate dopaminergic function in patients with frontotemporal dementia (FTD)...
  11. pmc Usefulness of a dopamine transporter PET ligand [(18)F]beta-CFT in assessing disability in Parkinson's disease
    J O Rinne
    Department of Neurology, University of Turku Turku PET Centre, Turku, Finland
    J Neurol Neurosurg Psychiatry 67:737-41. 1999
    ..The usefulness of a novel dopamine transporter PET ligand, [(18)F]beta-CFT in assessing disability in Parkinson's disease was studied...
  12. ncbi request reprint Endogenous dopamine release in Parkinson's disease
    Juha O Rinne
    Turku PET Centre, University of Turku, FIN 20520, Turku, Finland
    Lancet Neurol 2:460-1. 2003
  13. ncbi request reprint Drug development for neurodegenerative diseases: role of PET
    J O Rinne
    Department of Neurology, University of Turku and Turku PET Centre, Finland
    Ann Med 31:444-9. 1999
    ..However, in spite of the important role of PET in pathophysiological studies of neurodegenerative diseases, thus far the versatile possibilities of PET in drug development for neurodegenerative diseases have not been fully exploited...
  14. ncbi request reprint Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease
    N Kemppainen
    Department of Neurology, PO Box 52, University of Turku, FIN 20521 Turku, Finland
    Eur J Neurosci 18:149-54. 2003
    ..002). Our findings suggest a role for temporal lobe D2 receptors in the memory and naming performance in AD, and suggest that studies to evaluate the efficiency of dopaminergic medication on patients with early AD might be warranted...
  15. ncbi request reprint Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson's disease
    V Kaasinen
    Department of Neurology, University of Turku, Finland
    Neurology 54:1482-7. 2000
    ..To investigate whether dopamine D2 and D3 receptor subtypes (D2/3Rs) outside the caudate-putamen are affected in PD...
  16. ncbi request reprint PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment
    N M Kemppainen
    Turku PET Centre, University of Turku, Turku, Finland
    Neurology 68:1603-6. 2007
    ..In AD increased brain amyloid burden has been demonstrated in vivo with PET using N-methyl-[(11)C]2-(4'-methylaminophenyl)-6-hydroxybenzothiazole ([(11)C]PIB) as a tracer...
  17. doi request reprint Amyloid PET imaging in patients with mild cognitive impairment: a 2-year follow-up study
    J Koivunen
    Turku PET Centre, University of Turku, Turku, Finland
    Neurology 76:1085-90. 2011
    ..Increased brain amyloid burden in AD and MCI has been demonstrated with PET using [(11)C] Pittsburgh compound B (PiB) as a tracer...
  18. ncbi request reprint Choline acetytransferase activity and striatal dopamine receptors in Parkinson's disease in relation to cognitive impairment
    P M Mattila
    Department of Neurology, University of Turku, Finland
    Acta Neuropathol 102:160-6. 2001
    ..The present study showed that cognitive decline in PD is associated with reduced ChAT activity in the prefrontal cortex and the D1 dopamine receptor number in the caudate nucleus, even in the absence of AD-type pathology...
  19. doi request reprint Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease
    J J Virta
    Turku PET Centre, University of Turku, PO Box 52, FIN 20521 Turku, Finland
    J Neurol Neurosurg Psychiatry 80:259-66. 2009
    ..Therefore, twin pairs are useful in studying its pathogenesis and aetiology. Cerebral glucose metabolism has been found to be reduced in AD patients...
  20. ncbi request reprint Increased frontal [(18)F]fluorodopa uptake in early Parkinson's disease: sex differences in the prefrontal cortex
    V Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521 Turku, Finland
    Brain 124:1125-30. 2001
    ..The reported sex difference may be linked to clinical sex differences in the symptoms and treatment response in Parkinson's disease...
  21. ncbi request reprint Sex differences in extrastriatal dopamine d(2)-like receptors in the human brain
    V Kaasinen
    Department of Neurology and Psychiatry, University of Turku, Finland
    Am J Psychiatry 158:308-11. 2001
    ..The study examined gender differences in extrastriatal dopamine D2-like receptor levels in the human brain in vivo...
  22. doi request reprint PET amyloid ligand [11C]PIB uptake shows predominantly striatal increase in variant Alzheimer's disease
    J Koivunen
    Turku PET Centre, University of Turku, PO Box 52, 20521 Turku, Finland
    Brain 131:1845-53. 2008
    ....
  23. ncbi request reprint Positron emission tomography shows that impaired frontal lobe functioning in Parkinson's disease is related to dopaminergic hypofunction in the caudate nucleus
    A Bruck
    Turku PET Centre, University of Turku, FIN 20520, Turku, Finland
    Neurosci Lett 311:81-4. 2001
    ....
  24. ncbi request reprint Rate of progression in Parkinson's disease: a 6-[18F]fluoro-L-dopa PET study
    E Nurmi
    Department of Neurology, and Turku PET Centre, University of Turku, Turku, Finland
    Mov Disord 16:608-15. 2001
    ..In healthy controls, no significant decline in FDOPA was detected...
  25. ncbi request reprint Striatal 6-[18F]fluorodopa accumulation after combined inhibition of peripheral catechol-O-methyltransferase and monoamine oxidase type B: differing response in relation to presynaptic dopaminergic dysfunction
    H M Ruottinen
    Department of Neurology, University of Turku, Finland
    Synapse 27:336-46. 1997
    ..The milder response in levodopa-treated patients might reflect the reduced ability of the degenerated dopaminergic neurons to utilize the prolonged FDOPA availability, produced by entacapone...
  26. pmc Personality traits and brain dopaminergic function in Parkinson's disease
    V Kaasinen
    Departments of Neurology and Radiology, University of Turku, and Turku PET Centre, P.O. Box 52, FIN-20521, Turku, Finland
    Proc Natl Acad Sci U S A 98:13272-7. 2001
    ..The correlation between the personality trait of harm avoidance and (18)F-dopa may reflect a specific feedback circuitry of neurotransmitters that is associated with negative emotionality in Parkinson's disease...
  27. ncbi request reprint Extrastriatal dopamine D(2) receptors in Parkinson's disease: a longitudinal study
    V Kaasinen
    Department of Neurology, Turku PES Centre, Turku, Finland
    J Neural Transm 110:591-601. 2003
    ..Our longitudinal study shows first evidence concerning cortical D(2) receptor loss in the progression of PD, although it is not possible to distinguish between the effects of the therapy and the disease...
  28. ncbi request reprint Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease
    N M Kemppainen
    Turku PET Centre, University of Turku, Finland
    Neurology 67:1575-80. 2006
    ..PET studies with N-methyl-[(11)C]2-(4':-methylaminophenyl)-6-hydroxybenzothiazole ([(11)C]PIB) have revealed an increased tracer uptake in several brain regions in Alzheimer disease (AD)...
  29. doi request reprint Early detection of Alzheimer disease: ¹¹C-PiB PET in twins discordant for cognitive impairment
    N M Scheinin
    Turku PET Centre, University of Turku, Turku, Finland
    Neurology 77:453-60. 2011
    ..The aim of this study was to investigate whether cognitively preserved monozygotic or dizygotic cotwins of persons with Alzheimer disease (AD) exhibit increased brain amyloid accumulation...
  30. pmc Hippocampal and prefrontal atrophy in patients with early non-demented Parkinson's disease is related to cognitive impairment
    A Bruck
    Turku PET Centre, University of Turku, PO Box 52, FIN 20521 Turku, Finland
    J Neurol Neurosurg Psychiatry 75:1467-9. 2004
    ..Early stage patients with Parkinson's disease (PD) show cognitive impairment in frontal lobe functions and memory tests. Hippocampal atrophy is seen in medicated patients with advanced PD...
  31. doi request reprint Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls
    N M Scheinin
    Turku PET Centre, FIN 20521 Turku, Finland
    Neurology 73:1186-92. 2009
    ..We investigated the brain uptake of the amyloid ligand (11)C-labeled Pittsburgh compound B ([(11)C]PIB) and volumetric brain changes over a 2-year follow-up in patients with AD and in aged healthy controls...
  32. doi request reprint PET amyloid ligand [11C]PIB uptake and cerebrospinal fluid beta-amyloid in mild cognitive impairment
    J Koivunen
    Turku PET Centre, University of Turku, Turku, Finland
    Dement Geriatr Cogn Disord 26:378-83. 2008
    ..An increased brain amyloid burden in AD and MCI has been demonstrated with PET using [(11)C]PIB (Pittsburgh compound B). Little is known about the relationship between these biomarkers in MCI...
  33. doi request reprint [11C]PIB, [18F]FDG and MR imaging in patients with mild cognitive impairment
    A Bruck
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Eur J Nucl Med Mol Imaging 40:1567-72. 2013
    ..The aim of this study was to compare the prognostic ability of [(11)C]PIB PET, [(18)F]FDG PET and quantitative hippocampal volumes measured with MR imaging in predicting conversion to AD in patients with MCI...
  34. pmc Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease
    J O Rinne
    Department of Neurology, University of Turku, FIN 20521 Turku, Finland
    J Neurol Neurosurg Psychiatry 74:113-5. 2003
    ..Brain acetylcholinesterase activity was determined in healthy controls and in patients with mild cognitive impairment and early Alzheimer's disease...
  35. doi request reprint Cholinergic dysfunction after traumatic brain injury: preliminary findings from a PET study
    A Ostberg
    Department of Neurology, University of Turku and Turku University Central Hospital, Turku, Finland
    Neurology 76:1046-50. 2011
    ..There is evidence that the cholinergic system is frequently involved in the cognitive consequences of traumatic brain injury (TBI). We studied whether the brain cholinergic function is altered after TBI in vivo using PET...
  36. pmc Hippocampal MRI volumetry in cognitively discordant monozygotic twin pairs
    T Järvenpää
    Turku PET Centre and Department of Neurology, University of Turku, Turku, Finland
    J Neurol Neurosurg Psychiatry 75:116-20. 2004
    ..To investigate whether hippocampal atrophy, a proxy for incipient Alzheimer's disease, can be detected in non-demented monozygotic co-twins of demented twins by using volumetric magnetic resonance imaging (MRI)...
  37. ncbi request reprint Upregulation of putaminal dopamine D2 receptors in early Parkinson's disease: a comparative PET study with [11C] raclopride and [11C]N-methylspiperone
    V Kaasinen
    Department of Neurology, University of Turku, Finland
    J Nucl Med 41:65-70. 2000
    ..Dopamine D2 receptor function was assessed in a PET study with 2 dopamine D2 receptor PET ligands, [11C]raclopride (RAC) and [11C]N-methylspiperone (NMSP), in early Parkinson's disease...
  38. ncbi request reprint Different pattern of reduction of striatal dopamine reuptake sites in Alzheimer's disease and ageing
    N Kemppainen
    Department of Neurology, University of Turku, Finland
    J Neural Transm 108:827-36. 2001
    ..3%) than in the putamen (5.5%). In conclusion, the pattern of changes in AD is different from that seen during normal ageing, which seems to affect more severely the caudate nucleus than the putamen...
  39. doi request reprint Five-year follow-up of (11)C-PIB uptake in Alzheimer's disease and MCI
    N M Kemppainen
    Turku PET Centre, University of Turku, P O Box 52, 20521, Turku, Finland
    Eur J Nucl Med Mol Imaging 41:283-9. 2014
    ..The aim of this study was to evaluate the longitudinal changes in [(11)C]PIB uptake in mild cognitive impairment (MCI) and Alzheimer's disease (AD) over a long-term follow-up...
  40. ncbi request reprint Visual object recognition in early Alzheimer's disease: deficits in semantic processing
    S Laatu
    Centre for Cognitive Neuroscience, University of Turku, Finland
    Acta Neurol Scand 108:82-9. 2003
    ..The purpose of the present study was to divide visual object recognition into different stages and to reveal which of these stages are impaired in early Alzheimer's disease (AD)...
  41. doi request reprint Assessment of MAO-B occupancy in the brain with PET and [11C]-L-deprenyl-D2: a dose-finding study with a novel MAO-B inhibitor, EVT 301
    J Hirvonen
    Turku PET Centre, University of Turku and Turku University Central Hospital, Turku, Finland
    Clin Pharmacol Ther 85:506-12. 2009
    ..Determination of MAO-B inhibition in blood platelets underestimated the actual brain occupancy achieved with EVT 301. A daily EVT 301 dose of 75 or 150 mg appears suitable for clinical efficacy studies in patients with AD...
  42. ncbi request reprint Phenotype of a homozygous CADASIL patient in comparison to 9 age-matched heterozygous patients with the same R133C Notch3 mutation
    S Tuominen
    Department of Neurology, Turku University Hospital and University of Turku, Finland
    Stroke 32:1767-74. 2001
    ..Thus, CADASIL may follow the classic definition of a dominant disease, according to which the heterozygous and homozygous patients are clinically indistinguishable...
  43. ncbi request reprint Amyloid imaging as a surrogate marker in clinical trials in Alzheimer's disease
    Noora M Scheinin
    Turku PET Centre, University of Turku, Turku University Hospital, Turku, Finland
    Q J Nucl Med Mol Imaging 55:265-79. 2011
    ..This article aims to review the motives, prerequisites, potential, and challenges of using amyloid imaging as a surrogate marker in clinical therapeutic trials in AD...
  44. ncbi request reprint Left hemisphere activation during processing of morphologically complex word forms in adults
    M Laine
    Department of Neurology, University of Turku, Finland
    Neurosci Lett 271:85-8. 1999
    ..This suggests that besides their role in the production of grammatical morphology documented earlier, Broca's area and adjacent regions are important for the input processing of morphologically complex words...
  45. ncbi request reprint Mapping brain structure and personality in late adulthood
    V Kaasinen
    Department of Neurology, University of Turku, FIN 20521 Turku, Finland Turku PET Centre, FIN 20521 Turku, Finland
    Neuroimage 24:315-22. 2005
    ..The results suggest that high self-transcendence, which has adaptive advantages in the later part of life, is associated with relatively greater temporal cortical GM volumes...
  46. ncbi request reprint Role of the dopaminergic system in chronic pain -- a fluorodopa-PET study
    S K Jääskeläinen
    Department of Clinical Neurophysiology, Turku University Central Hospital, PL 52, FI 20 521 Turku, Finland
    Pain 90:257-60. 2001
    ..The present result provides direct evidence of the involvement of the nigrostriatal dopaminergic system in pain for the first time in a clinical pain condition...
  47. ncbi request reprint Unbiased morphological measurements show no neuronal loss in the substantia nigra in Alzheimer's disease
    N Kemppainen
    Department of Neurology, University of Turku, Finland
    Acta Neuropathol 103:43-7. 2002
    ..Studies on single sections revealed that even subregionally there was no significant difference in the neuronal number or area in the SNpc between AD patients and controls...
  48. ncbi request reprint Personality traits and striatal 6-[18F]fluoro-L-dopa uptake in healthy elderly subjects
    Valtteri Kaasinen
    Department of Neurology, University of Turku, P O Box 52, FIN 20521 Turku, Finland
    Neurosci Lett 332:61-4. 2002
    ..The results indicate that the previous positive findings concerning harm avoidance and (18)F-dopa uptake in Parkinson's disease are disease-related, and that they can not be generalized to healthy individuals...
  49. ncbi request reprint Brain function during multi-trial learning in mild cognitive impairment: a PET activation study
    Chris J A Moulin
    Institute of Psychological Sciences, University of Leeds, UK
    Brain Res 1136:132-41. 2007
    ..Subtle functional changes occur in the pre-Alzheimer brain before there are marked structural or behavioural abnormalities...
  50. ncbi request reprint Striatal subregional 6-[18F]fluoro-L-dopa uptake in early Parkinson's disease: a two-year follow-up study
    Anna Brück
    Turku PET Center, University of Turku, Turku, Finland
    Mov Disord 21:958-63. 2006
    ..In contrast to the striatal decline, the increased cortical F-dopa uptake prevails at least during the first years of PD...
  51. ncbi request reprint Age-related loss of extrastriatal dopamine D(2) -like receptors in women
    Valtteri Kaasinen
    Department of Neurology, University of Turku, Turku, Finland
    J Neurochem 81:1005-10. 2002
    ..The results may prove to be important in studies where the biochemical basis of clinical sex differences is examined in patients with dopamine-related neuropsychiatric disorders...
  52. ncbi request reprint Neural correlates of naming newly learned objects in MCI
    Petra Grönholm
    Department of Psychology, Abo Akademi University, FIN 20500 Abo, Finland
    Neuropsychologia 45:2355-68. 2007
    ..Our results suggest that the naming of newly learned objects posed additional executive and attentional demands on the patients...
  53. ncbi request reprint Brain white matter expansion in human obesity and the recovering effect of dieting
    Lauri T Haltia
    Department of Neurology, University of Turku, P O Box 52, FIN 20521 Turku, Finland
    J Clin Endocrinol Metab 92:3278-84. 2007
    ..We hypothesized that possible differences seen in the brains of obese subjects would disappear or diminish after an intensive dieting period...
  54. ncbi request reprint Effects of intravenous glucose on dopaminergic function in the human brain in vivo
    Lauri T Haltia
    Department of Neurology, University of Turku, Turku, Finland
    Synapse 61:748-56. 2007
    ....
  55. ncbi request reprint Different cerebral cortical areas influence the effect of subthalamic nucleus stimulation on parkinsonian motor deficits and freezing of gait
    Chul Hyoung Lyoo
    Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
    Mov Disord 22:2176-82. 2007
    ..In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG...
  56. ncbi request reprint Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease
    Nina M Kemppainen
    Turku Positron Emission Tomography Centre, University of Turku, Turku, Finland
    Ann Neurol 63:112-8. 2008
    ..Our aim was to find possible differences in brain amyloid ligand 11C-labeled Pittsburgh Compound B ([11C]PIB) uptake and glucose metabolism in high- and low-educated patients with mild AD...
  57. doi request reprint Effects of intravenous placebo with glucose expectation on human basal ganglia dopaminergic function
    Lauri T Haltia
    Department of Neurology, University of Turku, Turku, Finland
    Synapse 62:682-8. 2008
    ..g., amphetamine and glucose). Also, they suggest that the DA release in the ventral striatum mediates placebo responses in the context of glucose expectation...
  58. doi request reprint Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B
    Ville Leinonen
    Department of Neurosurgery, Kuopio University Hospital, PO Box 1777, 70211 Kuopio, Finland
    Arch Neurol 65:1304-9. 2008
    ..To compare carbon 11-labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) findings in patients with and without Alzheimer disease lesions in frontal cortical biopsy specimens...
  59. ncbi request reprint Different brain activation patterns during production of animals versus artefacts: a PET activation study on category-specific processing
    Matti Laine
    Department of Psychology, Abo Akademi University, FIN 20500 Turku, Finland
    Brain Res Cogn Brain Res 13:95-9. 2002
    ..In our study, it may represent an involvement of visual imagery in generation of animal names. In contrast, production of artefact names elicited increased rCBF in frontoparietal regions previously related to attention and mental effort...
  60. doi request reprint Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication
    Anne M Remes
    Clinical Research Centre, Oulu University Hospital, University of Oulu, Oulu, Finland
    Arch Neurol 65:540-4. 2008
    ..To investigate amyloid accumulation by carbon 11-labeled Pittsburgh Compound B (11C-PiB) in hereditary cerebral amyloid angiopathy and APP locus duplication...
  61. ncbi request reprint Mobile phone affects cerebral blood flow in humans
    Sargo Aalto
    Turku PET Centre, University of Turku, Turku, Finland
    J Cereb Blood Flow Metab 26:885-90. 2006
    ..Our results provide the first evidence, suggesting that the EMF emitted by a commercial mobile phone affects rCBF in humans. These results are consistent with the postulation that EMF induces changes in neuronal activity...
  62. ncbi request reprint Naming of newly learned objects: a PET activation study
    Petra Grönholm
    Department of Psychology, Abo Akademi University, FIN 20500 Abo, Finland
    Brain Res Cogn Brain Res 25:359-71. 2005
    ..Its activity is tentatively related to enhanced lexical-semantic and lexical-phonological retrieval, as well as associative memory processes...
  63. ncbi request reprint Positron emission tomography examination of cerebral blood flow and glucose metabolism in young CADASIL patients
    Susanna Tuominen
    Department of Neurology, Turku University Hospital and University of Turku, Turku, Finland
    Stroke 35:1063-7. 2004
    ..The purpose of this study was to assess whether cerebral blood flow (CBF) and regional cerebral metabolic rates of glucose (rCMR(gluc)) in CADASIL patients are affected in early adulthood...
  64. ncbi request reprint Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease
    Valtteri Kaasinen
    Department of Neurology, University of Turku, Turku, Finland
    J Clin Psychopharmacol 22:615-20. 2002
    ..We hypothesize that the clinical improvement in behavioral and attentional symptoms of AD due to AChE inhibitors is associated with the frontal AChE inhibition...
  65. ncbi request reprint Functional imaging studies of dopamine system and cognition in normal aging and Parkinson's disease
    Valtteri Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521, Turku, Finland
    Neurosci Biobehav Rev 26:785-93. 2002
    ..In particular, the focus is on describing and discussing the relationships between aging, cognition and the dopaminergic system in healthy subjects and in patients with Parkinson's disease...
  66. ncbi request reprint Naming multiple objects: neural correlates as measured by positron emission tomography
    Kati Renvall
    Department of Psychology, University of Turku, Finland
    Appl Neuropsychol 10:224-33. 2003
    ..These findings thus provide independent evidence for the claim that CP is a valid paradigm for the study of word production proper...
  67. ncbi request reprint Striatal dopamine D1 and D2 receptors in burning mouth syndrome
    Nora Hagelberg
    Department of Anesthesiology and Intensive Care, Turku University Central Hospital, PO Box 52, FIN 20521, Turku, Finland
    Pain 101:149-54. 2003
    ..65+/-0.05 vs. 0.70+/-0.05, P=0.05) when compared to controls. Increased 11C-raclopride uptake and the subsequent decrease in the D1/D2 ratio may indicate a decline in endogenous dopamine levels in the putamen in burning mouth patients...
  68. ncbi request reprint Expectation of caffeine induces dopaminergic responses in humans
    Valtteri Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521, Turku, Finland
    Eur J Neurosci 19:2352-6. 2004
    ..The results therefore suggest that caffeine and placebo caffeine may share some dopaminergic mechanisms of action...
  69. ncbi request reprint Dopaminergic effects of caffeine in the human striatum and thalamus
    Valtteri Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521, Turku, Finland
    Neuroreport 15:281-5. 2004
    ..81, p = 0.03). The findings indicate that caffeine has effects on dopaminergic neurotransmission in the human brain, which may be differential in the striatum and the thalamus...
  70. ncbi request reprint Altered dopamine D2 receptor binding in atypical facial pain
    Nora Hagelberg
    Department of Anesthesiology and Intensive Care, Turku University Central Hospital, P O Box 52, FIN 20521 Turku, Finland
    Pain 106:43-8. 2003
    ....
  71. ncbi request reprint Regional cerebral glucose metabolism in monozygotic twins discordant for Alzheimer's disease
    Tarja Järvenpää
    Turku PET Centre, University of Turku, Turku, Finland
    Dement Geriatr Cogn Disord 16:245-52. 2003
    ..Their non-demented co-twins showed milder reductions, which may be an indication of genetic susceptibility for dementia, and an early sign of a dementing illness in them...
  72. ncbi request reprint A 90-year-old monozygotic female twin pair discordant for Alzheimer's disease
    Tarja Järvenpää
    Turku PET Centre, University of Turku, P O Box 52, FIN 20521, Turku, Finland
    Neurobiol Aging 24:941-5. 2003
    ..Our results further address the influence of environmental factors on the onset of AD, especially the possible protective effect of anti-inflammatory medication...
  73. ncbi request reprint Insular dopamine D2 receptors and novelty seeking personality in Parkinson's disease
    Valtteri Kaasinen
    Department of Neurology, University of Turku, Finland
    Mov Disord 19:1348-51. 2004
    ..The results provide further support for a relationship between novelty seeking and insular D2 receptors. They indicate that the association is cross-cultural, independent of age, and unaffected by dopaminergic degeneration...
  74. ncbi request reprint Cortical 6-[18F]fluoro-L-dopa uptake and frontal cognitive functions in early Parkinson's disease
    Anna Brück
    Turku PET Center, University of Turku, POB 52, FIN 20521 Turku, Finland
    Neurobiol Aging 26:891-8. 2005
    ..The results show that cortical Fdopa uptake is increased in early non-medicated PD and suggest that the changes in frontal Fdopa uptake are related to cognitive impairments found in early PD...
  75. ncbi request reprint Progression of dopaminergic hypofunction in striatal subregions in Parkinson's disease using [18F]CFT PET
    Elina Nurmi
    Department of Neurology, University of Turku, FIN 20521, Turku, Finland
    Synapse 48:109-15. 2003
    ..Synapse 48:109-115, 2003...
  76. ncbi request reprint Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: a positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457
    Sargo Aalto
    Turku PET Centre, University of Turku, FIN 20014 Turku, Finland
    J Neurosci 25:2471-7. 2005
    ..Our results indicate that regionally specific components of the frontotemporal dopaminergic network are functionally involved in WM performance in humans...
  77. ncbi request reprint Brain oscillatory responses to an auditory-verbal working memory task in mild cognitive impairment and Alzheimer's disease
    Mira Karrasch
    Department of Psychology, Abo Akademi University, FIN 20500, Abo, Finland
    Int J Psychophysiol 59:168-78. 2006
    ..Future studies with larger patient groups are needed to establish the diagnostic value of ERD/ERS patterns in MCI and AD...
  78. ncbi request reprint Neuropsychological functions in variant Alzheimer's disease with spastic paraparesis
    Auli Verkkoniemi
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki FIN 00290, Finland
    J Neurol Sci 218:29-37. 2004
    ..However, all these early-onset patients (age range 43-63 years) with a deletion mutation of PS-1 gene showed prominent memory impairment and deficits in visuoconstructive and intellectual functions...
  79. ncbi request reprint Effects of a 902 MHz mobile phone on cerebral blood flow in humans: a PET study
    Christian Haarala
    Centre for Cognitive Neuroscience, University of Turku, Turku, Finland
    Neuroreport 14:2019-23. 2003
    ..Therefore, it is not reasoned to attribute this finding to the EMF emitted by the phone. Further study on human rCBF during exposure to EMF of a mobile phone is needed...
  80. ncbi request reprint Catechol-O-methyl transferase (COMT) inhibitors in patients with Parkinson's disease: is COMT genotype a useful indicator of clinical efficacy?
    Juha O Rinne
    Turku PET Center, University of Turku, Turku, Finland
    Am J Pharmacogenomics 3:11-5. 2003
    ..These data suggest that the COMT genotype is not a major factor in deciding the clinical efficacy of COMT inhibitors...
  81. ncbi request reprint Characteristics of two telephone screens for cognitive impairment
    Tarja Järvenpää
    Department of Neurology and Turku PET Centre, University of Turku, Finland
    Dement Geriatr Cogn Disord 13:149-55. 2002
    ..0001). These results indicate that both screens are sensitive and specific instruments for differentiating AD patients from healthy controls and have a strong correlation with face-to-face measures of cognitive function...
  82. ncbi request reprint No association between the brain-derived neurotrophic factor 196 G>A or 270 C>T polymorphisms and Alzheimer's or Parkinson's disease
    Marika S Saarela
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University, Tampere, Finland
    Folia Neuropathol 44:12-6. 2006
    ..Moreover, no interaction between either BDNF polymorphism and the epsilon 4 allele of apolipoprotein E was found. In conclusion, it seems that the BDNF gene does not contribute significantly to the risk of AD or PD in Finnish patients...
  83. ncbi request reprint Cost-utility model of rasagiline in the treatment of advanced Parkinson's disease in Finland
    Joumana Hudry
    International Department of Health Economics and Epidemiology, H Lundbeck A S, Paris, France
    Ann Pharmacother 40:651-7. 2006
    ..The economic burden of Parkinson's disease (PD) is high, especially in patients experiencing motor fluctuations. Rasagiline has demonstrated efficacy against symptoms of PD in early and advanced stages of the disease...
  84. ncbi request reprint Selective changes in the levels of nicotinic acetylcholine receptor protein and of corresponding mRNA species in the brains of patients with Parkinson's disease
    Zhi zhong Guan
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, S 141 86 Stockholm, Sweden
    Brain Res 956:358-66. 2002
    ..These findings reveal selective losses of the alpha3- and beta2-containing nAChRs and an increase in the alpha7 nAChRs that might be related to the pathogenesis of PD...
  85. ncbi request reprint Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study
    Petri Luoma
    Department of Neurology and Programme of Neurosciences, Biomedicum Helsinki, Helsinki University, and Helsinki University Central Hospital, Helsinki, Finland
    Lancet 364:875-82. 2004
    ..We aimed to analyse the gene sequence of POLG in patients with progressive external ophthalmoplegia and their healthy relatives...
  86. ncbi request reprint A rare mitochondrial DNA haplotype observed in Koreans
    Niina Snäll
    Department of Biology, University of Turku, Finland
    Hum Biol 74:253-62. 2002
    ..The observed rare haplotype was also found among Japanese, which suggests that it is one of the ancestral lineages originally peopling Japan...
  87. ncbi request reprint Interaction between matrix metalloproteinase 3 and the epsilon4 allele of apolipoprotein E increases the risk of Alzheimer's disease in Finns
    Marika S Saarela
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University Hospital, PO Box 2000, FIN 33521, Finland
    Neurosci Lett 367:336-9. 2004
    ..7, 95% CI: 5.8-144.9, P < 0.0001) compared to those who possess neither MMP3*5A nor APOE 4. In conclusion, our finding suggests that the MMP3 gene, especially together with APOE 4, may contribute to the development of AD...
  88. ncbi request reprint Visual object recognition deficits in early Parkinson's disease
    Sari Laatu
    Centre for Cognitive Neuroscience, University of Turku, Assistenkatu 7, 20014, University of Turku, Finland
    Parkinsonism Relat Disord 10:227-33. 2004
    ..The results indicate some selective problems in both basic perceptual and semantic visual processing at an early stage of cognitive deterioration in PD...
  89. ncbi request reprint Absence of association between an intercellular adhesion molecule 1 gene E469K polymorphism and Alzheimer's disease in Finnish patients
    Kari M Mattila
    Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Finland
    Neurosci Lett 337:61-3. 2003
    ..We therefore conclude that the E469K polymorphism of ICAM1 is not a risk factor for AD or PD...
  90. ncbi request reprint Cerebral glucose metabolism in dizygotic twin pairs discordant for Alzheimer's disease
    Jyri J Virta
    Turku PET Centre, University of Turku, Turku, Finland
    Dement Geriatr Cogn Disord 25:9-16. 2008
    ..The non-demented twins showed no such reductions on any cortical region compared to unrelated control subjects. This implies that both genes and environment, and not genes alone, are causative in the pathogenesis of AD...
  91. ncbi request reprint Binge drinking in midlife and dementia risk
    Tarja Järvenpää
    Turku PET Centre and Department of Neurology, University of Turku, Turku, Finland
    Epidemiology 16:766-71. 2005
    ..Our goal was to determine whether a long follow-up period combined with information about drinking patterns, in addition to total alcohol consumption, would provide new insights about the relationship of alcohol use with dementia risk...
  92. ncbi request reprint Biodistribution and radiation dosimetry of the amyloid imaging agent 11C-PIB in humans
    Noora M Scheinin
    Turku PET Centre, University of Turku, Turku, Finland
    J Nucl Med 48:128-33. 2007
    ..Previous radiation exposure estimates have been based on animal experiments. A dosimetry study in humans is essential for a balanced risk-benefit assessment of (11)C-PIB PET studies...