Samuli Rautava

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint Role of probiotics in food hypersensitivity
    Erika Isolauri
    Department of Pediatrics, University of Turku, Finland
    Curr Opin Allergy Clin Immunol 2:263-71. 2002
  2. pmc TGF-β2 induces maturation of immature human intestinal epithelial cells and inhibits inflammatory cytokine responses induced via the NF-κB pathway
    Samuli Rautava
    Division of Pediatric Gastroenterology, Massachusetts General Hospital for Children, Charlestown, MA 02192 4404, USA
    J Pediatr Gastroenterol Nutr 54:630-8. 2012
  3. doi request reprint Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant
    Samuli Rautava
    Department of Paediatrics, Turku University Central Hospital, Turku, Finland
    J Allergy Clin Immunol 130:1355-60. 2012
  4. ncbi request reprint Probiotics modulate host-microbe interaction in the placenta and fetal gut: a randomized, double-blind, placebo-controlled trial
    Samuli Rautava
    Department of Paediatrics, Turku University Hospital, Turku, Finland
    Neonatology 102:178-84. 2012
  5. pmc Breast milk-transforming growth factor-β₂ specifically attenuates IL-1β-induced inflammatory responses in the immature human intestine via an SMAD6- and ERK-dependent mechanism
    Samuli Rautava
    Developmental Gastroenterology Laboratory, Division of Pediatric Gastroenterology, Massachusetts General Hospital for Children, Charlestown, Mass, USA
    Neonatology 99:192-201. 2011
  6. pmc Academy of Breastfeeding Medicine founder's lecture 2008: breastfeeding--an extrauterine link between mother and child
    Samuli Rautava
    Developmental Gastroenterology Laboratory, Division of Pediatric Gastroenterology, Massachusetts General Hospital for Children, Charlestown, Massachusetts, USA
    Breastfeed Med 4:3-10. 2009
  7. ncbi request reprint Potential uses of probiotics in the neonate
    Samuli Rautava
    Department of Paediatrics, University of Turku, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Semin Fetal Neonatal Med 12:45-53. 2007
  8. ncbi request reprint Specific probiotics in enhancing maturation of IgA responses in formula-fed infants
    Samuli Rautava
    Department of Pediatrics, University of Turku, Finland
    Pediatr Res 60:221-4. 2006
  9. ncbi request reprint Cow's milk allergy in infants with atopic eczema is associated with aberrant production of interleukin-4 during oral cow's milk challenge
    Samuli Rautava
    Department of Paediatrics, University of Turku, Turku, Finland
    J Pediatr Gastroenterol Nutr 39:529-35. 2004
  10. ncbi request reprint The hygiene hypothesis of atopic disease--an extended version
    Samuli Rautava
    Department of Pediatrics, Turku University Central Hospital, Finland
    J Pediatr Gastroenterol Nutr 38:378-88. 2004

Detail Information

Publications22

  1. ncbi request reprint Role of probiotics in food hypersensitivity
    Erika Isolauri
    Department of Pediatrics, University of Turku, Finland
    Curr Opin Allergy Clin Immunol 2:263-71. 2002
    ....
  2. pmc TGF-β2 induces maturation of immature human intestinal epithelial cells and inhibits inflammatory cytokine responses induced via the NF-κB pathway
    Samuli Rautava
    Division of Pediatric Gastroenterology, Massachusetts General Hospital for Children, Charlestown, MA 02192 4404, USA
    J Pediatr Gastroenterol Nutr 54:630-8. 2012
    ..We sought to investigate whether conditioning with TGF-β2 may result in a more mature immune responder phenotype in immature human intestinal epithelial cells (IECs)...
  3. doi request reprint Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant
    Samuli Rautava
    Department of Paediatrics, Turku University Central Hospital, Turku, Finland
    J Allergy Clin Immunol 130:1355-60. 2012
    ..Probiotics have shown promising potential in reducing the risk of eczema in infants. Optimal probiotic intervention regimen remains to be determined...
  4. ncbi request reprint Probiotics modulate host-microbe interaction in the placenta and fetal gut: a randomized, double-blind, placebo-controlled trial
    Samuli Rautava
    Department of Paediatrics, Turku University Hospital, Turku, Finland
    Neonatology 102:178-84. 2012
    ..Early host-microbe interaction provides important maturational stimuli for the developing immune system. The role of prenatal microbial contact remains elusive...
  5. pmc Breast milk-transforming growth factor-β₂ specifically attenuates IL-1β-induced inflammatory responses in the immature human intestine via an SMAD6- and ERK-dependent mechanism
    Samuli Rautava
    Developmental Gastroenterology Laboratory, Division of Pediatric Gastroenterology, Massachusetts General Hospital for Children, Charlestown, Mass, USA
    Neonatology 99:192-201. 2011
    ..Breast milk is known to protect the infant against infectious and immuno-inflammatory diseases, but the mechanisms of this protection are poorly understood...
  6. pmc Academy of Breastfeeding Medicine founder's lecture 2008: breastfeeding--an extrauterine link between mother and child
    Samuli Rautava
    Developmental Gastroenterology Laboratory, Division of Pediatric Gastroenterology, Massachusetts General Hospital for Children, Charlestown, Massachusetts, USA
    Breastfeed Med 4:3-10. 2009
    ..The body of scientific data regarding the role of transforming growth factor-beta in breastmilk in enhancing healthy immune maturation and reducing the risk of disease is reviewed in this article...
  7. ncbi request reprint Potential uses of probiotics in the neonate
    Samuli Rautava
    Department of Paediatrics, University of Turku, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Semin Fetal Neonatal Med 12:45-53. 2007
    ..These data are preliminary, and a number of issues need to be resolved before general guidelines regarding the use of probiotics in the neonatal period can be given...
  8. ncbi request reprint Specific probiotics in enhancing maturation of IgA responses in formula-fed infants
    Samuli Rautava
    Department of Pediatrics, University of Turku, Finland
    Pediatr Res 60:221-4. 2006
    ....
  9. ncbi request reprint Cow's milk allergy in infants with atopic eczema is associated with aberrant production of interleukin-4 during oral cow's milk challenge
    Samuli Rautava
    Department of Paediatrics, University of Turku, Turku, Finland
    J Pediatr Gastroenterol Nutr 39:529-35. 2004
    ....
  10. ncbi request reprint The hygiene hypothesis of atopic disease--an extended version
    Samuli Rautava
    Department of Pediatrics, Turku University Central Hospital, Finland
    J Pediatr Gastroenterol Nutr 38:378-88. 2004
    ..Third, in addition to protection against atopy, protection against infectious, inflammatory, and autoimmune diseases may also depend upon healthy host-microbe interactions implicated in the hygiene hypothesis...
  11. ncbi request reprint The development of gut immune responses and gut microbiota: effects of probiotics in prevention and treatment of allergic disease
    Samuli Rautava
    Department of Paediatrics, University of Turku, Finland
    Curr Issues Intest Microbiol 3:15-22. 2002
    ..Thus probiotics may prove beneficial in the prevention and alleviation of allergic disease...
  12. doi request reprint Specific probiotics in reducing the risk of acute infections in infancy--a randomised, double-blind, placebo-controlled study
    Samuli Rautava
    Department of Paediatrics, University of Turku, Turku, Finland
    Br J Nutr 101:1722-6. 2009
    ..Further clinical trials are warranted...
  13. doi request reprint Obesity - extending the hygiene hypothesis
    Erika Isolauri
    Department of Pediatrics, Functional Foods Forum, and Department of Biochemistry and Food Chemistry, University of Turku, Turku University Central Hospital, Turku, Finland
    Nestle Nutr Workshop Ser Pediatr Program 64:75-85; discussion 85-9, 251-7. 2009
    ....
  14. doi request reprint Probiotics in the development and treatment of allergic disease
    Erika Isolauri
    Department of Paediatrics, University of Turku and Turku University Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Gastroenterol Clin North Am 41:747-62. 2012
    ..Probiotics also enhance gut-specific IgA responses, which are frequently defective in children with food allergy. In addition, probiotics have the potential to alleviate allergic inflammation locally and systemically...
  15. doi request reprint Immunological programming by breast milk creates an anti-inflammatory cytokine milieu in breast-fed infants compared to formula-fed infants
    Essi Kainonen
    Department of Paediatrics, Turku University Hospital, Kiinamyllynkatu 4 8, Turku 20520, Finland
    Br J Nutr 109:1962-70. 2013
    ..Such an immunological environment limits hyper-responsiveness and promotes tolerisation, possibly prohibiting the onset of allergic disease...
  16. ncbi request reprint Mode of delivery - effects on gut microbiota and humoral immunity
    Anu Huurre
    Department of Pediatrics, Turku University Central Hospital and University of Turku, Turku, Finland
    Neonatology 93:236-40. 2008
    ..The rate of caesarean deliveries has increased 10-fold worldwide during the past decades...
  17. doi request reprint Microbial contact during pregnancy, intestinal colonization and human disease
    Samuli Rautava
    Department of Pediatrics, Turku University Hospital, Finland
    Nat Rev Gastroenterol Hepatol 9:565-76. 2012
    ....
  18. ncbi request reprint Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant
    Samuli Rautava
    Department of Paediatrics, University of Turku, Finland
    J Allergy Clin Immunol 109:119-21. 2002
    ....
  19. ncbi request reprint New therapeutic strategy for combating the increasing burden of allergic disease: Probiotics-A Nutrition, Allergy, Mucosal Immunology and Intestinal Microbiota (NAMI) Research Group report
    Samuli Rautava
    Department of Paediatrics, University of Turku, Finland
    J Allergy Clin Immunol 116:31-7. 2005
    ..Understanding these complex phenomena provides the rationale for the use of probiotics in reducing the risk and nutritional management of atopic disease...
  20. pmc Probiotics prevent necrotizing enterocolitis by modulating enterocyte genes that regulate innate immune-mediated inflammation
    Kriston Ganguli
    Mucosal Immunology Laboratory, Division of Pediatric Gastroenterology, Massachusetts General Hospital for Children, 114 16th St 114 3503, Charlestown, MA 02192 4404, USA
    Am J Physiol Gastrointest Liver Physiol 304:G132-41. 2013
    ..We conclude that PCM promotes maturation of innate immune response gene expression, potentially explaining the protective effects of probiotics in clinical NEC...
  21. pmc Commensal bacteria and epithelial cross talk in the developing intestine
    Samuli Rautava
    Mucosal Immunology Laboratory, Massachusetts General Hospital, 114 16th Street 114 3503, Charlestown, MA 02129 4404, USA
    Curr Gastroenterol Rep 9:385-92. 2007
    ..Cross talk between the host and commensal microbes is an essential component of gut homeostasis mechanisms also in later life. During recent years, innovative research has shed light on the molecular mechanisms of these interactions...
  22. ncbi request reprint Unique cytokine secretion profile in children with both type I diabetes and asthma distinct from that of solely diabetic or asthmatic children
    Essi Kainonen
    Department of Paediatrics, University of Turku, Turku, Finland
    Cytokine 34:198-205. 2006
    ..In particular, these children appear to have a defect in regulation of IL-10 secretion...