Affiliation: University of Tampere
Myllymäki H, Niskanen M, Luukinen H, Parikka M, Ramet M. Identification of protective postexposure mycobacterial vaccine antigens using an immunosuppression-based reactivation model in the zebrafish. Dis Model Mech. 2018;11: pubmed publisher
..This article has an associated First Person interview with the first author of the paper. ..
Ojanen M, Uusi Mäkelä M, Harjula S, Saralahti A, Oksanen K, Kähkönen N, et al
. Intelectin 3 is dispensable for resistance against a mycobacterial infection in zebrafish (Danio rerio). Sci Rep. 2019;9:995 pubmed publisher
..Collectively, although itln3 expression is induced upon M. marinum infection in zebrafish, it is dispensable for protective mycobacterial immune response. ..
Myllymäki H, Niskanen M, Oksanen K, Ramet M. Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines. J Vis Exp. 2018;: pubmed publisher
..The method can be further applied to screening DNA-based vaccines against various bacterial and viral diseases. ..
Uusi Mäkelä M, Ramet M. Hijacking Host Angiogenesis to Drive Mycobacterial Growth. Cell Host Microbe. 2018;24:465-466 pubmed publisher
..Preventing abnormal angiogenesis in the granuloma represents a potential therapeutic approach for tuberculosis. ..
Harjula S, Ojanen M, Taavitsainen S, Nykter M, Ramet M. Interleukin 10 mutant zebrafish have an enhanced interferon gamma response and improved survival against a Mycobacterium marinum infection. Sci Rep. 2018;8:10360 pubmed publisher
..marinum infection in zebrafish by restricting ifng1 response. Importantly, our findings support the relevance of M. marinum infection in zebrafish as a model for tuberculosis. ..
Ramet M, Korppi M, Hallman M. Pattern recognition receptors and genetic risk for rsv infection: value for clinical decision-making?. Pediatr Pulmonol. 2011;46:101-10 pubmed publisher
..This information is useful in guiding efforts to develop better means to identify the high-risk infants and to treat this potentially fatal infection effectively. ..
Valanne S, RÃ¤met M. Uracil debases pathogenic but not commensal bacteria. Cell Host Microbe. 2013;13:505-506 pubmed publisher
..In a recent Cell paper, Lee et al. (2013) show that bacterial uracil, not secreted by commensal bacteria, triggers dual oxidase-dependent immunity. ..
Salminen T, Ramet M. Pickle Flavors Relish in Drosophila Immunity. Cell Host Microbe. 2016;20:273-274 pubmed publisher
..In this issue of Cell Host & Microbe, Morris et al. (2016) introduce Pickle, a nuclear I?B that inhibits Drosophila immune signaling by modulating the NF-?B Relish. ..
Oksanen K, MyllymÃ¤ki H, Ahava M, MÃ¤kinen L, Parikka M, RÃ¤met M. DNA vaccination boosts Bacillus Calmette-GuÃ©rin protection against mycobacterial infection in zebrafish. Dev Comp Immunol. 2016;54:89-96 pubmed publisher
..We conclude that zebrafish is a useful early-phase preclinical model for studying subunit vaccines designed for boosting the effects of BCG. ..