O T Raitakari

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint Carotid artery compliance in users of plant stanol ester margarine
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Eur J Clin Nutr 62:218-24. 2008
  2. doi request reprint Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk
    Olli T Raitakari
    Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Atherosclerosis 226:245-51. 2013
  3. pmc No association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study
    Kati Lähteelä
    Department of Medical Biochemistry, University of Tampere Medical School, Tampere, Finland
    BMC Med Genet 13:32. 2012
  4. doi request reprint Socioeconomic status, cardiovascular risk factors, and subclinical atherosclerosis in young adults: the cardiovascular risk in Young Finns Study
    Paula Kestilä
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, and Department of Medicine, Turku University Hospital, Turku, Finland
    Arterioscler Thromb Vasc Biol 32:815-21. 2012
  5. pmc Effects of cognac on coronary flow reserve and plasma antioxidant status in healthy young men
    Tuomas O Kiviniemi
    Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
    Cardiovasc Ultrasound 6:25. 2008
  6. pmc Does neuregulin-1 play a role in Type A behavior? The cardiovascular risk in young Finns study
    Helena M Service
    Department of Psychology, University of Helsinki, Finland
    Behav Brain Funct 4:40. 2008
  7. pmc Early atherosclerosis and cardiac autonomic responses to mental stress: a population-based study of the moderating influence of impaired endothelial function
    Nadja Chumaeva
    Institute of Behavioural Sciences, University of Helsinki, PO Box 9, FIN 00014 Helsinki, Finland
    BMC Cardiovasc Disord 10:16. 2010
  8. pmc Sex differences in the combined effect of chronic stress with impaired vascular endothelium functioning and the development of early atherosclerosis: the Cardiovascular Risk in Young Finns study
    Nadja Chumaeva
    Institute of Behavioral Sciences, University of Helsinki, PO Box 9, 00014 Helsinki, Finland
    BMC Cardiovasc Disord 10:34. 2010
  9. ncbi request reprint Associations between physical activity and risk factors for coronary heart disease: the Cardiovascular Risk in Young Finns Study
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    Med Sci Sports Exerc 29:1055-61. 1997
  10. ncbi request reprint Endothelial function in healthy 11-year-old children after dietary intervention with onset in infancy: the Special Turku Coronary Risk Factor Intervention Project for children (STRIP)
    Olli T Raitakari
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Circulation 112:3786-94. 2005

Detail Information

Publications139 found, 100 shown here

  1. ncbi request reprint Carotid artery compliance in users of plant stanol ester margarine
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Eur J Clin Nutr 62:218-24. 2008
    ..To investigate the effects of stanol ester margarine use in healthy subjects on arterial compliance, endothelial function and intima-media thickness...
  2. doi request reprint Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk
    Olli T Raitakari
    Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Atherosclerosis 226:245-51. 2013
    ..We used computational methods to estimate apoB and apoA1 from serum total cholesterol, HDL-cholesterol and triglycerides and tested their clinical value in comparison to measured apoB and apoA1 values...
  3. pmc No association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study
    Kati Lähteelä
    Department of Medical Biochemistry, University of Tampere Medical School, Tampere, Finland
    BMC Med Genet 13:32. 2012
    ....
  4. doi request reprint Socioeconomic status, cardiovascular risk factors, and subclinical atherosclerosis in young adults: the cardiovascular risk in Young Finns Study
    Paula Kestilä
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, and Department of Medicine, Turku University Hospital, Turku, Finland
    Arterioscler Thromb Vasc Biol 32:815-21. 2012
    ....
  5. pmc Effects of cognac on coronary flow reserve and plasma antioxidant status in healthy young men
    Tuomas O Kiviniemi
    Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
    Cardiovasc Ultrasound 6:25. 2008
    ..The purpose of this randomized controlled cross-over study was to determine whether moderate doses of cognac improve coronary reactivity as assessed with cold pressor testing (CPT) and coronary flow reserve (CFR) measurement...
  6. pmc Does neuregulin-1 play a role in Type A behavior? The cardiovascular risk in young Finns study
    Helena M Service
    Department of Psychology, University of Helsinki, Finland
    Behav Brain Funct 4:40. 2008
    ..abstract:..
  7. pmc Early atherosclerosis and cardiac autonomic responses to mental stress: a population-based study of the moderating influence of impaired endothelial function
    Nadja Chumaeva
    Institute of Behavioural Sciences, University of Helsinki, PO Box 9, FIN 00014 Helsinki, Finland
    BMC Cardiovasc Disord 10:16. 2010
    ..The present study aims to examine the interactive effect of acute mental stress-induced cardiac reactivity/recovery and endothelial function on the prevalence of carotid atherosclerosis...
  8. pmc Sex differences in the combined effect of chronic stress with impaired vascular endothelium functioning and the development of early atherosclerosis: the Cardiovascular Risk in Young Finns study
    Nadja Chumaeva
    Institute of Behavioral Sciences, University of Helsinki, PO Box 9, 00014 Helsinki, Finland
    BMC Cardiovasc Disord 10:34. 2010
    ....
  9. ncbi request reprint Associations between physical activity and risk factors for coronary heart disease: the Cardiovascular Risk in Young Finns Study
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    Med Sci Sports Exerc 29:1055-61. 1997
    ..The promotion of physical activity is important in childhood in preventing obesity and premature cardiovascular disease...
  10. ncbi request reprint Endothelial function in healthy 11-year-old children after dietary intervention with onset in infancy: the Special Turku Coronary Risk Factor Intervention Project for children (STRIP)
    Olli T Raitakari
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Circulation 112:3786-94. 2005
    ..Early childhood introduction of nutritional habits aimed at atherosclerosis prevention reduces children's serum total cholesterol concentration, but its effect on vascular endothelial function is unknown...
  11. doi request reprint Pulse pressure in youth and carotid intima-media thickness in adulthood: the cardiovascular risk in young Finns study
    Olli T Raitakari
    Departments of Clinical Physiology, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Stroke 40:1519-21. 2009
    ..We examined whether exposure to large pulse pressure in childhood predicts carotid artery intima-media thickness in adulthood...
  12. ncbi request reprint Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study
    Olli T Raitakari
    Department of Clinical Physiology and PET Centre, University of Turku, Turku
    JAMA 290:2277-83. 2003
    ..Exposure to cardiovascular risk factors during childhood and adolescence may be associated with the development of atherosclerosis later in life...
  13. ncbi request reprint Arterial abnormalities in children with familial hypercholesterolaemia
    Olli T Raitakari
    Cardiorespiratory Research Unit, University of Turku, FIN 20520 Turku, Finland
    Lancet 363:342-3. 2004
  14. doi request reprint Common variation in NOS1AP and KCNH2 genes and QT interval duration in young adults. The Cardiovascular Risk in Young Finns Study
    Olli T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    Ann Med 41:144-51. 2009
    ..Common genetic variants in the nitric oxide synthase 1 adaptor protein gene (NOS1AP) and in the HERG potassium channel gene (KCNH2) have been associated with cardiac repolarization in middle-aged and elderly subjects...
  15. ncbi request reprint Reduced myocardial flow reserve relates to increased carotid intima-media thickness in healthy young men
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Atherosclerosis 156:469-75. 2001
    ....
  16. ncbi request reprint Increased arterial intima-media thickness and in vivo LDL oxidation in young men with borderline hypertension
    J O Toikka
    Department of Clinical Physiology, Turku University Hospital, Finland
    Hypertension 36:929-33. 2000
    ..These results are consistent with the idea that enhanced ox-LDL may be one of the pathophysiological events related to development of atherosclerosis in men with borderline elevated blood pressure...
  17. ncbi request reprint Testing for endothelial dysfunction
    O T Raitakari
    Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
    Ann Med 32:293-304. 2000
    ..This review outlines the current status of markers of endothelial dysfunction, particularly those related to vasomotor control, as well as circulating markers of vascular health...
  18. ncbi request reprint Variation of the transcription factor 7-like 2 (TCF7L2) gene predicts impaired fasting glucose in healthy young adults: the Cardiovascular Risk in Young Finns Study
    Olli T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    Diabetes Care 30:2299-301. 2007
  19. ncbi request reprint In vivo low density lipoprotein oxidation relates to coronary reactivity in young men
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    J Am Coll Cardiol 30:97-102. 1997
    ..This study was undertaken to examine the relation of in vivo low density lipoprotein (LDL) oxidation and other lipid risk factors to coronary reactivity in normal subjects...
  20. ncbi request reprint Reduced myocardial flow reserve does not impair exercise capacity in asymptomatic men
    O T Raitakari
    Department of Clinical Physiology, Turku PET Center, University of Turku, Finland
    Am J Cardiol 84:1253-5, A8. 1999
    ....
  21. ncbi request reprint Coronary flow reserve is reduced in young men with IDDM
    O P Pitkanen
    Department of Medicine, University of Turku, Finland
    Diabetes 47:248-54. 1998
    ..The results imply early impairment of coronary vascular reactivity in IDDM patients, which may represent an early precursor of future coronary heart disease or may contribute to the pathogenesis of diabetic cardiomyopathy...
  22. ncbi request reprint Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the cardiovascular risk in young Finns study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Circulation 110:2918-23. 2004
    ..We examined their correlation and interaction with risk factors in a large, community-based cohort of young adults...
  23. doi request reprint Breast feeding in infancy and arterial endothelial function later in life. The Cardiovascular Risk in Young Finns Study
    M J Järvisalo
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Eur J Clin Nutr 63:640-5. 2009
    ..We examined the association between breast feeding in infancy and arterial function and structure in adulthood in a population-based cohort of Finnish adults...
  24. ncbi request reprint Angiotensin-converting enzyme gene polymorphism and coronary reactivity in young men
    M Kahonen
    Department of Clinical Physiology, Tampere University Hospital and Medical School, University of Tampere, Finland
    Scand J Clin Lab Invest 67:596-603. 2007
    ..In conclusion, the ACE I/D polymorphism does not seem to affect myocardial reactivity--an early indicator of atherosclerosis--in healthy subjects...
  25. ncbi request reprint Geographic origin as a determinant of carotid artery intima-media thickness and brachial artery flow-mediated dilation: the Cardiovascular Risk in Young Finns study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 25:392-8. 2005
    ..Whether this is because of genetic or environmental factors is unknown. We examined the effect of geographic family origin on subclinical atherosclerosis among young Finns...
  26. doi request reprint Follow-ups of the Cardiovascular Risk in Young Finns Study in 2001 and 2007: levels and 6-year changes in risk factors
    J R H Raiko
    Department of Cardiovascular Research Center, University of Turku, Turku, Finland
    J Intern Med 267:370-84. 2010
    ..To examine cardiovascular risk factor levels in 2007 and their 6-year changes between 2001 and 2007 using the data collected in the follow-ups of the Cardiovascular Risk in Young Finns Study...
  27. ncbi request reprint Increased aortic intima-media thickness: a marker of preclinical atherosclerosis in high-risk children
    M J Järvisalo
    Department of Clinical Physiology, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Circulation 104:2943-7. 2001
    ....
  28. ncbi request reprint Lifetime glycaemic exposure predicts reduced coronary vasoreactivity in Type 1 diabetic subjects
    J Sundell
    Turku PET Centre, University of Turku, FIN 2052 Turku, Finland
    Diabet Med 22:45-51. 2005
    ..We examined the effect of lifetime glycaemic exposure on coronary vasoreactivity in 43 otherwise healthy Type 1 diabetic subjects...
  29. ncbi request reprint Associations of education with cardiovascular risk factors in young adults: the Cardiovascular Risk in Young Finns Study
    M Leino
    Cardiorespiratory Research Unit, University of Turku, Finland
    Int J Epidemiol 28:667-75. 1999
    ..Low educational level is associated with an increased risk of coronary heart disease. The aim of the present study was to examine the relationships between education and common cardiovascular risk factors in young adults...
  30. doi request reprint Dietary and lifestyle counselling reduces the clustering of overweight-related cardiometabolic risk factors in adolescents
    M Hakanen
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Acta Paediatr 99:888-95. 2010
    ....
  31. ncbi request reprint Large-artery elastic properties in young men : relationships to serum lipoproteins and oxidized low-density lipoproteins
    J O Toikka
    Department of Clinical Physiology, Turku University Central Hospital, Finland
    Arterioscler Thromb Vasc Biol 19:436-41. 1999
    ..The current study demonstrates for the first time an in vivo association between ox-LDL and arterial elasticity suggesting that oxidative modification of LDL may play a role in the alteration of arterial wall elastic properties...
  32. doi request reprint Lifetime risk factors and arterial pulse wave velocity in adulthood: the cardiovascular risk in young Finns study
    Heikki Aatola
    Department of Clinical Physiology, Tampere University Hospital, PO Box 2000, FI 33521 Tampere, Finland
    Hypertension 55:806-11. 2010
    ..These results support efforts for a reduction of conventional risk factors both in childhood and adulthood in the primary prevention of atherosclerosis...
  33. ncbi request reprint Diabetic background retinopathy is associated with impaired coronary vasoreactivity in people with Type 1 diabetes
    J Sundell
    Turku PET Centre, Turku University Central Hospital, Turku, Finland
    Diabetologia 47:725-31. 2004
    ..We examined whether diabetic background retinopathy is associated with reduced coronary vasoreactivity in people with Type 1 diabetes...
  34. ncbi request reprint The effect of 12-month enzyme replacement therapy on myocardial perfusion in patients with Fabry disease
    R J Kalliokoski
    Turku PET Centre, University of Turku, PO Box 52, FIN 20521 Turku, Finland
    J Inherit Metab Dis 29:112-8. 2006
    ..However, individual variation in the response to therapy was large and the results suggest that the success of the therapy may depend on the degree of cardiac hypertrophy...
  35. ncbi request reprint Obesity in childhood and vascular changes in adulthood: insights into the Cardiovascular Risk in Young Finns Study
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    Int J Obes (Lond) 29:S101-4. 2005
    ..This paper reviews recent findings from the Cardiovascular Risk in Young Finns Study looking at the relationships between risk factors identified in childhood, including obesity, and arterial structure/function assessed in adulthood...
  36. ncbi request reprint Higher prevalence of Chlamydia pneumoniae seropositivity in Finnish twins compared with co-twins living in Sweden: relationships with markers of subclinical atherosclerosis
    Laura Jartti
    Department of Medicine, University of Turku, Turku, Finland
    Clin Sci (Lond) 105:303-13. 2003
    ..These findings offer insight into the mechanism whereby chronic Cpn infection may increase the risk of coronary heart disease...
  37. doi request reprint Migration at early age from a high to a lower coronary heart disease risk country lowers the risk of subclinical atherosclerosis in middle-aged men
    L Jartti
    Department of Geriatric Medicine, University of Turku, Turku, Finland
    J Intern Med 265:345-58. 2009
    ..In Sweden, CHD risk has been markedly lower than in Finland from where a large migration occurred in the 1970s...
  38. ncbi request reprint Relationship between leptin and C-reactive protein in young Finnish adults
    Liisa A Viikari
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20521 Turku, Finland
    J Clin Endocrinol Metab 92:4753-8. 2007
    ..Leptin and C-reactive protein (CRP) concentrations are increased in inflammation, and both have been linked to increased risk for cardiovascular diseases...
  39. ncbi request reprint Young adults with family history of coronary heart disease have increased arterial vulnerability to metabolic risk factors: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 26:1376-82. 2006
    ..We investigated the occurrence of subclinical atherosclerosis in young adults with family history of CHD and tested the hypothesis that their arteries are more vulnerable to the proatherogenic effects of metabolic risk factors...
  40. ncbi request reprint Weight reduction with very-low-caloric diet and endothelial function in overweight adults: role of plasma glucose
    Maria Raitakari
    Department of Clinical Chemistry, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 24:124-8. 2004
    ..Obesity is associated with endothelial dysfunction that may contribute to the development of atherosclerosis. We studied whether weight reduction improves endothelial function in overweight individuals...
  41. ncbi request reprint Impaired myocardial perfusion reserve but preserved peripheral endothelial function in patients with Fabry disease
    R J Kalliokoski
    Turku PET Centre, University of Turku, Turku, Finland
    J Inherit Metab Dis 28:563-73. 2005
    ..6, p=0.02), while the brachial artery flow-mediated dilatation was similar (5.9%+/-3.9% vs 4.5%+/-3.6%, p=0.27). Thus, inFabry disease, myocardial perfusion reserve is reduced while the peripheral artery endothelial function is preserved...
  42. ncbi request reprint Cardiovascular risk factors of young adults in relation to parental socioeconomic status: the Cardiovascular Risk in Young Finns Study
    M Leino
    Cardiorespiratory Research Unit, University of Turku, Finland
    Ann Med 32:142-51. 2000
    ....
  43. ncbi request reprint Myocardial perfusion reserve and peripheral endothelial function in patients with idiopathic dilated cardiomyopathy
    Kira Q Stolen
    Turku PET Centre, Turku, Finland
    Am J Cardiol 93:64-8. 2004
    ..57; p = 0.04). Thus, abnormal myocardial perfusion characterizes patients with IDC. Myocardial perfusion reserve and peripheral endothelial function do not parallel each other in patients with IDC...
  44. doi request reprint Metabolic syndrome and short-term heart rate variability in young adults. The cardiovascular risk in young Finns study
    T Koskinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Diabet Med 26:354-61. 2009
    ....
  45. doi request reprint The Leu7Pro polymorphism of the signal peptide of neuropeptide Y (NPY) gene is associated with increased levels of inflammatory markers preceding vascular complications in patients with type 2 diabetes
    U Jaakkola
    Centre for Biotechnology, University of Turku, Tykistokatu 6, Turku, Finland
    Microvasc Res 80:433-9. 2010
    ..Currently, we followed diabetes patients to investigate, if the Pro7 allele is associated with the inflammation related to atherosclerosis...
  46. ncbi request reprint Obesity in youth is not an independent predictor of carotid IMT in adulthood. The Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Atherosclerosis 185:388-93. 2006
    ..610 mm versus 0.627 mm, respectively. We conclude that being obese in youth is associated with increased carotid IMT in adulthood, but this relationship is explained by significant tracking of body mass from youth to adulthood...
  47. ncbi request reprint Childhood C-reactive protein in predicting CRP and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    The Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 26:1883-8. 2006
    ..The value of measuring inflammatory markers in the pediatric risk assessment, however, is uncertain. We examined whether childhood C-reactive protein (CRP) levels predict CRP and carotid intima-media thickness (IMT) in adulthood...
  48. pmc Insulin induced increase in coronary flow reserve is abolished by dexamethasone in young men with uncomplicated type 1 diabetes
    H Laine
    Turku PET Centre, Turku University Central Hospital, Turku, Finland
    Heart 90:270-6. 2004
    ..To examine the role of the sympathetic nervous system in regulating insulin's action on coronary perfusion in uncomplicated type 1 diabetes by blocking centrally mediated sympathetic activity with dexamethasone...
  49. ncbi request reprint Associations between diet and the hyperapobetalipoproteinemia phenotype expression in children and young adults: the Cardiovascular Risk in Young Finns Study
    I O Nuotio
    Department of Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 17:820-5. 1997
    ..33) than in others (0.28, P=.019). Our results imply that the fatty acid composition of the diet may be one of the environmental factors that influence the hyperapoB phenotype expression...
  50. pmc Relationship between limb and muscle blood flow in man
    M Raitakari
    Turku PET Center, Department of Medicine, University of Turku, Finland
    J Physiol 496:543-9. 1996
    ..4. These data provide a new equation for estimation of resting muscle blood flow in normal subjects, and demonstrate that muscle blood flow is the primary determinant of resting blood flow in man...
  51. doi request reprint Obesity, adipokines and asthma
    T Jartti
    The Department of Pediatrics, Turku University Hospital, PO Box 52, FIN 20520 Turku, Finland
    Allergy 64:770-7. 2009
    ..Our objective was to examine whether obesity is associated with asthma in three time points of life, and whether immunomodulatory adipokines, leptin and adiponectin are linked to overweight-associated asthma...
  52. doi request reprint Conventional cardiovascular risk factors and metabolic syndrome in predicting carotid intima-media thickness progression in young adults: the cardiovascular risk in young Finns study
    Juha Koskinen
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Circulation 120:229-36. 2009
    ..We evaluated the relations of conventional risk factors and MetS to the 6-year progression of carotid intima-media thickness (IMT) in a population of young adults...
  53. doi request reprint Associations of dyslipidemias from childhood to adulthood with carotid intima-media thickness, elasticity, and brachial flow-mediated dilatation in adulthood: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 28:1012-7. 2008
    ..In the present study, we examined the effects of dyslipidemias from childhood to adulthood and their interaction with nonlipid risk factors on markers of subclinical atherosclerosis...
  54. ncbi request reprint Elevated blood pressure in adolescent boys predicts endothelial dysfunction: the cardiovascular risk in young Finns study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Hypertension 48:424-30. 2006
    ....
  55. ncbi request reprint Enhanced endothelium-dependent vasodilation in subjects with Proline7 substitution in the signal peptide of neuropeptide Y
    Mikko J Jarvisalo
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Atherosclerosis 167:319-26. 2003
    ..Prospective studies are needed to determine whether Pro7 substitution is associated with increased or decreased risk of cardiovascular morbidity and mortality...
  56. doi request reprint HDL-cholesterol, blood pressure, and asymmetric dimethylarginine are significantly associated with arterial wall thickness in children
    Julian G Ayer
    Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
    Arterioscler Thromb Vasc Biol 29:943-9. 2009
    ..As the determinants of arterial wall thickness in childhood are unknown, we assessed the influence of cardiovascular risk factors on CIMT in 8-year-old children...
  57. doi request reprint Plant stanol ester consumption and arterial elasticity and endothelial function
    Olli T Raitakari
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Br J Nutr 100:603-8. 2008
    ..A controlled study is needed to test whether beneficial changes are obtained in subjects with initially reduced arterial elasticity and endothelial function...
  58. ncbi request reprint Pulse wave velocity reference values in healthy adults aged 26-75 years
    T Koivistoinen
    Department of Clinical Physiology, Medical School, University of Tampere, and Tampere University Hopsital, Tampere, Finland
    Clin Physiol Funct Imaging 27:191-6. 2007
    ..Reference values can be useful in the clinical management of patients, especially in detecting early vascular disease or an increased risk of cardiovascular complications...
  59. ncbi request reprint Patterns of intense physical activity among 15- to 30-year-old Finns. The Cardiovascular Risk in Young Finns Study
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    Scand J Med Sci Sports 6:36-9. 1996
    ..Young males seem to be physically more active than females...
  60. ncbi request reprint Risk factors for coronary heart disease in children and young adults
    J S A Viikari
    Department of Medicine, University of Turku, Turku, Finland
    Acta Paediatr Suppl 93:34-42. 2004
    ..Neurological development of the intervention children at age 5 y was at least as good as that of the control children. Counselling had no effect on children's growth...
  61. ncbi request reprint Effect of Lp(a) on the early functional and structural changes of atherosclerosis
    O T Raitakari
    Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
    Arterioscler Thromb Vasc Biol 19:990-5. 1999
    ..01). These data suggest that elevated Lp(a) levels do not confer cardiovascular risk by contributing to the early functional or structural changes of atherosclerosis...
  62. ncbi request reprint The 21-year follow-up of the Cardiovascular Risk in Young Finns Study: risk factor levels, secular trends and east-west difference
    M Juonala
    The Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    J Intern Med 255:457-68. 2004
    ..We have collected risk factor data in the 21-year follow-up performed in 2001. The aims of this analysis were to examine the levels, secular trends and east-west difference in risk factors amongst young adults...
  63. ncbi request reprint Decreased large artery distensibility in borderline hypertension is related to increased in vivo low-density lipoprotein oxidation
    J O Toikka
    Department of Clinical Physiology, Turku University Central Hospital, Finland
    Scand J Clin Lab Invest 62:301-6. 2002
    ....
  64. ncbi request reprint Elevated serum C-reactive protein levels and early arterial changes in healthy children
    Mikko J Jarvisalo
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Arterioscler Thromb Vasc Biol 22:1323-8. 2002
    ....
  65. ncbi request reprint Myocardial perfusion and perfusion reserve in endurance-trained men
    Kari K Kalliokoski
    Turku PET Centre, Turku, Finland
    Med Sci Sports Exerc 34:948-53. 2002
    ..This study was undertaken to determine whether endurance training is associated with changes in myocardial perfusion in humans...
  66. ncbi request reprint Relation of apolipoprotein E polymorphism to markers of early atherosclerotic changes in young adults--the Cardiovascular Risk in Young Finns Study
    Paula Grönroos
    Department of Clinical Chemistry, University of Turku, Turku, Finland
    Circ J 72:29-34. 2008
    ..Also brachial flow-mediated dilatation (FMD) and carotid artery compliance (CAC) were determined to clarify their relation to this genetic factor...
  67. doi request reprint Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects
    Antti P M Viljanen
    Turku PET Centre, University of Turku, Turku University Hospital, Finland
    Ann Med 41:152-60. 2009
    ..The aim was to investigate the effects of VLCD on adipose tissue regional glucose uptake (rGU) and perfusion and their association with adipokines...
  68. ncbi request reprint Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young Finns study
    Markus Juonala
    Department of Medicine, University of Turku, 20521 Turku, Finland
    Circulation 116:1367-73. 2007
    ..To gain insight into the effects of ADMA on systemic endothelial function, we examined the association between ADMA and brachial artery flow-mediated dilation (FMD) in a large population of young adults...
  69. ncbi request reprint The prevalence of the metabolic syndrome in young adults. The Cardiovascular Risk in Young Finns Study
    N Mattsson
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    J Intern Med 261:159-69. 2007
    ..We also investigated the secular trend in the metabolic syndrome amongst 24-year-old adults from 1986 to 2001...
  70. ncbi request reprint Deletion polymorphism in the alpha2B-adrenergic receptor gene is associated with flow-mediated dilatation of the brachial artery
    Paula Heinonen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itainen Pitkakatu 4B, Finland
    Clin Sci (Lond) 103:517-24. 2002
    ..It is not known whether the association of the alpha(2B)-AR polymorphism with endothelial function is direct, or is mediated via altered sympathetic activation...
  71. ncbi request reprint Arterial structure and function in young adults with the metabolic syndrome: the Cardiovascular Risk in Young Finns Study
    Noora Mattsson
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Eur Heart J 29:784-91. 2008
    ..To study the relations between the metabolic syndrome (MS) and subclinical atherosclerosis in young adults...
  72. ncbi request reprint Early impairment of coronary flow reserve is not associated with Chlamydia pneumoniae antibodies
    Tuula Janatuinen
    Turku PET Centre, University of Turku, Finland
    Ann Med 34:284-90. 2002
    ..We hypothesized that if chlamydial infection is causative of atherosclerosis, the occurrence of antibodies against C. pneumoniae should be associated with coronary vasomotor dysfunction - an early sign of atherosclerosis...
  73. ncbi request reprint Increased carotid atherosclerosis in andropausal middle-aged men
    Juuso Mäkinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    J Am Coll Cardiol 45:1603-8. 2005
    ..This study examined the association between carotid artery intima-media thickness (IMT), serum sex hormone levels, and andropausal symptoms in middle-aged men...
  74. ncbi request reprint Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults
    Tuula Janatuinen
    Turku PET Centre, University of Turku, Finland
    Vasc Med 8:185-9. 2003
    ..004), whereas high baseline ADMA (> or = median) was associated with no increase in adenosine-induced flow...
  75. ncbi request reprint Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Circulation 112:1486-93. 2005
    ..Exposure to risk factors in childhood may have long-term influences on vascular function. We examined the relationship between risk factors identified in childhood and arterial elasticity assessed in adulthood...
  76. ncbi request reprint Carotid artery intima-media thickness in children with type 1 diabetes
    Mikko J Jarvisalo
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Diabetes 51:493-8. 2002
    ..These data also suggest that increased oxidative modification of LDL may be related to early structural atherosclerotic vascular changes in children with diabetes...
  77. ncbi request reprint Impact of repeated dietary counseling between infancy and 14 years of age on dietary intakes and serum lipids and lipoproteins: the STRIP study
    Harri Niinikoski
    Department of Pediatrics, University of Turku, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Circulation 116:1032-40. 2007
    ..The aims of the present study were to evaluate the effect of low-saturated-fat, low-cholesterol dietary counseling on fat intakes, growth, serum cholesterol values, and pubertal development in children and adolescents...
  78. ncbi request reprint Imaging of the endothelial dysfunction in coronary atherosclerosis
    J T Kuikka
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and Niuvanniemi Hospital, Finland
    Eur J Nucl Med 28:1567-78. 2001
    ....
  79. ncbi request reprint High-sensitivity C-reactive protein and impaired coronary vasoreactivity in young men with uncomplicated type 1 diabetes
    J Sundell
    Turku PET Centre, Turku University Central Hospital, P O Box 52, 20521 Turku, Finland
    Diabetologia 47:1888-94. 2004
    ..Elevated high-sensitivity C-reactive protein (hsCRP) concentrations indicate increased risk of future coronary events. The association between hsCRP and coronary vasoreactivity has not yet been examined in type 1 diabetic subjects...
  80. doi request reprint Childhood predictors of the metabolic syndrome in adulthood. The Cardiovascular Risk in Young Finns Study
    Noora Mattsson
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Ann Med 40:542-52. 2008
    ..Obese youths may be susceptible to develop the metabolic syndrome (MS) later in life...
  81. doi request reprint Childhood levels of serum apolipoproteins B and A-I predict carotid intima-media thickness and brachial endothelial function in adulthood: the cardiovascular risk in young Finns study
    Markus Juonala
    Department of Medicine, University of Turku, Turku, Finland
    J Am Coll Cardiol 52:293-9. 2008
    ..The aim of this study was to determine whether apolipoproteins (apo) B and A-I measured in childhood and adolescence predict atherosclerosis in adulthood...
  82. ncbi request reprint High serum leptin is associated with attenuated coronary vasoreactivity
    Jan Sundell
    Department of Medicine, Turku University, Turku, Finland
    Obes Res 11:776-82. 2003
    ..We examined the association between circulating leptin concentration and coronary vasoreactivity in young obese and nonobese males...
  83. ncbi request reprint Nutritional influences on lipids and future atherosclerosis beginning prenatally and during childhood
    Jorma S A Viikari
    Department of Medicine, University of Turku, Turku, Finland
    Curr Opin Lipidol 13:11-8. 2002
    ..We now review recent studies that deal with the effects of fetal and childhood nutrition on serum lipid values, and discuss the likelihood that clinically meaningful changes of atherosclerosis may appear earlier than expected...
  84. ncbi request reprint Late-onset hypogonadism in men. Experience from the Turku Male Ageing Study (TuMAS)
    Ilpo Huhtaniemi
    Department of Physiology, University of Turku, Turku, Finland
    Hormones (Athens) 7:36-45. 2008
    ..This review summarises the recent key findings in this study, with special reference to the correlation of androgen levels with sexual symptoms and cardiovascular risk factors...
  85. ncbi request reprint Serum lipid profiles poorly correlate with Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus seropositivity in prospectively followed-up healthy children
    Iina Volanen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Arterioscler Thromb Vasc Biol 25:827-32. 2005
    ..We also looked for factors increasing probability of Cpn seropositivity in children...
  86. ncbi request reprint Effect of age and sex on carotid intima-media thickness, elasticity and brachial endothelial function in healthy adults: the cardiovascular risk in Young Finns Study
    Markus Juonala
    Department of Medicine, University of Turku, PO Box 52, 20521 Turku, Finland
    Eur Heart J 29:1198-206. 2008
    ..The objective was to produce reference values and to analyse the associations of age and sex with carotid intima-media thickness (IMT), carotid compliance (CAC), and brachial flow-mediated dilatation (FMD) in young healthy adults...
  87. ncbi request reprint Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes
    Mikko J Jarvisalo
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Circulation 109:1750-5. 2004
    ....
  88. doi request reprint Arterial intima-media thickness in 13-year-old adolescents and previous antichlamydial antimicrobial use: a retrospective follow-up study
    Iina Volanen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Pediatrics 122:e675-81. 2008
    ..Children with persistent Chlamydia pneumoniae infection may be at increased risk for atherosclerosis. The impact of antimicrobial therapy for primary prevention of atherosclerotic cardiovascular disease is unsolved...
  89. doi request reprint High dose of red wine elicits enhanced inhibition of fibrinolysis
    Tuomas O Kiviniemi
    Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
    Eur J Cardiovasc Prev Rehabil 16:161-3. 2009
    ..The purpose of this randomized controlled cross-over study was to determine the acute effects of high doses of alcoholic beverages on circulating markers related to atherosclerosis and fibrinolysis...
  90. ncbi request reprint Determinants of arterial nitrate-mediated dilatation in children: role of oxidized low-density lipoprotein, endothelial function, and carotid intima-media thickness
    Mikko J Jarvisalo
    Department of Clinical Physiology and Turku PET Centre, Turku University Hospital, Kiinamyllynkatu 4 8, FIN 20520 Turku, Finland
    Circulation 109:2885-9. 2004
    ..Because atherosclerosis begins in childhood, we examined the correlates of nitrate-mediated dilatation (NMD) in children, including brachial artery endothelial function, oxidized LDL, and carotid artery intima-media thickness (IMT)...
  91. ncbi request reprint A moderate dose of red wine, but not de-alcoholized red wine increases coronary flow reserve
    Tuomas O Kiviniemi
    Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Kiinamyllynkatu 4 8, FIN 20520 Turku, Finland
    Atherosclerosis 195:e176-81. 2007
    ..The purpose of this randomized controlled cross-over study was to determine whether moderate doses of red wine and de-alcoholized red wine improve coronary flow velocity reserve (CFR)...
  92. ncbi request reprint Determinants of coronary flow velocity reserve in healthy young men
    Tuomas O Kiviniemi
    Department of Clinical Physiology, Nuclear Medicine and PET, Turku University Hospital, Turku, Finland
    Am J Physiol Heart Circ Physiol 291:H564-9. 2006
    ..We found no relationship between CFVR and serum lipids or body mass index. We conclude that abdominal fat accumulation and low aerobic fitness are independently associated with CFVR in men...
  93. doi request reprint Effect of caloric restriction on myocardial fatty acid uptake, left ventricular mass, and cardiac work in obese adults
    Antti P M Viljanen
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Am J Cardiol 103:1721-6. 2009
    ..These results show that the increased fatty acid uptake found in the hearts of obese patients can be reversed by weight loss...
  94. doi request reprint Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine St
    Markus Juonala
    Department of Medicine, Turku University Hospital, Kiinamyllynkatu 4 8, FIN 20520 Turku, Finland
    Circulation 122:2514-20. 2010
    ..The aim of this study was to investigate the influence of age on the associations between childhood risk factors and carotid artery intima-media thickness, a marker of subclinical atherosclerosis...
  95. ncbi request reprint Positive family history of coronary artery disease is associated with reduced myocardial vasoreactivity in healthy men
    Jan Sundell
    Turku PET Centre, Turku University, Central Hospital, Turku, Finland
    Int J Cardiol 112:289-94. 2006
    ..We examined the association between family history of coronary artery disease and myocardial vasoreactivity in healthy men...
  96. ncbi request reprint Brachial artery dilatation responses in healthy children and adolescents
    Mikko J Jarvisalo
    Department of Clinical Physiology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Am J Physiol Heart Circ Physiol 282:H87-92. 2002
    ..When studying endothelial function in children with the use of the noninvasive ultrasound method, several brachial artery diameter measurements up to 120 s after cuff release are needed to determine the true FMD peak response...
  97. ncbi request reprint Vasodilation of epicardial coronary artery can be measured with transthoracic echocardiography
    Tuomas O Kiviniemi
    Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
    Ultrasound Med Biol 33:362-70. 2007
    ..6 to 8.2%), suggesting good reproducibility. This study demonstrates that TTE can be used to assess changes in both epicardial coronary artery diameter and flow velocity simultaneously in the distal LAD artery...
  98. doi request reprint Tracking of noninvasive ultrasound measurements of subclinical atherosclerosis in adulthood: findings from the Cardiovascular Risk in Young Finns Study
    Juho R H Raiko
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Ultrasound Med Biol 36:1237-44. 2010
    ..36; r = 0.19, p = 0.01). In conclusion, ultrasound measurements tracked low to moderate over 6-years and was influenced by cardiovascular disease (CVD) risk factor status...
  99. doi request reprint Metabolic syndrome and carotid intima-media thickness in young adults: roles of apolipoprotein B, apolipoprotein A-I, C-reactive protein, and secretory phospholipase A2: the cardiovascular risk in young Finns study
    Noora Mattsson
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Finland
    Arterioscler Thromb Vasc Biol 30:1861-6. 2010
    ..We examined whether the association between carotid atherosclerosis and MetS in a population of young adults is mediated by apoB and apoA-I and/or by inflammatory markers C-reactive protein and type II secretory phospholipase A2...
  100. doi request reprint Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study
    Markus Juonala
    Department of Medicine, University of Turku and Turku University Central Hospital, PO Box 52, 20500 Turku, Finland
    Eur Heart J 31:1745-51. 2010
    ..The aim of this study is to evaluate whether childhood risk factors are associated with a 6-year change in carotid intima-media thickness (IMT) in young adulthood independent of the current risk factors...
  101. ncbi request reprint Endogenous testosterone and serum lipids in middle-aged men
    Juuso I Mäkinen
    Department of Clinical Physiology, University of Turku, FIN 20520 Turku, Finland
    Atherosclerosis 197:688-93. 2008
    ..The role of decreasing testosterone levels influencing lipid metabolism in aging men is not well established...