Research Topics
| Oscar PuigSummaryAffiliation: University of Helsinki Country: Finland Publications
| Collaborators
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Detail Information
Publications
The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and humanOscar Puig
European Molecular Biology Laboratory, Meyerhofstrasse, 1, 69117 Heidelberg, Germany
Nucleic Acids Res 35:5874-85. 2007..Taken together, our data suggest that the formation of a wide network of protein-RNA interactions around the 5' splice site by U1 snRNP-associated factors contributes to alternative splicing regulation...- The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sitesPatrik Förch
Gene Expression Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
EMBO J 21:6882-92. 2002.... 
Nutrient availability and growth: regulation of insulin signaling by dFOXO/FOXO1Oscar Puig
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
Cell Cycle 5:503-5. 2006..Recent studies with the fruit fly Drosophila melanogaster have provided new insights into the regulatory circuitry that controls both growth and gene expression in response to nutrient availability...- Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathwayOscar Puig
Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Genes Dev 17:2006-20. 2003..Our results establish dFOXO as a key transcriptional regulator of the insulin pathway that modulates growth and proliferation... 
dFOXO regulates transcription of a Drosophila acid lipaseTerhi Vihervaara
Institute of Biotechnology, University of Helsinki, Viikinkaari 9, 00014 Helsinki, Finland
J Mol Biol 376:1215-23. 2008..Our results support a model where dFOXO acts as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis...- High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXOBoris Gershman
Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
Physiol Genomics 29:24-34. 2007.... - IRES-mediated functional coupling of transcription and translation amplifies insulin receptor feedbackMichael T Marr
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA
Genes Dev 21:175-83. 2007.... - Characterization of the Drosophila insulin receptor promoterSergio Casas Tinto
Institute of Biotechnology, University of Helsinki, Viikinkaari 9, FIN 00014, Finland
Biochim Biophys Acta 1769:236-43. 2007..Our results indicate that dInR expression in Drosophila displays an intricate pattern of regulation that assures an adequate control of growth, development and metabolism... - Foxo and Fos regulate the decision between cell death and survival in response to UV irradiationXi Luo
Department of Biology, University of Rochester, Rochester, NY 14627, USA
EMBO J 26:380-90. 2007..These data suggest that integrating stress and survival signals through Foxo drives the decision between cell death and repair of damaged cells in vivo... - Transcriptional feedback control of insulin receptor by dFOXO/FOXO1Oscar Puig
Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Genes Dev 19:2435-46. 2005..Our results reveal a key feedback control mechanism for dFOXO/FOXO1 in regulating metabolism and insulin signaling... - FOXO-regulated transcription restricts overgrowth of Tsc mutant organsKieran F Harvey
Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
J Cell Biol 180:691-6. 2008..Analogous transcriptional changes are observed in mammalian cells, which implies that FOXO attenuates TOR-driven growth in diverse species...