Ilkka H Porsti

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. ncbi request reprint Long-term physical exercise and atrial natriuretic peptide in obese Zucker rats
    Ilkka Porsti
    Department of Pharmacological Sciences, University of Tempere, 33014 Tampere, Finland
    Pharmacol Toxicol 91:8-12. 2002
  2. doi request reprint Expanding targets of vitamin D receptor activation: downregulation of several RAS components in the kidney
    Ilkka H Porsti
    Medical School, University of Tampere, Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Kidney Int 74:1371-3. 2008
  3. ncbi request reprint High calcium diet down-regulates kidney angiotensin-converting enzyme in experimental renal failure
    Ilkka Porsti
    Department of Internal Medicine, University of Tampere, Tampere, Finland
    Kidney Int 66:2155-66. 2004
  4. pmc High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica
    Tuula K Outinen
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    J Med Virol 83:731-7. 2011
  5. ncbi request reprint AT1 receptor blockade improves vasorelaxation in experimental renal failure
    Peeter Kööbi
    Department of Pharmacological Sciences, University of Tampere, Finland
    Hypertension 41:1364-71. 2003
  6. doi request reprint Metabolic syndrome may be associated with increased arterial stiffness even in the absence of hypertension: a study in 84 cases and 82 controls
    Pauliina Kangas
    School of Medicine, University of Tampere, 33014 Tampere, Finland
    Metabolism 62:1114-22. 2013
  7. pmc The severity of Puumala hantavirus induced nephropathia epidemica can be better evaluated using plasma interleukin-6 than C-reactive protein determinations
    Tuula K Outinen
    Department of Internal Medicine, Tampere University Hospital, POBox 2000, Tampere, FI 33521, Finland
    BMC Infect Dis 10:132. 2010
  8. doi request reprint The severity of acute Puumala hantavirus infection does not predict the long-term outcome of patients
    Marja H Miettinen
    Department of Internal Medicine, Central Hospital of Jyvaskyla, Jyvaskyla, Finland
    Nephron Clin Pract 116:c89-94. 2010
  9. doi request reprint Association of resting heart rate with cardiovascular function: a cross-sectional study in 522 Finnish subjects
    Jenni K Koskela
    School of Medicine, Department of Internal Medicine, University of Tampere, Tampere FIN 33014, Finland
    BMC Cardiovasc Disord 13:102. 2013
  10. doi request reprint Hemodynamic alterations in hypertensive patients at rest and during passive head-up tilt
    Antti J Tikkakoski
    School of Medicine, University of Tampere, Tampere, Finland
    J Hypertens 31:906-15. 2013

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Long-term physical exercise and atrial natriuretic peptide in obese Zucker rats
    Ilkka Porsti
    Department of Pharmacological Sciences, University of Tempere, 33014 Tampere, Finland
    Pharmacol Toxicol 91:8-12. 2002
    ....
  2. doi request reprint Expanding targets of vitamin D receptor activation: downregulation of several RAS components in the kidney
    Ilkka H Porsti
    Medical School, University of Tampere, Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Kidney Int 74:1371-3. 2008
    ....
  3. ncbi request reprint High calcium diet down-regulates kidney angiotensin-converting enzyme in experimental renal failure
    Ilkka Porsti
    Department of Internal Medicine, University of Tampere, Tampere, Finland
    Kidney Int 66:2155-66. 2004
    ..Calcium salts are used as phosphate binders in renal failure, while high calcium diet also improves vasorelaxation and enhances natriuresis. The influences of calcium intake on renal renin-angiotensin system (RAS) are largely unknown...
  4. pmc High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica
    Tuula K Outinen
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    J Med Virol 83:731-7. 2011
    ..1,900 ml/day, P<0.001) and longer hospital stays (8 vs. 5 days, P<0.001). In conclusion, high serum IDO activity was associated with increased disease severity and renal impairment in NE...
  5. ncbi request reprint AT1 receptor blockade improves vasorelaxation in experimental renal failure
    Peeter Kööbi
    Department of Pharmacological Sciences, University of Tampere, Finland
    Hypertension 41:1364-71. 2003
    ..The mechanism of improved vasodilation by losartan may include enhanced relaxation through potassium channels...
  6. doi request reprint Metabolic syndrome may be associated with increased arterial stiffness even in the absence of hypertension: a study in 84 cases and 82 controls
    Pauliina Kangas
    School of Medicine, University of Tampere, 33014 Tampere, Finland
    Metabolism 62:1114-22. 2013
    ..To evaluate the hemodynamic characteristics of metabolic syndrome (MetS) in the absence and presence of hypertension...
  7. pmc The severity of Puumala hantavirus induced nephropathia epidemica can be better evaluated using plasma interleukin-6 than C-reactive protein determinations
    Tuula K Outinen
    Department of Internal Medicine, Tampere University Hospital, POBox 2000, Tampere, FI 33521, Finland
    BMC Infect Dis 10:132. 2010
    ..The clinical course of the disease varies greatly in severity. The aim of the present study was to evaluate whether plasma C-reactive protein (CRP) and interleukin (IL)-6 levels associate with the severity of NE...
  8. doi request reprint The severity of acute Puumala hantavirus infection does not predict the long-term outcome of patients
    Marja H Miettinen
    Department of Internal Medicine, Central Hospital of Jyvaskyla, Jyvaskyla, Finland
    Nephron Clin Pract 116:c89-94. 2010
    ..The present aim was to establish whether the long-term outcome is determined by the severity of acute illness...
  9. doi request reprint Association of resting heart rate with cardiovascular function: a cross-sectional study in 522 Finnish subjects
    Jenni K Koskela
    School of Medicine, Department of Internal Medicine, University of Tampere, Tampere FIN 33014, Finland
    BMC Cardiovasc Disord 13:102. 2013
    ..We studied the association of resting HR with cardiovascular function, and examined whether the hemodynamics remained similar during passive head-up tilt...
  10. doi request reprint Hemodynamic alterations in hypertensive patients at rest and during passive head-up tilt
    Antti J Tikkakoski
    School of Medicine, University of Tampere, Tampere, Finland
    J Hypertens 31:906-15. 2013
    ..We compared hemodynamics in hypertensive versus normotensive patients at rest and during passive head-up tilt...
  11. ncbi request reprint High-calcium vs high-phosphate intake and small artery tone in advanced experimental renal insufficiency
    Peeter Kööbi
    Medical School, Department of Internal Medicine, FIN 33014, University of Tampere, Finland
    Nephrol Dial Transplant 21:2754-61. 2006
    ..Disturbed calcium-phosphorus balance significantly contributes to uraemic changes in large arteries. We examined the influences of high-calcium and high-phosphate intake on small artery tone in experimental renal insufficiency...
  12. ncbi request reprint Increased calcium intake reduces plasma cholesterol and improves vasorelaxation in experimental renal failure
    Pasi Jolma
    Department of Pharmacological Sciences, Medical School, University of Tampere, Tampere, FIN 33014, Finland
    Am J Physiol Heart Circ Physiol 285:H1882-9. 2003
    ....
  13. doi request reprint Supine and upright haemodynamic effects of sublingual nitroglycerin and inhaled salbutamol: a double-blind, placebo-controlled, randomized study
    Anna M Tahvanainen
    School of Medicine, University of Tampere, Tampere, Finland
    J Hypertens 30:297-306. 2012
    ..Our objective was to examine the effects of nitroglycerin and salbutamol on central haemodynamics, arterial stiffness, cardiac function, and vascular resistance in supine and upright positions...
  14. ncbi request reprint Effect of angiotensin II type 1 receptor blockade on conduit artery tone in subtotally nephrectomized rats
    Peeter Kööbi
    Department of Pharmacological Sciences, Medical School, University of Tamperel, Tampere, Finland
    Nephron Physiol 96:p91-8. 2004
    ..Angiotensin II type 1 (AT1) receptor antagonists provide end-organ protection and enhance resistance artery relaxation in uremia. The effect of AT1 blockade on conduit artery function in renal failure is unknown...
  15. ncbi request reprint Prostacyclin and thromboxane A2 production in nitric oxide-deficient hypertension in vivo. Effects of high calcium diet and angiotensin receptor blockade
    Juha Alanko
    Department of Internal Medicine, Tampere University Hospital, P O Box 2000, Tampere FIN 33521, Finland
    Prostaglandins Leukot Essent Fatty Acids 69:345-50. 2003
    ..Independent of the level of blood pressure and blockade of nitric oxide synthesis the high calcium diet decreased prostacyclin production by one third and increased thromboxane A(2) production almost two-fold in vivo...
  16. doi request reprint Ageing and cardiovascular responses to head-up tilt in healthy subjects
    Anna Tahvanainen
    Medical School, Department of Internal Medicine, University of Tampere, Tampere, Finland
    Atherosclerosis 207:445-51. 2009
    ..As the background of these changes remains uncertain, we examined arterial stiffness, cardiac function and vascular resistance in healthy subjects in supine position and during orthostatic challenge...
  17. pmc Non-invasive measurement of the haemodynamic effects of inhaled salbutamol, intravenous L-arginine and sublingual nitroglycerin
    Anna Tahvanainen
    Department of Internal Medicine, University of Tampere, Tampere, Sweden
    Br J Clin Pharmacol 68:23-33. 2009
    ..To examine the effects of salbutamol and L-arginine, two compounds acting largely on the endothelium, and the endothelium-independent agent nitroglycerin on blood pressure, arterial compliance, cardiac function and vascular resistance...
  18. ncbi request reprint Vascular influences of calcium supplementation and vitamin D-induced hypercalcemia in NaCl-hypertensive rats
    Mika Kahonen
    Department of Pharmacological Sciences, Medical School, University of Tampere, Finland
    J Cardiovasc Pharmacol 42:319-28. 2003
    ..In contrast, chronic hypercalcemia induced by 1OH-D3 was associated with moderately lowered blood pressure, possibly because of reduced vasoconstrictor responses in arterial smooth muscle...
  19. pmc Reduced systemic vascular resistance in healthy volunteers with presyncopal symptoms during a nitrate-stimulated tilt-table test
    Anna Tahvanainen
    Department of Internal Medicine, Tampere School of Public Health, University of Tampere, Tampere, Finland
    Br J Clin Pharmacol 71:41-51. 2011
    ..The purpose of the present study was to compare the underlying haemodynamic mechanisms in subjects without and with presyncopal symptoms during a nitroglycerin-stimulated tilt-table test...
  20. ncbi request reprint Preserved endothelium-dependent but impaired beta-adrenergic relaxation of the resistance vessels in experimental renal failure
    Pasi Jolma
    Department of Pharmacological Sciences, Medical School, University of Tampere, Tampere, Finland
    Exp Nephrol 10:348-54. 2002
    ..However, the responses induced by isoprenaline were slightly reduced, indicating impaired relaxation via beta-adrenoceptors in experimental renal failure...
  21. doi request reprint Analysis of cardiovascular responses to passive head-up tilt using continuous pulse wave analysis and impedance cardiography
    Anna Tahvanainen
    Department of Internal Medicine, University of Tampere, Tampere, Finland
    Scand J Clin Lab Invest 69:128-37. 2009
    ....
  22. doi request reprint Effect of common KCNE1 and SCN5A ion channel gene variants on T-wave alternans, a marker of cardiac repolarization, during clinical exercise stress test: the Finnish Cardiovascular Study
    Jenni Koskela
    Department of Internal Medicine, Tampere University Hospital and Medical School at the University of Tampere, Tampere, Finland
    Transl Res 152:49-58. 2008
    ..The common KCNE1 gene variant rs1805127 is associated with TWA during an exercise test in a Finnish population, which provides additional evidence that KCNE1 genetics may influence cardiac repolarization and cardiovascular mortality...
  23. ncbi request reprint The p22phox C242T gene polymorphism is associated with a reduced risk of angiographically verified coronary artery disease in a high-risk Finnish Caucasian population. The Finnish Cardiovascular Study
    Meng Fan
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and Tampere University Medical School, Tampere, Finland
    Am Heart J 152:538-42. 2006
    ....
  24. ncbi request reprint CYBA C242T gene polymorphism and flow-mediated vasodilation in a population of young adults: the Cardiovascular Risk in Young Finns Study
    Meng Fan
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Finland
    J Hypertens 25:1381-7. 2007
    ..We examined the relationship of the C242T polymorphism with endothelial-dependent brachial artery flow-mediated vasodilatation (FMD) in a population-based sample of young healthy adults...
  25. ncbi request reprint Neuropeptide Y signal peptide Pro7 substitution protects against coronary artery atherosclerosis: the Helsinki Sudden Death Study
    Erkki Ilveskoski
    Department of Cardiology, Medical School, University of Tampere and Heart Center, Tampere University Hospital, Tampere, Finland
    Atherosclerosis 199:445-50. 2008
    ..The aim of the present study was to investigate the association of the Leu7Pro polymorphism with coronary atherosclerosis and its consequences...
  26. ncbi request reprint Treatment of secondary hyperparathyroidism by high calcium diet is associated with enhanced resistance artery relaxation in experimental renal failure
    Pasi Jolma
    Department of Pharmacological Sciences, Medical School, University of Tampere, FIN 33014 Tampere, Finland
    Nephrol Dial Transplant 18:2560-9. 2003
    ..Oral calcium salts are used as phosphate binders in RF. However, the effect of increased calcium intake on arterial tone in RF is unknown...
  27. doi request reprint Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency
    Arttu Eräranta
    Institute of Medical Technology, Department of Internal Medicine, University of Tampere, Tampere, Finland
    J Hypertens 26:1661-8. 2008
    ..Hyperuricemia is associated with renal insufficiency and may predispose to Na retention and hypertension. Whether hyperuricemia plays a causal role in the pathogenesis of cardiovascular disease remains controversial...
  28. ncbi request reprint Renal insufficiency-induced bone loss is associated with an increase in bone size and preservation of strength in rat proximal femur
    Jarkko Jokihaara
    Medical School and the Institute of Medical Technology, University of Tampere, Tampere, Finland
    Bone 39:353-60. 2006
    ..Although high calcium diet suppressed plasma PTH to under normal physiological levels, it prevented the CRI-induced loss of bone mass without an adverse influence on bone strength...
  29. ncbi request reprint Increased wall tension in response to vasoconstrictors in isolated mesenteric arterial rings from patients with high blood pressure
    Anna Tahvanainen
    Department of Internal Medicine, University of Tampere, 33014 University of Tampere, Tampere, Finland
    Basic Clin Pharmacol Toxicol 99:440-9. 2006
    ..Since the mesenteric circulation is an important regulator of peripheral arterial resistance, possible functional alterations in this vascular bed should be further investigated in hypertensive patients...
  30. doi request reprint Hyperuricemia, oxidative stress, and carotid artery tone in experimental renal insufficiency
    Venla Kurra
    Medical School, University of Tampere, Tampere, Finland
    Am J Hypertens 22:964-70. 2009
    ..We investigated the effects of oxonic acid-induced hyperuricemia on carotid artery tone in experimental renal insufficiency...
  31. doi request reprint Tubular proteinuria and glomerular filtration 6 years after puumala hantavirus-induced acute interstitial nephritis
    Marja H Miettinen
    Department of Internal Medicine, Central Hospital of Jyvaskyla, Jyvaskyla, Finland
    Nephron Clin Pract 112:c115-20. 2009
    ..Here, we evaluated the long-term outcome after NE in a prospectively recruited patient group...
  32. ncbi request reprint Paricalcitol [19-nor-1,25-(OH)2D2] in the treatment of experimental renal bone disease
    Jarkko Jokihaara
    Medical School and the Institute of Medical Technology, University of Tampere, Finland
    J Bone Miner Res 21:745-51. 2006
    ..In this study, we show that paricalcitol also ameliorates the renal insufficiency-induced loss of bone mineral and the mechanical competence of bone...
  33. ncbi request reprint Insulin resistance and the progression of IgA glomerulonephritis
    Kati Kaartinen
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Nephrol Dial Transplant 22:778-83. 2007
    ..Hypertension, proteinuria and renal insufficiency are risk factors associated with poor prognosis. The role of insulin resistance is unclear in IgAGN...
  34. doi request reprint IgA immune responses against acetaldehyde adducts and biomarkers of alcohol consumption in patients with IgA glomerulonephritis
    Kati Kaartinen
    Department of Laboratory Medicine and Medical Research Unit, Medical School, University of Tampere, Tampere, Finland
    Alcohol Clin Exp Res 33:1231-7. 2009
    ....
  35. ncbi request reprint Intermittent ethanol exposure increases the number of cerebellar microglia
    Jarno Riikonen
    Tampere School of Public Health, FIN 33014 University of Tampere, Tampere, Finland
    Alcohol Alcohol 37:421-6. 2002
    ..The number of cerebellar microglia after 5(1)/2 months of continuous or intermittent ethanol exposure was studied using the optical dissector method...
  36. doi request reprint Paricalcitol treatment and arterial tone in experimental renal insufficiency
    Emmanouil Karavalakis
    Medical School, University of Tampere, Tampere, Finland
    Nephron Exp Nephrol 109:e84-93. 2008
    ..To examine whether treatment of secondary hyperparathyroidism with paricalcitol provides benefits to arteries in uremic rats...