Tarja Porkka-Heiskanen

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. pmc Prolonged sleep restriction affects glucose metabolism in healthy young men
    Wessel M A van Leeuwen
    Brain and Work Research Centre, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 00250 Helsinki, Finland
    Int J Endocrinol 2010:108641. 2010
  2. doi request reprint Adenosine, energy metabolism and sleep homeostasis
    Tarja Porkka-Heiskanen
    Institute of Biomedicine, University of Helsinki, PO Box 63, 00014 University of Helsinki, Helsinki, Finland
    Sleep Med Rev 15:123-35. 2011
  3. ncbi request reprint Orexin A and B levels in the hypothalamus of female rats: the effects of the estrous cycle and age
    T Porkka-Heiskanen
    Institute of Biomedicine, Department of Physiology, Biomedicum Helsinki, PO Box 63, 00014 University of Helsinki, Helsinki, Finland
    Eur J Endocrinol 150:737-42. 2004
  4. ncbi request reprint Methylxanthines and sleep
    Tarja Porkka-Heiskanen
    University of Helsinki, 63, Haartmaninkatu 8, Helsinki, Finland
    Handb Exp Pharmacol 200:331-48. 2011
  5. ncbi request reprint The effect of age on prepro-orexin gene expression and contents of orexin A and B in the rat brain
    Tarja Porkka-Heiskanen
    Institute of Biomedicine, University of Helsinki, P O Box 63, 000014 Helsinki, Finland
    Neurobiol Aging 25:231-8. 2004
  6. ncbi request reprint Adenosine, energy metabolism, and sleep
    Tarja Porkka-Heiskanen
    Institute of Biomedicine, University of Helsinki, Finland
    ScientificWorldJournal 3:790-8. 2003
  7. ncbi request reprint Gene expression during sleep, wakefulness and sleep deprivation
    Tarja Porkka-Heiskanen
    Institute of Biomedicine, Department of Physiology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Front Biosci 8:s421-37. 2003
  8. ncbi request reprint Adenosine and sleep
    Tarja Porkka-Heiskanen
    Institute of Biomedicine, Department of Physiology, Biomedicum Helsinki, Finland
    Sleep Med Rev 6:321-32. 2002
  9. doi request reprint Contribution of adenosine related genes to the risk of depression with disturbed sleep
    Natalia Gass
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    J Affect Disord 126:134-9. 2010
  10. pmc Shared genetic background for regulation of mood and sleep: association of GRIA3 with sleep duration in healthy Finnish women
    Siddheshwar Utge
    Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    Sleep 34:1309-16. 2011

Collaborators

Detail Information

Publications65

  1. pmc Prolonged sleep restriction affects glucose metabolism in healthy young men
    Wessel M A van Leeuwen
    Brain and Work Research Centre, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 00250 Helsinki, Finland
    Int J Endocrinol 2010:108641. 2010
    ..No changes were observed in CON. The observed increase of serum IGF-1 and insulin-to-glucose ratio indicates that sleep restriction may result in an increased risk to develop type 2 diabetes...
  2. doi request reprint Adenosine, energy metabolism and sleep homeostasis
    Tarja Porkka-Heiskanen
    Institute of Biomedicine, University of Helsinki, PO Box 63, 00014 University of Helsinki, Helsinki, Finland
    Sleep Med Rev 15:123-35. 2011
    ..It can be noted that this assumption in no way excludes the possibility that later in evolution additional functions may have developed, e.g., related to complex neuronal network functions like memory and learning...
  3. ncbi request reprint Orexin A and B levels in the hypothalamus of female rats: the effects of the estrous cycle and age
    T Porkka-Heiskanen
    Institute of Biomedicine, Department of Physiology, Biomedicum Helsinki, PO Box 63, 00014 University of Helsinki, Helsinki, Finland
    Eur J Endocrinol 150:737-42. 2004
    ..The steroid- and nutritional state-dependent modulation of LH release by orexins, as well as an increase of vigilance, suggest that orexins may co-ordinate these functions in the course of the estrous cycle...
  4. ncbi request reprint Methylxanthines and sleep
    Tarja Porkka-Heiskanen
    University of Helsinki, 63, Haartmaninkatu 8, Helsinki, Finland
    Handb Exp Pharmacol 200:331-48. 2011
    ..Caffeine may also decrease the accumulation of sleep propensity during waking, thus inducing long-term harmful effects on sleep quality...
  5. ncbi request reprint The effect of age on prepro-orexin gene expression and contents of orexin A and B in the rat brain
    Tarja Porkka-Heiskanen
    Institute of Biomedicine, University of Helsinki, P O Box 63, 000014 Helsinki, Finland
    Neurobiol Aging 25:231-8. 2004
    ..Deterioration of the orexin system may play a role in the phenomenon associated with aging, e.g. decreased consolidation of vigilance states, endocrine changes and dysfunctions of autonomic nervous system...
  6. ncbi request reprint Adenosine, energy metabolism, and sleep
    Tarja Porkka-Heiskanen
    Institute of Biomedicine, University of Helsinki, Finland
    ScientificWorldJournal 3:790-8. 2003
    ..The key molecule in the induction of sleep appears to be adenosine, which induces sleep locally in the basal forebrain...
  7. ncbi request reprint Gene expression during sleep, wakefulness and sleep deprivation
    Tarja Porkka-Heiskanen
    Institute of Biomedicine, Department of Physiology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Front Biosci 8:s421-37. 2003
    ..The results of such assays are dependent on what area the tissue for the analysis is collected and the time point of the collection in respect to the duration of the specific vigilance state...
  8. ncbi request reprint Adenosine and sleep
    Tarja Porkka-Heiskanen
    Institute of Biomedicine, Department of Physiology, Biomedicum Helsinki, Finland
    Sleep Med Rev 6:321-32. 2002
    ..These changes may at least partially mediate the long term effects of prolonged wakefulness. Adenosine may also be a common mediator of the effects of several other sleep-inducing factors...
  9. doi request reprint Contribution of adenosine related genes to the risk of depression with disturbed sleep
    Natalia Gass
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    J Affect Disord 126:134-9. 2010
    ..One of the key substances regulating sleep is adenosine. We hypothesized that variations in polymorphic sites of adenosine related genes may predispose to depression with sleep disturbances...
  10. pmc Shared genetic background for regulation of mood and sleep: association of GRIA3 with sleep duration in healthy Finnish women
    Siddheshwar Utge
    Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    Sleep 34:1309-16. 2011
    ..Here, we examined whether, in healthy individuals, sleep duration is associated with genes that we earlier found to be associated with depressive disorder...
  11. ncbi request reprint Stimulus-induced brain lactate: effects of aging and prolonged wakefulness
    Anna S Urrila
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Biomedicum Helsinki, Finland
    J Sleep Res 13:111-9. 2004
    ..We propose that the absence of the lactate response may be a sign of malfunctioning of normal brain energy metabolism. The behavioral effects of prolonged wakefulness and aging may arise from this dysfunction...
  12. ncbi request reprint Growth hormone-insulin-like growth factor-1 axis, leptin and sleep in anorexia nervosa patients
    Nina Lindberg
    Department of Psychiatry, University of Helsinki, Helsinki, Finland
    Neuropsychobiology 47:78-85. 2003
    ..Sleep disturbances in anorectics may be mediated through changes in the levels of the GH-IGF-1 axis hormones, as well as the levels of leptin...
  13. ncbi request reprint Sleep among habitually violent offenders with antisocial personality disorder
    Nina Lindberg
    Institute of Biomedicine, Department of Psychiatry, Biomedicum Helsinki, PO Box 63, University of Helsinki, Fl 00014 Helsinki, Finland
    Neuropsychobiology 47:198-205. 2003
    ..Whether this increase in persons with antisocial personality disorder reflects a specific brain pathology, or a delay in the normal development of sleep patterns in the course of ageing needs to be clarified with further experiments...
  14. ncbi request reprint Preliminary findings of proton magnetic resonance spectroscopy in occipital cortex during sleep deprivation
    Anna S Urrila
    Institute of Biomedicine, University of Helsinki, Finland
    Psychiatry Res 147:41-6. 2006
    ..The results suggest that NAA/H(2)O and Cho/H(2)O may depend on the state of alertness...
  15. ncbi request reprint Nitric oxide modulates the discharge rate of basal forebrain neurones: a study in freely moving rats
    Andrey Kostin
    Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    J Sleep Res 18:447-53. 2009
    ..A small subpopulation of neurones increased the discharge rate. The increase in NO in the BF during prolonged wakefulness may facilitate sleep via inhibition of wake-promoting neurones...
  16. doi request reprint Effect of sleep deprivation on multi-unit discharge activity of basal forebrain
    Andrey Kostin
    Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    J Sleep Res 19:269-79. 2010
    ....
  17. ncbi request reprint Human impulsive aggression: a sleep research perspective
    Nina Lindberg
    Department of Psychiatry, University of Helsinki, Helsinki, Finland
    J Psychiatr Res 37:313-24. 2003
    ..The differences in impulsiveness are reflected in sleep architecture as well...
  18. doi request reprint Sleep restriction for the duration of a work week impairs multitasking performance
    Marja Leena Haavisto
    Brain and Work Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland
    J Sleep Res 19:444-54. 2010
    ..The recovery process of performance and sleepiness from the SR continued over the two recovery sleep opportunities. In all, our findings emphasise the importance of shift systems that do not restrict sleep for several consecutive days...
  19. doi request reprint Effects of cumulative sleep restriction on self-perceptions while multitasking
    Mikael Sallinen
    Centre of Expertise for Human Factors at Work, Finnish Institute of Occupational Health, Helsinki, Finland
    J Sleep Res 22:273-81. 2013
    ..However, at the individual level these measures seem to be inaccurate in revealing actual performance impairments...
  20. ncbi request reprint Histamine release in the basal forebrain mediates cortical activation through cholinergic neurons
    Janneke C Zant
    Institute of Biomedicine Physiology, University of Helsinki, Helsinki, FIN 00014 Finland
    J Neurosci 32:13244-54. 2012
    ..The level of histamine release is tightly connected to behavioral state, but conveys no information about sleep pressure...
  21. doi request reprint Basal forebrain lactate release and promotion of cortical arousal during prolonged waking is attenuated in aging
    Henna Kaisa Wigren
    Institute of Biomedicine Physiology, Biomedicum Helsinki, University of Helsinki, FIN 00014 Helsinki, Finland
    J Neurosci 29:11698-707. 2009
    ..As the quality of waking is important in regulating the subsequent sleep, reduced cortical arousal during SD may contribute to the age-related reduction in sleep intensity...
  22. pmc Insomnia is a frequent finding in adults with Asperger syndrome
    Pekka Tani
    Department of Psychiatry, University of Helsinki, Finland
    BMC Psychiatry 3:12. 2003
    ..It is probable that sleep difficulties are present in adulthood as well. Our hypothesis was that adults with AS suffer from difficulty in initiating and maintaining sleep and nonrestorative sleep (insomnia)...
  23. pmc Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance
    Siddheshwar J Utge
    Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 5:e9259. 2010
    ..These findings support a connection between circadian genes and gender-dependent depression and defective sleep regulation...
  24. ncbi request reprint Nitrobenzylthioinosine (NBMPR) binding and nucleoside transporter ENT1 mRNA expression after prolonged wakefulness and recovery sleep in the cortex and basal forebrain of rat
    Lauri Alanko
    Institute of Biomedicine Physiology, University of Helsinki, Helsinki, Finland
    J Sleep Res 12:299-304. 2003
    ..We conclude that the regional decrease in adenosine transport could contribute to the gradual accumulation of extracellular adenosine in the basal forebrain during prolonged wakefulness...
  25. doi request reprint Nitric oxide mediated recovery sleep is attenuated with aging
    Kirsi Marja Rytkönen
    Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Neurobiol Aging 31:2011-9. 2010
    ..Together, these results support our hypothesis that aging impairs the mechanism through which NO in the BF induces sleep...
  26. doi request reprint Inter-tissue networks between the basal forebrain, hippocampus, and prefrontal cortex in a model for depression caused by disturbed sleep
    Markus Lagus
    Public Health Genomics Unit and Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland
    J Neurogenet 26:397-412. 2012
    ..We used two already existing tools in a new way, and by careful planning of the input data, managed to extrapolate intricate hidden inter-tissue networks to build a molecular picture of disease...
  27. ncbi request reprint Nitric oxide modulates the discharge rate of basal forebrain neurons
    Andrey Kostin
    Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Psychopharmacology (Berl) 201:147-60. 2008
    ..Although NO in the BF increases adenosine and promotes sleep, it is not clear whether the sleep promotion by NO is mediated through adenosine increase, or NO independently of adenosine could modulate sleep...
  28. ncbi request reprint Sleep in young adults with Asperger syndrome
    Pekka Tani
    Department of Psychiatry, Helsinki University, Helsinki, Finland
    Neuropsychobiology 50:147-52. 2004
    ..It seems that nonorganic insomnia, due to anxiety inherent in AS, is responsible for the low sleep quality in these subjects...
  29. ncbi request reprint Asperger syndrome, alexithymia and perception of sleep
    Pekka Tani
    Department of Psychiatry, University of Helsinki, Helsinki, Finland
    Neuropsychobiology 49:64-70. 2004
    ..It is possible that alexithymic traits predispose to anxiety, which in turn lowers the sleep quality in AS adults. Alternatively, low sleep quality might be due to AS itself...
  30. ncbi request reprint Local energy depletion in the basal forebrain increases sleep
    Anna V Kalinchuk
    Department of Physiology, Institute of Biomedicine, PO Box 63, 00014 University of Helsinki, Finland
    Eur J Neurosci 17:863-9. 2003
    ..Here we show that energy depletion in localized brain areas can generate sleep. The energy depletion model of sleep induction could be applied to in vitro research into the cellular mechanisms of prolonged wakefulness...
  31. ncbi request reprint Neurological soft signs in homicidal men with antisocial personality disorder
    Nina Lindberg
    Department of Psychiatry, University of Helsinki, Finland
    Eur Psychiatry 19:433-7. 2004
    ..One of these syndromes may be antisocial personality disorder with severe aggression...
  32. ncbi request reprint Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor
    Dag Stenberg
    Institute of Biomedicine Physiology, University of Helsinki, Helsinki, Finland
    J Sleep Res 12:283-90. 2003
    ..We conclude that constitutional lack of adenosine A1R does not prevent the homeostatic regulation of sleep...
  33. ncbi request reprint The role of the basal forebrain adenosine receptors in sleep homeostasis
    Natalia Gass
    Institute of Biomedicine, Department of Physiology, University of Helsinki, Helsinki, Finland
    Neuroreport 20:1013-8. 2009
    ..We conclude that adenosine can promote recovery non-REM sleep when acting through A1 receptors in the basal forebrain...
  34. ncbi request reprint Adenosine kinase and 5'-nucleotidase activity after prolonged wakefulness in the cortex and the basal forebrain of rat
    Lauri Alanko
    Institute of Biomedicine Physiology, University of Helsinki, P O Box 63, FIN 00014 Helsinki, Finland
    Neurochem Int 42:449-54. 2003
    ..Endo-5'-nucleotidase lacked diurnal variation. These activity patterns may be associated with the lower level of energy metabolism during sleep compared to wakefulness...
  35. doi request reprint Inducible nitric oxide synthase and AMP-activated protein kinase in basal forebrain during prolonged waking
    Henna Kaisa M Wigren
    Institute of Biomedicine Physiology, University of Helsinki, Biomedicum Helsinki, Finland
    Neuroreport 20:97-101. 2009
    ..In contrast, no changes were found in the cortex. These results further support the hypothesis that basal forebrain, as compared to cortex, is selectively sensitive to the effects of prolonged waking...
  36. ncbi request reprint Gene expression patterns in a rodent model for depression
    Markus Lagus
    Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Biomedicum, Helsinki, Finland
    Eur J Neurosci 31:1465-73. 2010
    ..The results also highlight the molecular mechanisms in the murine clomipramine model, previously shown to be a valid model for depression...
  37. ncbi request reprint ADHD and sleep in homicidal men with antisocial personality disorder
    Nina Lindberg
    Department of Psychiatry, University of Helsinki, Helsinki, Finland
    Neuropsychobiology 50:41-7. 2004
    ..The present study supports the idea that childhood ADHD is associated with the abnormal sleep architecture in habitually violent men with ASP. These two disorders seem to share, at least partly, the same central nervous system deficit...
  38. doi request reprint Automated sleep scoring in rats and mice using the naive Bayes classifier
    Kirsi Marja Rytkönen
    Department of Physiology, Institute of Biomedicine, PO Box 63, 00014 University of Helsinki, Helsinki, Finland
    J Neurosci Methods 202:60-4. 2011
    ..24-h recordings from 30 different animals were used, with approximately 5% of the data manually scored as training data for the classification algorithm...
  39. ncbi request reprint Adenosine A1 receptor-dependent G-protein activity in the rat brain during prolonged wakefulness
    Lauri O Alanko
    Institute of Biomedicine, University of Helsinki, P O Box 63, FIN 00014 Helsinki, Finland
    Neuroreport 15:2133-7. 2004
    ....
  40. ncbi request reprint Actigraphic assessment of sleep in young adults with Asperger syndrome
    Pekka Tani
    Department of Psychiatry, University of Helsinki, Helsinki, Finland
    Psychiatry Clin Neurosci 59:206-8. 2005
    ..The subjective low sleep quality in patients was not reflected in actigraphic assessment of sleep. This finding suggests that pervasive anxiety inherent in persons with Asperger syndrome predisposes them to insomnia complaints...
  41. pmc Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP
    Wessel M A van Leeuwen
    Brain and Work Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland
    PLoS ONE 4:e4589. 2009
    ..Our objective was to investigate the immunological effects of prolonged sleep restriction and subsequent recovery sleep, by simulating a working week and following recovery weekend in a laboratory environment...
  42. pmc Partial sleep restriction activates immune response-related gene expression pathways: experimental and epidemiological studies in humans
    Vilma Aho
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    PLoS ONE 8:e77184. 2013
    ..Some of these changes appear to be long-lasting and may at least partly explain how prolonged sleep restriction can contribute to inflammation-associated pathological states, such as cardiometabolic diseases...
  43. ncbi request reprint Quantitative electroencephalographic measures in homicidal men with antisocial personality disorder
    Nina Lindberg
    Institute of Clinical Medicine, Department of Psychiatry, University of Helsinki, Lapinlahti Hospital, Lapinlahdentie, P O Box 320, 00029 HUS, Helsinki, Finland
    Psychiatry Res 136:7-15. 2005
    ..Decreased vigilance, together with social and psychological variables, may explain their aberrant behavior in everyday life. New studies are, however, needed to specify the vigilance problems of this patient group...
  44. ncbi request reprint Localization of equilibrative nucleoside transporters in the rat brain
    Lauri Alanko
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
    J Chem Neuroanat 31:162-8. 2006
    ..Both transporters were present in practically all neurons. Some astrocytes showed equilibrative nucleoside transporter 1 staining, while equilibrative nucleoside transporter 2 staining on astrocytes was observed only sporadically...
  45. doi request reprint Sleep quality and cognitive performance in 8-year-old children
    E Juulia Paavonen
    National Institute for Health and Welfare, Helsinki, Finland
    Sleep Med 11:386-92. 2010
    ..The present study examined how sleep duration and sleep quality are associated with cognitive performance in 8-year-old children using standardized neurocognitive tests...
  46. ncbi request reprint Psychomotor vigilance task performance during total sleep deprivation in young and postmenopausal women
    Anna S Urrila
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
    Behav Brain Res 180:42-7. 2007
    ..OC use does not significantly affect young women's PVT performance during SD in the early phase of the menstrual cycle...
  47. doi request reprint Short sleep duration and behavioral symptoms of attention-deficit/hyperactivity disorder in healthy 7- to 8-year-old children
    E Juulia Paavonen
    Departments of Psychology, University of Helsinki, Helsinki, Finland
    Pediatrics 123:e857-64. 2009
    ..The objective of our study was to evaluate whether short sleep is associated with behavioral symptoms of attention-deficit/hyperactivity disorder in 7- to 8-year-old children...
  48. ncbi request reprint Sleep quality, duration and behavioral symptoms among 5-6-year-old children
    E Juulia Paavonen
    Child and Adolescent Mental Health, National Institute for Health and Welfare, P O Box 30, Lintulahdenkuja 4, 00271 Helsinki, Finland
    Eur Child Adolesc Psychiatry 18:747-54. 2009
    ..Intervention studies are needed to study whether children's behavioral symptoms can be reduced by lengthening sleep duration or improving sleep quality...
  49. ncbi request reprint Transcriptional activity in the brain during sleep deprivation
    J Toppila
    Institute of Biomedicine, Department of Physiology, University of Helsinki, Finland
    Ann Med 31:146-51. 1999
    ..The purpose of this article is to give a short overview of those genes whose transcription is affected by sleep deprivation according to the current literature, and to characterize the possible role of these genes in sleep regulation...
  50. ncbi request reprint The effect of REM sleep deprivation on somatostatin and growth hormone-releasing hormone gene expression in the rat hypothalamus
    J Toppila
    Department of Physiology, University of Helsinki, Finland
    J Sleep Res 5:115-22. 1996
    ..Serum GH levels were decreased in animals maintained on either small or large platforms. It is concluded that the expression of the SRIF and GHRH genes is modulated by REM sleep deprivation...
  51. ncbi request reprint Sleep deprivation increases somatostatin and growth hormone-releasing hormone messenger RNA in the rat hypothalamus
    J Toppila
    Institute of Biomedicine, University of Helsinki, Finland
    J Sleep Res 6:171-8. 1997
    ..00 hours), and SD had no effect. We conclude that SRIF cells in ARC and GHRH cells in PA are modulated by sleep loss, which is in accordance with the possible sleep regulatory function of these neuropeptides...
  52. ncbi request reprint Intracerebroventricular and locus coeruleus microinjections of somatostatin antagonist decrease REM sleep in rats
    J Toppila
    Institute of Biomedicine, Department of Physiology, P O Box 9, FIN 00014 University of Helsinki, Helsinki, Finland
    Pharmacol Biochem Behav 66:721-7. 2000
    ..The results suggest that endogenous somatostatin may contribute to facilitation of REMS. Somatostatin receptors in the LC may be one possible mediator of this effect...
  53. doi request reprint Sleep homeostasis
    Tarja Porkka-Heiskanen
    University of Helsinki, Institute of Biomedicine, Department of Physiology, PO Box 63, 00014 University of Helsinki, Finland Electronic address
    Curr Opin Neurobiol 23:799-805. 2013
    ..Presently three main concepts are being actively studied: the energy (depletion) hypothesis, the neural plasticity hypothesis and the (immune) defense hypothesis...
  54. doi request reprint The temporal relationship between growth hormone and slow wave sleep is weaker after menopause
    Nea Kalleinen
    Sleep Research Unit, Department of Physiology, University of Turku, Finland
    Sleep Med 13:96-101. 2012
    ..To study the temporal association between growth hormone (GH) and slow wave sleep (SWS) in middle-aged women...
  55. ncbi request reprint Amigo adhesion protein regulates development of neural circuits in zebrafish brain
    Xiang Zhao
    From the Neuroscience Center
    J Biol Chem 289:19958-75. 2014
    ..1 potassium channel to form functional neural circuitry that controls locomotion. ..
  56. doi request reprint Periodic properties of the histaminergic system of the mouse brain
    Stanislav V Rozov
    Neuroscience Centre and Institute of Biomedicine Anatomy, University of Helsinki, P O Box 63, FI 00014 Helsinki, Finland
    Eur J Neurosci 39:218-28. 2014
    ..The complex and non-uniform temporal patterns of the histaminergic system of the mouse brain suggest that histamine is strongly involved in the maintenance of active wakefulness. ..
  57. ncbi request reprint Metabolic imaging of human cognition: an fMRI/1H-MRS study of brain lactate response to silent word generation
    Anna S Urrila
    Institute of Biomedicine, University of Helsinki, Finland
    J Cereb Blood Flow Metab 23:942-8. 2003
    ..The cognitive stimulus-activation produced a 50% increase in the brain lactate level in the left inferior frontal gyrus. The results show that metabolic imaging of neuronal activity related to cognition is possible using 1H-MRS...
  58. ncbi request reprint Childhood inattention and hyperactivity symptoms self-reported by adults with Asperger syndrome
    Pekka Tani
    Department of Psychiatry, University of Helsinki, Helsinki, Finland
    Psychopathology 39:49-54. 2006
    ..As these disorders have their origin in childhood, instruments for retrospective evaluation of childhood behavior are needed...
  59. doi request reprint A population-based association study of candidate genes for depression and sleep disturbance
    Siddheshwar Utge
    Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 153:468-76. 2010
    ..These differences may partially explain the broad spectrum of depressive symptoms, and their systematic monitoring could potentially be used for diagnostic purposes...
  60. ncbi request reprint Glutamatergic stimulation of the basal forebrain elevates extracellular adenosine and increases the subsequent sleep
    H K Wigren
    Institute of Biomedicine Physiology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Neuroscience 147:811-23. 2007
    ..These results indicate that increased neuronal activity in the BF, and particularly the type of neuronal activity coinciding with active waking, is one of the factors contributing to the buildup of the sleep pressure...
  61. ncbi request reprint 24-hour serum levels of growth hormone, prolactin, and cortisol in pre- and postmenopausal women: the effect of combined estrogen and progestin treatment
    Nea Kalleinen
    Sleep Research Unit, Department of Physiology, University of Turku, Lemminkaisenkatu 2, Turku, Finland
    J Clin Endocrinol Metab 93:1655-61. 2008
    ..Our objective was to study the 24-h profiles of GH, prolactin (PRL), and cortisol concentrations in older postmenopausal and middle-aged premenopausal women, before and after estrogen-progestin treatment (EPT)...
  62. ncbi request reprint Clinical neurological abnormalities in young adults with Asperger syndrome
    Pekka Tani
    Department of Psychiatry, and Institute of Biomedicine, Department of Physiology, University of Helsinki, Helsinki, Finland
    Psychiatry Clin Neurosci 60:253-5. 2006
    ..Consistent with other features of AS, neurological abnormalities seem to persist into adulthood...
  63. ncbi request reprint Basal forebrain and saporin cholinergic lesions: the devil dwells in delivery details
    Anna V Kalinchuk
    Sleep 29:1385-7; discussion 1387-9. 2006
  64. ncbi request reprint Women's sleep in health and disease
    Andrea Dzaja
    Max Planck Institute of Psychiatry, Munich, Germany
    J Psychiatr Res 39:55-76. 2005
    ..We also address specific aspects of sleep loss and sleep disorders in women. Finally, very recent studies on the sociology of sleep are summarized and future directions in the field are discussed...
  65. ncbi request reprint Is Asperger syndrome associated with abnormal nocturnal motor phenomena?
    Pekka Tani
    Psychiatry Clin Neurosci 60:527-8. 2006