A Pitkanen

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi American Epilepsy Society--58th Annual Meeting. Novel compounds for the treatment of seizures
    Asla Pitkanen
    University of Kuopio, Epilepsy Research Laboratory, AI Virtanen Institute for Molecular Sciences, PO Box 1627, FIN 70 211 Kuopio, Finland
    IDrugs 8:14-6. 2005
  2. ncbi Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy
    Asla Pitkanen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Prog Brain Res 135:67-83. 2002
  3. ncbi Comparison of the distribution of calcium-binding proteins and intrinsic connectivity in the lateral nucleus of the rat, monkey, and human amygdala
    Asla Pitkanen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FIN 70 211, Kuopio, Finland
    Pharmacol Biochem Behav 71:369-77. 2002
  4. ncbi Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat
    Asla Pitkanen
    A I Virtanen Institute, University of Kuopio, PO Box 1627, FIN 70 211 Kuopio, Finland
    Epilepsy Res 74:45-54. 2007
  5. ncbi Epileptogenesis in experimental models
    Asla Pitkanen
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    Epilepsia 48:13-20. 2007
  6. ncbi [On the neurobiology of emotions]
    Asla Pitkanen
    Kuopion yliopisto, A I Virtanen instituutti PL 1627, 70211 Kuopio
    Duodecim 119:1471-8. 2003
  7. ncbi Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models
    Asla Pitkanen
    A I Virtanen Institute, University of Kuopio, PO Box 1627, Kuopio, Finland
    Epilepsy Res 50:141-60. 2002
  8. ncbi Drug-mediated neuroprotection and antiepileptogenesis: animal data
    Asla Pitkanen
    A I Virtanen Institute, University Hospital, University of Kuopio, PO Box 1627, FIN 70 211 Kuopio, Finland
    Neurology 59:S27-33. 2002
  9. ncbi Intrinsic synaptic circuitry of the amygdala
    Asla Pitkanen
    Epilepsy Research Laboratory, A I Virtanen Institute, University of Kuopio, FIN 70 211 Kuopio, Finland
    Ann N Y Acad Sci 985:34-49. 2003
  10. ncbi Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy
    Asla Pitkanen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Lancet Neurol 1:173-81. 2002

Research Grants

Collaborators

Detail Information

Publications66

  1. ncbi American Epilepsy Society--58th Annual Meeting. Novel compounds for the treatment of seizures
    Asla Pitkanen
    University of Kuopio, Epilepsy Research Laboratory, AI Virtanen Institute for Molecular Sciences, PO Box 1627, FIN 70 211 Kuopio, Finland
    IDrugs 8:14-6. 2005
  2. ncbi Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy
    Asla Pitkanen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Prog Brain Res 135:67-83. 2002
    ..The ongoing hippocampal damage in these epileptic animals detected even 2 month after SE was associated with epileptogenic insult, that is, SE rather than spontaneous seizures...
  3. ncbi Comparison of the distribution of calcium-binding proteins and intrinsic connectivity in the lateral nucleus of the rat, monkey, and human amygdala
    Asla Pitkanen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FIN 70 211, Kuopio, Finland
    Pharmacol Biochem Behav 71:369-77. 2002
    ..There are also dissimilarities, however, which might relate to differences in the function of the amygdala in rodents and primates...
  4. ncbi Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat
    Asla Pitkanen
    A I Virtanen Institute, University of Kuopio, PO Box 1627, FIN 70 211 Kuopio, Finland
    Epilepsy Res 74:45-54. 2007
    ..These findings suggest that AMPA receptor blockade by NS1209 provides a novel and mechanistically complimentary addition to the armamentarium of drugs used to treat SE in humans...
  5. ncbi Epileptogenesis in experimental models
    Asla Pitkanen
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    Epilepsia 48:13-20. 2007
    ....
  6. ncbi [On the neurobiology of emotions]
    Asla Pitkanen
    Kuopion yliopisto, A I Virtanen instituutti PL 1627, 70211 Kuopio
    Duodecim 119:1471-8. 2003
  7. ncbi Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models
    Asla Pitkanen
    A I Virtanen Institute, University of Kuopio, PO Box 1627, Kuopio, Finland
    Epilepsy Res 50:141-60. 2002
    ..An understanding of the molecular mechanisms underlying the progression of epileptic process will eventually show what role AEDs have in the neuroprotective and antiepileptogenic treatment regimen...
  8. ncbi Drug-mediated neuroprotection and antiepileptogenesis: animal data
    Asla Pitkanen
    A I Virtanen Institute, University Hospital, University of Kuopio, PO Box 1627, FIN 70 211 Kuopio, Finland
    Neurology 59:S27-33. 2002
    ....
  9. ncbi Intrinsic synaptic circuitry of the amygdala
    Asla Pitkanen
    Epilepsy Research Laboratory, A I Virtanen Institute, University of Kuopio, FIN 70 211 Kuopio, Finland
    Ann N Y Acad Sci 985:34-49. 2003
    ....
  10. ncbi Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy
    Asla Pitkanen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Lancet Neurol 1:173-81. 2002
    ..Therapeutic modification of seizure-induced molecular and cellular responses offers new opportunities for intervention beyond seizure suppression...
  11. ncbi American Epilepsy Society - 57th Annual Meeting
    Asla Pitkanen
    AI Virtanen Institute for Molecular Sciences, University of Kuopio, Epilepsy Research Laboratory, PO Box 1627, FIN 70 211 Kuopio, Finland
    IDrugs 7:125-7. 2004
  12. ncbi Antiepileptic drugs in neuroprotection
    Asla Pitkanen
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    Expert Opin Pharmacother 5:777-98. 2004
    ..These observations emphasise the need to use additional outcome measures, such as markers of normal development or cognitive performance, when the benefits of neuroprotection achieved by the use of neuroprotective AEDs are assessed...
  13. doi From traumatic brain injury to posttraumatic epilepsy: what animal models tell us about the process and treatment options
    Asla Pitkanen
    Epilepsy Research Group, Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    Epilepsia 50:21-9. 2009
    ....
  14. doi Molecular and cellular basis of epileptogenesis in symptomatic epilepsy
    Asla Pitkanen
    Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    Epilepsy Behav 14:16-25. 2009
    ..Currently we are learning how these pathways contribute to postinjury epileptogenesis and recovery process and whether they could be used as treatment targets...
  15. ncbi Amygdala damage in experimental and human temporal lobe epilepsy
    A Pitkanen
    A I Virtanen Institute, University of Kuopio, Finland
    Epilepsy Res 32:233-53. 1998
    ..Furthermore, damage to select nuclei in the amygdala may predict impairment of performance in behavioral tasks that depend on the integrity of the amygdaloid circuits...
  16. ncbi Atipamezole, an alpha(2)-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats
    Asla Pitkanen
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, P O Box 1627, FIN 70 211 Kuopio, Finland
    Epilepsy Res 61:119-40. 2004
    ..There is, however, a disease-modifying effect; that is, the epilepsy that develops is milder and non-progressive. These data warrant further studies...
  17. ncbi Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat
    Asla Pitkanen
    A I Virtanen Institute, University of Kuopio, P O Box 1627, FIN 70 211 Kuopio, Finland
    Epilepsy Res 63:27-42. 2005
    ..These data indicate that treatment of SE with DZP within 2 h reduces the risk of epilepsy later in life, and if epilepsy develops, it is milder...
  18. ncbi Animal models of post-traumatic epilepsy
    Asla Pitkanen
    Epilepsy Research Laboratory, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    J Neurotrauma 23:241-61. 2006
    ....
  19. ncbi Anatomic heterogeneity of the rat amygdaloid complex
    A Pitkanen
    A I Virtanen Institute for Molecular Sciences University of Kuopio, Finland
    Folia Morphol (Warsz) 59:1-23. 2000
    ..Here, we briefly review the principles of amygdaloid neuronal wiring that underlie the computations necessary to perform such complex behavioural functions...
  20. ncbi Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. A review
    A Pitkanen
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Ann N Y Acad Sci 911:369-91. 2000
    ..The connectional data are summarized and the underlying principles of organization of these projections are discussed...
  21. ncbi Association between the density of mossy fiber sprouting and seizure frequency in experimental and human temporal lobe epilepsy
    A Pitkanen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, Kuopio University Hospital, Finland
    Epilepsia 41:S24-9. 2000
    ..This hypothesis was tested by analyzing the data gathered from experimental and human epilepsy...
  22. ncbi Clinical trials in neuroprotection. 23-25 January 2003, Key Biscayne, FL, USA
    Asla Pitkanen
    Al Virtanen Institute for Molecular Sciences Epilepsy Research Laboratory, Finland
    IDrugs 6:200-2. 2003
    ....
  23. ncbi Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala
    A Pitkanen
    A I Virtanen Institute, University of Kuopio, Finland
    Epilepsy Res 24:29-45. 1996
    ..Vigabatrin decreased neuronal damage in the hippocampus but not in the amygdala. These results demonstrate that different brain regions and neuronal networks may be protected unequally by different anticonvulsants...
  24. ncbi Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus
    A Pitkanen
    A I Virtanen Institute, University of Kuopio, Finland
    Epilepsy Res 33:67-85. 1999
    ..05 compared to the vehicle group). Our data show that chronic elevation of brain GABA levels after status epilepticus does not have any substantial effects on neuronal loss or mossy fiber sprouting in the rat hippocampus...
  25. ncbi Neurobiology of epileptogenesis in the temporal lobe
    L Jutila
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    Adv Tech Stand Neurosurg 27:5-22. 2002
  26. ncbi Administration of caspase 3 inhibitor during and after status epilepticus in rat: effect on neuronal damage and epileptogenesis
    S Narkilahti
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, P O Box 1627, FIN 70 211, Kuopio, Finland
    Neuropharmacology 44:1068-88. 2003
    ..These findings challenge the idea that prevention of cell death is the primary target for the development of antiepileptogenic compounds...
  27. ncbi Status epilepticus-induced neuronal damage in the rat amygdaloid complex: distribution, time-course and mechanisms
    J Tuunanen
    A I Virtanen Institute, University of Kuopio, Finland
    Neuroscience 94:473-95. 1999
    ..At least one mechanism underlying the damage involves apoptosis, which continues long after the behavioral and electrographic seizures have subsided...
  28. ncbi Is mossy fiber sprouting present at the time of the first spontaneous seizures in rat experimental temporal lobe epilepsy?
    J Nissinen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Hippocampus 11:299-310. 2001
    ..Our data indicate that although mossy fiber sprouting is present in all animals with spontaneous seizures, its presence is not necessarily associated with the occurrence of spontaneous seizures...
  29. ncbi Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat
    T Halonen
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Epilepsy Res 34:251-69. 1999
    ..Our data provide evidence that pretreatment with remacemide has a moderate neuroprotective effect against status epilepticus-induced neuronal damage...
  30. ncbi Epileptogenesis after cortical photothrombotic brain lesion in rats
    H Karhunen
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, FIN 70211 Kuopio, Finland
    Neuroscience 148:314-24. 2007
    ..Our observations support the hypothesis that photothrombotic stroke in rats is a useful animal model for investigating the mechanisms of post-stroke epileptogenesis...
  31. ncbi Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats
    M Niittykoski
    Epilepsy Research Laboratory, Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Neuroscience 124:269-81. 2004
    ..Further, the basal nucleus is more prone to epileptic activity than the lateral nucleus. Finally, the severity of SE and spontaneous seizures in vivo is associated with electrophysiologic alterations in vitro...
  32. ncbi Hippocampal and amygdaloid damage in partial epilepsy: a cross-sectional MRI study of 241 patients
    T Salmenpera
    Department of Neurology, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Epilepsy Res 46:69-82. 2001
    ..The data provided have important implications with regard to early and effective management and seizure control in vulnerable patients...
  33. doi Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy
    X E Ndode-Ekane
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Neuroscience 166:312-32. 2010
    ....
  34. doi Association of the severity of cortical damage with the occurrence of spontaneous seizures and hyperexcitability in an animal model of posttraumatic epilepsy
    Irina Kharatishvili
    Epilepsy Research Laboratory, Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, and Department of Neurology, Kuopio University Hospital, FIN 70211 Kuopio, Finland
    Epilepsy Res 90:47-59. 2010
    ..These findings indicate that, like in humans, the severity of cortical injury correlates with epileptogenesis and epilepsy in an experimental model of posttraumatic epilepsy...
  35. ncbi Damage to the amygdalo-hippocampal projection in temporal lobe epilepsy: a tract-tracing study in chronic epileptic rats
    S Kemppainen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Neuroscience 126:485-501. 2004
    ....
  36. ncbi A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats
    I Kharatishvili
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, and Department of Neurology, Kuopio University Hospital, Finland
    Neuroscience 140:685-97. 2006
    ....
  37. ncbi Cholinergic deafferentation exacerbates seizure-induced loss of somatostatin-immunoreactive neurons in the rat hippocampus
    J Jolkkonen
    A I Virtanen Institute, University of Kuopio, Finland
    Neuroscience 80:401-11. 1997
    ..Damage to cholinergic neurons results in the loss of hilar somatostatin-immunoreactive neurons and exacerbates the seizure-induced loss of somatostatin-immunoreactive neurons...
  38. ncbi Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy
    S Narkilahti
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FIN 70 211 Kuopio, Finland
    Neuroscience 131:887-97. 2005
    ..Further, caspase 6 protein is not exclusively located in the somata of neurons, but also in dendrites. These data suggest that caspase 6 has functions other than execution of programmed cell death in epileptogenic hippocampus...
  39. ncbi Epileptogenesis alters gene expression pattern in rats subjected to amygdala-dependent emotional learning
    K Majak
    Epilepsy Research Laboratory, Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FIN 70211, Kuopio, Finland
    Neuroscience 159:468-82. 2009
    ..Understanding the function of those genes in emotional learning provides an attractive avenue for identification of novel drug targets for treatment of emotional disorders after epileptogenesis-inducing insult...
  40. ncbi Effect of antiepileptic drugs on spontaneous seizures in epileptic rats
    Jari Nissinen
    A I Virtanen Institute, University of Kuopio, P O Box 1627, FIN 70 211 Kuopio, Finland
    Epilepsy Res 73:181-91. 2007
    ..Like in humans, the response to AEDs can vary substantially between animals. These observations support the idea that spontaneously seizing animals are a useful tool for testing novel compounds for the treatment of human epilepsy...
  41. ncbi Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis
    Irina Kharatishvili
    Epilepsy Research Group, Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, FIN 70211 Kuopio, Finland
    Brain 130:3155-68. 2007
    ..These results for the first time demonstrate that quantitative diffusion MRI can serve as a tool to facilitate prediction of increased seizure susceptibility in a clinically relevant model of human PTE...
  42. ncbi Hippocampal damage in newly diagnosed focal epilepsy: a prospective MRI study
    T Salmenpera
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Neurology 64:62-8. 2005
    ..To examine the longitudinal appearance of hippocampal (HC) damage in a prospective follow-up study of patients with newly diagnosed epilepsy...
  43. ncbi Long-term cognitive and EEG effects of tiagabine in drug-resistant partial epilepsy
    R Kalviainen
    Department of Neurology, University Hospital of Kuopio, Finland
    Epilepsy Res 25:291-7. 1996
    ..7 mg/day, range 30-80 mg/day) and after 18-24 months (mean dose 67.6 mg/day, range 24-80 mg/day). The daily dosages in the long-term follow-up of the present study are higher than in the previous reports...
  44. doi Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus
    Riikka J Immonen
    Department of Neurobiology, University of Kuopio, FIN 70211 Kuopio, Finland
    Neuroimage 40:1718-30. 2008
    ..Present data show that systemic MEMRI can reveal axonal sprouting, and thus, can potentially serve as a marker for neuroplasticity in preclinical studies...
  45. ncbi Projections from the amygdaloid complex to the magnocellular cholinergic basal forebrain in rat
    E Jolkkonen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Neuroscience 111:133-49. 2002
    ..Further, the central nucleus efferents modulate cholinergic neurons in the basal forebrain indirectly via the GABAergic interneurons...
  46. ncbi Ex vivo MR microimaging of neuronal damage after kainate-induced status epilepticus in rat: correlation with quantitative histology
    T R Pirttilä
    National Bio NMR Facility, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    Magn Reson Med 46:946-54. 2001
    ....
  47. doi Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus
    L Lahtinen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Neuroscience 163:316-28. 2009
    ....
  48. ncbi Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse
    Terhi J Pirttilä
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Neurobiol Dis 20:241-53. 2005
    ..These data demonstrate that cystatin C has a role in neuronal death and neurogenesis during SE-induced network reorganization...
  49. doi Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus
    Laura Lahtinen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Neurobiol Dis 37:692-703. 2010
    ..Our results favor the idea that elevated uPA during the post-injury phase is neuroprotective...
  50. ncbi New pharmacotherapy for epilepsy
    Asla Pitkanen
    University of Kuopio, AI Virtanen Institute for Molecular Sciences, Department of Neurobiology, PO Box 1627, FIN 70 211 Kuopio, Finland
    IDrugs 7:471-7. 2004
    ....
  51. ncbi Magnetic resonance imaging in animal models of epilepsy-noninvasive detection of structural alterations
    Olli Gröhn
    Biomedical NMR Research Group, Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    Epilepsia 48:3-10. 2007
    ..Understanding of molecular and cellular mechanisms underlying changes in various MRI techniques will help to better understand complex progressive pathological processes associated with epileptogenesis and epilepsy...
  52. ncbi Cystatin C expression is increased in the hippocampus following photothrombotic stroke in rat
    Terhi J Pirttilä
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurosci Lett 395:108-13. 2006
    ..The present study provides evidence that cystatin C may be involved in cellular alterations that occur after an epileptogenic insult, not only after SE but also after photothrombotic stroke...
  53. doi Diffusion tensor MRI of axonal plasticity in the rat hippocampus
    Teemu Laitinen
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FI 70211 Kuopio, Finland
    Neuroimage 51:521-30. 2010
    ..As DTI is completely a non-invasive imaging method, these results may pave the way for non-invasive in vivo imaging of axonal plasticity after brain insults...
  54. pmc Therapeutic approaches to epileptogenesis--hope on the horizon
    Asla Pitkanen
    Epilepsy Research Laboratory, AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
    Epilepsia 51:2-17. 2010
    ..Furthermore, a novel scheme for defining epileptogenesis-related terms is presented...
  55. ncbi Increased expression of caspase 2 in experimental and human temporal lobe epilepsy
    Susanna Narkilahti
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, and Department of Neurology, Kuopio University Hospital, Finland
    Neuromolecular Med 9:129-44. 2007
    ..Our data suggest that caspase 2-mediated programmed cell death participates in the seizure-induced degenerative process in experimental and human TLE...
  56. doi Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat--11 months follow-up
    Riikka J Immonen
    Biomedical NMR Research Group, Biomedical Imaging Unit, Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, P O B 1627, FIN 70211 Kuopio, Finland
    Exp Neurol 215:29-40. 2009
    ..This information is valuable for targeting and timing interventions in studies aiming at alleviating or reversing the molecular and/or cellular cascades causing the delayed injury...
  57. ncbi Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats
    A Pitkanen
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, FI 70211 Kuopio, Finland Department of Neurology, Kuopio University Hospital, PO Box 1777, FI 70211 Kuopio, Finland Electronic address
    Epilepsy Res 108:653-65. 2014
    ..Composite neuroscore in the TBI-LCM group lagged behind that in the TBI-Veh group at 15d post-injury, but no compromise was found in other indices of post-TBI recovery in the LCM treated animals. ..
  58. ncbi Quantitative MRI predicts long-term structural and functional outcome after experimental traumatic brain injury
    Riikka J Immonen
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Neuroimage 45:1-9. 2009
    ..01), and also with the water maze performance (p<0.01). We conclude that, assessment of early quantitative MRI changes in the hippocampus and in the perifocal area may help to predict the long-term outcome after experimental TBI...
  59. ncbi Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI
    N Huusko
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, FI 70211 Kuopio, Finland Electronic address
    Neuroscience 267:30-45. 2014
    ..The contribution of RT damage to seizure susceptibility and post-traumatic epileptogenesis deserves further studies. ..
  60. ncbi Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling
    S Lähteinen
    Laboratory of Molecular Pharmacology, A I Virtanen Institute, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Neuroscience 122:1081-92. 2003
    ..Our data support the role of BDNF and trkB signaling in seizure generation and acute cellular damage after S.E. Long-term outcome was not, however, exacerbated by trkB overexpression...
  61. doi Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat
    Irina Kharatishvili
    Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, Epilepsy Research Laboratory, University of Kuopio, Kuopio, Finland
    Exp Neurol 217:154-64. 2009
    ....
  62. doi Posttraumatic epilepsy
    Irina Kharatishvili
    Epilepsy Research Laboratory, Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Curr Opin Neurol 23:183-8. 2010
    ..The purpose of this study is to focus on recent advances in understanding of the genetic and epidemiologic risk factors, development, modeling, and prevention of epilepsy after traumatic brain injury (TBI)...
  63. doi Elevated cerebral blood flow and vascular density in the amygdala after status epilepticus in rats
    Nick M E A Hayward
    Department of Neurobiology, Biomedical NMR Group, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, P O Box 1627, FIN 70211, Kuopio, Finland
    Neurosci Lett 484:39-42. 2010
    ..05). In conclusion, epileptogenesis may involve hemodynamic changes that are associated with vascular reorganization during post-SE remodeling in the amygdaloid complex...
  64. doi Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy
    Rimante Minkeviciene
    A I Virtanen Institute, University of Kuopio, FIN 70211 Kuopio, Finland
    J Neurosci 29:3453-62. 2009
    ..Overall, these data identify fibrillar Abeta as a pathogenic entity powerfully altering neuronal membrane properties such that hyperexcitability of pyramidal cells culminates in epileptiform activity...
  65. ncbi Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocampus-dependent learning
    Hanna Siiskonen
    Department of Biotechnology Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    Mol Cell Neurosci 34:199-208. 2007
    ..Our transgenic mouse line demonstrates that endogenously overexpressed DBI impairs hippocampus-dependent learning without anxiety or proconflict behavior...
  66. ncbi Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop
    James P Stables
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Epilepsia 44:1472-8. 2003

Research Grants1

  1. Antiepileptogenic & Disease Modifying Effects of AEDs
    Asla Pitkanen; Fiscal Year: 2005
    ..abstract_text> ..