J Pispa

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis
    Johanna Pispa
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Gene Expr Patterns 3:675-9. 2003
  2. ncbi request reprint Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF
    J Pispa
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Biol 216:521-34. 1999
  3. ncbi request reprint Signaling and subcellular localization of the TNF receptor Edar
    P Koppinen
    Developmental Biology Program, University of Helsinki, Helsinki, 00014, Finland
    Exp Cell Res 269:180-92. 2001
  4. ncbi request reprint TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis
    J Laurikkala
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 229:443-55. 2001
  5. ncbi request reprint Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion
    M L Mikkola
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Helsinki, Finland
    Mech Dev 88:133-46. 1999
  6. ncbi request reprint The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats
    M Bayes
    Department of Medical Genetics, Haartman Institute, PO Box 21, University of Helsinki, 00014 Helsinki, Finland
    Hum Mol Genet 7:1661-9. 1998
  7. ncbi request reprint Stimulation of ectodermal organ development by Ectodysplasin-A1
    Tuija Mustonen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 259:123-36. 2003
  8. ncbi request reprint Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar
    Johanna Laurikkala
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Development 129:2541-53. 2002
  9. ncbi request reprint Tooth patterning and enamel formation can be manipulated by misexpression of TNF receptor Edar
    Johanna Pispa
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki, Finland
    Dev Dyn 231:432-40. 2004
  10. ncbi request reprint Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages
    Tuija Mustonen
    Developmental Biology Program, Institute of Biotechnology, PO Box 56 Viikinkaari 9, University of Helsinki, Finland
    Development 131:4907-19. 2004

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis
    Johanna Pispa
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Gene Expr Patterns 3:675-9. 2003
    ..We also studied the expression pattern of a related TNF receptor, TNFRSF19, and show that it is expressed in an overlapping domain with Edar in the tooth, mammary gland, whiskers, and limb bud suggesting a potentially redundant role...
  2. ncbi request reprint Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF
    J Pispa
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Biol 216:521-34. 1999
    ..Instead FGF-10 partially restored morphogenesis and stimulated the development of additional tooth cusps in cultured Tabby molars...
  3. ncbi request reprint Signaling and subcellular localization of the TNF receptor Edar
    P Koppinen
    Developmental Biology Program, University of Helsinki, Helsinki, 00014, Finland
    Exp Cell Res 269:180-92. 2001
    ..This together with differences in NF-kappaB responses suggests an explanation for the different mode of inheritance of the different downless alleles...
  4. ncbi request reprint TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis
    J Laurikkala
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 229:443-55. 2001
    ..This is the first demonstration of integration of the Wnt, activin, and TNF signaling pathways...
  5. ncbi request reprint Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion
    M L Mikkola
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Helsinki, Finland
    Mech Dev 88:133-46. 1999
    ..Ectodysplasin is the first TNF-like signaling molecule described known to be required for epithelial morphogenesis...
  6. ncbi request reprint The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats
    M Bayes
    Department of Medical Genetics, Haartman Institute, PO Box 21, University of Helsinki, 00014 Helsinki, Finland
    Hum Mol Genet 7:1661-9. 1998
    ..Our results will allow mutation diagnostics in the majority of patients...
  7. ncbi request reprint Stimulation of ectodermal organ development by Ectodysplasin-A1
    Tuija Mustonen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 259:123-36. 2003
    ..We conclude that ectodysplasin-Edar signaling has several roles in ectodermal organ development controlling their initiation, as well as morphogenesis and differentiation...
  8. ncbi request reprint Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar
    Johanna Laurikkala
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Development 129:2541-53. 2002
    ..In conclusion, we suggest that Eda and Edar are associated with the onset of ectodermal patterning and that ectodysplasin/edar signaling also regulates the morphogenesis of hair follicles...
  9. ncbi request reprint Tooth patterning and enamel formation can be manipulated by misexpression of TNF receptor Edar
    Johanna Pispa
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki, Finland
    Dev Dyn 231:432-40. 2004
    ..In addition, tooth enamel formation is defective in a dose-dependent manner. We speculate that the tooth patterning defects are caused by ectopic Edar activity outside the signaling centers...
  10. ncbi request reprint Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages
    Tuija Mustonen
    Developmental Biology Program, Institute of Biotechnology, PO Box 56 Viikinkaari 9, University of Helsinki, Finland
    Development 131:4907-19. 2004
    ..Taken together, our results suggest that Eda-A1 signalling promotes placodal cell fate during early development of ectodermal organs...
  11. ncbi request reprint Drosophila non-muscle alpha-actinin is localized in nurse cell actin bundles and ring canals, but is not required for fertility
    Gudrun Wahlström
    Developmental Biology Program Institute of Biotechnology, Viikki Biocenter, P O Box 56 Viikinkaari 9, FIN 00014, University of Helsinki, Finland
    Mech Dev 121:1377-91. 2004
    ..We also show that ectopically expressed adult muscle-specific alpha-actinin localizes to all F-actin containing structures in the nurse cells in the absence of endogenous non-muscle alpha-actinin...
  12. pmc C. elegans dss-1 is functionally conserved and required for oogenesis and larval growth
    Johanna Pispa
    Cellular Biotechnology Research Program, Institute of Biotechnology, University of Helsinki, Finland
    BMC Dev Biol 8:51. 2008
    ..While the fungal orthologues of Dss1 are not essential for viability, the significance of Dss1 in metazoans has remained unknown due to a lack of knockout animal models...
  13. ncbi request reprint Mechanisms of ectodermal organogenesis
    Johanna Pispa
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 262:195-205. 2003
    ..Here the current knowledge on the molecular regulation of the initiation, placode formation, and morphogenesis of ectodermal organs is discussed with emphasis on feathers, hair, and teeth...
  14. ncbi request reprint Transgenic mouse models support HCR as an effector gene in the PSORS1 locus
    Outi Elomaa
    Department of Medical Genetics, University of Helsinki, Helsinki University Central Hospital, Finland
    Hum Mol Genet 13:1551-61. 2004
    ..These observations are also compatible with a model that a susceptibility gene for psoriasis induces changes that are contributory but not sufficient by itself to produce the clinical phenotype...