Herranen A, Ikäheimo K, Virkkala J, Pirvola U. The Stress Response in the Non-sensory Cells of the Cochlea Under Pathological Conditions-Possible Role in Mediating Noise Vulnerability. J Assoc Res Otolaryngol. 2018;19:637-652 pubmed publisher
..Together, we propose that the molecular stress response in the lateral wall modulates the outcome of the stressed cochlea. ..
Kirjavainen A, Laos M, Anttonen T, Pirvola U. The Rho GTPase Cdc42 regulates hair cell planar polarity and cellular patterning in the developing cochlea. Biol Open. 2015;4:516-26 pubmed publisher
..The data also suggest that defects in apical polarization are influenced by disturbed cellular patterning in the OC. In addition, our data demonstrates that Cdc42 is required for stereociliogenesis in the immature cochlea. ..
Pirvola U, Spencer Dene B, Xing Qun L, Kettunen P, Thesleff I, Fritzsch B, et al. FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis. J Neurosci. 2000;20:6125-34 pubmed
..Our findings provide genetic evidence that signaling by FGFR-2(IIIb) is critical for the morphological development of the inner ear. ..
Pirvola U, Ylikoski J, Trokovic R, Hebert J, McConnell S, Partanen J. FGFR1 is required for the development of the auditory sensory epithelium. Neuron. 2002;35:671-80 pubmed
..Our data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium. ..
Pirvola U, Zhang X, Mantela J, Ornitz D, Ylikoski J. Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions. Dev Biol. 2004;273:350-60 pubmed
..Together, these data show that Fgf9 signaling is required for inner ear morphogenesis. ..