Research Topics
Genomes and Genes
| Ulla PirvolaSummaryAffiliation: University of Helsinki Country: Finland Publications
| Collaborators
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Detail Information
Publications
FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesisU Pirvola
Institute of Biotechnology and Department of Otorhinolaryngology, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 20:6125-34. 2000..Our findings provide genetic evidence that signaling by FGFR-2(IIIb) is critical for the morphological development of the inner ear...- Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactionsUlla Pirvola
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Dev Biol 273:350-60. 2004..Together, these data show that Fgf9 signaling is required for inner ear morphogenesis... - FGFR1 is required for the development of the auditory sensory epitheliumUlla Pirvola
Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland
Neuron 35:671-80. 2002..Our data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium... - Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell deathJukka Ylikoski
Institute of Biotechnology, University of Helsinki, Finland
Hear Res 166:33-43. 2002..Thus, our results imply that activation of JNK cascade may be a common molecular outcome of cellular stress in the inner ear sensory epithelia and that attenuation of the lesion can be provided by inhibiting JNK activation... 
FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signalsRas Trokovic
Institute of Biotechnology, Viikki Biocenter, PO Box 56, 00014 University of Helsinki, Finland
EMBO J 22:1811-23. 2003..In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell-adhesion molecules at the midbrain-hindbrain border...- The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner earJohanna Mantela
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Development 132:2377-88. 2005..Our findings demonstrate that the pRb pathway is required for hair cell quiescence and that manipulation of the cell cycle machinery disrupts the coordinated development within the inner ear sensory epithelia... 
Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 inductionMarilin Sulg
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
J Neurochem 112:1513-26. 2010..These data have important clinical implications as they show the importance of p53 in sensory cells that are essential in hearing function...- Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitorsHeidi Laine
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Dev Biol 337:134-46. 2010..Thus, cyclin D1 critically contributes to the proliferative plasticity of supporting cells. These data suggest that targeted cyclin D1 induction in supporting cells might be an avenue for proliferative regeneration in the inner ear... - Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epitheliaAnna Kirjavainen
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Dev Biol 322:33-45. 2008..The data point to the tight regulation of phenotypic characteristics of hair cells and supporting cells... - The ototoxic interaction of styrene and noiseAntti A Makitie
Department of Otorhinolaryngology, Helsinki University Central Hospital, P O Box 220, 00029 HUCH, Helsinki, Finland
Hear Res 179:9-20. 2003..We conclude that: (1) There is an ototoxic interaction between styrene and noise. (2) Synergism is manifested only if styrene is applied in concentrations above the critical level (between 300 and 600 ppm in this study)... - p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosisHeidi Laine
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 27:1434-44. 2007.... - Restrictions in cell cycle progression of adult vestibular supporting cells in response to ectopic cyclin D1 expressionHeidi Loponen
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
PLoS ONE 6:e27360. 2011..In addition, a part of ectopic cyclin D1 was sequestered in the cytoplasm, reflecting its ineffective nuclear import. Combined, our data reveal intrinsic barriers that limit proliferative capacity of utricular supporting cells... - Occupational noise-induced hearing loss reports and tinnitus in FinlandRoderik Mrena
Department of ORL, Helsinki University Central Hospital, Helsinki, Finland
Acta Otolaryngol 127:729-35. 2007..In occupational noise-induced hearing loss (NIHL) reports, many tinnitus sufferers probably remain undetected and untreated at present. Attention should be focused on tinnitus, as well as threshold shifts resulting from NIHL... - CD2-associated protein is widely expressed and differentially regulated during embryonic developmentSanna Lehtonen
Department of Pathology, Haartman Institute, University of Helsinki, PO Box 21, FIN 00014 Helsinki, Finland, and Helsinki University Central Hospital, FIN 00290 Helsinki, Finland
Differentiation 76:506-17. 2008..The cell-type specific spatio-temporal regulation of CD2AP during development suggests that this adapter protein is a key regulatory partner in many signaling pathways and cellular processes governing differentiation and morphogenesis... - Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activationU Pirvola
Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland
J Neurosci 20:43-50. 2000..These results suggest that therapeutic intervention in the JNK signaling cascade, possibly by using CEP-1347, may offer opportunities to treat inner ear injuries... - Guinea pig auditory neurons are protected by glial cell line-derived growth factor from degeneration after noise traumaJ Ylikoski
Department of ORL, University of Helsinki, Finland
Hear Res 124:17-26. 1998.... - Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell deathJukka Ylikoski
Institute of Biotechnology, University of Helsinki, Finland
Hear Res 163:71-81. 2002..These results suggest that activation of the JNK cascade may be a common molecular outcome of cellular stress in the inner ear sensory epithelia, and that attenuation of the lesion can be provided by inhibiting JNK activation... - Functional and morphological effects of styrene on the auditory system of the ratAntti Mäkitie
Department of Otorhinolaryngology and Head and Neck Surgery, Helsinki University Central Hospital, PO Box 220, 00029 HUCH, Helsinki, Finland
Arch Toxicol 76:40-7. 2002..We conclude that there appears to be a concentration threshold for styrene ototoxicity in rats (between 300 and 600 ppm)... - Neurotrophic factors during inner ear developmentUlla Pirvola
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Curr Top Dev Biol 57:207-23. 2003 - Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthoodTommi Anttonen
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Sci Rep 2:978. 2012..Thus, Cdc42 is required for structural differentiation of auditory supporting cells and this proper maturation is necessary for wound healing in adults... - Otologic consequences of blast exposure: a Finnish case study of a shopping mall bomb explosionRoderik Mrena
Department of ORL, Helsinki University Central Hospital, Helsinki, Finland
Acta Otolaryngol 124:946-52. 2004..We investigated the acute and subacute otologic consequences of the explosion... - Apoptosis in auditory brainstem neurons after a severe noise trauma of the organ of Corti: intracochlear GDNF treatment reduces the number of apoptotic cellsA A Aarnisalo
Department of Otolaryngology, University of Helsinki, Finland
ORL J Otorhinolaryngol Relat Spec 62:330-4. 2000..This can be prevented partially by rescuing primary cochlear neurons from degeneration with local GDNF treatment... - Hyperbaric oxygen therapy seems to enhance recovery from acute acoustic traumaJ Ylikoski
Helsinki Ear Institute and Department of Otolaryngology, University of Helsinki, Helsinki, Finland
Acta Otolaryngol 128:1110-5. 2008..HBOT can be valuable adjuvant therapy for patients with acute acoustic trauma (AAT)... - Expression and function of FGF10 in mammalian inner ear developmentSarah Pauley
Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
Dev Dyn 227:203-15. 2003..Together these data suggest that FGF10 plays a major role in ear morphogenesis. Most of these data are consistent with earlier findings on a null mutation in FGFR2b, one of FGF10's main receptors... - Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervationMengqing Xiang
Center for Advanced Biotechnology and Medicine, Department of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
BMC Neurosci 4:2. 2003..We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins... - Characteristics of acute acoustical trauma in the Finnish Defence ForcesRoderik Mrena
Department of ORL, Helsinki University Central Hospital, HUS, Finland
Int J Audiol 43:177-81. 2004..7% of conscripts had hearing impairment and 94.2% tinnitus. Hearing loss, tinnitus or both were experienced by 45% of conscripts at the last follow-up. Careful planning of training exercises could probably prevent some but not all AATs... - Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsuleMichael Ficker
Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK
Dev Biol 268:7-23. 2004..Furthermore, the expression patterns also reveal molecular heterogeneity in the developing capsule and indicate that for some genes, the chondrogenic otic capsule is composed of distinct domains of gene expression...