Ulla Pirvola

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions
    Ulla Pirvola
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 273:350-60. 2004
  2. ncbi request reprint FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis
    U Pirvola
    Institute of Biotechnology and Department of Otorhinolaryngology, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 20:6125-34. 2000
  3. ncbi request reprint FGFR1 is required for the development of the auditory sensory epithelium
    Ulla Pirvola
    Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland
    Neuron 35:671-80. 2002
  4. ncbi request reprint Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death
    Jukka Ylikoski
    Institute of Biotechnology, University of Helsinki, Finland
    Hear Res 166:33-43. 2002
  5. pmc The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
    Johanna Mantela
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 132:2377-88. 2005
  6. pmc FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals
    Ras Trokovic
    Institute of Biotechnology, Viikki Biocenter, PO Box 56, 00014 University of Helsinki, Finland
    EMBO J 22:1811-23. 2003
  7. doi request reprint Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia
    Anna Kirjavainen
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 322:33-45. 2008
  8. doi request reprint Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction
    Marilin Sulg
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Neurochem 112:1513-26. 2010
  9. doi request reprint Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors
    Heidi Laine
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 337:134-46. 2010
  10. ncbi request reprint The ototoxic interaction of styrene and noise
    Antti A Makitie
    Department of Otorhinolaryngology, Helsinki University Central Hospital, P O Box 220, 00029 HUCH, Helsinki, Finland
    Hear Res 179:9-20. 2003

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions
    Ulla Pirvola
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 273:350-60. 2004
    ..Together, these data show that Fgf9 signaling is required for inner ear morphogenesis...
  2. ncbi request reprint FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis
    U Pirvola
    Institute of Biotechnology and Department of Otorhinolaryngology, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 20:6125-34. 2000
    ..Our findings provide genetic evidence that signaling by FGFR-2(IIIb) is critical for the morphological development of the inner ear...
  3. ncbi request reprint FGFR1 is required for the development of the auditory sensory epithelium
    Ulla Pirvola
    Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland
    Neuron 35:671-80. 2002
    ..Our data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium...
  4. ncbi request reprint Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death
    Jukka Ylikoski
    Institute of Biotechnology, University of Helsinki, Finland
    Hear Res 166:33-43. 2002
    ..Thus, our results imply that activation of JNK cascade may be a common molecular outcome of cellular stress in the inner ear sensory epithelia and that attenuation of the lesion can be provided by inhibiting JNK activation...
  5. pmc The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
    Johanna Mantela
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 132:2377-88. 2005
    ..Our findings demonstrate that the pRb pathway is required for hair cell quiescence and that manipulation of the cell cycle machinery disrupts the coordinated development within the inner ear sensory epithelia...
  6. pmc FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals
    Ras Trokovic
    Institute of Biotechnology, Viikki Biocenter, PO Box 56, 00014 University of Helsinki, Finland
    EMBO J 22:1811-23. 2003
    ..In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell-adhesion molecules at the midbrain-hindbrain border...
  7. doi request reprint Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia
    Anna Kirjavainen
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 322:33-45. 2008
    ..The data point to the tight regulation of phenotypic characteristics of hair cells and supporting cells...
  8. doi request reprint Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction
    Marilin Sulg
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Neurochem 112:1513-26. 2010
    ..These data have important clinical implications as they show the importance of p53 in sensory cells that are essential in hearing function...
  9. doi request reprint Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors
    Heidi Laine
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 337:134-46. 2010
    ..Thus, cyclin D1 critically contributes to the proliferative plasticity of supporting cells. These data suggest that targeted cyclin D1 induction in supporting cells might be an avenue for proliferative regeneration in the inner ear...
  10. ncbi request reprint The ototoxic interaction of styrene and noise
    Antti A Makitie
    Department of Otorhinolaryngology, Helsinki University Central Hospital, P O Box 220, 00029 HUCH, Helsinki, Finland
    Hear Res 179:9-20. 2003
    ..We conclude that: (1) There is an ototoxic interaction between styrene and noise. (2) Synergism is manifested only if styrene is applied in concentrations above the critical level (between 300 and 600 ppm in this study)...
  11. ncbi request reprint p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis
    Heidi Laine
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 27:1434-44. 2007
    ....
  12. ncbi request reprint Occupational noise-induced hearing loss reports and tinnitus in Finland
    Roderik Mrena
    Department of ORL, Helsinki University Central Hospital, Helsinki, Finland
    Acta Otolaryngol 127:729-35. 2007
    ..In occupational noise-induced hearing loss (NIHL) reports, many tinnitus sufferers probably remain undetected and untreated at present. Attention should be focused on tinnitus, as well as threshold shifts resulting from NIHL...
  13. pmc Restrictions in cell cycle progression of adult vestibular supporting cells in response to ectopic cyclin D1 expression
    Heidi Loponen
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    PLoS ONE 6:e27360. 2011
    ..In addition, a part of ectopic cyclin D1 was sequestered in the cytoplasm, reflecting its ineffective nuclear import. Combined, our data reveal intrinsic barriers that limit proliferative capacity of utricular supporting cells...
  14. doi request reprint CD2-associated protein is widely expressed and differentially regulated during embryonic development
    Sanna Lehtonen
    Department of Pathology, Haartman Institute, University of Helsinki, PO Box 21, FIN 00014 Helsinki, Finland, and Helsinki University Central Hospital, FIN 00290 Helsinki, Finland
    Differentiation 76:506-17. 2008
    ..The cell-type specific spatio-temporal regulation of CD2AP during development suggests that this adapter protein is a key regulatory partner in many signaling pathways and cellular processes governing differentiation and morphogenesis...
  15. ncbi request reprint Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation
    U Pirvola
    Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland
    J Neurosci 20:43-50. 2000
    ..These results suggest that therapeutic intervention in the JNK signaling cascade, possibly by using CEP-1347, may offer opportunities to treat inner ear injuries...
  16. ncbi request reprint Guinea pig auditory neurons are protected by glial cell line-derived growth factor from degeneration after noise trauma
    J Ylikoski
    Department of ORL, University of Helsinki, Finland
    Hear Res 124:17-26. 1998
    ....
  17. doi request reprint Transcutaneous vagus nerve stimulation in tinnitus: a pilot study
    Jarmo Lehtimäki
    Tinnoff Inc, Helsinki, Finland
    Acta Otolaryngol 133:378-82. 2013
    ..Our magnetoencephalography (MEG) results show that auditory cortical activation can be modulated by the application of tVNS. Thus, tVNS might offer a new avenue to treat tinnitus and tinnitus-associated distress...
  18. ncbi request reprint Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death
    Jukka Ylikoski
    Institute of Biotechnology, University of Helsinki, Finland
    Hear Res 163:71-81. 2002
    ..These results suggest that activation of the JNK cascade may be a common molecular outcome of cellular stress in the inner ear sensory epithelia, and that attenuation of the lesion can be provided by inhibiting JNK activation...
  19. pmc Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood
    Tommi Anttonen
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Sci Rep 2:978. 2012
    ..Thus, Cdc42 is required for structural differentiation of auditory supporting cells and this proper maturation is necessary for wound healing in adults...
  20. ncbi request reprint Neurotrophic factors during inner ear development
    Ulla Pirvola
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Curr Top Dev Biol 57:207-23. 2003
  21. ncbi request reprint Functional and morphological effects of styrene on the auditory system of the rat
    Antti Mäkitie
    Department of Otorhinolaryngology and Head and Neck Surgery, Helsinki University Central Hospital, PO Box 220, 00029 HUCH, Helsinki, Finland
    Arch Toxicol 76:40-7. 2002
    ..We conclude that there appears to be a concentration threshold for styrene ototoxicity in rats (between 300 and 600 ppm)...
  22. ncbi request reprint Otologic consequences of blast exposure: a Finnish case study of a shopping mall bomb explosion
    Roderik Mrena
    Department of ORL, Helsinki University Central Hospital, Helsinki, Finland
    Acta Otolaryngol 124:946-52. 2004
    ..We investigated the acute and subacute otologic consequences of the explosion...
  23. ncbi request reprint Apoptosis in auditory brainstem neurons after a severe noise trauma of the organ of Corti: intracochlear GDNF treatment reduces the number of apoptotic cells
    A A Aarnisalo
    Department of Otolaryngology, University of Helsinki, Finland
    ORL J Otorhinolaryngol Relat Spec 62:330-4. 2000
    ..This can be prevented partially by rescuing primary cochlear neurons from degeneration with local GDNF treatment...
  24. doi request reprint Hyperbaric oxygen therapy seems to enhance recovery from acute acoustic trauma
    J Ylikoski
    Helsinki Ear Institute and Department of Otolaryngology, University of Helsinki, Helsinki, Finland
    Acta Otolaryngol 128:1110-5. 2008
    ..HBOT can be valuable adjuvant therapy for patients with acute acoustic trauma (AAT)...
  25. pmc Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation
    Mengqing Xiang
    Center for Advanced Biotechnology and Medicine, Department of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    BMC Neurosci 4:2. 2003
    ..We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins...
  26. ncbi request reprint Expression and function of FGF10 in mammalian inner ear development
    Sarah Pauley
    Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
    Dev Dyn 227:203-15. 2003
    ..Together these data suggest that FGF10 plays a major role in ear morphogenesis. Most of these data are consistent with earlier findings on a null mutation in FGFR2b, one of FGF10's main receptors...
  27. ncbi request reprint Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule
    Michael Ficker
    Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK
    Dev Biol 268:7-23. 2004
    ..Furthermore, the expression patterns also reveal molecular heterogeneity in the developing capsule and indicate that for some genes, the chondrogenic otic capsule is composed of distinct domains of gene expression...
  28. ncbi request reprint Characteristics of acute acoustical trauma in the Finnish Defence Forces
    Roderik Mrena
    Department of ORL, Helsinki University Central Hospital, HUS, Finland
    Int J Audiol 43:177-81. 2004
    ..7% of conscripts had hearing impairment and 94.2% tinnitus. Hearing loss, tinnitus or both were experienced by 45% of conscripts at the last follow-up. Careful planning of training exercises could probably prevent some but not all AATs...