Genomes and Genes
Affiliation: University of Helsinki
- Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activationU Pirvola
Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland
J Neurosci 20:43-50. 2000..These results suggest that therapeutic intervention in the JNK signaling cascade, possibly by using CEP-1347, may offer opportunities to treat inner ear injuries...
- Guinea pig auditory neurons are protected by glial cell line-derived growth factor from degeneration after noise traumaJ Ylikoski
Department of ORL, University of Helsinki, Finland
Hear Res 124:17-26. 1998....
- Apoptosis in auditory brainstem neurons after a severe noise trauma of the organ of Corti: intracochlear GDNF treatment reduces the number of apoptotic cellsA A Aarnisalo
Department of Otolaryngology, University of Helsinki, Finland
ORL J Otorhinolaryngol Relat Spec 62:330-4. 2000..This can be prevented partially by rescuing primary cochlear neurons from degeneration with local GDNF treatment...
- Hyperbaric oxygen therapy seems to enhance recovery from acute acoustic traumaJ Ylikoski
Helsinki Ear Institute and Department of Otolaryngology, University of Helsinki, Helsinki, Finland
Acta Otolaryngol 128:1110-5. 2008..HBOT can be valuable adjuvant therapy for patients with acute acoustic trauma (AAT)...
- FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesisU Pirvola
Institute of Biotechnology and Department of Otorhinolaryngology, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 20:6125-34. 2000..Our findings provide genetic evidence that signaling by FGFR-2(IIIb) is critical for the morphological development of the inner ear...