Affiliation: University of Tampere
Oksanen A, AittomÃ¤ki S, Jankovic D, Ortutay Z, Pulkkinen K, HÃ¤mÃ¤lÃ¤inen S, et al
. Proprotein convertase FURIN constrains Th2 differentiation and is critical for host resistance against Toxoplasma gondii. J Immunol. 2014;193:5470-9 pubmed publisher
..In conclusion, our results demonstrate that in addition to peripheral immune tolerance, T cell-expressed FURIN is also a central regulator of cell-mediated immunity and Th1/2 cell balance. ..
Ortutay Z, Oksanen A, AittomÃ¤ki S, Ortutay C, Pesu M. Proprotein convertase FURIN regulates T cell receptor-induced transactivation. J Leukoc Biol. 2015;98:73-83 pubmed publisher
..Collectively, our work confirms the hypothesis that the TCR-regulated protease FURIN plays an important role in T cell activation and that it can specifically modulate TCR-activated transactivation. ..
Ojanen M, Turpeinen H, Cordova Z, HammarÃ©n M, Harjula S, Parikka M, et al
. The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum. Infect Immun. 2015;83:1431-42 pubmed publisher
..marinum infection model. Our data show that upregulated furinA expression can serve as a marker for mycobacterial disease, since it inhibits early host responses and consequently promotes bacterial growth in a chronic infection. ..
AittomÃ¤ki S, Valanne S, Lehtinen T, Matikainen S, Nyman T, RÃ¤met M, et al
. Proprotein convertase Furin1 expression in the Drosophila fat body is essential for a normal antimicrobial peptide response and bacterial host defense. FASEB J. 2017;31:4770-4782 pubmed publisher
..Lehtinen, T., Matikainen, S., Nyman, T. A., RÃ¤met, M., Pesu, M. Proprotein convertase Furin1 expression in the Drosophila fat body is essential for a normal antimicrobial peptide response and bacterial host defense. ..