A Pertovaara

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. doi request reprint The noradrenergic pain regulation system: a potential target for pain therapy
    Antti Pertovaara
    Institute of Biomedicine Physiology, University of Helsinki, POB 63, Helsinki 00014, Finland Electronic address
    Eur J Pharmacol 716:2-7. 2013
  2. ncbi request reprint Dual influence of the striatum on neuropathic hypersensitivity
    Antti Pertovaara
    Biomedicum Helsinki, Institute of Biomedicine Physiology, POB 63, University of Helsinki, FIN 00014, Finland
    Pain 137:50-9. 2008
  3. doi request reprint TRPA1 ion channel in the spinal dorsal horn as a therapeutic target in central pain hypersensitivity and cutaneous neurogenic inflammation
    Antti Pertovaara
    Institute of Biomedicine Physiology, POB 63, University of Helsinki, 00014 Helsinki, Finland
    Eur J Pharmacol 666:1-4. 2011
  4. ncbi request reprint Noradrenergic pain modulation
    Antti Pertovaara
    Biomedicum Helsinki, Institute of Biomedicine Physiology, PO Box 63, University of Helsinki, FIN 00014 Helsinki, Finland
    Prog Neurobiol 80:53-83. 2006
  5. ncbi request reprint Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective alpha2-adrenoceptor antagonist
    Antti Pertovaara
    Institute of Biomedicine Physiology, University of Helsinki, Helsinki, Finland
    CNS Drug Rev 11:273-88. 2005
  6. ncbi request reprint RFamide-related peptides signal through the neuropeptide FF receptor and regulate pain-related responses in the rat
    A Pertovaara
    Department of Physiology, University of Turku, Turku, Finland
    Neuroscience 134:1023-32. 2005
  7. ncbi request reprint Response properties of neurons in the rostroventromedial medulla of neuropathic rats: attempted modulation of responses by [1DMe]NPYF, a neuropeptide FF analogue
    A Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
    Neuroscience 105:457-68. 2001
  8. ncbi request reprint Attenuation of ascending nociceptive signals to the rostroventromedial medulla induced by a novel alpha2-adrenoceptor agonist, MPV-2426, following intrathecal application in neuropathic rats
    A Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Turku, Finland
    Anesthesiology 92:1082-92. 2000
  9. ncbi request reprint Modulation of pain by [1DMe]NPYF, a stable analogue of neuropeptide FF, in neuropathic rats
    H Wei
    Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland
    Brain Res 900:234-43. 2001
  10. ncbi request reprint Peripheral effects of morphine in neuropathic rats: role of sympathetic postganglionic nerve fibers
    A Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Eur J Pharmacol 429:139-45. 2001

Collaborators

Detail Information

Publications52

  1. doi request reprint The noradrenergic pain regulation system: a potential target for pain therapy
    Antti Pertovaara
    Institute of Biomedicine Physiology, University of Helsinki, POB 63, Helsinki 00014, Finland Electronic address
    Eur J Pharmacol 716:2-7. 2013
    ..Adrenoceptor agonists have proven effective in treating various pain conditions...
  2. ncbi request reprint Dual influence of the striatum on neuropathic hypersensitivity
    Antti Pertovaara
    Biomedicum Helsinki, Institute of Biomedicine Physiology, POB 63, University of Helsinki, FIN 00014, Finland
    Pain 137:50-9. 2008
    ..Furthermore, our findings indicate that striatal NMDA receptors provide a tonic supramedullary drive for medullospinal facilitatory influence that is known to be of importance for neuropathic hypersensitivity...
  3. doi request reprint TRPA1 ion channel in the spinal dorsal horn as a therapeutic target in central pain hypersensitivity and cutaneous neurogenic inflammation
    Antti Pertovaara
    Institute of Biomedicine Physiology, POB 63, University of Helsinki, 00014 Helsinki, Finland
    Eur J Pharmacol 666:1-4. 2011
    ..Blockade of the spinal TRPA1 channel-mediated regulation of transmission may also attenuate cutaneous neurogenic inflammation...
  4. ncbi request reprint Noradrenergic pain modulation
    Antti Pertovaara
    Biomedicum Helsinki, Institute of Biomedicine Physiology, PO Box 63, University of Helsinki, FIN 00014 Helsinki, Finland
    Prog Neurobiol 80:53-83. 2006
    ..Following injury or inflammation, the central as well as peripheral noradrenergic system is subject to various plastic changes that influence its antinociceptive efficacy...
  5. ncbi request reprint Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective alpha2-adrenoceptor antagonist
    Antti Pertovaara
    Institute of Biomedicine Physiology, University of Helsinki, Helsinki, Finland
    CNS Drug Rev 11:273-88. 2005
    ..In phase I studies atipamezole has been well tolerated by human subjects...
  6. ncbi request reprint RFamide-related peptides signal through the neuropeptide FF receptor and regulate pain-related responses in the rat
    A Pertovaara
    Department of Physiology, University of Turku, Turku, Finland
    Neuroscience 134:1023-32. 2005
    ..In neuropathic animals, the pain suppressive effect of RFamide-related peptide varies depending on the submodality of noxious test stimulation and the site of RFamide-related peptide administration...
  7. ncbi request reprint Response properties of neurons in the rostroventromedial medulla of neuropathic rats: attempted modulation of responses by [1DMe]NPYF, a neuropeptide FF analogue
    A Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
    Neuroscience 105:457-68. 2001
    ....
  8. ncbi request reprint Attenuation of ascending nociceptive signals to the rostroventromedial medulla induced by a novel alpha2-adrenoceptor agonist, MPV-2426, following intrathecal application in neuropathic rats
    A Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Turku, Finland
    Anesthesiology 92:1082-92. 2000
    ..In the current study, the potency and spread of the antinociception induced by MPV-2426, a novel alpha2-adrenoceptor agonist, was characterized in neuropathic and non-neuropathic animals...
  9. ncbi request reprint Modulation of pain by [1DMe]NPYF, a stable analogue of neuropeptide FF, in neuropathic rats
    H Wei
    Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland
    Brain Res 900:234-43. 2001
    ..The amide-group is essential for the [1DMe]NPYF-induced attenuation of pain...
  10. ncbi request reprint Peripheral effects of morphine in neuropathic rats: role of sympathetic postganglionic nerve fibers
    A Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Eur J Pharmacol 429:139-45. 2001
    ..Sympathectomy of the neuropathic limb may underlie, at least partly, the increased peripheral efficacy of morphine in neuropathy...
  11. pmc Inhibitors of catechol-O-methyltransferase sensitize mice to pain
    O Kambur
    Primary laboratory of origin Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
    Br J Pharmacol 161:1553-65. 2010
    ..Here, we have assessed the effects of acute and repeated administrations of COMT inhibitors on mechanical, thermal and carrageenan-induced nociception in male mice...
  12. ncbi request reprint Modulation of visceral nociceptive responses of rat spinal dorsal horn neurons by sympathectomy
    J Kalmari
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
    Neuroreport 12:797-801. 2001
    ....
  13. ncbi request reprint Spinal transient receptor potential ankyrin 1 channel induces mechanical hypersensitivity, increases cutaneous blood flow, and mediates the pronociceptive action of dynorphin A
    H Wei
    Institute of Biomedicine Physiology, POB 63, University of Helsinki, 00014 Helsinki, Finland
    J Physiol Pharmacol 64:331-40. 2013
    ..Moreover, the spinal TRPA1 channel is involved in mediating the pronociceptive action of dynorphin A, but not that of the spinal cholecystokinin or prostaglandin F(2α)...
  14. ncbi request reprint The influence of stimulus temperature rise rate, adapting temperature, and stimulus duration on suprathreshold responses evoked by noxious heat in the glabrous skin of the limb. Comparison of neuronal discharge in the rat spinal dorsal horn with human sen
    A Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
    Exp Brain Res 126:482-94. 1999
    ..The effect of spinalization indicated that descending pathways control not only the response magnitude in the spinal dorsal horn WDR neurons but also the temporal characteristics of the spinal neuronal response...
  15. ncbi request reprint Neuropeptide FF and modulation of pain
    P Panula
    Department of Biology, Abo Akademi University, BioCity, Tykistokatu 6A, 20520, Turku, Finland
    Brain Res 848:191-6. 1999
    ..NPFF thus modulates pain sensation and morphine analgesia under normal and pathological conditions through both spinal and brain mechanisms...
  16. ncbi request reprint Lidocaine in the rostroventromedial medulla and the periaqueductal gray attenuates allodynia in neuropathic rats
    A Pertovaara
    Department of Physiology, University of Helsinki, Finland
    Neurosci Lett 218:127-30. 1996
    ..The selective attenuation of allodynia induced by lidocaine in the RVM and the PAG is independent of opiate receptors, and it can not be explained by a systemic spread of the drug...
  17. ncbi request reprint Influence of peripheral nerve injury on response properties of locus coeruleus neurons and coeruleospinal antinociception in the rat
    H Viisanen
    Biomedicum Helsinki, Institute of Biomedicine Physiology, POB 63, University of Helsinki, FIN 00014 Helsinki, Finland
    Neuroscience 146:1785-94. 2007
    ..Furthermore, we propose the hypothesis that emotions processed by the amygdala enhance pain due to increased inhibition of the LC in peripheral neuropathy...
  18. ncbi request reprint The influence of chemical sympathectomy on pain responsivity and alpha 2-adrenergic antinociception in neuropathic animals
    H Wei
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Neuroscience 114:655-68. 2002
    ....
  19. ncbi request reprint Influence of skin temperature on heat pain threshold in humans
    A Pertovaara
    Department of Physiology, University of Turku, Finland
    Exp Brain Res 107:497-503. 1996
    ..With an increase in the duration of the heat stimulus, the critical temperature for eliciting pain sensation was significantly decreased, which may be explained by central neuronal mechanisms (temporal summation)...
  20. doi request reprint Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits
    M Uutela
    Institute of Biomedicine, Physiology, University of Helsinki, Finland
    Genes Brain Behav 11:513-23. 2012
    ..Our results show that the absence of FMRP modifies the diverse effects of BDNF on the FXS phenotype...
  21. ncbi request reprint Changes in tooth pulpal detection and pain thresholds in relation to jaw movement in man
    P Kemppainen
    Department of Prosthetic Dentistry, Institute of Dentistry, University of Helsinki, PO Box 41, FIN 00014 Helsinki, Finland
    Arch Oral Biol 46:33-7. 2001
    ..The jaw movement-related suppression of pulpal sensitivity may be explained by activation of segmental afferent-induced inhibition, corollary efferent barrage from motor to sensory areas, or a combination of both...
  22. doi request reprint Dose-related effects of memantine on a mismatch negativity-like response in anesthetized rats
    D Tikhonravov
    Neuroscience Unit, Institute of Biomedicine Physiology, University of Helsinki, Helsinki, Finland
    Neuroscience 167:1175-82. 2010
    ..The high dose of memantine, in contrast, blocked the generation of the auditory MMN-like response. The findings suggest that memantine may, with appropriate doses, facilitate already this early stage of auditory processing...
  23. ncbi request reprint Pain-related behavior following REM sleep deprivation in the rat: influence of peripheral nerve injury, spinal glutamatergic receptors and nitric oxide
    Hong Wei
    School of Pharmacy, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, China
    Brain Res 1148:105-12. 2007
    ..Furthermore, mechanical hypersensitivities following REMSD and peripheral nerve injury share common spinal mechanisms involving, at least, the mGluR(5) and nitric oxide...
  24. doi request reprint Role of spinal 5-HT receptors in cutaneous hypersensitivity induced by REM sleep deprivation
    Hong Wei
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
    Pharmacol Res 57:469-75. 2008
    ..Spinal 5-HT(3) receptors do not contribute to cutaneous hypersensitivity induced by sleep deprivation...
  25. ncbi request reprint Striatal dopamine D2 receptors attenuate neuropathic hypersensitivity in the rat
    Osei B Ansah
    Biomedicum Helsinki, Institute of Biomedicine Physiology, POB 63, University of Helsinki, 00014 Helsinki, Finland
    Exp Neurol 205:536-46. 2007
    ....
  26. ncbi request reprint Peripheral suppression of arthritic pain by intraarticular fadolmidine, an alpha 2-adrenoceptor agonist, in the rat
    Osei B Ansah
    Biomedicum Helsinki, Institute of Biomedicine Physiology, University of Helsinki, Helsinki, Finland
    Anesth Analg 105:245-50. 2007
    ..We assessed the peripheral antinociceptive properties of fadolmidine and the potential contribution of peripheral opioid receptors to its antinociceptive effect in experimental monoarthritis...
  27. ncbi request reprint Correlation of human cold pressor pain responses with 5-HT(1A) receptor binding in the brain
    Ilkka K Martikainen
    Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland
    Brain Res 1172:21-31. 2007
    ..In general, subjects with high availability of 5-HT(1A) receptors have low CPP intensity accompanied by a high capacity for central suppression of pain or a sympathetic vasoconstriction response by a Valsalva maneuver...
  28. ncbi request reprint Prolactin-releasing peptide affects pain, allodynia and autonomic reflexes through medullary mechanisms
    Maija Liisa Kalliomäki
    Department of Biology, Abo Akademi University, Biocity Artillerigatan 6A, 20520 Turku, SF, Finland
    Neuropharmacology 46:412-24. 2004
    ..The results show that PrRP modulates nociception due to supraspinal rather than spinal action, and that its antinociceptive mechanism differs from that previously characterized for NPFF...
  29. ncbi request reprint Pronociceptive changes in response properties of rostroventromedial medullary neurons in a rat model of peripheral neuropathy
    Leonor Gonçalves
    Biomedicum Helsinki, Biomedicine Physiology, POB 63, 00014 University of Helsinki, Finland
    Eur J Neurosci 26:2188-95. 2007
    ....
  30. doi request reprint Effects of an NMDA-receptor antagonist MK-801 on an MMN-like response recorded in anesthetized rats
    Dmitry Tikhonravov
    Neuroscience Unit, Institute of Biomedicine Physiology, University of Helsinki, Finland Helsinki Brain Research Center, Finland
    Brain Res 1203:97-102. 2008
    ..Further, this response was dose-dependently blocked by MK-801. These results suggest that the MMN-like response in rats depends on an intact NMDA-receptor system...
  31. ncbi request reprint Neuropathy reduces viscero-somatic inhibition via segmental mechanisms in rats
    Antti Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku
    Neuroreport 13:1047-50. 2002
    ..The decreased inhibition of somatic signals may contribute to the hypersensitivity observed in neuropathic conditions...
  32. ncbi request reprint Comparison of the visceral antinociceptive effects of spinally administered MPV-2426 (fadolmidine) and clonidine in the rat
    Antti Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Anesthesiology 98:189-94. 2003
    ..They also determined whether the sympathetic nervous system or intact descending pathways are critical for the alpha 2 -adrenoceptor-induced visceral antinociception...
  33. ncbi request reprint Striatal dopamine D2/D3 receptor availability correlates with individual response characteristics to pain
    Antti Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Turku, Jiinamyllynkatu 10, FIN 20520 Turku, Finland
    Eur J Neurosci 20:1587-92. 2004
    ..Alternatively, striatal dopamine D2/D3 receptors could control a modulatory pathway producing a parallel shift in the stimulus-response function for sensory signals, mimicking a change in the subject's response criterion...
  34. ncbi request reprint Colorectal distension-induced suppression of a nociceptive somatic reflex response in the rat: modulation by tissue injury or inflammation
    Jaakko Kalmari
    Biomedicum Helsinki, Institute of Biomedicine Physiology, University of Helsinki, 00014, Finland
    Brain Res 1018:106-10. 2004
    ....
  35. ncbi request reprint Alpha(2A) adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia
    Heikki Mansikka
    Department of Anesthesia and Intensive Care, Turku University Central Hospital, Turku, Finland
    Anesthesiology 101:185-90. 2004
    ....
  36. ncbi request reprint Spinal and pontine alpha2-adrenoceptors have opposite effects on pain-related behavior in the neuropathic rat
    Hong Wei
    Biomedicum Helsinki, Institute of Biomedicine Physiology, POB 63, 00014 University of Helsinki, Finland
    Eur J Pharmacol 551:41-9. 2006
    ..Thus, spinal and pontine alpha(2)-adrenoceptors have opposite effects on pain-related behavior in neuropathic animals...
  37. ncbi request reprint Spatial integration of cold pressor pain sensation in humans
    Ilkka K Martikainen
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Neurosci Lett 361:140-3. 2004
    ..A decrease in the test stimulus area increased the suppressive effect by conditioning CPP. Thus, CPP shows spatial summation or inhibition depending on experimental parameters...
  38. ncbi request reprint Influence of the dopamine D2 receptor knockout on pain-related behavior in the mouse
    Heikki Mansikka
    Department of Physiology, Institute of Biomedicine, University of Turku, 20520 Turku, Finland
    Brain Res 1052:82-7. 2005
    ..Additionally, dopamine D2 receptors may contribute to attenuation of referred hypersensitivity caused by sustained nociception...
  39. ncbi request reprint A dissociative change in the efficacy of supraspinal versus spinal morphine in the neuropathic rat
    Antti Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Pain 101:237-50. 2003
    ..Descending influence from brainstem-spinal pathways, involving NMDA receptors in the rostroventromedial medulla, may contribute to the selective reduction in tactile antiallodynic efficacy of spinal morphine...
  40. ncbi request reprint Thermal sensation and pain in oral lichen planus and lichenoid reaction
    Sirkku Niissalo
    Department of Oral Pathology, Institute of Dentistry, University of Helsinki and Laboratory Diagnostics Oral Pathology Unit, Helsinki University Central Hospital, Helsinki, Finland
    J Oral Pathol Med 32:41-5. 2003
    ..Our previous findings in oral lichen planus (OLP) and lichenoid reactions (LR) raised the question whether the histopathological changes observed in sensory and autonomic innervation produce oral sensory disorders...
  41. ncbi request reprint Localization of touch versus heat pain in the human hand: a dissociative effect of temporal parameters on discriminative capacity and decision strategy
    Shelley Ylioja
    Institute of Biomedicine Physiology, University of Helsinki, Helsinki, Finland
    Pain 121:6-13. 2006
    ..In a cutaneous localization task, the subject's accuracy and response strategy vary with the modality and temporal parameters of sequential test stimulation...
  42. ncbi request reprint 5-HT(1A) receptors in endogenous regulation of neuropathic hypersensitivity in the rat
    Hong Wei
    Biomedicum Helsinki, Institute of Biomedicine Physiology, POB 63, 00014 University of Helsinki, Finland
    Eur J Pharmacol 535:157-65. 2006
    ..This leads to selective attenuation of neuropathic hypersensitivity, due to action on spinal 5-HT(1A) receptors and alpha2-adrenoceptors...
  43. ncbi request reprint Cutaneous vascular responses evoked by noxious stimulation in rats with the spinal nerve ligation-induced model of neuropathy
    Timo Kauppila
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Brain Res Bull 58:21-6. 2002
    ..The attenuation of antidromically-induced vascular responses was not caused by overriding sympathetic activity, as indicated by lack of blood flow effects by lidocaine blocks or a transection of the sciatic nerve...
  44. ncbi request reprint Association of striatal dopamine D2/D3 receptor binding potential with pain but not tactile sensitivity or placebo analgesia
    Ilkka K Martikainen
    Department of Physiology, University of Turku, Turku, Finland
    Neurosci Lett 376:149-53. 2005
    ..Moreover, striatal dopamine D2/D3 receptor BP appears not to predict individual's analgesic response to placebo...
  45. doi request reprint Neuropathic pain is associated with depressive behaviour and induces neuroplasticity in the amygdala of the rat
    Leonor Gonçalves
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Exp Neurol 213:48-56. 2008
    ..Given the established role of the AMY in emotional behaviour, we propose that these neuroplastic changes might contribute for the development of depressive-like symptoms that are usually present in prolonged pain syndromes in humans...
  46. doi request reprint Navigated transcranial magnetic stimulation of the primary somatosensory cortex impairs perceptual processing of tactile temporal discrimination
    Henri Hannula
    Neuroscience Unit, Institute of Biomedicine Physiology, University of Helsinki, Helsinki, Finland
    Neurosci Lett 437:144-7. 2008
    ..The result indicates that S1 area representing a cutaneous test site is involved in perceptual processing of tactile temporal discrimination...
  47. ncbi request reprint Antinociceptive properties of fadolmidine (MPV-2426), a novel alpha2-adrenoceptor agonist
    Antti Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Turku, Finland, Kiinamyllynkatu 10, FIN 20520, Turku, Finland
    CNS Drug Rev 10:117-26. 2004
    ..Additionally, peripheral administration of fadolmidine might provide a selective treatment for some hypersensitivity states that involve dysfunction of the sympathetic nervous system...
  48. doi request reprint Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamus
    Filipa Pinto-Ribeiro
    Biomedicum Helsinki, Institute of Biomedicine Physiology, POB 63, University of Helsinki, 00014 Helsinki, Finland
    Brain Res 1197:63-75. 2008
    ..Arthritis has a dual influence on the PVN-induced drive of relay cells in the RVM which reduces the arthritis-induced net change in the descending antinociceptive influence from the PVN...
  49. ncbi request reprint A potential aphrodisiac for female macaques
    Antti Pertovaara
    Neuroscience Unit, Helsinki Brain Research Center, Institute of Biomedicine Physiology, University of Helsinki, Helsinki, Finland
    Pharmacol Biochem Behav 79:137-41. 2004
    ....
  50. ncbi request reprint Striatal dopamine D2 receptors in modulation of pain in humans: a review
    Nora Hagelberg
    Turku PET Centre, Turku University Central Hospital and University of Turku, 20520 Turku, Finland
    Eur J Pharmacol 500:187-92. 2004
    ..We propose that the striatal dopamine D2 receptor may be an important target for the diagnosis and treatment of chronic pain...
  51. ncbi request reprint The alpha2A-adrenoceptor subtype is not involved in inflammatory hyperalgesia or morphine-induced antinociception
    Janne Lähdesmäki
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    Eur J Pharmacol 468:183-9. 2003
    ..In addition, alpha(2A)-adrenoceptors do not appear to play an important role in mu-opioid receptor-mediated antinociception or antihyperalgesia...
  52. ncbi request reprint Dopamine D2 receptor binding in the human brain is associated with the response to painful stimulation and pain modulatory capacity
    Nora Hagelberg
    Department of Anaesthesiology and Intensive Care, University of Turku, Turku, Finland
    Pain 99:273-9. 2002
    ....