Seppo Parkkila

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. pmc Carbonic anhydrase II in the endothelium of glial tumors: a potential target for therapy
    Joonas Haapasalo
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, FIN 33520 Tampere, Finland
    Neuro Oncol 9:308-13. 2007
  2. pmc The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV
    Seppo Parkkila
    Department of Clinical Chemistry, 90014 University of Oulu, Finland
    BMC Gastroenterol 2:13. 2002
  3. pmc Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors
    Seppo Parkkila
    Department of Anatomy, University of Tampere and Tampere University Hospital, Tampere, Finland
    Mod Pathol 23:743-50. 2010
  4. doi request reprint Significance of pH regulation and carbonic anhydrases in tumour progression and implications for diagnostic and therapeutic approaches
    Seppo Parkkila
    Institute of Medical Technology and School of Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
    BJU Int 101:16-21. 2008
  5. pmc Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa
    Laura Kummola
    Institute of Medical Technology, University of Tampere, and Tampere University Hospital, Tampere, Finland
    BMC Cancer 5:41. 2005
  6. pmc Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas
    Joonas Haapasalo
    Institute of Medical Technology, University of Tampere, Biokatu 6, FI 33520 Tampere, Finland
    Neuro Oncol 10:131-8. 2008
  7. doi request reprint Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster
    Leo Syrjänen
    Institute of Biomedical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Bioorg Med Chem 21:1516-21. 2013
  8. pmc Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice
    Peiwen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, 33520 Tampere, Finland
    J Physiol 571:319-27. 2006
  9. doi request reprint Carbonic anhydrases in the mouse harderian gland
    Pei wen Pan
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520 Tampere, Finland
    J Mol Histol 41:411-7. 2010
  10. doi request reprint Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases
    Fatemeh Bootorabi
    Institute of Biomedical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Enzyme Inhib Med Chem 26:862-70. 2011

Detail Information

Publications88

  1. pmc Carbonic anhydrase II in the endothelium of glial tumors: a potential target for therapy
    Joonas Haapasalo
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, FIN 33520 Tampere, Finland
    Neuro Oncol 9:308-13. 2007
    ..From a clinical perspective, the results also open new avenues for selecting tumor types for dendritic cell therapy trials...
  2. pmc The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV
    Seppo Parkkila
    Department of Clinical Chemistry, 90014 University of Oulu, Finland
    BMC Gastroenterol 2:13. 2002
    ..The present study was designed to examine whether CA XIV could contribute to the CA activity described in the hepatocytes...
  3. pmc Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors
    Seppo Parkkila
    Department of Anatomy, University of Tampere and Tampere University Hospital, Tampere, Finland
    Mod Pathol 23:743-50. 2010
    ..0001). The present results indicate that CA II is overexpressed in most GISTs, is quite selective to this tumor type among mesenchymal tumors, and therefore might be a useful biomarker in diagnostics...
  4. doi request reprint Significance of pH regulation and carbonic anhydrases in tumour progression and implications for diagnostic and therapeutic approaches
    Seppo Parkkila
    Institute of Medical Technology and School of Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
    BJU Int 101:16-21. 2008
  5. pmc Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa
    Laura Kummola
    Institute of Medical Technology, University of Tampere, and Tampere University Hospital, Tampere, Finland
    BMC Cancer 5:41. 2005
    ..It is a cytosolic isozyme which is expressed in a number of normal tissues. The present study was designed to investigate CA XIII expression in prospectively collected colorectal tumor samples...
  6. pmc Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas
    Joonas Haapasalo
    Institute of Medical Technology, University of Tampere, Biokatu 6, FI 33520 Tampere, Finland
    Neuro Oncol 10:131-8. 2008
    ..The absence of 11 amino acids in the shorter isoform, which seems to be common in astrocytomas, may affect the normal quaternary structure and biological function of CA XII...
  7. doi request reprint Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster
    Leo Syrjänen
    Institute of Biomedical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Bioorg Med Chem 21:1516-21. 2013
    ..melanogaster may provide a new animal model for CA-related eye diseases. A series of dithiocarbamates were also screened as inhibitors of these enzymes, with some representatives showing inhibition in the low nanomolar range...
  8. pmc Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice
    Peiwen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, 33520 Tampere, Finland
    J Physiol 571:319-27. 2006
    ..These results suggest that the loss of function of cytosolic CA II in the stomach of Car2-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium...
  9. doi request reprint Carbonic anhydrases in the mouse harderian gland
    Pei wen Pan
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520 Tampere, Finland
    J Mol Histol 41:411-7. 2010
    ..The high expression of mitochondrial CAVB at both mRNA and protein levels suggests a role in lipid synthesis, a key physiological process of the harderian gland...
  10. doi request reprint Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases
    Fatemeh Bootorabi
    Institute of Biomedical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Enzyme Inhib Med Chem 26:862-70. 2011
    ..The present study provides the first evidence that acetaldehyde can bind to several cytosolic CA isozymes. The functional consequences of such modifications will be further investigated in vivo by using animal models...
  11. pmc The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis
    Kristiina Nordfors
    Department of Pathology, Tampere University Hospital, Tampere, Finland
    BMC Cancer 10:148. 2010
    ....
  12. ncbi request reprint Gastric pit cell hyperplasia and glandular atrophy in carbonic anhydrase IX knockout mice: studies on two strains C57/BL6 and BALB/C
    Mari Leppilampi
    Department of Clinical Chemistry, University of Oulu, P O Box 5000, FIN 90014 Oulu, Finland
    Transgenic Res 14:655-63. 2005
    ..The findings suggest that although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach...
  13. pmc The most recently discovered carbonic anhydrase, CA XV, is expressed in the thick ascending limb of Henle and in the collecting ducts of mouse kidney
    Sina Saari
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    PLoS ONE 5:e9624. 2010
    ..CA XV is a unique isozyme among mammalian CAs, because it has become a pseudogene in primates even though expressed in several other species...
  14. pmc Expression of iron-related genes in human brain and brain tumors
    Milla M Hänninen
    Institute of Medical Technology and School of Medicine, University of Tampere, Tampere University Hospital, Tampere, Finland
    BMC Neurosci 10:36. 2009
    ..The specimens included 5 normal brain tissue samples, 4 meningiomas, one medulloblastoma, 3 oligodendrocytic gliomas, 2 oligoastrocytic gliomas, 8 astrocytic gliomas, and 3 astrocytoma cell lines...
  15. pmc Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach
    Heini Kallio
    Institute of Medical Technology and School of Medicine, University of Tampere, Biokatu 6, FI 33520 Tampere, Finland
    BMC Genomics 11:397. 2010
    ..This was done using Illumina SentrixMouse-6 Expression BeadChip arrays. The expression of several genes with notable fold change values was confirmed by QRT-PCR...
  16. doi request reprint Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV
    Mika Hilvo
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, FI 33520, Tampere, Finland
    J Med Chem 52:646-54. 2009
    ..Due to the presence of this enzyme in rather high amounts in the rodent kidneys, the contribution of this isoform to the overall drug response should be taken into account when animal models are used to investigate CA inhibitors...
  17. doi request reprint The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms
    Seppo Parkkila
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Bioorg Med Chem Lett 19:4102-6. 2009
    ..4-20.2microM). In cancer cells, these inhibitors may interact with CAs in addition to the targets for which they were designed, the PTKs...
  18. pmc A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system
    Pei wen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33520, Tampere, Finland
    BMC Mol Biol 8:22. 2007
    ..In the present study, we systematically examined the mRNA expression levels of all known CA isozymes by quantitative real-time PCR in eight tissues of the digestive system of male and female mice...
  19. doi request reprint Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme
    Fatemeh Bootorabi
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33014 Tampere, Finland
    Biochimie 92:1072-80. 2010
    ..In addition to the brain, CA VII is expressed in several other organs including the stomach, duodenum, colon, liver, and skeletal muscle. The distribution pattern suggests multiple functions for CA VII in different organs...
  20. doi request reprint Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes
    Mika Hilvo
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, FI 33014 Tampere, Finland
    J Biol Chem 283:27799-809. 2008
    ..This study provides novel information on the biochemical properties of CA IX and may help characterize the various cellular and pathophysiological processes in which this unique enzyme is involved...
  21. pmc Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum
    Alejandra Rodriguez
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    PLoS ONE 4:e7212. 2009
    ..In conclusion, Hfe deficiency caused a previously unrecognized increase in gene expression of hepatic acute phase proteins and duodenal digestive enzymes...
  22. pmc Carbonic anhydrase IX in oligodendroglial brain tumors
    Sally Jarvela
    Department of Pathology, Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
    BMC Cancer 8:1. 2008
    ..Carbonic anhydrase IX is a hypoxia-induced enzyme that has many biologically important functions, including its role in cell adhesion and invasion...
  23. doi request reprint Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease
    Peiwen Pan
    Institute of Biomedical Technology, Fimlab Ltd, School of Medicine and BioMediTech, University of Tampere and Tampere University Hospital, Medisiinarinkatu 3, 33520 Tampere, Finland
    J Med Chem 56:1761-71. 2013
    ..6-93.6 nM. The thiols were the most potent in vitro inhibitors (K(I) values of 21.1-79.0 nM), and some of them also inhibited the epimastigotes growth of two T. cruzi strains in vivo...
  24. doi request reprint Brain phenotype of carbonic anhydrase IX-deficient mice
    Pei wen Pan
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520, Tampere, Finland
    Transgenic Res 21:163-76. 2012
    ..Furthermore, the brain phenotype of Car9 (-/-) mice seems to be age-dependent. The results indicate that the functional changes precede the microscopic alterations in the brains of Car9 (-/-) mice...
  25. doi request reprint Carbonic anhydrases II and XII are up-regulated in osteoclast-like cells in advanced human atherosclerotic plaques-Tampere Vascular Study
    Niku Oksala
    Centre for Laboratory Medicine, Tampere University Hospital and Department of Clinical Chemistry, Medical School, University of Tampere, Tampere, Finland
    Ann Med 42:360-70. 2010
    ..According to previous histochemical studies, advanced atherosclerotic plaques share similarities with bone. However, whether CAs are expressed in plaques is not known...
  26. pmc Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors
    Sally Jarvela
    Department of Pathology, Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
    BMC Cancer 10:104. 2010
    ..Peroxiredoxins (Prxs) have recently been suggested to have a role in tumorigenesis...
  27. pmc Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates
    Leo Syrjänen
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Finland
    BMC Biochem 11:28. 2010
    ..g., Drosophila melanogaster...
  28. pmc Expression of carbonic anhydrases IX and XII during mouse embryonic development
    Heini Kallio
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 8, FIN 33520 Tampere, Finland
    BMC Dev Biol 6:22. 2006
    ..Since active cell migration is a characteristic feature of embryonic development, we set out to explore whether these isozymes are expressed in mouse embryos of different ages. The studies were focused on organogenesis stage...
  29. doi request reprint Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice
    Pei wen Pan
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520, Tampere, Finland
    Transgenic Res 20:675-98. 2011
    ....
  30. ncbi request reprint Hereditary hemochromatosis gene (HFE) mutations C282Y, H63D and S65C in patients with idiopathic dilated cardiomyopathy
    Jokke Hannuksela
    Department of Clinical Chemistry, University of Oulu, P O Box 5000, Oulu, Finland
    Eur J Heart Fail 7:103-8. 2005
    ..Hence we set out here to evaluate the prevalence and potential role of HFE mutations in patients with IDCM...
  31. ncbi request reprint Membrane-bound carbonic anhydrases in osteoclasts
    Riikka Riihonen
    Bone Biology Research Consortium, Department of Anatomy, Institute of Biomedicine, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Bone 40:1021-31. 2007
    ..In addition, the inhibitor experiments provide novel evidence to support the hypothesis that intracellular pH regulation in osteoclasts may indeed involve transport metabolons...
  32. pmc Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins
    Heini Kallio
    Institute of Biomedical Technology, University of Tampere, Tampere, Finland
    PLoS ONE 6:e27152. 2011
    ..These studies provide ample evidence that the current name, "non-specific cytotoxic cell receptor protein 1," is not appropriate. We therefore propose that the gene name be changed to FBXO50...
  33. pmc Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs
    Piritta Hynninen
    Department of Gynecology and Obstetrics, University of Tampere and Tampere University Hospital, Tampere, Finland
    Reprod Biol Endocrinol 2:73. 2004
    ..The twelve active CA isozymes are thought to regulate a variety of cellular functions including several processes in the reproductive systems...
  34. pmc Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2
    Mari Leppilampi
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, FI 33520 Tampere, Finland
    Proc Natl Acad Sci U S A 102:15247-52. 2005
    ..Our data demonstrate a gastrointestinal phenotypic abnormality associated with CA II deficiency. The results show that the stimulatory effect of the duodenal secretagogue PGE2 completely depends on CA II...
  35. pmc Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase
    Mika Hilvo
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, 33520 Tampere, Finland
    Biochem J 392:83-92. 2005
    ..Both specific and non-specific chaperones increase the production of active enzyme. The results suggest that CA XV is the first member of the alpha-CA gene family that is expressed in several species, but not in humans and chimpanzees...
  36. ncbi request reprint Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin
    Alejandra Rodriguez Martinez
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Haematologica 89:1441-5. 2004
    ..A previous report based on Northern blotting showed human HJV mRNA expression only in the skeletal muscle, liver and heart...
  37. ncbi request reprint Expression of carbonic anhydrase IX in mouse tissues
    Mika Hilvo
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520 Tampere, Finland
    J Histochem Cytochem 52:1313-22. 2004
    ..This result suggests a tight tissue-specific post-transcriptional control for CA IX expression, possibly related to the physiological demands...
  38. pmc Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity
    Fatemeh Bootorabi
    Institute of Medical Technology, Tampere University Hospital, 33520 Tampere, Finland
    BMC Biochem 9:32. 2008
    ....
  39. ncbi request reprint Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV
    Mika Hilvo
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, University of Tampere, Finland
    Curr Top Med Chem 7:893-9. 2007
    ..A detailed biochemical characterization of this isozyme is under way in our laboratories...
  40. ncbi request reprint Carbonic anhydrase isozymes IX and XII in gastric tumors
    Mari Leppilampi
    Department of Clinical Chemistry, P O Box 5000, FIN 90014 University of Oulu, Finland
    World J Gastroenterol 9:1398-403. 2003
    ..To systematically study the expression of carbonic anhydrase (CA) isozymes IX and XII in gastric tumors...
  41. ncbi request reprint Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design
    Jonna M Lehtonen
    Institute of Medical Technology, University of Tampere, and Tampere University Hospital, Biokatu 6, 33520 Tampere, Finland
    Bioorg Med Chem Lett 14:3757-62. 2004
    ....
  42. ncbi request reprint Expression of hypoxia-inducible, membrane-bound carbonic anhydrase isozyme XII in mouse tissues
    Piia Halmi
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Anat Rec A Discov Mol Cell Evol Biol 277:171-7. 2004
    ..However, the present findings demonstrated that CA XII has a very limited distribution in mouse tissues outside these two organs...
  43. ncbi request reprint Clinical utility and outcome of HFE-genotyping in the search for hereditary hemochromatosis
    Jokke Hannuksela
    Department of Clinical Chemistry, P O Box 5000, 90014 University of Oulu, Oulu, Finland
    Clin Chim Acta 331:61-7. 2003
    ..The gene mutated in this disorder is termed HFE. The present study was designed to evaluate the diagnostic utility and outcome of genetic testing for HH in the service of public health care...
  44. ncbi request reprint Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family
    Jonna Lehtonen
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    J Biol Chem 279:2719-27. 2004
    ..In conclusion, the predicted amino acid sequence, structural model, distribution, and activity data suggest that CA XIII represents a novel enzyme, which may play important physiological roles in several organs...
  45. ncbi request reprint Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines
    Seppo Parkkila
    Institute of Medical Technology, University of Tampere, Tampere University Hospital, Biokatu 6, 33520 Tampere, Finland
    Bioorg Med Chem Lett 16:3955-9. 2006
    ....
  46. pmc The expression patterns of gremlin 1 and noggin in normal adult and tumor tissues
    Riikka Laurila
    Institute of Biomedical Technology, University of Tampere and BioMediTech, Tampere, Finland
    Int J Clin Exp Pathol 6:1400-8. 2013
    ..Even though gremlin 1 and noggin were not widely expressed in adult tissues, in a subset of organs their expression pattern indicated a potential role in normal tissue homeostasis as well as in malignancies. ..
  47. pmc Phylogeny and expression of carbonic anhydrase-related proteins
    Ashok Aspatwar
    Bioinformatics Group, Institute of Medical Technology, 33014 University of Tampere, Tampere, Finland
    BMC Mol Biol 11:25. 2010
    ....
  48. ncbi request reprint Carbonic anhydrase related protein VIII and its role in neurodegeneration and cancer
    Ashok Aspatwar
    University of Tampere School of Medicine, B Building, University of Tampere, Tampere, Finland
    Curr Pharm Des 16:3264-76. 2010
    ..The present review article describes the previous data on CARP VIII, including its structure, role in neurodegeneration and cancer; and bioinformatic and expression analyses recently performed in our laboratory...
  49. doi request reprint Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases
    Seppo Parkkila
    BioMediTech and School of Medicine, University of Tampere, and Tampere University Hospital, Tampere, Finland
    Chem Commun (Camb) 48:3551-3. 2012
    ....
  50. ncbi request reprint Expression of carbonic anhydrases II, IV, VII, VIII and XII in rat brain after kainic acid induced status epilepticus
    Piia Halmi
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33521 Tampere, Finland
    Neurochem Int 48:24-30. 2006
    ..Cytosolic CA II is known to participate in CSF secretion, and the high expression of CA XII in the choroid plexus suggests an analogous role for this membrane-bound isozyme...
  51. ncbi request reprint Expression studies of neogenin and its ligand hemojuvelin in mouse tissues
    Alejandra Rodriguez
    Institute of Medical Technology, University of Tampere, Biokatu 6 FIN 33520, Tampere, Finland
    J Histochem Cytochem 55:85-96. 2007
    ..Moreover, Hjv and Neo1 mRNAs are simultaneously expressed in skeletal muscle, heart, esophagus, and liver...
  52. doi request reprint The effects of storage time and sampling season on the stability of serum 25-hydroxy vitamin D and androstenedione
    Calypse Agborsangaya
    University of Tampere, Tampere, Finland
    Nutr Cancer 62:51-7. 2010
    ..Stored serum samples can be used to study disease associations with both hormones. However, sampling season needs to be taken into account for 25-OHD by considering matching and stratification and, if possible, serial sampling...
  53. doi request reprint Carbonic anhydrase related proteins: molecular biology and evolution
    Ashok Aspatwar
    Institute of Biomedical Technology and School of Medicine, University of Tampere and BioMediTech, Tampere, Finland
    Subcell Biochem 75:135-56. 2014
    ..The findings so far suggest many novel functions for the CARP subfamily, most likely related to binding to other proteins. ..
  54. doi request reprint Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease
    Peiwen Pan
    Institute of Biomedical Technology, Fimlab Ltd, School of Medicine and BioMediTech, University of Tampere and Tampere University Hospital, Medisiinarinkatu 3, 33520 Tampere, Finland
    Bioorg Med Chem 21:4472-6. 2013
    ....
  55. ncbi request reprint Human platelets express hemochromatosis protein (HFE) and transferrin receptor 2
    Jokke Hannuksela
    Department of Clinical Chemistry, University of Oulu, Oulu, Finland
    Eur J Haematol 70:201-6. 2003
    ..HFE, the protein defective in hereditary hemochromatosis, and transferrin receptor 2 (TfR2) are two novel protein candidates that could be involved in mechanisms of iron transport across the platelet plasma membrane...
  56. doi request reprint Novel carbonic anhydrase autoantibodies and renal manifestations in patients with primary Sjogren's syndrome
    Marja Pertovaara
    Department of Internal Medicine, Rheumatology Centre, Tampere University Hospital, Tampere, Finland
    Rheumatology (Oxford) 50:1453-7. 2011
    ..Recently, several novel CA isoenzymes have been recognized and we aimed to investigate whether antibodies to these are associated with renal manifestations of pSS...
  57. ncbi request reprint Generation of protein adducts with malondialdehyde and acetaldehyde in muscles with predominantly type I or type II fibers in rats exposed to ethanol and the acetaldehyde dehydrogenase inhibitor cyanamide
    Onni Niemela
    Department of Clinical Chemistry, Anatomy and Cell Biology, University of Oulu, Oulu, Finland
    Am J Clin Nutr 76:668-74. 2002
    ..Alcoholic myopathy is known to primarily affect type II muscle fibers (glycolytic, fast-twitch, anaerobic), whereas type I fibers (oxidative, slow-twitch, aerobic) are relatively protected...
  58. ncbi request reprint Prevalence of HFE genotypes, C282Y and H63D, in patients with hematologic disorders
    Jokke Hannuksela
    Department of Clinical Chemistry, University of Oulu, Finland
    Haematologica 87:131-5. 2002
    ..Since HFE gene mutations have recently been implicated in unbalanced iron homeostasis, we set out to examine the prevalence of these mutations in patients with hematologic disorders...
  59. doi request reprint An update on carbonic anhydrase-related proteins VIII, X and XI
    Ashok Aspatwar
    University of Tampere, Institute of Biomedical Technology, Tampere, Finland
    J Enzyme Inhib Med Chem 28:1129-42. 2013
    ..Detailed analysis of CARPs is in progress in our laboratory to understand their role in normal physiology. We present a review of literature on CARPs and present some novel data on CARPs obtained in our laboratory. ..
  60. doi request reprint Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development
    Emma Leena Alarmo
    Institute of Biomedical Technology, University of Tampere and BioMediTech, Tampere, Finland
    Mod Pathol 26:10-21. 2013
    ..This role is biphasic in breast cancer as BMP4 expression is linked to reduced proliferation and increased recurrence, thus corroborating our previous in-vitro functional data...
  61. doi request reprint Serum 25-hydroxyvitamin D at pregnancy and risk of breast cancer in a prospective study
    Calypse B Agborsangaya
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Eur J Cancer 46:467-70. 2010
    ..In a longitudinal study, we evaluated the association between vitamin D levels at pregnancy over time with the risk of breast cancer, and pregnancy-associated breast cancer...
  62. ncbi request reprint Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma
    Adrian Chrastina
    Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Int J Cancer 105:873-81. 2003
    ..Specificity of M75 localization was confirmed by low tumor uptake of control antibody. Altogether, our data demonstrate that M75 MAb is a promising tool for selective immunotargeting of hypoxic human tumors that express CA IX...
  63. ncbi request reprint Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9
    Marta Ortova Gut
    Department of Molecular Genetics, Institute of Molecular Pharmacology and Medical Center of Free University of Berlin, Germany
    Gastroenterology 123:1889-903. 2002
    ..It is normally present in basolateral membranes of gastrointestinal epithelial cells and ectopically expressed in various carcinomas. To show its physiologic relevance, we have cloned the Car9 gene and generated CA IX-deficient mice...
  64. ncbi request reprint Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2
    Maria Bartosova
    Department of Molecular Biology, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    J Pathol 197:314-21. 2002
    ..02). No significant association was found with the other markers. The results of this study support the possible importance of CA IX for breast carcinogenesis and suggest its potential use as a breast tumour marker...
  65. ncbi request reprint Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification
    Kari Kaunisto
    Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland
    Kidney Int 61:2111-8. 2002
    ..Although CA XIV mRNA has been demonstrated in mouse and human kidney, the localization of this newly discovered CA has not been established...
  66. ncbi request reprint Localization of carbonic anhydrase XII to the basolateral membrane of H+-secreting cells of mouse and rat kidney
    Matti S Kyllönen
    Departments of Anatomy and Cell Biology, University of Oulu, Oulu, Finland
    J Histochem Cytochem 51:1217-24. 2003
    ..The localization of CA XII in the peritubular space of proximal tubules suggests that it may play a role in renal HCO(3)(-) absorption, whereas the function of CA XII in the type A intercalated cells needs further investigation...
  67. ncbi request reprint Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX
    Miriam Zat'ovicová
    Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 845 05, Bratislava, Slovak Republic
    J Immunol Methods 282:117-34. 2003
    ....
  68. doi request reprint Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates
    Alessio Innocenti
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino, Firenze, Italy
    Bioorg Med Chem Lett 18:2267-71. 2008
    ..CA XIII was the most effective esterase and phosphatase. CA XIII might catalyze other physiological reactions than CO(2) hydration, based on its relevant phosphatase activity...
  69. doi request reprint Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols
    Alessio Innocenti
    Universita degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, 50019 Sesto Fiorentino Florence, Italy
    Bioorg Med Chem Lett 18:3593-6. 2008
    ..Phenols show a different inhibition mechanism as compared to sulfonamides and their isosteres, and may lead to the design of compounds with selectivity for inhibiting different CA isozymes with medicinal chemistry applications...
  70. ncbi request reprint Expression of membrane-bound carbonic anhydrases IV, IX, and XIV in the mouse heart
    Renate J Scheibe
    Zentrum Physiologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Histochem Cytochem 54:1379-91. 2006
    ..Therefore, the unique subcellular localization of CA IX and CA XIV in cardiac myocytes suggests different functions of both enzymes in excitation-contraction coupling...
  71. ncbi request reprint Key promoter elements involved in transcriptional activation of the cancer-related gene coding for S100P calcium-binding protein
    Adriana Gibadulinova
    Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia
    Oncol Rep 20:391-6. 2008
    ..This study represents the first coherent contribution to understanding of factors and pathways responsible for S100P gene activation in cancer...
  72. doi request reprint Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX
    Alessio Innocenti
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Room 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    Bioorg Med Chem Lett 18:1898-903. 2008
    ....
  73. ncbi request reprint Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa
    Antti J Kivela
    Department of Anatomy and Cell Biology, University of Oulu, Finland
    World J Gastroenterol 11:2616-25. 2005
    ..To analyze possible relationships between CA IX/CA XII and pVHL expression in normal and neoplastic colorectal mucosa...
  74. ncbi request reprint A distinct carbonic anhydrase in the mucus of the colon of humans and other mammals
    Tanja Kleinke
    Zentrum Physiologie, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    J Exp Biol 208:487-96. 2005
    ..The results obtained for mucus CA of other species collectively point in the same direction...
  75. ncbi request reprint Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer
    Anssi M Niemelä
    Department of Surgery, Jyvaskyla Central Hospital, Keskussairaalantie 19, 40620 Jyvaskyla, Finland
    Cancer Epidemiol Biomarkers Prev 16:1760-6. 2007
    ..Our results show that CAs are differentially expressed in the subgroups of colorectal cancer, and CA IX expression seems to be very high in most cases of HNPCC. CA IX could be a potential diagnostic and therapeutic target in HNPCC...
  76. ncbi request reprint Carbonic anhydrases: current state of the art, therapeutic applications and future prospects
    Silvia Pastorekova
    Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 842 45 Bratislava, Slovak Republic
    J Enzyme Inhib Med Chem 19:199-229. 2004
    ..e., CA I, II, III and IV. The possible physiological relevance of CA activation/inhibition is also addressed, together with recent pharmacological/ biomedical applications of such compounds in different fields of life sciences...
  77. ncbi request reprint Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions
    Alessio Innocenti
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Florence, Italy
    Bioorg Med Chem Lett 14:5435-9. 2004
    ....
  78. ncbi request reprint The cytoprotective effect of alpha-tocopherol and daidzein against d-galactosamine-induced oxidative damage in the rat liver
    Max C Y Wong
    Nutritional Sciences Research Division, King s College London, SE1 9NH London, UK
    Metabolism 56:865-75. 2007
    ..05), and both lobular (P < .05) and portal (P = .05) inflammations were significantly ameliorated. To conclude, both daidzein and ATC protect the liver against oxidative damage possibly via different pathways...
  79. ncbi request reprint Pathogenesis of hereditary hemochromatosis: genetics and beyond
    Robert S Britton
    Department of Internal Medicine, Saint Louis University School of Medicine, Mo 63110 0250, USA
    Semin Gastrointest Dis 13:68-79. 2002
    ..Future investigations will refine our knowledge of the mechanisms of action of HFE protein, the phenotypic variability observed in persons homozygous for the C282Y mutation, and the mechanisms responsible for non-HFE-related HH...
  80. doi request reprint Demonstration of ethanol-induced protein adducts in oral leukoplakia (pre-cancer) and cancer
    Saman Warnakulasuriya
    Department of Oral Medicine, King s College London Dental Institute at Guy s, King s and St Thomas Hospitals, WHO Collaborating Centre for Oral Cancer and Precancer, London, UK
    J Oral Pathol Med 37:157-65. 2008
    ..Excessive alcohol consumption is a common cause for upper gastrointestinal tract cancers. However, the primary mechanisms of alcohol-induced carcinogenesis have remained poorly defined...
  81. ncbi request reprint Hypoxia-inducible expression of the mouse carbonic anhydrase IX demonstrated by new monoclonal antibodies
    Martina Takacova
    Institute of Virology, Centre of Molecular Medicine, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic
    Int J Oncol 31:1103-10. 2007
    ..The new monoclonal antibodies represent potent tools for accomplishment of these future studies...
  82. ncbi request reprint The expression of carbonic anhydrase II in hematological malignancies
    Mari Leppilampi
    Departments of Anatomy and Cell Biology, Clinical Chemistry, University of Oulu, 90220 Oulu, Finland
    Clin Cancer Res 8:2240-5. 2002
    ..Recent studies have shown that they are functionally involved in the growth and invasion of cancer cells. However, there are only a few publications on CAs in hematological malignancies...
  83. ncbi request reprint Tumor-associated carbonic anhydrases and their clinical significance
    Silvia Pastorekova
    Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic
    Adv Clin Chem 42:167-216. 2006
    ..Here we summarize a current knowledge on CA IX and CA XII, and discuss possibilities of their exploitation for cancer detection, diagnostics, and therapy...
  84. ncbi request reprint Effect of Kupffer cell inactivation on ethanol-induced protein adducts in the liver
    Onni Niemela
    Laboratory Medicine, EP Central Hospital, Seinajoki, Finland
    Free Radic Biol Med 33:350-5. 2002
    ..The data indicates that Kupffer cells are involved in the generation of protein adducts with both acetaldehyde and ethanol-induced lipid peroxidation products in alcoholic liver disease...
  85. ncbi request reprint Recent advances in alcohol-induced adduct formation
    Thomas L Freeman
    University of Nebraska Medical Center and the Veterans Administration Medical Center, Omaha, Nebraska, USA
    Alcohol Clin Exp Res 29:1310-6. 2005
  86. ncbi request reprint Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours
    Antti J Kivela
    Department of Anatomy and Cell Biology, University of Oulu, Finland
    World J Gastroenterol 11:155-63. 2005
    ..They are induced by tumour hypoxia and may also play a role in von Hippel-Lindau (VHL)-mediated carcinogenesis...
  87. ncbi request reprint Salivary carbonic anhydrase VI and its relation to salivary flow rate and buffer capacity in pregnant and non-pregnant women
    Jyrki Kivela
    Department of Anatomy and Cell Biology, University of Oulu, FIN 90014 Oulu, Finland
    Arch Oral Biol 48:547-51. 2003
    ..Since estrogens and androgens are known to regulate CA expression in some tissues, we studied here whether salivary CA VI concentration shows pregnancy-related changes...
  88. pmc Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig
    Charles H Halsted
    Department of Internal Medicine, School of Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 99:10072-7. 2002
    ..Steatohepatitis occurred in five of six pigs in FDE but not in the other groups. In summary, folate deficiency enhances perturbations in hepatic methionine metabolism and DNA damage while promoting alcoholic liver injury...